A Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin

Copy Number Variations of TBK1 in Australian Patients With Primary Open-Angle Glaucoma

(2015) Mona S. Awadalla et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

TBK1 Regulates Prostate Cancer Dormancy through mTOR Inhibition

(2015) Jin Koo Kim et al.   NEOPLASIA

E50K-OPTN-Induced Retinal Cell Death Involves the Rab GTPase-Activating Protein, TBC1D17 Mediated Block in Autophagy

(2014) Madhavi Latha Somaraju Chalasani et al.   PLoS One

Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation

(2014) Yvette C. Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of mutations and deletions in the human optineurin gene

(2014) Sanja Turturro et al.   SpringerPlus

M98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cells

(2013) Kapil Sirohi et al.   Autophagy

Recent insights into the complexity of Tank-binding kinase 1 signaling networks: The emerging role of cellular localization in the activation and substrate specificity of TBK1

(2013) Elizabeth Helgason et al.   FEBS LETTERS

Enhanced optineurin E50K–TBK1 interaction evokes protein insolubility and initiates familial primary open-angle glaucoma

(2013) Yuriko Minegishi et al.   HUMAN MOLECULAR GENETICS

TBK1and Flanking Genes in Human Retina

(2013) John H. Fingert et al.   OPHTHALMIC GENETICS

Toward an integrative view of Optineurin functions

(2012) David Kachaner et al.   CELL CYCLE

Anatomical and functional damage in experimental glaucoma

(2012) M Agudo-Barriuso et al.   CURRENT OPINION IN PHARMACOLOGY

TBK-1 Promotes Autophagy-Mediated Antimicrobial Defense by Controlling Autophagosome Maturation

(2012) Manohar Pilli et al.   IMMUNITY

Optineurin mediates a negative regulation of Rab8 by the GTPase-activating protein TBC1D17

(2012) V. Vaibhava et al.   JOURNAL OF CELL SCIENCE

Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates

(2012) J. Korac et al.   JOURNAL OF CELL SCIENCE

Plk1-Dependent Phosphorylation of Optineurin Provides a Negative Feedback Mechanism for Mitotic Progression

(2012) David Kachaner et al.   MOLECULAR CELL

Autophagy receptors link myosin VI to autophagosomes to mediate Tom1-dependent autophagosome maturation and fusion with the lysosome

(2012) David A. Tumbarello et al.   NATURE CELL BIOLOGY

Activation of autophagy induces retinal ganglion cell death in a chronic hypertensive glaucoma model

(2012) H-Y Lopilly Park et al.   Cell Death & Disease

Syntaxin 17 cycles between the ER and ERGIC and is required to maintain the architecture of ERGIC and Golgi

(2011) Madhavi Muppirala et al.   BIOLOGY OF THE CELL

Depletion of optineurin in RGC-5 cells derived from retinal neurons causes apoptosis and reduces the secretion of neurotrophins

(2011) Christiane Sippl et al.   EXPERIMENTAL EYE RESEARCH

Primary open-angle glaucoma genes

(2011) J H Fingert   EYE

Variants in ASB10 are associated with open-angle glaucoma

(2011) F. Pasutto et al.   HUMAN MOLECULAR GENETICS

Copy number variations on chromosome 12q14 in patients with normal tension glaucoma

(2011) John H. Fingert et al.   HUMAN MOLECULAR GENETICS

Polyubiquitin Binding to Optineurin Is Required for Optimal Activation of TANK-binding Kinase 1 and Production of Interferon β

(2011) Catherine E. Gleason et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Optineurin Is Required for CYLD-Dependent Inhibition of TNFα-Induced NF-κB Activation

(2011) Ananthamurthy Nagabhushana et al.   PLoS One

Activation of Autophagy in a Rat Model of Retinal Ischemia following High Intraocular Pressure

(2011) Antonio Piras et al.   PLoS One

TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2

(2011) M. Delhase et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth

(2011) P. Wild et al.   SCIENCE

Regulation of endocytic trafficking of transferrin receptor by optineurin and its impairment by a glaucoma-associated mutant

(2010) Ananthamurthy Nagabhushana et al.   BMC CELL BIOLOGY

Evidence of outer retinal changes in glaucoma patients as revealed by ultrahigh-resolution in vivo retinal imaging

(2010) S. S. Choi et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice

(2010) Zai-Long Chi et al.   HUMAN MOLECULAR GENETICS

Processing of Optineurin in Neuronal Cells

(2010) Xiang Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mice lacking Tbk1 activity exhibit immune cell infiltrates in multiple tissues and increased susceptibility to LPS-induced lethality

(2010) Erica Marchlik et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Impairment of Protein Trafficking upon Overexpression and Mutation of Optineurin

(2010) BumChan Park et al.   PLoS One

Heterozygous NTF4 Mutations Impairing Neurotrophin-4 Signaling in Patients with Primary Open-Angle Glaucoma

(2009) Francesca Pasutto et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Use of the Pharmacological Inhibitor BX795 to Study the Regulation and Physiological Roles of TBK1 and IκB Kinase ϵ

(2009) Kristopher Clark et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria

(2009) Teresa L M Thurston et al.   NATURE IMMUNOLOGY

Optineurin and Its Mutants: Molecules Associated with Some Forms of Glaucoma

(2009) Madhavi Latha Chalasani et al.   OPHTHALMIC RESEARCH

NF-κB Mediates Tumor Necrosis Factor α-Induced Expression of Optineurin, a Negative Regulator of NF-κB

(2009) Cherukuri Sudhakar et al.   PLoS One

NRP/Optineurin Cooperates with TAX1BP1 to Potentiate the Activation of NF-κB by Human T-Lymphotropic Virus Type 1 Tax Protein

(2009) Chloé Journo et al.   PLoS Pathogens

Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma

(2008) Simon Morton et al.   FEBS LETTERS

Are the IKKs and IKK-related kinases TBK1 and IKK-ɛ similarly activated?

(2008) Tieu-Lan Chau et al.   TRENDS IN BIOCHEMICAL SCIENCES