Anticancer Gold(III) Porphyrins Target Mitochondrial Chaperone Hsp60

Induction of Immunogenic Cell Death by Chemotherapeutic Platinum Complexes

(2015) Daniel Yuan Qiang Wong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Crystal structure of the human mitochondrial chaperonin symmetrical football complex

(2015) Shahar Nisemblat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Target profiling of an antimetastatic RAPTA agent by chemical proteomics: relevance to the mode of action

(2015) Maria V. Babak et al.   Chemical Science

Platinum-RNA Modifications Following Drug Treatment in S. cerevisiae Identified by Click Chemistry and Enzymatic Mapping

(2014) Maire F. Osborn et al.   ACS Chemical Biology

A cytotoxic and cytostatic gold(iii) corrole

(2014) Ruijie D. Teo et al.   CHEMICAL COMMUNICATIONS

Metallodrugs in Medicinal Inorganic Chemistry

(2014) Katja Dralle Mjos et al.   CHEMICAL REVIEWS

Metal complexes as structural templates for targeting proteins

(2014) Markus Dörr et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Metal-based anticancer chemotherapeutic agents

(2014) Nafees Muhammad et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

A Breast Cancer Stem Cell-Selective, Mammospheres-Potent Osmium(VI) Nitrido Complex

(2014) Kogularamanan Suntharalingam et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Gold(III) Macrocycles: Nucleotide-Specific Unconventional Catalytic Inhibitors of Human Topoisomerase I

(2014) Kate J. Akerman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The cellular thermal shift assay for evaluating drug target interactions in cells

(2014) Rozbeh Jafari et al.   Nature Protocols

Gold(iii) complexes inhibit growth of cisplatin-resistant ovarian cancer in association with upregulation of proapoptotic PMS2 gene

(2014) Ching Tung Lum et al.   Chemical Science

Using Fluorescent Post-Labeling To Probe the Subcellular Localization of DNA-Targeted Platinum Anticancer Agents

(2013) Song Ding et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Gold(III) Complexes Containing N-Heterocyclic Carbene Ligands: Thiol “Switch-on” Fluorescent Probes and Anti-Cancer Agents

(2013) Taotao Zou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Target Identification for Small Bioactive Molecules: Finding the Needle in the Haystack

(2013) Slava Ziegler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hsp60 chaperonopathies and chaperonotherapy: targets and agents

(2013) Francesco Cappello et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Anticancer Activity of Small-Molecule and Nanoparticulate Arsenic(III) Complexes

(2013) Elden P. Swindell et al.   INORGANIC CHEMISTRY

Potential Anticancer Heterometallic Fe–Au and Fe–Pd Agents: Initial Mechanistic Insights

(2013) Nicholas Lease et al.   JOURNAL OF MEDICINAL CHEMISTRY

Picazoplatin, an Azide-Containing Platinum(II) Derivative for Target Analysis by Click Chemistry

(2013) Jonathan D. White et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

(2013) D. M. Molina et al.   SCIENCE

Latest Insights into the Anticancer Activity of Gold(III)-Dithiocarbamato Complexes

(2012) Luca Ronconi et al.   Anti-Cancer Agents in Medicinal Chemistry

Chemical Proteomics Reveals Heat Shock Protein 60 To Be the Main Cellular Target of the Marine Bioactive Sesterterpene Suvanine

(2012) Chiara Cassiano et al.   CHEMBIOCHEM

A Luminescent Cyclometalated Iridium(III) Complex Accumulates in Mitochondria and Induces Mitochondrial Shortening by Conjugation to Specific Protein Targets

(2012) Baojiang Wang et al.   CHEMBIOCHEM

A gold(iii) porphyrin complex as an anti-cancer candidate to inhibit growth of cancer-stem cells

(2012) Ching Tung Lum et al.   CHEMICAL COMMUNICATIONS

HSP60 as a Drug Target

(2012) Hiroyuki Nakamura et al.   CURRENT PHARMACEUTICAL DESIGN

Therapeutic applications of gold complexes: lipophilic gold(iii) cations and gold(i) complexes for anti-cancer treatment

(2011) Chi-Ming Che et al.   CHEMICAL COMMUNICATIONS

Molecular Mechanisms and Proposed Targets for Selected Anticancer Gold Compounds

(2011) Angela Casini et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Gold compounds as therapeutic agents for human diseases

(2011) Susan J. Berners-Price et al.   Metallomics

One-step synthesis of composite vesicles: Direct polymerization and in situ over-oxidation of thiophene

(2011) Hang Sun et al.   Chemical Science

Hsp60 expression, new locations, functions, and perspectives for cancer diagnosis and therapy

(2010) Francesco Cappello et al.   CANCER BIOLOGY & THERAPY

Heat Shock Protein 60 Regulation of the Mitochondrial Permeability Transition Pore in Tumor Cells

(2010) J. C. Ghosh et al.   CANCER RESEARCH

Cyclometalated gold(iii) complexes with N-heterocyclic carbene ligands as topoisomerase I poisons

(2010) Jessie Jing Yan et al.   CHEMICAL COMMUNICATIONS

Stable Anticancer Gold(III)-Porphyrin Complexes: Effects of Porphyrin Structure

(2010) Raymond Wai-Yin Sun et al.   CHEMISTRY-A EUROPEAN JOURNAL

Organometallic Anticancer Compounds

(2010) Gilles Gasser et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of HSP60 as a Primary Target ofo-Carboranylphenoxyacetanilide, an HIF-1α Inhibitor

(2010) Hyun Seung Ban et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Photoaffinity Labeling Reveals Nuclear Proteins That Uniquely Recognize Cisplatin−DNA Interstrand Cross-Links

(2009) Guangyu Zhu et al.   BIOCHEMISTRY

Inhibition of Akt sensitises neuroblastoma cells to gold(III) porphyrin 1a, a novel antitumour drug induced apoptosis and growth inhibition

(2009) W Li et al.   BRITISH JOURNAL OF CANCER

A Gold(III) Porphyrin Complex with Antitumor Properties Targets the Wnt/ -catenin Pathway

(2009) K. H.-M. Chow et al.   CANCER RESEARCH

On the medicinal chemistry of gold complexes as anticancer drugs

(2009) Ingo Ott   COORDINATION CHEMISTRY REVIEWS

Metal complexes in medicine with a focus on enzyme inhibition

(2009) Chi-Ming Che et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Chemistry, antiproliferative properties, tumor selectivity, and molecular mechanisms of novel gold(III) compounds for cancer treatment: a systematic study

(2009) Angela Casini et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

New trends for metal complexes with anticancer activity

(2008) Pieter CA Bruijnincx et al.   CURRENT OPINION IN CHEMICAL BIOLOGY