Recent Advances in Chemical Biology of Mitochondria Targeting

Pentacyclic triterpene acid conjugated with mitochondria-targeting cation F16: Synthesis and evaluation of cytotoxic activities

(2021) Anna Yu. Spivak et al.   MEDICINAL CHEMISTRY RESEARCH

Smart Design of Nanomaterials for Mitochondria-Targeted Nanotherapeutics

(2020) Shao Q. Yao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Triphenylphosphonium (TPP)‐Based Antioxidants: A New Perspective on Antioxidant Design

(2020) Jiayao Y. Wang et al.   ChemMedChem

Strategies for fighting mitochondrial diseases

(2020) Carlo Viscomi et al.   JOURNAL OF INTERNAL MEDICINE

The special considerations of gene therapy for mitochondrial diseases

(2020) Jesse Slone et al.   npj Genomic Medicine

Sulfenic Acid-Mediated on-Site-Specific Immobilization of Mitochondrial-Targeted NIR Fluorescent Probe for Prolonged Tumor Imaging

(2020) Yinjia Gao et al.   ANALYTICAL CHEMISTRY

Mitochondrial structure-inspired high specific surface area polymer microspheres by encapsulating modified graphene oxide nanosheets

(2020) Lei Zhang et al.   EUROPEAN POLYMER JOURNAL

Targeting mitochondrial metabolite transporters in Penicillium expansum for reducing patulin production

(2020) Vincenzo Tragni et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

Urupocidin C: a new marine guanidine alkaloid which selectively kills prostate cancer cells via mitochondria targeting

(2020) Sergey A. Dyshlovoy et al.   Scientific Reports

Mitochondrial pathways in human health and aging

(2020) Rebecca Bornstein et al.   MITOCHONDRION

Quality-control mechanisms targeting translationally stalled and C-terminally extended poly(GR) associated with ALS/FTD

(2020) Shuangxi Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma

(2019) Yufeng Shi et al.   NATURE

Plant-derived mitochondria-targeting cysteine-rich peptide modulates cellular bioenergetics

(2019) Antony Kam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Off–On Two-Photon Carbazole-Based Fluorescent Probe: Highly Targeting and Super-Resolution Imaging of mtDNA

(2019) Fengli Gao et al.   ANALYTICAL CHEMISTRY

Fluorescent Probes for Nanoscopic Imaging of Mitochondria

(2019) Soham Samanta et al.   Chem

A Mitochondrial Approach to Cardiovascular Risk and Disease

(2019) Caroline D. Veloso et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Mitochondrion-Targeting Peptides and Peptidomimetics: Recent Progress and Design Principles

(2019) Soyoung Kim et al.   BIOCHEMISTRY

Leberʼsche hereditäre Optikusneuropathie

(2019) Claudia Priglinger et al.   KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE

Development and Application of Sub-Mitochondrial Targeted Ca2 + Biosensors

(2019) Markus Waldeck-Weiermair et al.   Frontiers in Cellular Neuroscience

Somatic mitochondrial mutation discovery using ultra-deep sequencing of the mitochondrial genome reveals spatial tumor heterogeneity in head and neck squamous cell carcinoma

(2019) Adrian D. Schubert et al.   CANCER LETTERS

Autonomic dysfunction in Parkinson’s disease: Implications for pathophysiology, diagnosis, and treatment

(2019) Zhichun Chen et al.   NEUROBIOLOGY OF DISEASE

Recent Progress in Mitochondria-Targeted Drug and Drug-Free Agents for Cancer Therapy

(2019) M.T. Jeena et al.   Cancers

Overcoming Multidrug Resistance through the GLUT1-Mediated and Enzyme-Triggered Mitochondrial Targeting Conjugate with Redox-Sensitive Paclitaxel Release

(2018) Pengkai Ma et al.   ACS Applied Materials & Interfaces

Mitochondrial membrane potential

(2018) Ljubava D. Zorova et al.   ANALYTICAL BIOCHEMISTRY

Targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance

(2018) Hai Wang et al.   Nature Communications

A review of the basics of mitochondrial bioenergetics, metabolism, and related signaling pathways in cancer cells: Therapeutic targeting of tumor mitochondria with lipophilic cationic compounds

(2018) Balaraman Kalyanaraman et al.   Redox Biology

Mitochondrial-targeted penetrating peptide delivery for cancer therapy

(2018) Jiao Wu et al.   Expert Opinion on Drug Delivery

Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo

(2018) Payam A. Gammage et al.   NATURE MEDICINE

Mitochondria as a therapeutic target for common pathologies

(2018) Michael P. Murphy et al.   NATURE REVIEWS DRUG DISCOVERY

TPGS-chitosan cross-linked targeted nanoparticles for effective brain cancer therapy

(2017) Poornima Agrawal et al.   Materials Science & Engineering C-Materials for Biological Applications

Carbon quantum dots with intrinsic mitochondrial targeting ability for mitochondria-based theranostics

(2017) Xian-Wu Hua et al.   Nanoscale

Mitochondrial-targeted multifunctional mesoporous Au@Pt nanoparticles for dual-mode photodynamic and photothermal therapy of cancers

(2017) Yang Song et al.   Nanoscale

Anti-cancer effects of F16: A novel vascular endothelial growth factor receptor–specific inhibitor

(2017) Appu Rathinavelu et al.   TUMOR BIOLOGY

Targeting cancer cell metabolism with mitochondria-immobilized phosphorescent cyclometalated iridium(iii) complexes

(2017) Jian-Jun Cao et al.   Chemical Science

Nanopreparations for mitochondria targeting drug delivery system: Current strategies and future prospective

(2017) Zhenjie Wang et al.   Asian Journal of Pharmaceutical Sciences

Oxoaporphine Metal Complexes (CoII, NiII, ZnII) with High Antitumor Activity by Inducing Mitochondria-Mediated Apoptosis and S-phase Arrest in HepG2

(2017) Jiao-Lan Qin et al.   Scientific Reports

More about interactions of rhodamine 19 butyl ester with rat liver mitochondria

(2016) A. G. Rogov et al.   BIOCHEMISTRY-MOSCOW

Self-Assembled Peptide-Based System for Mitochondrial-Targeted Gene Delivery: Functional and Structural Insights

(2016) Jo-Ann Chuah et al.   BIOMACROMOLECULES

Metal complexes for the detection of disease-related protein biomarkers

(2016) Dik-Lung Ma et al.   COORDINATION CHEMISTRY REVIEWS

Mitochondria-targeted dodecyltriphenylphosphonium (C12TPP) combats high-fat-diet-induced obesity in mice

(2016) A V Kalinovich et al.   INTERNATIONAL JOURNAL OF OBESITY

Mitochondrial dysfunction in Parkinson's disease

(2016) Anindita Bose et al.   JOURNAL OF NEUROCHEMISTRY

A graphene oxide based smart drug delivery system for tumor mitochondria-targeting photodynamic therapy

(2016) Yanchun Wei et al.   Nanoscale

Identification and Characterization of Roseltide, a Knottin-type Neutrophil Elastase Inhibitor Derived from Hibiscus sabdariffa

(2016) Shining Loo et al.   Scientific Reports

Luminescent Rhenium(I) and Iridium(III) Polypyridine Complexes as Biological Probes, Imaging Reagents, and Photocytotoxic Agents

(2015) Kenneth Kam-Wing Lo   ACCOUNTS OF CHEMICAL RESEARCH

Anticancer Gold(III) Porphyrins Target Mitochondrial Chaperone Hsp60

(2015) Di Hu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hierarchical targeted hepatocyte mitochondrial multifunctional chitosan nanoparticles for anticancer drug delivery

(2015) Zhipeng Chen et al.   BIOMATERIALS

Ruthenium(II) polypyridyl complexes as mitochondria-targeted two-photon photodynamic anticancer agents

(2015) Jiangping Liu et al.   BIOMATERIALS

Intracellular delivery of nanocarriers and targeting to subcellular organelles

(2015) Aditi Jhaveri et al.   Expert Opinion on Drug Delivery

A Perspective on Transport of Proteins into Mitochondria: A Myriad of Open Questions

(2015) Walter Neupert   JOURNAL OF MOLECULAR BIOLOGY

Enhanced NIR Radiation-Triggered Hyperthermia by Mitochondrial Targeting

(2015) Hyo Sung Jung et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mitochondrial dysfunction in schizophrenia: Pathways, mechanisms and implications

(2015) Ashwini Rajasekaran et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

The energy blocker inside the power house: mitochondria targeted delivery of 3-bromopyruvate

(2015) Sean Marrache et al.   Chemical Science

Mitochondria-Localized Fluorescent BODIPY-Platinum Conjugate

(2015) Tingting Sun et al.   ACS Medicinal Chemistry Letters

A novel bifunctional mitochondria-targeted anticancer agent with high selectivity for cancer cells

(2015) Huan He et al.   Scientific Reports

Dual subcellular compartment delivery of doxorubicin to overcome drug resistant and enhance antitumor activity

(2015) Yan-feng Song et al.   Scientific Reports

Mitochondria in lung biology and pathology: more than just a powerhouse

(2014) Paul T. Schumacker et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

A short-chain alkyl derivative of Rhodamine 19 acts as a mild uncoupler of mitochondria and a neuroprotector

(2014) Ljudmila S. Khailova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Imaging of mitochondrial Ca2+ dynamics in astrocytes using cell-specific mitochondria-targeted GCaMP5G/6s: Mitochondrial Ca2+ uptake and cytosolic Ca2+ availability via the endoplasmic reticulum store

(2014) Hailong Li et al.   CELL CALCIUM

Targeted nanoparticles in mitochondrial medicine

(2014) Rakesh K. Pathak et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

A mitochondrion-targeting copper complex exhibits potent cytotoxicity against cisplatin-resistant tumor cells through multiple mechanisms of action

(2014) Wen Zhou et al.   Chemical Science

A mitochondria-targeted fluorescent probe based on TPP-conjugated carbon dots for both one- and two-photon fluorescence cell imaging

(2014) Beibei Wang et al.   RSC Advances

Bioactive Luminescent Transition-Metal Complexes for Biomedical Applications

(2013) Dik-Lung Ma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeting of cytosolic mRNA to mitochondria: Naked RNA can bind to the mitochondrial surface

(2013) Morgane Michaud et al.   BIOCHIMIE

Progress with, and prospects for, metal complexes in cell imaging

(2013) Michael P. Coogan et al.   CHEMICAL COMMUNICATIONS

Structural features within the nascent chain regulate alternative targeting of secretory proteins to mitochondria

(2013) Natalie V Pfeiffer et al.   EMBO JOURNAL

The Mitochondrial-Targeted Compound SS-31 Re-Energizes Ischemic Mitochondria by Interacting with Cardiolipin

(2013) A. V. Birk et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cellular and molecular mechanisms of mitochondrial function

(2012) Laura D. Osellame et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Surface conjugation of triphenylphosphonium to target poly(amidoamine) dendrimers to mitochondria

(2012) Swati Biswas et al.   BIOMATERIALS

PEG-nanolized ultrasmall selenium nanoparticles overcome drug resistance in hepatocellular carcinoma HepG2 cells through induction of mitochondria dysfunction

(2012) Tianfeng Chen et al.   International Journal of Nanomedicine

Liposomes loaded with paclitaxel and modified with novel triphenylphosphonium-PEG-PE conjugate possess low toxicity, target mitochondria and demonstrate enhanced antitumor effects in vitro and in vivo

(2012) Swati Biswas et al.   JOURNAL OF CONTROLLED RELEASE

Localization of mRNAs encoding human mitochondrial oxidative phosphorylation proteins

(2012) Shinya Matsumoto et al.   MITOCHONDRION

Direct Induction of Apoptosis Using an Optimal Mitochondrially Targeted p53

(2012) Mohanad Mossalam et al.   MOLECULAR PHARMACEUTICS

Mitochondrial pharmacology

(2012) Robin A.J. Smith et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

JC-1: alternative excitation wavelengths facilitate mitochondrial membrane potential cytometry

(2012) A Perelman et al.   Cell Death & Disease

De novo designed peptides for biological applications

(2011) Aimee L. Boyle et al.   CHEMICAL SOCIETY REVIEWS

Derivatives of Rhodamine 19 as Mild Mitochondria-targeted Cationic Uncouplers

(2011) Yuri N. Antonenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chiral inorganic nanoparticles: origin, optical properties and bioapplications

(2011) Yunsheng Xia et al.   Nanoscale

The role of mitochondria in insulin resistance and type 2 diabetes mellitus

(2011) Julia Szendroedi et al.   Nature Reviews Endocrinology

Novel Therapies Targeting Inner Mitochondrial Membrane—From Discovery to Clinical Development

(2011) Hazel H. Szeto et al.   PHARMACEUTICAL RESEARCH

Manganese nanoparticle activates mitochondrial dependent apoptotic signaling and autophagy in dopaminergic neuronal cells

(2011) Hilary Afeseh Ngwa et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Biodegradable nanoparticles are excellent vehicle for site directed in-vivo delivery of drugs and vaccines

(2011) Anil Mahapatro et al.   JOURNAL OF NANOBIOTECHNOLOGY

Gold Nanoparticles for Biology and Medicine

(2010) David A. Giljohann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In vitro effects of silver nanoparticles on the mitochondrial respiratory chain

(2010) Cláudio Sérgio Costa et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

New Insights of Transmembranal Mechanism and Subcellular Localization of Noncovalently Modified Single-Walled Carbon Nanotubes

(2010) Feifan Zhou et al.   NANO LETTERS

Clues from cell metabolism

(2010) William G. Kaelin et al.   NATURE

RNA trafficking in plant cells: targeting of cytosolic mRNAs to the mitochondrial surface

(2010) Morgane Michaud et al.   PLANT MOLECULAR BIOLOGY

Mitochondria-Penetrating Peptides: Sequence Effects and Model Cargo Transport

(2009) Lema F. Yousif et al.   CHEMBIOCHEM

Targeting Mitochondria with Organelle-Specific Compounds: Strategies and Applications

(2009) Lema F. Yousif et al.   CHEMBIOCHEM

Properties and emerging applications of self-assembled structures made from inorganic nanoparticles

(2009) Zhihong Nie et al.   Nature Nanotechnology

Targeting lipophilic cations to mitochondria

(2008) Michael P. Murphy   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondria-Penetrating Peptides

(2008) Kristin L. Horton et al.   CHEMISTRY & BIOLOGY

Targeting mitochondrial permeability in cancer drug development

(2008) Michael V. Berridge et al.   MOLECULAR NUTRITION & FOOD RESEARCH