Aspartyl Protease 5 Matures Dense Granule Proteins That Reside at the Host-Parasite Interface in Toxoplasma gondii

MYR1-Dependent Effectors Are the Major Drivers of a Host Cell’s Early Response to Toxoplasma , Including Counteracting MYR1-Independent Effects

(2018) Adit Naor et al.   mBio

A druggable secretory protein maturase of Toxoplasma essential for invasion and egress

(2017) Sunil Kumar Dogga et al.   eLife

Hydrophobic Tagging-Assisted N-Termini Enrichment for In-Depth N-Terminome Analysis

(2016) Lingfan Chen et al.   ANALYTICAL CHEMISTRY

A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes

(2016) Saima M. Sidik et al.   CELL

Toxoplasma Effector Recruits the Mi-2/NuRD Complex to Repress STAT1 Transcription and Block IFN-γ-Dependent Gene Expression

(2016) Philipp Olias et al.   Cell Host & Microbe

Secreted protein kinases regulate cyst burden during chronic toxoplasmosis

(2016) Nathaniel G. Jones et al.   CELLULAR MICROBIOLOGY

Role of the ER and Golgi in protein export by Apicomplexa

(2016) Michael J Coffey et al.   CURRENT OPINION IN CELL BIOLOGY

Toxoplasma gondiiTgIST co-opts host chromatin repressors dampening STAT1-dependent gene regulation and IFN-γ–mediated host defenses

(2016) Gabrielle Gay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The ProteomeXchange consortium in 2017: supporting the cultural change in proteomics public data deposition

(2016) Eric W. Deutsch et al.   NUCLEIC ACIDS RESEARCH

The Toxoplasma gondii Rhoptry Kinome Is Essential for Chronic Infection

(2016) Barbara A. Fox et al.   mBio

A Novel Secreted Protein, MYR1, Is Central to Toxoplasma ’s Manipulation of Host Cells

(2016) Magdalena Franco et al.   mBio

In Vivo Biotinylation of the Toxoplasma Parasitophorous Vacuole Reveals Novel Dense Granule Proteins Important for Parasite Growth and Pathogenesis

(2016) Santhosh M. Nadipuram et al.   mBio

The aspartyl protease TgASP5 mediates the export of theToxoplasmaGRA16 and GRA24 effectors into host cells

(2015) Aurélie Curt-Varesano et al.   CELLULAR MICROBIOLOGY

A Lipolytic Lecithin:Cholesterol Acyltransferase Secreted byToxoplasmaFacilitates Parasite Replication and Egress

(2015) Viviana Pszenny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes

(2015) Anthony N Hodder et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

2016 update of the PRIDE database and its related tools

(2015) Juan Antonio Vizcaíno et al.   NUCLEIC ACIDS RESEARCH

Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes

(2015) Anthony N Hodder et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Fundamental Roles of the Golgi-Associated Toxoplasma Aspartyl Protease, ASP5, at the Host-Parasite Interface

(2015) Pierre-Mehdi Hammoudi et al.   PLoS Pathogens

An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell

(2015) Michael J Coffey et al.   eLife

Transition State Mimetics of the Plasmodium Export Element Are Potent Inhibitors of Plasmepsin V from P. falciparum and P. vivax

(2014) Brad E. Sleebs et al.   JOURNAL OF MEDICINAL CHEMISTRY

PTEX is an essential nexus for protein export in malaria parasites

(2014) Brendan Elsworth et al.   NATURE

PTEX component HSP101 mediates export of diverse malaria effectors into host erythrocytes

(2014) Josh R. Beck et al.   NATURE

Efficient Genome Engineering of Toxoplasma gondii Using CRISPR/Cas9

(2014) Saima M. Sidik et al.   PLoS One

Efficient Gene Disruption in Diverse Strains of Toxoplasma gondii Using CRISPR/CAS9

(2014) B. Shen et al.   mBio

Toxoplasma Effector MAF1 Mediates Recruitment of Host Mitochondria and Impacts the Host Response

(2014) Lena Pernas et al.   PLOS BIOLOGY

Inhibition of Plasmepsin V Activity Demonstrates Its Essential Role in Protein Export, PfEMP1 Display, and Survival of Malaria Parasites

(2014) Brad E. Sleebs et al.   PLOS BIOLOGY

Plasmodium Nesting: Remaking the Erythrocyte from the Inside Out

(2013) Justin A. Boddey et al.   Annual Review of Microbiology

Host Cell Subversion by Toxoplasma GRA16, an Exported Dense Granule Protein that Targets the Host Cell Nucleus and Alters Gene Expression

(2013) Alexandre Bougdour et al.   Cell Host & Microbe

Toxoplasmaexports dense granule proteins beyond the vacuole to the host cell nucleus and rewires the host genome expression

(2013) Alexandre Bougdour et al.   CELLULAR MICROBIOLOGY

Toxoplasma gondii Rhoptry 16 Kinase Promotes Host Resistance to Oral Infection and Intestinal Inflammation Only in the Context of the Dense Granule Protein GRA15

(2013) Kirk D. C. Jensen et al.   INFECTION AND IMMUNITY

AToxoplasmadense granule protein, GRA24, modulates the early immune response to infection by promoting a direct and sustained host p38 MAPK activation

(2013) Laurence Braun et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Role of Plasmepsin V in Export of Diverse Protein Families from thePlasmodium falciparumExportome

(2013) Justin A. Boddey et al.   TRAFFIC

Toxoplasmosis in humans and animals in Brazil: high prevalence, high burden of disease, and epidemiology

(2012) J. P. DUBEY et al.   PARASITOLOGY

Toxoplasma gondii Clonal Strains All Inhibit STAT1 Transcriptional Activity but Polymorphic Effectors Differentially Modulate IFNγ Induced Gene Expression and STAT1 Phosphorylation

(2012) Emily E. Rosowski et al.   PLoS One

The Rhoptry Proteins ROP18 and ROP5 Mediate Toxoplasma gondii Evasion of the Murine, But Not the Human, Interferon-Gamma Response

(2012) Wendy Niedelman et al.   PLoS Pathogens

Strain-specific activation of the NF-κB pathway by GRA15, a novelToxoplasma gondiidense granule protein

(2011) Emily E. Rosowski et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neurological complications of HIV infection in critically ill patients: Clinical features and outcomes

(2011) R. Sonneville et al.   JOURNAL OF INFECTION

SignalP 4.0: discriminating signal peptides from transmembrane regions

(2011) Thomas Nordahl Petersen et al.   NATURE METHODS

Integrative Genomic Approaches Highlight a Family of Parasite-Specific Kinases that Regulate Host Responses

(2010) Lucia Peixoto et al.   Cell Host & Microbe

Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole

(2010) Aliaksandr Khaminets et al.   CELLULAR MICROBIOLOGY

ToxoplasmaRhoptry Protein 16 (ROP16) Subverts Host Function by Direct Tyrosine Phosphorylation of STAT6

(2010) Yi-Ching Ong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An aspartyl protease directs malaria effector proteins to the host cell

(2010) Justin A. Boddey et al.   NATURE

Plasmepsin V licenses Plasmodium proteins for export into the host erythrocyte

(2010) Ilaria Russo et al.   NATURE

Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products

(2010) Oded Kleifeld et al.   NATURE BIOTECHNOLOGY

A single polymorphic amino acid onToxoplasma gondiikinase ROP16 determines the direct and strain-specific activation of Stat3

(2009) Masahiro Yamamoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A newly discovered protein export machine in malaria parasites

(2009) Tania F. de Koning-Ward et al.   NATURE

Role of thePlasmodiumExport Element in Trafficking Parasite Proteins to the Infected Erythrocyte

(2008) Justin A Boddey et al.   TRAFFIC