Quality-control mechanisms targeting translationally stalled and C-terminally extended poly(GR) associated with ALS/FTD
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Title
Quality-control mechanisms targeting translationally stalled and C-terminally extended poly(GR) associated with ALS/FTD
Authors
Keywords
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Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 117, Issue 40, Pages 25104-25115
Publisher
Proceedings of the National Academy of Sciences
Online
2020-09-22
DOI
10.1073/pnas.2005506117
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Note: Only part of the references are listed.- Altered MICOS Morphology and Mitochondrial Ion Homeostasis Contribute to Poly(GR) Toxicity Associated with C9-ALS/FTD
- (2020) Shuangxi Li et al. Cell Reports
- C9orf72 arginine-rich dipeptide proteins interact with ribosomal proteins in vivo to induce a toxic translational arrest that is rescued by eIF1A
- (2019) Thomas G. Moens et al. ACTA NEUROPATHOLOGICA
- C9ORF72-ALS/FTD-associated poly(GR) binds Atp5a1 and compromises mitochondrial function in vivo
- (2019) So Yoen Choi et al. NATURE NEUROSCIENCE
- Mechanisms and functions of ribosome-associated protein quality control
- (2019) Claudio A. P. Joazeiro NATURE REVIEWS MOLECULAR CELL BIOLOGY
- CAT tails drive degradation of stalled polypeptides on and off the ribosome
- (2019) Cole S. Sitron et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Mechanism for recycling tRNAs on stalled ribosomes
- (2019) Matthew C. J. Yip et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Partial inhibition of the overactivated Ku80-dependent DNA repair pathway rescues neurodegeneration in C9ORF72-ALS/FTD
- (2019) Rodrigo Lopez-Gonzalez et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response
- (2019) Peng Wang et al. PLoS Genetics
- Drosophila Ref1/ALYREF regulates transcription and toxicity associated with ALS/FTD disease etiologies
- (2019) Amit Berson et al. Acta Neuropathologica Communications
- MISTERMINATE Mechanistically Links Mitochondrial Dysfunction with Proteostasis Failure
- (2019) Zhihao Wu et al. MOLECULAR CELL
- Ageing as a risk factor for neurodegenerative disease
- (2019) Yujun Hou et al. Nature Reviews Neurology
- Amyotrophic Lateral Sclerosis-associated GGGGCC repeat expansion promotes Tau phosphorylation and toxicity
- (2019) Hua He et al. NEUROBIOLOGY OF DISEASE
- Physiological, Pathological, and Targetable Membraneless Organelles in Neurons
- (2019) Veronica H. Ryan et al. TRENDS IN NEUROSCIENCES
- Sense and antisense RNA are not toxic in Drosophila models of C9orf72-associated ALS/FTD
- (2018) Thomas G. Moens et al. ACTA NEUROPATHOLOGICA
- Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis
- (2018) Yong-Jie Zhang et al. NATURE MEDICINE
- Insights into C9ORF72 -Related ALS/FTD from Drosophila and iPSC Models
- (2018) Yeliz Yuva-Aydemir et al. TRENDS IN NEUROSCIENCES
- Vms1p is a release factor for the ribosome-associated quality control complex
- (2018) Olga Zurita Rendón et al. Nature Communications
- C9orf72 Dipeptide Repeats Cause Selective Neurodegeneration and Cell-Autonomous Excitotoxicity inDrosophilaGlutamatergic Neurons
- (2018) Wangchao Xu et al. JOURNAL OF NEUROSCIENCE
- Release of Ubiquitinated and Non-ubiquitinated Nascent Chains from Stalled Mammalian Ribosomal Complexes by ANKZF1 and Ptrh1
- (2018) Kazushige Kuroha et al. MOLECULAR CELL
- Vms1 and ANKZF1 peptidyl-tRNA hydrolases release nascent chains from stalled ribosomes
- (2018) Rati Verma et al. NATURE
- C9orf72-mediated ALS and FTD: multiple pathways to disease
- (2018) Rubika Balendra et al. Nature Reviews Neurology
- Homeostatic plasticity can be induced and expressed to restore synaptic strength at neuromuscular junctions undergoing ALS-related degeneration
- (2017) Sarah Perry et al. HUMAN MOLECULAR GENETICS
- Pathways of cellular proteostasis in aging and disease
- (2017) Courtney L. Klaips et al. JOURNAL OF CELL BIOLOGY
- Cytosolic proteostasis through importing of misfolded proteins into mitochondria
- (2017) Linhao Ruan et al. NATURE
- CAT-tailing as a fail-safe mechanism for efficient degradation of stalled nascent polypeptides
- (2017) Kamena K. Kostova et al. SCIENCE
- Disease Mechanisms of C9ORF72 Repeat Expansions
- (2017) Tania F. Gendron et al. Cold Spring Harbor Perspectives in Medicine
- In vitro analysis of RQC activities provides insights into the mechanism and function of CAT tailing
- (2017) Beatriz A Osuna et al. eLife
- C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles
- (2016) Kyung-Ha Lee et al. CELL
- Rqc1 and Ltn1 Prevent C-terminal Alanine-Threonine Tail (CAT-tail)-induced Protein Aggregation by Efficient Recruitment of Cdc48 on Stalled 60S Subunits
- (2016) Quentin Defenouillère et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- OPA1 processing in cell death and disease – the long and short of it
- (2016) Thomas MacVicar et al. JOURNAL OF CELL SCIENCE
- Decoding ALS: from genes to mechanism
- (2016) J. Paul Taylor et al. NATURE
- Failure of RQC machinery causes protein aggregation and proteotoxic stress
- (2016) Young-Jun Choe et al. NATURE
- Ribosome-associated protein quality control
- (2016) Onn Brandman et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Poly(GR) in C9ORF72 -Related ALS/FTD Compromises Mitochondrial Function and Increases Oxidative Stress and DNA Damage in iPSC-Derived Motor Neurons
- (2016) Rodrigo Lopez-Gonzalez et al. NEURON
- Spt4 selectively regulates the expression of C9orf72 sense and antisense mutant transcripts
- (2016) N. J. Kramer et al. SCIENCE
- Engineered AAA+ proteases reveal principles of proteolysis at the mitochondrial inner membrane
- (2016) Hui Shi et al. Nature Communications
- Ribosome-associated protein quality control
- (2016) Onn Brandman et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- The Rqc2/Tae2 subunit of the ribosome-associated quality control (RQC) complex marks ribosome-stalled nascent polypeptide chains for aggregation
- (2016) Ryo Yonashiro et al. eLife
- Gene-specific mitochondria dysfunctions in human TARDBP and C9ORF72 fibroblasts
- (2016) Elisa Onesto et al. Acta Neuropathologica Communications
- Drosophila screen connects nuclear transport genes to DPR pathology in c9ALS/FTD
- (2016) Steven Boeynaems et al. Scientific Reports
- FTD/ALS-associated poly(GR) protein impairs the Notch pathway and is recruited by poly(GA) into cytoplasmic inclusions
- (2015) Dejun Yang et al. ACTA NEUROPATHOLOGICA
- The C9orf72 repeat expansion disrupts nucleocytoplasmic transport
- (2015) Ke Zhang et al. NATURE
- GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport
- (2015) Brian D. Freibaum et al. NATURE
- Differential Toxicity of Nuclear RNA Foci versus Dipeptide Repeat Proteins in a Drosophila Model of C9ORF72 FTD/ALS
- (2015) Helene Tran et al. NEURON
- Localized translation near the mitochondrial outer membrane: An update
- (2015) Chen Lesnik et al. RNA Biology
- Rqc2p and 60S ribosomal subunits mediate mRNA-independent elongation of nascent chains
- (2015) P. S. Shen et al. SCIENCE
- FUS Interacts with HSP60 to Promote Mitochondrial Damage
- (2015) Jianwen Deng et al. PLoS Genetics
- GGGGCC microsatellite RNA is neuritically localized, induces branching defects, and perturbs transport granule function
- (2015) Alondra Schweizer Burguete et al. eLife
- Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration
- (2014) R. Ishimura et al. SCIENCE
- C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins
- (2014) S. Mizielinska et al. SCIENCE
- Roles of PINK1, mTORC2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway
- (2013) K.-S. Lee et al. GENES & DEVELOPMENT
- A Cotranslational Ubiquitination Pathway for Quality Control of Misfolded Proteins
- (2013) Feng Wang et al. MOLECULAR CELL
- Principles of Cotranslational Ubiquitination and Quality Control at the Ribosome
- (2013) Stefanie Duttler et al. MOLECULAR CELL
- Reactivation of stalled polyribosomes in synaptic plasticity
- (2013) T. E. Graber et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Expanded GGGGCC repeat RNA associated with amyotrophic lateral sclerosis and frontotemporal dementia causes neurodegeneration
- (2013) Z. Xu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Multiplex Genome Engineering Using CRISPR/Cas Systems
- (2013) L. Cong et al. SCIENCE
- A Ribosome-Bound Quality Control Complex Triggers Degradation of Nascent Peptides and Signals Translation Stress
- (2012) Onn Brandman et al. CELL
- Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death
- (2012) H. Jo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Production of Ribosome-Released Nascent Proteins with Optimal Physical Properties
- (2010) David R. Ziehr et al. ANALYTICAL CHEMISTRY
- MK-2206, an Allosteric Akt Inhibitor, Enhances Antitumor Efficacy by Standard Chemotherapeutic Agents or Molecular Targeted Drugs In vitro and In vivo
- (2010) H. Hirai et al. MOLECULAR CANCER THERAPEUTICS
- The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
- (2009) Raphael Kopan et al. CELL
- A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration
- (2009) J. Chu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Electrostatics in the Ribosomal Tunnel Modulate Chain Elongation Rates
- (2008) Jianli Lu et al. JOURNAL OF MOLECULAR BIOLOGY
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