Neuroinflammatory Mechanisms of Mitochondrial Dysfunction and Neurodegeneration in Glaucoma

The Association of Oxidative Stress Status with Open-Angle Glaucoma and Exfoliation Glaucoma: A Systematic Review and Meta-Analysis

(2019) Binghua Tang et al.   Journal of Ophthalmology

Mitochondrial integrity in neurodegeneration

(2019) Katrina Cowan et al.   CNS Neuroscience & Therapeutics

Potential metabolic markers in glaucoma and their regulation in response to hypoxia

(2019) Rupali Vohra et al.   ACTA OPHTHALMOLOGICA

Mendelian genes in primary open angle glaucoma

(2019) Nathan C. Sears et al.   EXPERIMENTAL EYE RESEARCH

Overcoming the Brain Barriers: From Immune Cells to Nanoparticles

(2019) Marc Charabati et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Intravitreal Therapy Against the Complement Factor C5 Prevents Retinal Degeneration in an Experimental Autoimmune Glaucoma Model

(2019) Sabrina Reinehr et al.   Frontiers in Pharmacology

Optic nerve head cupping in glaucomatous and non-glaucomatous optic neuropathy

(2018) Masoud Aghsaei Fard et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Mitochondrial dysfunction and damage associated molecular patterns (DAMPs) in chronic inflammatory diseases

(2018) Charles S. Dela Cruz et al.   MITOCHONDRION

Comparison of T Helper Cell Patterns in Primary Open-Angle Glaucoma and Normal-Pressure Glaucoma

(2018) Chunyu Guo et al.   MEDICAL SCIENCE MONITOR

Altered Functions and Interactions of Glaucoma-Associated Mutants of Optineurin

(2018) Ghanshyam Swarup et al.   Frontiers in Immunology

TANK-Binding Kinase 1-Dependent Responses in Health and Autoimmunity

(2018) Cynthia Louis et al.   Frontiers in Immunology

Dysfunction of Optineurin in Amyotrophic Lateral Sclerosis and Glaucoma

(2018) Reka P. Toth et al.   Frontiers in Immunology

Degraded Mitochondrial DNA is a Newly Identified Subtype of the Damage Associated Molecular Pattern (DAMP) Family and Possible Trigger of Neurodegeneration

(2018) Alex Mathew et al.   JOURNAL OF ALZHEIMERS DISEASE

The role of mitochondria in NLRP3 inflammasome activation

(2018) Qiuyun Liu et al.   MOLECULAR IMMUNOLOGY

Complement C3-Targeted Gene Therapy Restricts Onset and Progression of Neurodegeneration in Chronic Mouse Glaucoma

(2018) Alejandra Bosco et al.   MOLECULAR THERAPY

Author Correction: Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma

(2018) Huihui Chen et al.   Nature Communications

Investigation of whole mitochondrial genome variation in normal tension glaucoma

(2018) Agnieszka Piotrowska-Nowak et al.   EXPERIMENTAL EYE RESEARCH

All roads lead to glaucoma: Induced retinal injury cascades contribute to a common neurodegenerative outcome

(2018) Samih Alqawlaq et al.   EXPERIMENTAL EYE RESEARCH

Reactive Oxygen Species-Mediated Damage of Retinal Neurons: Drug Development Targets for Therapies of Chronic Neurodegeneration of the Retina

(2018) Landon Rohowetz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genetics of glaucoma

(2017) Janey L. Wiggs et al.   HUMAN MOLECULAR GENETICS

Identification of optineurin as an interleukin-1 receptor-associated kinase 1-binding protein and its role in regulation of MyD88-dependent signaling

(2017) Mitsuyoshi Tanishima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial function in Müller cells - Does it matter?

(2017) Anne Katrine Toft-Kehler et al.   MITOCHONDRION

Mitochondrial dynamics, transport, and quality control: A bottleneck for retinal ganglion cell viability in optic neuropathies

(2017) Yoko A. Ito et al.   MITOCHONDRION

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Mitochondrial dysfunction as a trigger of innate immune responses and inflammation

(2017) A. Phillip West   TOXICOLOGY

The Role of Microglia in Retinal Neurodegeneration: Alzheimer's Disease, Parkinson, and Glaucoma

(2017) Ana I. Ramirez et al.   Frontiers in Aging Neuroscience

Investigations into Hypoxia and Oxidative Stress at the Optic Nerve Head in a Rat Model of Glaucoma

(2017) Glyn Chidlow et al.   Frontiers in Neuroscience

Metabolic Vulnerability in the Neurodegenerative Disease Glaucoma

(2017) Denise M. Inman et al.   Frontiers in Neuroscience

Mitochondria-Derived Damage-Associated Molecular Patterns in Neurodegeneration

(2017) Heather M. Wilkins et al.   Frontiers in Immunology

Longitudinal Analysis of Serum Autoantibody-Reactivities in Patients with Primary Open Angle Glaucoma and Optic Disc Hemorrhage

(2017) Katrin Lorenz et al.   PLoS One

Parkinson’s Disease-Related Proteins PINK1 and Parkin Repress Mitochondrial Antigen Presentation

(2016) Diana Matheoud et al.   CELL

Early astrocyte redistribution in the optic nerve precedes axonopathy in the DBA/2J mouse model of glaucoma

(2016) Melissa L. Cooper et al.   EXPERIMENTAL EYE RESEARCH

TransgenicTBK1mice have features of normal tension glaucoma

(2016) John H. Fingert et al.   HUMAN MOLECULAR GENETICS

Glaucoma: recent advances in the involvement of autoimmunity

(2016) Maria Ida Rizzo et al.   IMMUNOLOGIC RESEARCH

Evidence Supporting an Association Between Expression of Major Histocompatibility Complex II by Microglia and Optic Nerve Degeneration During Experimental Glaucoma

(2016) Glyn Chidlow et al.   JOURNAL OF GLAUCOMA

Generation of Immunity against Pathogens via Single-Domain Antibody–Antigen Constructs

(2016) Joao N. Duarte et al.   JOURNAL OF IMMUNOLOGY

Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma

(2016) Jessica N Cooke Bailey et al.   NATURE GENETICS

Glia–neuron interactions in the mammalian retina

(2016) Elena Vecino et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Oxidative and Anti-Oxidative Stress Markers in Chronic Glaucoma: A Systematic Review and Meta-Analysis

(2016) Cédric Benoist d’Azy et al.   PLoS One

Retinal Ganglion Cell Loss is Delayed Following Optic Nerve Crush in NLRP3 Knockout Mice

(2016) Zhen Puyang et al.   Scientific Reports

Mitochondrial pathogenic mechanism and degradation in optineurin E50K mutation-mediated retinal ganglion cell degeneration

(2016) Myoung Sup Shim et al.   Scientific Reports

The Roles of Mitochondrial Damage-Associated Molecular Patterns in Diseases

(2015) Kiichi Nakahira et al.   ANTIOXIDANTS & REDOX SIGNALING

Protective effect of molecular hydrogen against oxidative stress caused by peroxynitrite derived from nitric oxide in rat retina

(2015) Takashi Yokota et al.   CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Neurodegeneration severity can be predicted from early microglia alterations monitored in vivo in a mouse model of chronic glaucoma

(2015) A. Bosco et al.   Disease Models & Mechanisms

Mitochondria-targeted antioxidant SkQ1 reverses glaucomatous lesions in rabbits

(2015) Vladimir P. Skulachev   Frontiers in Bioscience-Landmark

TBK1 controls autophagosomal engulfment of polyubiquitinated mitochondria through p62/SQSTM1 phosphorylation

(2015) Gen Matsumoto et al.   HUMAN MOLECULAR GENETICS

Crocin protects retinal ganglion cells against H2O2-induced damage through the mitochondrial pathway and activation of NF-κB

(2015) BOCHANG LV et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Contribution of Microglia-Mediated Neuroinflammation to Retinal Degenerative Diseases

(2015) Maria H. Madeira et al.   MEDIATORS OF INFLAMMATION

Mitochondria: diversity in the regulation of the NLRP3 inflammasome

(2015) Prajwal Gurung et al.   TRENDS IN MOLECULAR MEDICINE

Adoptive transfer of immune cells from glaucomatous mice provokes retinal ganglion cell loss in recipients

(2015) Oliver W. Gramlich et al.   Acta Neuropathologica Communications

PINK1-Parkin-Mediated Mitophagy Protects Mitochondrial Integrity and Prevents Metabolic Stress-Induced Endothelial Injury

(2015) Weiwei Wu et al.   PLoS One

A Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin

(2015) Kapil Sirohi et al.   PLoS One

Measurement of Systemic Mitochondrial Function in Advanced Primary Open-Angle Glaucoma and Leber Hereditary Optic Neuropathy

(2015) Nicole J Van Bergen et al.   PLoS One

Oxidative stress induces autophagy in response to multiple noxious stimuli in retinal ganglion cells

(2014) Wen-jian Lin et al.   Autophagy

Whole-mitochondrial genome sequencing in primary open-angle glaucoma using massively parallel sequencing identifies novel and known pathogenic variants

(2014) Periasamy Sundaresan et al.   GENETICS IN MEDICINE

Hydroxycinnamic Acids in Crepidiastrum denticulatum Protect Oxidative Stress-Induced Retinal Damage

(2014) Hong Ryul Ahn et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy

(2014) J. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase-8 promotes NLRP1/NLRP3 inflammasome activation and IL-1  production in acute glaucoma

(2014) W. Chi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Complex Role of Neuroinflammation in Glaucoma

(2014) I. Soto et al.   Cold Spring Harbor Perspectives in Medicine

Bioenergetic Dysfunction and Inflammation in Alzheimer’s Disease: A Possible Connection

(2014) Heather M. Wilkins et al.   Frontiers in Aging Neuroscience

Toll-Like Receptor Signaling Pathways

(2014) Takumi Kawasaki et al.   Frontiers in Immunology

Reversible reactivity by optic nerve astrocytes

(2013) Daniel Sun et al.   GLIA

Enhanced optineurin E50K–TBK1 interaction evokes protein insolubility and initiates familial primary open-angle glaucoma

(2013) Yuriko Minegishi et al.   HUMAN MOLECULAR GENETICS

Zinc oxide nanoparticles decrease the expression and activity of plasma membrane calcium ATPase, disrupt the intracellular calcium homeostasis in rat retinal ganglion cells

(2013) Dadong Guo et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mitochondrial Reactive Oxygen Species Induces NLRP3-Dependent Lysosomal Damage and Inflammasome Activation

(2013) M. E. Heid et al.   JOURNAL OF IMMUNOLOGY

Deficiency of complement component 5 ameliorates glaucoma in DBA/2J mice

(2013) Gareth R Howell et al.   Journal of Neuroinflammation

Enhanced Insight into the Autoimmune Component of Glaucoma: IgG Autoantibody Accumulation and Pro-Inflammatory Conditions in Human Glaucomatous Retina

(2013) Oliver W. Gramlich et al.   PLoS One

α-Lipoic Acid Antioxidant Treatment Limits Glaucoma-Related Retinal Ganglion Cell Death and Dysfunction

(2013) Denise M. Inman et al.   PLoS One

Mitochondrial Sequence Variation in African-American Primary Open-Angle Glaucoma Patients

(2013) David W. Collins et al.   PLoS One

The Role of Inflammation in the Pathogenesis of Glaucoma

(2013) Rupali Vohra et al.   SURVEY OF OPHTHALMOLOGY

ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy

(2012) Yuqing Wang et al.   Autophagy

The secretome signature of reactive glial cells and its pathological implications

(2012) Mithilesh Kumar Jha et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Immune regulation toward immunomodulation for neuroprotection in glaucoma

(2012) Gülgün Tezel   CURRENT OPINION IN PHARMACOLOGY

Oxidative stress and mitochondrial dysfunction in glaucoma

(2012) Vicki Chrysostomou et al.   CURRENT OPINION IN PHARMACOLOGY

Nutrient intake and risk of open-angle glaucoma: the Rotterdam Study

(2012) Wishal D. Ramdas et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

PAMPs and DAMPs: signal 0s that spur autophagy and immunity

(2012) Daolin Tang et al.   IMMUNOLOGICAL REVIEWS

Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma

(2012) Gareth R. Howell et al.   JOURNAL OF CLINICAL INVESTIGATION

Innate immunity in the central nervous system

(2012) Richard M. Ransohoff et al.   JOURNAL OF CLINICAL INVESTIGATION

Impact of aging and diet restriction on retinal function during and after acute intraocular pressure injury

(2012) Yu Xiang George Kong et al.   NEUROBIOLOGY OF AGING

siRNA knock down of glutamate dehydrogenase in astrocytes affects glutamate metabolism leading to extensive accumulation of the neuroactive amino acids glutamate and aspartate

(2012) Dorte M. Skytt et al.   NEUROCHEMISTRY INTERNATIONAL

Retinal Ganglion Cell Loss Is Accompanied by Antibody Depositions and Increased Levels of Microglia after Immunization with Retinal Antigens

(2012) Stephanie C. Joachim et al.   PLoS One

Visual Field Loss Morphology in High- and Normal-Tension Glaucoma

(2012) Michele Iester et al.   Journal of Ophthalmology

The optic nerve head is the site of axonal transport disruption, axonal cytoskeleton damage and putative axonal regeneration failure in a rat model of glaucoma

(2011) Glyn Chidlow et al.   ACTA NEUROPATHOLOGICA

Glial cell response and iNOS expression in the optic nerve head and retina of the rat following acute high IOP ischemia–reperfusion

(2011) Kyong Jin Cho et al.   BRAIN RESEARCH

Structural basis of glaucoma: The fortified astrocytes of the optic nerve head are the target of raised intraocular pressure

(2011) Chao Dai et al.   GLIA

Copy number variations on chromosome 12q14 in patients with normal tension glaucoma

(2011) John H. Fingert et al.   HUMAN MOLECULAR GENETICS

Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma

(2011) Gareth R. Howell et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial dysfunction in glaucoma: Understanding genetic influences

(2011) Gerassimos Lascaratos et al.   MITOCHONDRION

Complement mediated apoptosis leads to the loss of retinal ganglion cells in animal model of glaucoma

(2011) Purushottam Jha et al.   MOLECULAR IMMUNOLOGY

During autophagy mitochondria elongate, are spared from degradation and sustain cell viability

(2011) Ligia C. Gomes et al.   NATURE CELL BIOLOGY

Optineurin Is Required for CYLD-Dependent Inhibition of TNFα-Induced NF-κB Activation

(2011) Ananthamurthy Nagabhushana et al.   PLoS One

Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation

(2011) A. S. Rambold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myelination transition zone astrocytes are constitutively phagocytic and have synuclein dependent reactivity in glaucoma

(2011) J. V. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The molecular basis of retinal ganglion cell death in glaucoma

(2011) Mohammadali Almasieh et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Increased serum total antioxidant status and decreased urinary 8-hydroxy-2′-deoxyguanosine levels in patients with normal-tension glaucoma

(2010) Kenya Yuki et al.   ACTA OPHTHALMOLOGICA

Expression of Myocilin Mutants Sensitizes Cells to Oxidative Stress-Induced Apoptosis

(2010) Myung Kuk Joe et al.   AMERICAN JOURNAL OF PATHOLOGY

Somatic Mitochondrial DNA Mutations in Mammalian Aging

(2010) Nils-Göran Larsson   Annual Review of Biochemistry

Superoxide is an associated signal for apoptosis in axonal injury

(2010) A. Kanamori et al.   BRAIN

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Vascular risk factors in glaucoma: a review

(2010) Masahide Yanagi et al.   CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Dietary Deficiency of Vitamin E Aggravates Retinal Ganglion Cell Death in Experimental Glaucoma of Rats

(2010) Mei-Lan Ko et al.   CURRENT EYE RESEARCH

Complex I: Inhibitors, inhibition and neurodegeneration

(2010) A.H.V. Schapira   EXPERIMENTAL NEUROLOGY

Glaucomatous optic nerve injury involves early astrocyte reactivity and late oligodendrocyte loss

(2010) Janice L. Son et al.   GLIA

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

Distal axonopathy with structural persistence in glaucomatous neurodegeneration

(2010) S. D. Crish et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Network analysis of human glaucomatous optic nerve head astrocytes

(2009) Tatiana Nikolskaya et al.   BMC Medical Genomics

Retinal Oxidative Stress Induced by Intraocular Hypertension in Rats May be Ameliorated by Brimonidine Treatment and N-acetyl Cysteine Supplementation

(2009) Gokhan Ozdemir et al.   JOURNAL OF GLAUCOMA

Friend or Foe? Resolving the Impact of Glial Responses in Glaucoma

(2009) Elaine C. Johnson et al.   JOURNAL OF GLAUCOMA

NF-κB Mediates Tumor Necrosis Factor α-Induced Expression of Optineurin, a Negative Regulator of NF-κB

(2009) Cherukuri Sudhakar et al.   PLoS One

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

(2009) C. Vives-Bauza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hereditary optic neuropathies share a common mitochondrial coupling defect

(2008) Arnaud Chevrollier et al.   ANNALS OF NEUROLOGY

Bioinformatic and statistical analysis of the optic nerve head in a primate model of ocular hypertension

(2008) Kenneth S Kompass et al.   BMC NEUROSCIENCE

Optic disc hemorrhages in glaucoma and ocular hypertension: implications and recommendations

(2008) Tara A Uhler et al.   CURRENT OPINION IN OPHTHALMOLOGY

Normal-tension glaucoma: is it different from primary open-angle glaucoma?

(2008) M Bruce Shields   CURRENT OPINION IN OPHTHALMOLOGY

Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma

(2008) Simon Morton et al.   FEBS LETTERS

Innate immunity to virus infection

(2008) Osamu Takeuchi et al.   IMMUNOLOGICAL REVIEWS

Induced Autoimmunity to Heat Shock Proteins Elicits Glaucomatous Loss of Retinal Ganglion Cell Neurons via Activated T-Cell-Derived Fas-Ligand

(2008) M. B. Wax et al.   JOURNAL OF NEUROSCIENCE

Oxidative-induced apoptosis to an immortalized ganglion cell line is caspase independent but involves the activation of poly(ADP-ribose)polymerase and apoptosis-inducing factor

(2007) Guang-Yu Li et al.   BRAIN RESEARCH