Partners in Mischief: Functional Networks of Heat Shock Proteins of Plasmodium falciparum and Their Influence on Parasite Virulence

Uncoupling the Threading and Unfoldase Actions of Plasmodium HSP101 Reveals Differences in Export between Soluble and Insoluble Proteins

(2019) Kathryn M. Matthews et al.   mBio

Identification of Hsp90 Inhibitors with Anti -Plasmodium Activity

(2018) Dora Posfai et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Global analysis of Plasmodium falciparum histidine-rich protein-2 ( pfhrp2 ) and pfhrp3 gene deletions using whole-genome sequencing data and meta-analysis

(2018) Nuno Sepúlveda et al.   INFECTION GENETICS AND EVOLUTION

Error-prone protein synthesis in parasites with the smallest eukaryotic genome

(2018) Sergey V. Melnikov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Uncovering the essential genes of the human malaria parasitePlasmodium falciparumby saturation mutagenesis

(2018) Min Zhang et al.   SCIENCE

Oxidative stress and protein damage responses mediate artemisinin resistance in malaria parasites

(2018) Frances Rocamora et al.   PLoS Pathogens

Structural and biochemical characterization of Plasmodium falciparum Hsp70-x reveals functional versatility of its C-terminal EEVN motif

(2018) Blessing Mabate et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Discovering Putative Prion-Like Proteins in Plasmodium falciparum: A Computational and Experimental Analysis

(2018) Irantzu Pallarès et al.   Frontiers in Microbiology

Targeting Heat Shock Proteins in Cancer: A Promising Therapeutic Approach

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Plasmodium Hsp40 and human Hsp70: A potential cochaperone-chaperone complex

(2017) Payal Jha et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Extracts Obtained from Pterocarpus angolensis DC and Ziziphus mucronata Exhibit Antiplasmodial Activity and Inhibit Heat Shock Protein 70 (Hsp70) Function

(2017) Tawanda Zininga et al.   MOLECULES

(−)-Epigallocatechin-3-Gallate Inhibits the Chaperone Activity of Plasmodium falciparum Hsp70 Chaperones and Abrogates Their Association with Functional Partners

(2017) Tawanda Zininga et al.   MOLECULES

The influence of related and unrelated co-infections on parasite dynamics and virulence

(2017) A. M. Gleichsner et al.   OECOLOGIA

The exported chaperone Hsp70-x supports virulence functions for Plasmodium falciparum blood stage parasites

(2017) Sarah C. Charnaud et al.   PLoS One

The Exported Chaperone PfHsp70x Is Dispensable for the Plasmodium falciparum Intraerythrocytic Life Cycle

(2017) David W. Cobb et al.   mSphere

Proteomic analysis of exported chaperone/co-chaperone complexes of P. falciparum reveals an array of complex protein-protein interactions

(2017) Qi Zhang et al.   Scientific Reports

Plasmodium falciparum Hsp70-z, an Hsp110 homologue, exhibits independent chaperone activity and interacts with Hsp70-1 in a nucleotide-dependent fashion

(2016) Tawanda Zininga et al.   CELL STRESS & CHAPERONES

Plasmodium actin is incompletely folded by heterologous protein-folding machinery and likely requires the native Plasmodium chaperonin complex to enter a mature functional state

(2016) Maya A. Olshina et al.   FASEB JOURNAL

Inhibition of Plasmodium falciparum Hsp90 Contributes to the Antimalarial Activities of Aminoalcohol-carbazoles

(2016) Tai Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Malarial Exported PFA0660w Is an Hsp40 Co-Chaperone of PfHsp70-x

(2016) Michael O. Daniyan et al.   PLoS One

Prevalence of pfhrp2 and/or pfhrp3 Gene Deletion in Plasmodium falciparum Population in Eight Highly Endemic States in India

(2016) Praveen Kumar Bharti et al.   PLoS One

Use of a Chimeric Hsp70 to Enhance the Quality of Recombinant Plasmodium falciparum S-Adenosylmethionine Decarboxylase Protein Produced in Escherichia coli

(2016) Xolani Henry Makhoba et al.   PLoS One

Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasitesPlasmodium falciparum3D7

(2016) Hanafy M. Ismail et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A broad analysis of resistance development in the malaria parasite

(2016) Victoria C. Corey et al.   Nature Communications

Imidazopyridazine Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 Also Target Cyclic GMP-Dependent Protein Kinase and Heat Shock Protein 90 To Kill the Parasite at Different Stages of Intracellular Development

(2015) Judith L. Green et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Host Erythrocyte Environment Influences the Localization of Exported Protein 2, an Essential Component of the Plasmodium Translocon

(2015) Elamaran Meibalan et al.   EUKARYOTIC CELL

PFB0595w is a Plasmodium falciparum J protein that co-localizes with PfHsp70-1 and can stimulate its in vitro ATP hydrolysis activity

(2015) James M. Njunge et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Overexpression, Purification and Characterisation of the Plasmodium falciparum Hsp70-z (PfHsp70-z) Protein

(2015) Tawanda Zininga et al.   PLoS One

Plasmodium falciparum Hop (PfHop) Interacts with the Hsp70 Chaperone in a Nucleotide-Dependent Fashion and Exhibits Ligand Selectivity

(2015) Tawanda Zininga et al.   PLoS One

Selective modulation of plasmodial Hsp70s by small molecules with antimalarial activity

(2014) Ingrid L. Cockburn et al.   BIOLOGICAL CHEMISTRY

Protein export in malaria parasites: an update

(2014) Brendan Elsworth et al.   CELLULAR MICROBIOLOGY

PTEX is an essential nexus for protein export in malaria parasites

(2014) Brendan Elsworth et al.   NATURE

PTEX component HSP101 mediates export of diverse malaria effectors into host erythrocytes

(2014) Josh R. Beck et al.   NATURE

Dual targeting of heat shock proteins 90 and 70 promotes cell death and enhances the anticancer effect of chemotherapeutic agents in bladder cancer

(2014) LIANG MA et al.   ONCOLOGY REPORTS

Co-chaperones of Hsp90 in Plasmodium falciparum and their concerted roles in cellular regulation

(2014) CHUN-SONG CHUA et al.   PARASITOLOGY

Plasmodial Hsp40 and Hsp70 chaperones: current and future perspectives

(2014) E.-R. PESCE et al.   PARASITOLOGY

Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance

(2014) S. Mok et al.   SCIENCE

The fungal Achilles’ heel: targeting Hsp90 to cripple fungal pathogens

(2013) Leah E Cowen   CURRENT OPINION IN MICROBIOLOGY

ThePlasmodiumtranslocon of exported proteins (PTEX) component thioredoxin-2 is important for maintaining normal blood-stage growth

(2013) Kathryn Matthews et al.   MOLECULAR MICROBIOLOGY

A Purine Analog Synergizes with Chloroquine (CQ) by Targeting Plasmodium falciparum Hsp90 (PfHsp90)

(2013) Dea Shahinas et al.   PLoS One

Plasmodium falciparum-encoded exported hsp70/hsp40 chaperone/co-chaperone complexes within the host erythrocyte

(2012) Simone Külzer et al.   CELLULAR MICROBIOLOGY

Hsp70s and J Proteins of Plasmodium Parasites Infecting Rodents and Primates: Structure, Function, Clinical Relevance, and Drug Targets

(2012) James M. Njunge et al.   CURRENT PHARMACEUTICAL DESIGN

The epidemiology of postpartum malaria: a systematic review

(2012) Machteld E Boel et al.   MALARIA JOURNAL

Molecular dynamics simulations of PfAQP from the malarial parasite Plasmodium falciparum

(2012) Yubao Cui   Molecular Medicine Reports

An Exported Heat Shock Protein 40 Associates with Pathogenesis-Related Knobs in Plasmodium falciparum Infected Erythrocytes

(2012) Pragyan Acharya et al.   PLoS One

A Major Genome Region Underlying Artemisinin Resistance in Malaria

(2012) I. H. Cheeseman et al.   SCIENCE

Screening for small molecule modulators of Hsp70 chaperone activity using protein aggregation suppression assays: inhibition of the plasmodial chaperone PfHsp70-1

(2011) Ingrid L. Cockburn et al.   BIOLOGICAL CHEMISTRY

Characterisation of the Plasmodium falciparum Hsp70–Hsp90 organising protein (PfHop)

(2011) Grace W. Gitau et al.   CELL STRESS & CHAPERONES

Functional Analysis of the Exported Type IV HSP40 Protein PfGECO in Plasmodium falciparum Gametocytes

(2011) Belinda J. Morahan et al.   EUKARYOTIC CELL

Drug-resistant malaria: Molecular mechanisms and implications for public health

(2011) Ines Petersen et al.   FEBS LETTERS

Plasmodium sporozoite motility: an update

(2011) Georgina et al.   Frontiers in Bioscience-Landmark

Co-expression of the Plasmodium falciparum molecular chaperone, PfHsp70, improves the heterologous production of the antimalarial drug target GTP cyclohydrolase I, PfGCHI

(2011) Linda L. Stephens et al.   PROTEIN EXPRESSION AND PURIFICATION

The pathogenesis of Plasmodium falciparum malaria in humans: insights from splenic physiology

(2010) P. A. Buffet et al.   BLOOD

Parasite-encoded Hsp40 proteins define novel mobile structures in the cytosol of the P. falciparum-infected erythrocyte

(2010) Simone Külzer et al.   CELLULAR MICROBIOLOGY

Heat Shock Protein 90 as a Drug Target against Protozoan Infections

(2010) Rani Pallavi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Malaria Parasite Actin Polymerization and Filament Structure

(2010) Stephan Schmitz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chaperone expression profiles correlate with distinct physiological states of Plasmodium falciparum in malaria patients

(2010) Rani Pallavi et al.   MALARIA JOURNAL

Moving in and renovating: exporting proteins from Plasmodium into host erythrocytes

(2010) Daniel E. Goldberg et al.   NATURE REVIEWS MICROBIOLOGY

A Large Proportion of P. falciparum Isolates in the Amazon Region of Peru Lack pfhrp2 and pfhrp3: Implications for Malaria Rapid Diagnostic Tests

(2010) Dionicia Gamboa et al.   PLoS One

Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum

(2009) Annette N. Chiang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Plasmodial heat shock proteins: targets for chemotherapy

(2009) Addmore Shonhai   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Co-ordinated stage-dependent enhancement of Plasmodium falciparum antioxidant enzymes and heat shock protein expression in parasites growing in oxidatively stressed or G6PD-deficient red blood cells

(2009) Oscar Akide-Ndunge et al.   MALARIA JOURNAL

A Small Molecule Inhibitor of Inducible Heat Shock Protein 70

(2009) J. I-Ju Leu et al.   MOLECULAR CELL

Malaria parasite proteins that remodel the host erythrocyte

(2009) Alexander G. Maier et al.   NATURE REVIEWS MICROBIOLOGY

Protein export in malaria parasites: do multiple export motifs add up to multiple export pathways?

(2009) Tobias Spielmann et al.   TRENDS IN PARASITOLOGY

Exported Proteins Required for Virulence and Rigidity of Plasmodium falciparum-Infected Human Erythrocytes

(2008) Alexander G. Maier et al.   CELL

Molecular Chaperones in Pathogen Virulence: Emerging New Targets for Therapy

(2008) Len Neckers et al.   Cell Host & Microbe

Malaria: progress, perils, and prospects for eradication

(2008) Brian M. Greenwood et al.   JOURNAL OF CLINICAL INVESTIGATION

PlasmoDB: a functional genomic database for malaria parasites

(2008) C. Aurrecoechea et al.   NUCLEIC ACIDS RESEARCH