Variant surface antigens of Plasmodium falciparum and their roles in severe malaria

Indels, structural variation, and recombination drive genomic diversity inPlasmodium falciparum

(2016) Alistair Miles et al.   GENOME RESEARCH

Randomized assessment of imatinib in patients with acute ischaemic stroke treated with intravenous thrombolysis

(2016) N. Wahlgren et al.   JOURNAL OF INTERNAL MEDICINE

Plasmodium species: master renovators of their host cells

(2016) Tania F. de Koning-Ward et al.   NATURE REVIEWS MICROBIOLOGY

The role of PfEMP1 as targets of naturally acquired immunity to childhood malaria: prospects for a vaccine

(2016) PETER C. BULL et al.   PARASITOLOGY

Severe adult malaria is associated with specific PfEMP1 adhesion types and high parasite biomass

(2016) Maria Bernabeu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The TatD-like DNase of Plasmodium is a virulence factor and a potential malaria vaccine candidate

(2016) Zhiguang Chang et al.   Nature Communications

The structural basis for CD36 binding by the malaria parasite

(2016) Fu-Lien Hsieh et al.   Nature Communications

Architecture of Human IgM in Complex with P. falciparum Erythrocyte Membrane Protein 1

(2016) Reetesh Raj Akhouri et al.   Cell Reports

Structural Conservation Despite Huge Sequence Diversity Allows EPCR Binding by the PfEMP1 Family Implicated in Severe Childhood Malaria

(2015) Clinton K.Y. Lau et al.   Cell Host & Microbe

Investigating the function of Fc-specific binding of IgM toPlasmodium falciparumerythrocyte membrane protein 1 mediating erythrocyte rosetting

(2015) Liz Stevenson et al.   CELLULAR MICROBIOLOGY

Multiple Plasmodium falciparum Erythrocyte Membrane Protein 1 Variants per Genome Can Bind IgM via Its Fc Fragment Fcμ

(2015) Anine Jeppesen et al.   INFECTION AND IMMUNITY

Mapping the Binding Site of a Cross-ReactivePlasmodium falciparumPfEMP1 Monoclonal Antibody Inhibitory of ICAM-1 Binding

(2015) Frank Lennartz et al.   JOURNAL OF IMMUNOLOGY

Quantitative Assessment of Multiorgan Sequestration of Parasites in Fatal Pediatric Cerebral Malaria

(2015) Danny A. Milner et al.   JOURNAL OF INFECTIOUS DISEASES

Sequestration and Red Cell Deformability as Determinants of Hyperlactatemia in Falciparum Malaria

(2015) Haruhiko Ishioka et al.   JOURNAL OF INFECTIOUS DISEASES

Inhaled nitric oxide as adjunctive therapy for severe malaria: a randomized controlled trial

(2015) Michael T. Hawkes et al.   MALARIA JOURNAL

A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens

(2015) Joshua Tan et al.   NATURE

A novel locus of resistance to severe malaria in a region of ancient balancing selection

(2015)   NATURE

RIFINs are adhesins implicated in severe Plasmodium falciparum malaria

(2015) Suchi Goel et al.   NATURE MEDICINE

Evasion of Immunity to Plasmodium falciparum: Rosettes of Blood Group A Impair Recognition of PfEMP1

(2015) Kirsten Moll et al.   PLoS One

A Novel Virus-Like Particle Based Vaccine Platform Displaying the Placental Malaria Antigen VAR2CSA

(2015) Susan Thrane et al.   PLoS One

Targeting glutamine metabolism rescues mice from late-stage cerebral malaria

(2015) Emile B. Gordon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ape parasite origins of human malaria virulence genes

(2015) Daniel B. Larremore et al.   Nature Communications

α2-Macroglobulin Can Crosslink Multiple Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) Molecules and May Facilitate Adhesion of Parasitized Erythrocytes

(2015) Liz Stevenson et al.   PLoS Pathogens

Binding of Subdomains 1/2 of PfEMP1-DBL1α to Heparan Sulfate or Heparin Mediates Plasmodium falciparum Rosetting

(2015) Davide Angeletti et al.   PLoS One

The Influence of Sub-Unit Composition and Expression System on the Functional Antibody Response in the Development of a VAR2CSA Based Plasmodium falciparum Placental Malaria Vaccine

(2015) Morten A. Nielsen et al.   PLoS One

STEVOR Is a Plasmodium falciparum Erythrocyte Binding Protein that Mediates Merozoite Invasion and Rosetting

(2014) Makhtar Niang et al.   Cell Host & Microbe

A Plasmodium falciparum PHIST protein binds the virulence factor PfEMP1 and comigrates to knobs on the host cell surface

(2014) Alexander Oberli et al.   FASEB JOURNAL

Identification of Residues in the C 4 Domain of Polymeric IgM Essential for Interaction with Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1)

(2014) A. Ghumra et al.   JOURNAL OF IMMUNOLOGY

The role of PfEMP1 adhesion domain classification in Plasmodium falciparum pathogenesis research

(2014) Joseph D. Smith   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Severe Malaria

(2014)   TROPICAL MEDICINE & INTERNATIONAL HEALTH

Generation of Antigenic Diversity in Plasmodium falciparum by Structured Rearrangement of Var Genes During Mitosis

(2014) Antoine Claessens et al.   PLoS Genetics

Affinity Proteomics Reveals Elevated Muscle Proteins in Plasma of Children with Cerebral Malaria

(2014) Julie Bachmann et al.   PLoS Pathogens

Molecular Architecture of a Complex between an Adhesion Protein from the Malaria Parasite and Intracellular Adhesion Molecule 1

(2013) Alan Brown et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Randomized Controlled Trial of Levamisole Hydrochloride as Adjunctive Therapy in Severe Falciparum Malaria With High Parasitemia

(2013) Richard J. Maude et al.   JOURNAL OF INFECTIOUS DISEASES

Vector transmission regulates immune control of Plasmodium virulence

(2013) Philip J. Spence et al.   NATURE

Severe malaria is associated with parasite binding to endothelial protein C receptor

(2013) Louise Turner et al.   NATURE

Plasmodium falciparum Expressing Domain Cassette 5 Type PfEMP1 (DC5-PfEMP1) Bind PECAM1

(2013) Sanne S. Berger et al.   PLoS One

DC8 and DC13 var Genes Associated with Severe Malaria Bind Avidly to Diverse Endothelial Cells

(2013) Marion Avril et al.   PLoS Pathogens

A switch in infected erythrocyte deformability at the maturation and blood circulation of Plasmodium falciparum transmission stages

(2012) M. Tiburcio et al.   BLOOD

Early gametocytes of the malaria parasitePlasmodium falciparumspecifically remodel the adhesive properties of infected erythrocyte surface

(2012) Marta Tibúrcio et al.   CELLULAR MICROBIOLOGY

Structural and Functional Insight into How thePlasmodium falciparumVAR2CSA Protein Mediates Binding to Chondroitin Sulfate A in Placental Malaria

(2012) Thomas M. Clausen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The cellular and molecular basis for malaria parasite invasion of the human red blood cell

(2012) Alan F. Cowman et al.   JOURNAL OF CELL BIOLOGY

A Novel Domain Cassette Identifies Plasmodium falciparum PfEMP1 Proteins Binding ICAM-1 and Is a Target of Cross-Reactive, Adhesion-Inhibitory Antibodies

(2012) A. Bengtsson et al.   JOURNAL OF IMMUNOLOGY

Plasmodium falciparum erythrocyte membrane protein 1 domain cassettes 8 and 13 are associated with severe malaria in children

(2012) T. Lavstsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Whole Genome Sequencing of Field Isolates Provides Robust Characterization of Genetic Diversity in Plasmodium vivax

(2012) Ernest R. Chan et al.   PLoS Neglected Tropical Diseases

Plasmodium falciparum STEVOR proteins impact erythrocyte mechanical properties

(2011) S. Sanyal et al.   BLOOD

RSpred, a set of Hidden Markov Models to detect and classify the RIFIN and STEVOR proteins of Plasmodium falciparum

(2011) Nicolas Joannin et al.   BMC GENOMICS

Malaria Parasite clag3 Genes Determine Channel-Mediated Nutrient Uptake by Infected Red Blood Cells

(2011) Wang Nguitragool et al.   CELL

Exposure of the Plasmodium falciparum clonally variant STEVOR proteins on the merozoite surface

(2011) Ayman Khattab et al.   MALARIA JOURNAL

var gene transcription and PfEMP1 expression in the rosetting and cytoadhesive Plasmodium falciparum clone FCR3S1.2

(2011) Letusa Albrecht et al.   MALARIA JOURNAL

The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine

(2011) Youyou Tu   NATURE MEDICINE

Specific Receptor Usage in Plasmodium falciparum Cytoadherence Is Associated with Disease Outcome

(2011) Lucy B. Ochola et al.   PLoS One

Association of Severe Malaria Outcomes with Platelet-Mediated Clumping and Adhesion to a Novel Host Receptor

(2011) Alfredo Mayor et al.   PLoS One

clag9 Is Not Essential for PfEMP1 Surface Expression in Non-Cytoadherent Plasmodium falciparum Parasites with a Chromosome 9 Deletion

(2011) Adéla Nacer et al.   PLoS One

Structure of a Plasmodium falciparum PfEMP1 rosetting domain reveals a role for the N-terminal segment in heparin-mediated rosette inhibition

(2011) A. Juillerat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evasion of immunity to Plasmodium falciparum malaria by IgM masking of protective IgG epitopes in infected erythrocyte surface-exposed PfEMP1

(2011) L. Barfod et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intravenous immunoglobulin in the treatment of paediatric cerebral malaria

(2010) T. E. TAYLOR et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Full-Length Recombinant Plasmodium falciparum VAR2CSA Binds Specifically to CSPG and Induces Potent Parasite Adhesion-Blocking Antibodies

(2010) Pongsak Khunrae et al.   JOURNAL OF MOLECULAR BIOLOGY

Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial

(2010) Arjen M Dondorp et al.   LANCET

The pir multigene family of Plasmodium: Antigenic variation and beyond

(2010) Deirdre Cunningham et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Origin of the human malaria parasite Plasmodium falciparum in gorillas

(2010) Weimin Liu et al.   NATURE

Plasmodium falciparum FIKK Kinase Members Target Distinct Components of the Erythrocyte Membrane

(2010) Marta C. Nunes et al.   PLoS One

Full-length extracellular region of the var2CSA variant of PfEMP1 is required for specific, high-affinity binding to CSA

(2010) A. Srivastava et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retinal Pathology of Pediatric Cerebral Malaria in Malawi

(2009) Valerie A. White et al.   PLoS One

Absence of Erythrocyte Sequestration and Lack of Multicopy Gene Family Expression in Plasmodium falciparum from a Splenectomized Malaria Patient

(2009) Anna Bachmann et al.   PLoS One

The murine cerebral malaria phenomenon

(2009) Nicholas J. White et al.   TRENDS IN PARASITOLOGY

The Plasmodium falciparum STEVOR Multigene Family Mediates Antigenic Variation of the Infected Erythrocyte

(2009) Makhtar Niang et al.   PLoS Pathogens

Antigenic Variation in Plasmodium falciparum

(2008) Artur Scherf et al.   Annual Review of Microbiology

Sub-grouping and sub-functionalization of the RIFIN multi-copy protein family

(2008) Nicolas Joannin et al.   BMC GENOMICS

Exported Proteins Required for Virulence and Rigidity of Plasmodium falciparum-Infected Human Erythrocytes

(2008) Alexander G. Maier et al.   CELL

Plasmodium falciparum STEVOR Proteins Are Highly Expressed in Patient Isolates and Located in the Surface Membranes of Infected Red Blood Cells and the Apical Tips of Merozoites

(2008) J. E. Blythe et al.   INFECTION AND IMMUNITY

The Structure of a Chondroitin Sulfate-binding Domain Important in Placental Malaria

(2008) Matthew K. Higgins   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasmodium falciparum variant STEVOR antigens are expressed in merozoites and possibly associated with erythrocyte invasion

(2008) Ayman Khattab et al.   MALARIA JOURNAL

A highly conserved segmental duplication in the subtelomeres of Plasmodium falciparum chromosomes varies in copy number

(2008) Bobo W Mok et al.   MALARIA JOURNAL

Structure of the DBL3x domain of pregnancy-associated malaria protein VAR2CSA complexed with chondroitin sulfate A

(2008) Kavita Singh et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Plasmodium Export Element Revisited

(2008) Jan Alexander Hiss et al.   PLoS One

Diverse Expression Patterns of Subgroups of the rif Multigene Family during Plasmodium falciparum Gametocytogenesis

(2008) Michaela Petter et al.   PLoS One

Severe malaria in children and pregnancy: an update and perspective

(2008) Danny A. Milner et al.   TRENDS IN PARASITOLOGY

Direct In Vivo Assessment of Microcirculatory Dysfunction in Severe Falciparum Malaria

(2007) A. M. Dondorp et al.   JOURNAL OF INFECTIOUS DISEASES