Journal
TRENDS IN PHARMACOLOGICAL SCIENCES
Volume 41, Issue 1, Pages 42-54Publisher
CELL PRESS
DOI: 10.1016/j.tips.2019.11.001
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Funding
- Fonds de Recherche du Quebec - Sante (FRQS)
- Multiple Sclerosis Society of Canada (MSSC)
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- NSERC
- Fondation Armand-Frappier
- International Progressive Multiple Sclerosis Alliance
- Canadian Institutes of Health Research (CIHR)
- MSSC
- MSRF
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Nanoparticulate carriers, often referred to as nanoparticles (NPs), represent an important pharmacological advance for drug protection and tissue-specific drug delivery. Accessing the central nervous system (CNS), however, is a complex process regulated by mainly three brain barriers. While some leukocyte (i.e., immune cell) subsets are equipped with the adequate molecular machinery to infiltrate the CNS in physiological and/or pathological contexts, the successful delivery of NPs into the CNS remains hindered by the tightness of the brain barriers. Here, we present an overview of the three major brain barriers and the mechanisms allowing leukocytes to migrate across each of them. We subsequently review different immune-inspired and -mediated strategies to deliver NPs into the CNS. Finally, we discuss the prospect of exploiting leukocyte trafficking mechanisms for further progress.
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