Transport mechanisms at the malaria parasite-host cell interface

Malaria parasites use a soluble RhopH complex for erythrocyte invasion and an integral form for nutrient uptake

(2021) Marc A Schureck et al.   eLife

A Kelch13-defined endocytosis pathway mediates artemisinin resistance in malaria parasites

(2020) Jakob Birnbaum et al.   SCIENCE

Coimmunoprecipitation with MYR1 Identifies Three Additional Proteins within the Toxoplasma gondii Parasitophorous Vacuole Required for Translocation of Dense Granule Effectors into Host Cells

(2020) Alicja M. Cygan et al.   mSphere

The Secreted Acid Phosphatase Domain-Containing GRA44 from Toxoplasma gondii Is Required for c-Myc Induction in Infected Cells

(2020) William J. Blakely et al.   mSphere

Endocytosis in Plasmodium and Toxoplasma Parasites

(2020) Tobias Spielmann et al.   TRENDS IN PARASITOLOGY

Contacting domains segregate a lipid transporter from a solute transporter in the malarial host–parasite interface

(2020) Matthias Garten et al.   Nature Communications

Molecular Mechanisms of Drug Resistance in Plasmodium falciparum Malaria

(2020) Kathryn J. Wicht et al.   Annual Review of Microbiology

Live-Cell FRET Reveals that Malaria Nutrient Channel Proteins CLAG3 and RhopH2 Remain Associated throughout Their Tortuous Trafficking

(2020) Moaz Ahmad et al.   mBio

Genome-wide screens identify Toxoplasma gondii determinants of parasite fitness in IFNγ-activated murine macrophages

(2020) Yifan Wang et al.   Nature Communications

Novel Babesia bovis exported proteins that modify properties of infected red blood cells

(2020) Hassan Hakimi et al.   PLoS Pathogens

PV1 Protein from Plasmodium falciparum Exhibits Chaperone-Like Functions and Cooperates with Hsp100s

(2020) Kazuaki Hakamada et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Toxoplasma gondii PPM3C, a secreted protein phosphatase, affects parasitophorous vacuole effector export

(2020) Joshua Mayoral et al.   PLoS Pathogens

Cholesterol bound Plasmodium falciparum co-chaperone ‘PFA0660w’ complexes with major virulence factor ‘PfEMP1’ via chaperone ‘PfHsp70-x’

(2019) Ankita Behl et al.   Scientific Reports

Toxoplasma Controls Host Cyclin E Expression through the Use of a Novel MYR1-Dependent Effector Protein, HCE1

(2019) Michael W. Panas et al.   mBio

Plasmodium Niemann-Pick type C1-related protein is a druggable target required for parasite membrane homeostasis

(2019) Eva S Istvan et al.   eLife

The Toxoplasma effector TEEGR promotes parasite persistence by modulating NF-κB signalling via EZH2

(2019) Laurence Braun et al.   Nature Microbiology

Proteomic Analysis of Plasmodium Merosomes: The Link between Liver and Blood Stages in Malaria

(2019) Melanie J. Shears et al.   JOURNAL OF PROTEOME RESEARCH

Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase

(2019) Alexandrea N. Rizo et al.   Nature Communications

Two-Step Activation Mechanism of the ClpB Disaggregase for Sequential Substrate Threading by the Main ATPase Motor

(2019) Célia Deville et al.   Cell Reports

Translocation of Dense Granule Effectors across the Parasitophorous Vacuole Membrane in Toxoplasma-Infected Cells Requires the Activity of ROP17, a Rhoptry Protein Kinase

(2019) Michael W. Panas et al.   mSphere

Partners in Mischief: Functional Networks of Heat Shock Proteins of Plasmodium falciparum and Their Influence on Parasite Virulence

(2019) Michael O. Daniyan et al.   Biomolecules

EXP1 is critical for nutrient uptake across the parasitophorous vacuole membrane of malaria parasites

(2019) Paolo Mesén-Ramírez et al.   PLOS BIOLOGY

Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins

(2019) Mikael B.L. Winkler et al.   CELL

Translocation of effector proteins into host cells by Toxoplasma gondii

(2019) Suchita Rastogi et al.   CURRENT OPINION IN MICROBIOLOGY

The malaria PTEX component PTEX88 interacts most closely with HSP101 at the host-parasite interface

(2018) Scott A. Chisholm et al.   FEBS Journal

Cholesterol promotes Cytolysin A activity by stabilizing the intermediates during pore formation

(2018) Pradeep Sathyanarayana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasmodium parasite exploits host aquaporin-3 during liver stage malaria infection

(2018) Dora Posfai et al.   PLoS Pathogens

Identification of a novel protein complex essential for effector translocation across the parasitophorous vacuole membrane of Toxoplasma gondii

(2018) Nicole D. Marino et al.   PLoS Pathogens

BioID Reveals Novel Proteins of the Plasmodium Parasitophorous Vacuole Membrane

(2018) Cilly Bernardette Schnider et al.   mSphere

Malaria parasite translocon structure and mechanism of effector export

(2018) Chi-Min Ho et al.   NATURE

Plasmepsin V cleaves malaria effector proteins in a distinct endoplasmic reticulum translocation interactome for export to the erythrocyte

(2018) Danushka S. Marapana et al.   Nature Microbiology

EXP2 is a nutrient-permeable channel in the vacuolar membrane of Plasmodium and is essential for protein export via PTEX

(2018) Matthias Garten et al.   Nature Microbiology

PfVPS45 Is Required for Host Cell Cytosol Uptake by Malaria Blood Stage Parasites

(2018) Ernst Jonscher et al.   Cell Host & Microbe

The N-terminus of EXP2 forms the membrane-associated pore of the protein exporting translocon PTEX in Plasmodium falciparum

(2018) Paul R Sanders et al.   JOURNAL OF BIOCHEMISTRY

Malaria prevention: from immunological concepts to effective vaccines and protective antibodies

(2018) Ian A. Cockburn et al.   NATURE IMMUNOLOGY

Knockdown of the translocon protein EXP2 in Plasmodium falciparum reduces growth and protein export

(2018) Sarah C. Charnaud et al.   PLoS One

Aspartyl Protease 5 Matures Dense Granule Proteins That Reside at the Host-Parasite Interface in Toxoplasma gondii

(2018) Michael J. Coffey et al.   mBio

Plasmodium Hsp40 and human Hsp70: A potential cochaperone-chaperone complex

(2017) Payal Jha et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Variant surface antigens of Plasmodium falciparum and their roles in severe malaria

(2017) Mats Wahlgren et al.   NATURE REVIEWS MICROBIOLOGY

The exported chaperone Hsp70-x supports virulence functions for Plasmodium falciparum blood stage parasites

(2017) Sarah C. Charnaud et al.   PLoS One

Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104

(2017) Stephanie N. Gates et al.   SCIENCE

Structure of the mitochondrial inner membrane AAA+ protease YME1 gives insight into substrate processing

(2017) Cristina Puchades et al.   SCIENCE

Structural Basis for the Subversion of MAP Kinase Signaling by an Intrinsically Disordered Parasite Secreted Agonist

(2017) Erika Pellegrini et al.   STRUCTURE

An exported protein-interacting complex involved in the trafficking of virulence determinants in Plasmodium-infected erythrocytes

(2017) Steven Batinovic et al.   Nature Communications

Toxoplasma gondii Clp family protein: TgClpB1 plays a crucial role in thermotolerance

(2017) Shinuo Cao et al.   Oncotarget

Plasmodium falciparum parasites deploy RhopH2 into the host erythrocyte to obtain nutrients, grow and replicate

(2017) Natalie A Counihan et al.   eLife

The Plasmodium falciparum rhoptry protein RhopH3 plays essential roles in host cell invasion and nutrient uptake

(2017) Emma S Sherling et al.   eLife

Structural pathway of regulated substrate transfer and threading through an Hsp100 disaggregase

(2017) Célia Deville et al.   Science Advances

Toxoplasma Effector Recruits the Mi-2/NuRD Complex to Repress STAT1 Transcription and Block IFN-γ-Dependent Gene Expression

(2016) Philipp Olias et al.   Cell Host & Microbe

Proteomic analysis reveals novel proteins associated with thePlasmodiumprotein exporter PTEX and a loss of complex stability upon truncation of the core PTEX component, PTEX150

(2016) Brendan Elsworth et al.   CELLULAR MICROBIOLOGY

J-dot targeting of an exported HSP40 in Plasmodium falciparum-infected erythrocytes

(2016) Wiebke Petersen et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Regulation and Essentiality of the StAR-related Lipid Transfer (START) Domain-containing Phospholipid Transfer Protein PFA0210c in Malaria Parasites

(2016) Ross J. Hill et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toxoplasma gondiiTgIST co-opts host chromatin repressors dampening STAT1-dependent gene regulation and IFN-γ–mediated host defenses

(2016) Gabrielle Gay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ticket to ride: export of proteins to thePlasmodium falciparum-infected erythrocyte

(2016) Jude M. Przyborski et al.   MOLECULAR MICROBIOLOGY

Plasmodium species: master renovators of their host cells

(2016) Tania F. de Koning-Ward et al.   NATURE REVIEWS MICROBIOLOGY

Biomechanics of red blood cells in human spleen and consequences for physiology and disease

(2016) Igor V. Pivkin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Novel Secreted Protein, MYR1, Is Central to Toxoplasma ’s Manipulation of Host Cells

(2016) Magdalena Franco et al.   mBio

In Vivo Biotinylation of the Toxoplasma Parasitophorous Vacuole Reveals Novel Dense Granule Proteins Important for Parasite Growth and Pathogenesis

(2016) Santhosh M. Nadipuram et al.   mBio

Protective efficacy and safety of liver stage attenuated malaria parasites

(2016) Hirdesh Kumar et al.   Scientific Reports

UIS2: A Unique Phosphatase Required for the Development of Plasmodium Liver Stages

(2016) Min Zhang et al.   PLoS Pathogens

Variant Exported Blood-Stage Proteins Encoded by Plasmodium Multigene Families Are Expressed in Liver Stages Where They Are Exported into the Parasitophorous Vacuole

(2016) Aurélie Fougère et al.   PLoS Pathogens

Stable Translocation Intermediates Jam Global Protein Export in Plasmodium falciparum Parasites and Link the PTEX Component EXP2 with Translocation Activity

(2016) Paolo Mesén-Ramírez et al.   PLoS Pathogens

Contrasting Inducible Knockdown of the Auxiliary PTEX Component PTEX88 in P. falciparum and P. berghei Unmasks a Role in Parasite Virulence

(2016) Scott A. Chisholm et al.   PLoS One

Protein Export into Malaria Parasite–Infected Erythrocytes: Mechanisms and Functional Consequences

(2015) Natalie J. Spillman et al.   Annual Review of Biochemistry

Crystal structure and solution characterization of the thioredoxin-2 from Plasmodium falciparum, a constituent of an essential parasitic protein export complex

(2015) Mindy Peng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Toxoplasma Dense Granule Proteins GRA17 and GRA23 Mediate the Movement of Small Molecules between the Host and the Parasitophorous Vacuole

(2015) Daniel A. Gold et al.   Cell Host & Microbe

ThePlasmodiumtranslocon of exported proteins component EXP2 is critical for establishing a patent malaria infection in mice

(2015) Ming Kalanon et al.   CELLULAR MICROBIOLOGY

The aspartyl protease TgASP5 mediates the export of theToxoplasmaGRA16 and GRA24 effectors into host cells

(2015) Aurélie Curt-Varesano et al.   CELLULAR MICROBIOLOGY

In Vivo Function of PTEX88 in Malaria Parasite Sequestration and Virulence

(2015) Joachim M. Matz et al.   EUKARYOTIC CELL

Amino acid efflux by asexual blood-stage Plasmodium falciparum and its utility in interrogating the kinetics of hemoglobin endocytosis and catabolism in vivo

(2015) Seema Dalal et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

ThePlasmodium falciparumexportome contains non-canonical PEXEL/HT proteins

(2015) Jana Schulze et al.   MOLECULAR MICROBIOLOGY

Mechanistic insights into the recycling machine of the SNARE complex

(2015) Minglei Zhao et al.   NATURE

Atomic structure of anthrax protective antigen pore elucidates toxin translocation

(2015) Jiansen Jiang et al.   NATURE

Pore-forming toxins: ancient, but never really out of fashion

(2015) Matteo Dal Peraro et al.   NATURE REVIEWS MICROBIOLOGY

Secretion systems in Gram-negative bacteria: structural and mechanistic insights

(2015) Tiago R. D. Costa et al.   NATURE REVIEWS MICROBIOLOGY

ClpB N-terminal domain plays a regulatory role in protein disaggregation

(2015) Rina Rosenzweig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural mapping of the ClpBATPases of Plasmodium falciparum : Targeting protein folding and secretion for antimalarial drug design

(2015) Andrew P. AhYoung et al.   PROTEIN SCIENCE

Critical Steps in Protein Export of Plasmodium falciparum Blood Stages

(2015) Tobias Spielmann et al.   TRENDS IN PARASITOLOGY

The Plasmodium berghei translocon of exported proteins reveals spatiotemporal dynamics of tubular extensions

(2015) Joachim M. Matz et al.   Scientific Reports

Fundamental Roles of the Golgi-Associated Toxoplasma Aspartyl Protease, ASP5, at the Host-Parasite Interface

(2015) Pierre-Mehdi Hammoudi et al.   PLoS Pathogens

An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell

(2015) Michael J Coffey et al.   eLife

Two Plasmodium 6-Cys family-related proteins have distinct and critical roles in liver-stage development

(2014) Takeshi Annoura et al.   FASEB JOURNAL

The Plasmodium protein P113 supports efficient sporozoite to liver stage conversion in vivo

(2014) Vittoria Offeddu et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

PTEX is an essential nexus for protein export in malaria parasites

(2014) Brendan Elsworth et al.   NATURE

PTEX component HSP101 mediates export of diverse malaria effectors into host erythrocytes

(2014) Josh R. Beck et al.   NATURE

Erratum: Biogenesis and homeostasis of chloroplasts and other plastids

(2014) Paul Jarvis et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

d-Glucose concentration is the key factor facilitating liver stage maturation of Plasmodium

(2014) Satoko Itani et al.   PARASITOLOGY INTERNATIONAL

Proteolysis at a Specific Extracellular Residue Implicates Integral Membrane CLAG3 in Malaria Parasite Nutrient Channels

(2014) Wang Nguitragool et al.   PLoS One

The Spatiotemporal Dynamics and Membranous Features of thePlasmodiumLiver Stage Tubovesicular Network

(2014) Josephine Grützke et al.   TRAFFIC

Why do malaria parasites increase host erythrocyte permeability?

(2014) Sanjay A. Desai   TRENDS IN PARASITOLOGY

Antigen Export during Liver Infection of the Malaria Parasite Augments Protective Immunity

(2014) G. N. Montagna et al.   mBio

Inward cholesterol gradient of the membrane system in P. falciparum-infected erythrocytes involves a dilution effect from parasite-produced lipids

(2014) F. Tokumasu et al.   Biology Open

Plasmodium Nesting: Remaking the Erythrocyte from the Inside Out

(2013) Justin A. Boddey et al.   Annual Review of Microbiology

Host Cell Subversion by Toxoplasma GRA16, an Exported Dense Granule Protein that Targets the Host Cell Nucleus and Alters Gene Expression

(2013) Alexandre Bougdour et al.   Cell Host & Microbe

Spatial and temporal mapping of the PfEMP1 export pathway inPlasmodium falciparum

(2013) Paul J. McMillan et al.   CELLULAR MICROBIOLOGY

Feeling at home from arrival to departure: protein export and host cell remodelling duringPlasmodiumliver stage and gametocyte maturation

(2013) Alyssa Ingmundson et al.   CELLULAR MICROBIOLOGY

Identification of aPlasmodium falciparumPhospholipid Transfer Protein

(2013) Christiaan van Ooij et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ThePlasmodiumtranslocon of exported proteins (PTEX) component thioredoxin-2 is important for maintaining normal blood-stage growth

(2013) Kathryn Matthews et al.   MOLECULAR MICROBIOLOGY

Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection

(2013) Peter Liehl et al.   NATURE MEDICINE

Role of Plasmepsin V in Export of Diverse Protein Families from thePlasmodium falciparumExportome

(2013) Justin A. Boddey et al.   TRAFFIC

Spatial association with PTEX complexes defines regions for effector export into Plasmodium falciparum-infected erythrocytes

(2013) David T. Riglar et al.   Nature Communications

Identification of New PNEPs Indicates a Substantial Non-PEXEL Exportome and Underpins Common Features in Plasmodium falciparum Protein Export

(2013) Arlett Heiber et al.   PLoS Pathogens

Uncovering Common Principles in Protein Export of Malaria Parasites

(2012) Christof Grüring et al.   Cell Host & Microbe

Plasmodium falciparum-encoded exported hsp70/hsp40 chaperone/co-chaperone complexes within the host erythrocyte

(2012) Simone Külzer et al.   CELLULAR MICROBIOLOGY

Biosynthesis, Localization, and Macromolecular Arrangement of thePlasmodium falciparumTranslocon of Exported Proteins (PTEX)

(2012) Hayley E. Bullen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complete Plasmodium falciparum liver-stage development in liver-chimeric mice

(2012) Ashley M. Vaughan et al.   JOURNAL OF CLINICAL INVESTIGATION

Liver-specific protein 2: a Plasmodium protein exported to the hepatocyte cytoplasm and required for merozoite formation

(2012) Yuki Orito et al.   MOLECULAR MICROBIOLOGY

Hsp70 proteins bind Hsp100 regulatory M domains to activate AAA+ disaggregase at aggregate surfaces

(2012) Fabian Seyffer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Gliding Motility of Babesia bovis Merozoites Visualized by Time-Lapse Video Microscopy

(2012) Masahito Asada et al.   PLoS One

Malaria Parasite clag3 Genes Determine Channel-Mediated Nutrient Uptake by Infected Red Blood Cells

(2011) Wang Nguitragool et al.   CELL

Super-Resolution Dissection of Coordinated Events during Malaria Parasite Invasion of the Human Erythrocyte

(2011) David T. Riglar et al.   Cell Host & Microbe

Soft X-ray microscopy analysis of cell volume and hemoglobin content in erythrocytes infected with asexual and sexual stages of Plasmodium falciparum

(2011) Eric Hanssen et al.   JOURNAL OF STRUCTURAL BIOLOGY

Structural insights into thioredoxin-2: a component of malaria parasite protein secretion machinery

(2011) Ashwani Sharma et al.   Scientific Reports

Dendritic Cells and Hepatocytes Use Distinct Pathways to Process Protective Antigen from Plasmodium in vivo

(2011) Ian A. Cockburn et al.   PLoS Pathogens

The Clp Chaperones and Proteases of the Human Malaria Parasite Plasmodium falciparum

(2010) Majida El Bakkouri et al.   JOURNAL OF MOLECULAR BIOLOGY

An aspartyl protease directs malaria effector proteins to the host cell

(2010) Justin A. Boddey et al.   NATURE

Plasmepsin V licenses Plasmodium proteins for export into the host erythrocyte

(2010) Ilaria Russo et al.   NATURE

Host cell transcriptional profiling during malaria liver stage infection reveals a coordinated and sequential set of biological events

(2009) Sónia S Albuquerque et al.   BMC GENOMICS

Importing Mitochondrial Proteins: Machineries and Mechanisms

(2009) Agnieszka Chacinska et al.   CELL

Recruitment of human aquaporin 3 to internal membranes in the Plasmodium falciparum infected erythrocyte

(2009) Sven Bietz et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

A newly discovered protein export machine in malaria parasites

(2009) Tania F. de Koning-Ward et al.   NATURE

Adapting the machine: adaptor proteins for Hsp100/Clp and AAA+ proteases

(2009) Janine Kirstein et al.   NATURE REVIEWS MICROBIOLOGY

Malaria parasite proteins that remodel the host erythrocyte

(2009) Alexander G. Maier et al.   NATURE REVIEWS MICROBIOLOGY

Plasmodium falciparum: Chemically defined medium for continuous intraerythrocytic growth using lipids and recombinant albumin

(2008) Hiroko Asahi   EXPERIMENTAL PARASITOLOGY

N-terminal processing of proteins exported by malaria parasites

(2008) Henry H. Chang et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Protein unfolding is an essential requirement for transport across the parasitophorous vacuolar membrane ofPlasmodium falciparum

(2008) Nina Gehde et al.   MOLECULAR MICROBIOLOGY

A combined transcriptome and proteome survey of malaria parasite liver stages

(2008) A. S. Tarun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA