Cancer epigenetics: Past, present and future

HDAC8 cooperates with SMAD3/4 complex to suppress SIRT7 and promote cell survival and migration

(2020) Xiaolong Tang et al.   NUCLEIC ACIDS RESEARCH

Epigenetic reprogramming at estrogen-receptor binding sites alters 3D chromatin landscape in endocrine-resistant breast cancer

(2020) Joanna Achinger-Kawecka et al.   Nature Communications

Acute Myeloid Leukemia: Aging and Epigenetics

(2020) Polina Zjablovskaja et al.   Cancers

Mutant EZH2 Induces a Pre-malignant Lymphoma Niche by Reprogramming the Immune Response

(2020) Wendy Béguelin et al.   CANCER CELL

Single-cell epigenomics in cancer: charting a course to clinical impact

(2020) Danielle R Bond et al.   Epigenomics

Reciprocal H3.3 gene editing identifies K27M and G34R mechanisms in pediatric glioma including NOTCH signaling

(2020) Kuang-Yui Chen et al.   Communications Biology

KDM5B is essential for the hyper-activation of PI3K/AKT signaling in prostate tumorigenesis

(2020) Guoliang Li et al.   CANCER RESEARCH

Revisiting 3D chromatin architecture in cancer development and progression

(2020) Yuliang Feng et al.   NUCLEIC ACIDS RESEARCH

Constitutive BRCA1 Promoter Hypermethylation Can Be a Predisposing Event in Isolated Early-Onset Breast Cancer

(2019) Jacopo Azzollini et al.   Cancers

The expanding landscape of ‘oncohistone’ mutations in human cancers

(2019) Benjamin A. Nacev et al.   NATURE

Dual roles of EZH2 in acute myeloid leukemia

(2019) Radek C. Skoda et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML

(2019) Faisal Basheer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance

(2019) Kunihiko Hinohara et al.   CANCER CELL

HDAC8 regulates a stress response pathway in melanoma to mediate escape from BRAF inhibitor therapy

(2019) Michael F. Emmons et al.   CANCER RESEARCH

Cancer cell niche factors secreted from cancer-associated fibroblast by loss of H3K27me3

(2019) Masahiro Maeda et al.   GUT

Histone methyltransferase SETDB1 contributes to melanoma tumorigenesis and serves as a new potential therapeutic target

(2019) Elias Orouji et al.   INTERNATIONAL JOURNAL OF CANCER

KDM5B promotes breast cancer cell proliferation and migration via AMPK-mediated lipid metabolism reprogramming

(2019) Zhong-Guo Zhang et al.   EXPERIMENTAL CELL RESEARCH

High-throughput single-cell ChIP-seq identifies heterogeneity of chromatin states in breast cancer

(2019) Kevin Grosselin et al.   NATURE GENETICS

Temporal dynamic reorganization of 3D chromatin architecture in hormone-induced breast cancer and endocrine resistance

(2019) Yufan Zhou et al.   Nature Communications

Mutant H3 histones drive human pre-leukemic hematopoietic stem cell expansion and promote leukemic aggressiveness

(2019) Meaghan Boileau et al.   Nature Communications

Oncogenic KRAS sensitizes lung adenocarcinoma to GSK-J4-induced metabolic and oxidative stress

(2019) Beom-Jin Hong et al.   CANCER RESEARCH

Epigenetics of lung cancer: a translational perspective

(2019) Álvaro Quintanal-Villalonga et al.   CELLULAR ONCOLOGY

EGFR–c-Src-Mediated HDAC3 Phosphorylation Exacerbates Invasion of Breast Cancer Cells

(2019) Sung-Min Kwak et al.   Cells

HDAC5-mediated deacetylation and nuclear localisation of SOX9 is critical for tamoxifen resistance in breast cancer

(2019) Yue Xue et al.   BRITISH JOURNAL OF CANCER

Altered chromosomal topology drives oncogenic programs in SDH-deficient GISTs

(2019) William A. Flavahan et al.   NATURE

A high-resolution 3D epigenomic map reveals insights into the creation of the prostate cancer transcriptome

(2019) Suhn Kyong Rhie et al.   Nature Communications

Phosphorylation of the histone demethylase KDM5B and regulation of the phenotype of triple negative breast cancer

(2019) I-Ju Yeh et al.   Scientific Reports

Suppression of TGFβ-mediated conversion of endothelial cells and fibroblasts into cancer associated (myo)fibroblasts via HDAC inhibition

(2018) Dae Joong Kim et al.   BRITISH JOURNAL OF CANCER

Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma

(2018) Yong Yu et al.   CANCER CELL

EZH2-Mediated Primary Cilium Deconstruction Drives Metastatic Melanoma Formation

(2018) Daniel Zingg et al.   CANCER CELL

Loss of XIST in Breast Cancer Activates MSN-c-Met and Reprograms Microglia via Exosomal miRNA to Promote Brain Metastasis

(2018) Fei Xing et al.   CANCER RESEARCH

PRMT9 promotes hepatocellular carcinoma invasion and metastasis via activating PI3K/Akt/GSK-3β/Snail signaling

(2018) Hai Jiang et al.   CANCER SCIENCE

Alteration of Epigenetic Regulation by Long Noncoding RNAs in Cancer

(2018) Mariangela Morlando et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Histone deacetylase 6 regulates the immunosuppressive properties of cancer-associated fibroblasts in breast cancer through the STAT3–COX2-dependent pathway

(2018) Ang Li et al.   ONCOGENE

Histone demethylase JMJD1A promotes alternative splicing of AR variant 7 (AR-V7) in prostate cancer cells

(2018) Lingling Fan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting EZH2 reactivates a breast cancer subtype-specific anti-metastatic transcriptional program

(2018) Alison Hirukawa et al.   Nature Communications

Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis

(2018) Shuhei Asada et al.   Nature Communications

Epigenetics and Epi-miRNAs: Potential markers/therapeutics in leukemia

(2018) Fatemeh Memari et al.   BIOMEDICINE & PHARMACOTHERAPY

Stromal epigenetic alterations drive metabolic and neuroendocrine prostate cancer reprogramming

(2018) Rajeev Mishra et al.   JOURNAL OF CLINICAL INVESTIGATION

Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods

(2018) J. Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

AKT Inhibition Modulates H3K4 Demethylase Levels in PTEN-Null Prostate Cancer

(2018) Mohammad Imran Khan et al.   MOLECULAR CANCER THERAPEUTICS

NSD2 is a conserved driver of metastatic prostate cancer progression

(2018) Alvaro Aytes et al.   Nature Communications

Automethylation of protein arginine methyltransferase 7 and its impact on breast cancer progression

(2017) Pengyu Geng et al.   FASEB JOURNAL

Linking long non-coding RNAs and SWI/SNF complexes to chromatin remodeling in cancer

(2017) Yanyan Tang et al.   Molecular Cancer

Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas

(2017) Simon Papillon-Cavanagh et al.   NATURE GENETICS

Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance

(2017) Sheng Yu Ku et al.   SCIENCE

Epigenetics in multiple myeloma: From mechanisms to therapy

(2017) Mohammad Alzrigat et al.   SEMINARS IN CANCER BIOLOGY

PRMT8 demonstrates variant-specific expression in cancer cells and correlates with patient survival in breast, ovarian and gastric cancer

(2017) Sarah J. Hernandez et al.   Oncology Letters

KDM3A promotes inhibitory cytokines secretion by participating in TLR4 regulation of Foxp3 transcription in lung adenocarcinoma cells

(2017) Yinan Li et al.   Oncology Letters

Overexpression of EZH2 in multiple myeloma is associated with poor prognosis and dysregulation of cell cycle control

(2017) C Pawlyn et al.   Blood Cancer Journal

Histone demethylase JMJD2C: epigenetic regulators in tumors

(2017) Chengcheng Zhang et al.   Oncotarget

The DNA methyl-transferase protein DNMT1 enhances tumor-promoting properties of breast stromal fibroblasts

(2017) Layla A. Al-Kharashi et al.   Oncotarget

Upregulation of long noncoding RNA Xist promotes proliferation of osteosarcoma by epigenetic silencing of P21

(2017) Tianyang Xu et al.   Oncotarget

Cohesin mutations: contributors to myeloid malignancies

(2017) Alison E. Meyer et al.   Oncotarget

PRMT5 Is a Critical Regulator of Breast Cancer Stem Cell Function via Histone Methylation and FOXP1 Expression

(2017) Kelly Chiang et al.   Cell Reports

Prostaglandin E2 Leads to the Acquisition of DNMT3A-Dependent Tolerogenic Functions in Human Myeloid-Derived Suppressor Cells

(2017) Javier Rodríguez-Ubreva et al.   Cell Reports

Tumor-Associated Macrophages Promote Epigenetic Silencing of Gelsolin through DNA Methyltransferase 1 in Gastric Cancer Cells

(2017) Hao-Chen Wang et al.   Cancer Immunology Research

MLL-Rearranged Leukemias—An Update on Science and Clinical Approaches

(2017) Amanda C. Winters et al.   Frontiers in Pediatrics

Human Colorectal Cancer Stage-dependent Global DNA Hypomethylation of Cancer-associated Fibroblasts

(2016) EDUARD LING et al.   ANTICANCER RESEARCH

DOT1L histone methyltransferase regulates the expression of BCAT1 and is involved in sphere formation and cell migration of breast cancer cell lines

(2016) Dulamsuren Oktyabri et al.   BIOCHIMIE

N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer

(2016) Etienne Dardenne et al.   CANCER CELL

H3K27 Demethylase JMJD3 Employs the NF- B and BMP Signaling Pathways to Modulate the Tumor Microenvironment and Promote Melanoma Progression and Metastasis

(2016) W.-Y. Park et al.   CANCER RESEARCH

The Spectrum and Clinical Impact of Epigenetic Modifier Mutations in Myeloma

(2016) C. Pawlyn et al.   CLINICAL CANCER RESEARCH

Histone demethylase JMJD2A drives prostate tumorigenesis through transcription factor ETV1

(2016) Tae-Dong Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Essential role of HDAC6 in the regulation of PD-L1 in melanoma

(2016) M. Lienlaf et al.   Molecular Oncology

Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation

(2016) Min Pan et al.   NATURE CELL BIOLOGY

Epigenetic activation of the prostaglandin receptor EP4 promotes resistance to endocrine therapy for breast cancer

(2016) J F Hiken et al.   ONCOGENE

A TGFβ-PRMT5-MEP50 axis regulates cancer cell invasion through histone H3 and H4 arginine methylation coupled transcriptional activation and repression

(2016) H Chen et al.   ONCOGENE

HIFI-α activation underlies a functional switch in the paradoxical role of Ezh2/PRC2 in breast cancer

(2016) Sylvia Mahara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutational landscape of uterine and ovarian carcinosarcomas implicates histone genes in epithelial–mesenchymal transition

(2016) Siming Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of proto-oncogenes by disruption of chromosome neighborhoods

(2016) D. Hnisz et al.   SCIENCE

Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape

(2016) C. Lu et al.   SCIENCE

The KDM3A–KLF2–IRF4 axis maintains myeloma cell survival

(2016) Hiroto Ohguchi et al.   Nature Communications

Bmi1 marks distinct castration-resistant luminal progenitor cells competent for prostate regeneration and tumour initiation

(2016) Young A. Yoo et al.   Nature Communications

In Vivo Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype

(2016) D. Bossi et al.   Cancer Discovery

KDM1A promotes tumor cell invasion by silencing TIMP3 in non-small cell lung cancer cells

(2016) Lingzhi Kong et al.   Oncotarget

Long non-coding RNA LINC01133 represses KLF2, P21 and E-cadherin transcription through binding with EZH2, LSD1 in non small cell lung cancer

(2016) Chongshuang Zang et al.   Oncotarget

PI3K/AKT Signaling Regulates H3K4 Methylation in Breast Cancer

(2016) Jennifer M. Spangle et al.   Cell Reports

Epigenetic regulation of p14ARF and p16INK4A expression in cutaneous and uveal melanoma

(2015) Mario Venza et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

EZH2 promotes tumor progression via regulating VEGF-A/AKT signaling in non-small cell lung cancer

(2015) Jian Geng et al.   CANCER LETTERS

Gene mutations in primary tumors and corresponding patient-derived xenografts derived from non-small cell lung cancer

(2015) Chuncheng Hao et al.   CANCER LETTERS

Δ9 -Tetrahydrocannabinol attenuates allogeneic host-versus-graft response and delays skin graft rejection through activation of cannabinoid receptor 1 and induction of myeloid-derived suppressor cells

(2015) Jessica M. Sido et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Δ9 -Tetrahydrocannabinol-mediated epigenetic modifications elicit myeloid-derived suppressor cell activation via STAT3/S100A8

(2015) Jessica Margaret Sido et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Histone Variant H2A.Z.2 Mediates Proliferation and Drug Sensitivity of Malignant Melanoma

(2015) Chiara Vardabasso et al.   MOLECULAR CELL

Insulator dysfunction and oncogene activation in IDH mutant gliomas

(2015) William A. Flavahan et al.   NATURE

Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy

(2015) Dongjun Peng et al.   NATURE

DOT1L cooperates with the c-Myc-p300 complex to epigenetically derepress CDH1 transcription factors in breast cancer progression

(2015) Min-Hyung Cho et al.   Nature Communications

TET2 repression by androgen hormone regulates global hydroxymethylation status and prostate cancer progression

(2015) Ken-ichi Takayama et al.   Nature Communications

Genome-wide profiling of p53-regulated enhancer RNAs uncovers a subset of enhancers controlled by a lncRNA

(2015) Nicolas Léveillé et al.   Nature Communications

Chromatin Dynamics and the RNA Exosome Function in Concert to Regulate Transcriptional Homeostasis

(2015) Mayuri Rege et al.   Cell Reports

Transcription factor MITF and remodeller BRG1 define chromatin organisation at regulatory elements in melanoma cells

(2015) Patrick Laurette et al.   eLife

Cervical (pre)neoplastic microenvironment promotes the emergence of tolerogenic dendritic cells via RANKL secretion

(2015) Stéphanie A Demoulin et al.   OncoImmunology

EZH2 promotes progression of small cell lung cancer by suppressing the TGF-β-Smad-ASCL1 pathway

(2015) Fumihiko Murai et al.   Cell Discovery

Mutations in linker histone genes HIST1H1 B, C, D, and E; OCT2 (POU2F2); IRF8; and ARID1A underlying the pathogenesis of follicular lymphoma

(2014) H. Li et al.   BLOOD

Genome-wide Mapping and Characterization of Notch-Regulated Long Noncoding RNAs in Acute Leukemia

(2014) Thomas Trimarchi et al.   CELL

AF9 YEATS Domain Links Histone Acetylation to DOT1L-Mediated H3K79 Methylation

(2014) Yuanyuan Li et al.   CELL

SWI/SNF Chromatin Remodeling Enzymes in Melanocyte Differentiation and Melanoma

(2014) A. Mehrotra et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Dysregulated Class I histone deacetylases are indicators of poor prognosis in multiple myeloma

(2014) Sridurga Mithraprabhu et al.   Epigenetics

Transcriptional Repression of Histone Deacetylase 3 by the Histone Demethylase KDM2A Is Coupled to Tumorigenicity of Lung Cancer Cells

(2014) Shilpa S. Dhar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functions of lncRNA HOTAIR in lung cancer

(2014) Gregory Loewen et al.   Journal of Hematology & Oncology

Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia

(2014) Panagiotis Ntziachristos et al.   NATURE

Control of NF-kB activity in human melanoma by bromodomain and extra-terminal protein inhibitor I-BET151

(2014) Stuart J. Gallagher et al.   Pigment Cell & Melanoma Research

Exome sequencing identifies frequent mutation of MLL2 in non–small cell lung carcinoma from Chinese patients

(2014) Shanye Yin et al.   Scientific Reports

The Histone-H3K4-Specific Demethylase KDM5B Binds to Its Substrate and Product through Distinct PHD Fingers

(2014) Brianna J. Klein et al.   Cell Reports

CARM1 and PRMT1 are dysregulated in lung cancer without hierarchical features

(2013) Rania Elakoum et al.   BIOCHIMIE

Low frequency of H3.3 mutations and upregulated DAXX expression in MDS

(2013) Y. Attieh et al.   BLOOD

Overcoming Intrinsic Multidrug Resistance in Melanoma by Blocking the Mitochondrial Respiratory Chain of Slow-Cycling JARID1Bhigh Cells

(2013) Alexander Roesch et al.   CANCER CELL

BRD4 Sustains Melanoma Proliferation and Represents a New Target for Epigenetic Therapy

(2013) M. F. Segura et al.   CANCER RESEARCH

Xist RNA Is a Potent Suppressor of Hematologic Cancer in Mice

(2013) Eda Yildirim et al.   CELL

Cancer-associated fibroblasts enhance the migration ability of ovarian cancer cells by increasing EZH2 expression

(2013) LINJUAN XU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling

(2013) Klaus W. Wagner et al.   JOURNAL OF CLINICAL INVESTIGATION

Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma

(2013) Jessica Okosun et al.   NATURE GENETICS

The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI/SNF complex

(2013) John R Prensner et al.   NATURE GENETICS

Epigenetic silencing of retinoblastoma gene regulates pathologic differentiation of myeloid cells in cancer

(2013) Je-In Youn et al.   NATURE IMMUNOLOGY

DNA methylation: roles in mammalian development

(2013) Zachary D. Smith et al.   NATURE REVIEWS GENETICS

TETonic shift: biological roles of TET proteins in DNA demethylation and transcription

(2013) William A. Pastor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

Genomic Deregulation of the E2F/Rb Pathway Leads to Activation of the Oncogene EZH2 in Small Cell Lung Cancer

(2013) Bradley P. Coe et al.   PLoS One

Expression of the cancer-testis antigen BORIS correlates with prostate cancer

(2013) Zubair Cheema et al.   PROSTATE

Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma

(2013) P. W. Lewis et al.   SCIENCE

Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma

(2012) Dominik Sturm et al.   CANCER CELL

Histone Lysine Methyltransferase SETD8 Promotes Carcinogenesis by Deregulating PCNA Expression

(2012) M. Takawa et al.   CANCER RESEARCH

A Landscape of Driver Mutations in Melanoma

(2012) Eran Hodis et al.   CELL

Decreased DNA methylation in acute myeloid leukemia patients with DNMT3A mutations and prognostic implications of DNA methylation

(2012) Hana Hájková et al.   LEUKEMIA RESEARCH

Histone Demethylase KDM5B Collaborates with TFAP2C and Myc To Repress the Cell Cycle Inhibitor p21cip (CDKN1A)

(2012) P.-P. Wong et al.   MOLECULAR AND CELLULAR BIOLOGY

Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact

(2012) Joshua C. Black et al.   MOLECULAR CELL

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

(2012) Jeremy Schwartzentruber et al.   NATURE

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

(2012) Laurens Kruidenier et al.   NATURE

Topological domains in mammalian genomes identified by analysis of chromatin interactions

(2012) Jesse R. Dixon et al.   NATURE

Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas

(2012) Gang Wu et al.   NATURE GENETICS

Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia

(2012) Panagiotis Ntziachristos et al.   NATURE MEDICINE

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

The histone methyltransferase MMSET/WHSC1 activates TWIST1 to promote an epithelial–mesenchymal transition and invasive properties of prostate cancer

(2012) T Ezponda et al.   ONCOGENE

TET1 Suppresses Cancer Invasion by Activating the Tissue Inhibitors of Metalloproteinases

(2012) Chih-Hung Hsu et al.   Cell Reports

Oxidative Damage Targets Complexes Containing DNA Methyltransferases, SIRT1, and Polycomb Members to Promoter CpG Islands

(2011) Heather M. O'Hagan et al.   CANCER CELL

BORIS Binding to the Promoters of Cancer Testis Antigens, MAGEA2, MAGEA3, and MAGEA4, Is Associated with Their Transcriptional Activation in Lung Cancer

(2011) S. Bhan et al.   CLINICAL CANCER RESEARCH

Epigenetics and B-cell lymphoma

(2011) Rita Shaknovich et al.   CURRENT OPINION IN HEMATOLOGY

Regulation of mammalian DNA methyltransferases: a route to new mechanisms

(2011) Hélène Denis et al.   EMBO REPORTS

Colon cancer associated transcript-1: A novel RNA expressed in malignant and pre-malignant human tissues

(2011) Aviram Nissan et al.   INTERNATIONAL JOURNAL OF CANCER

The JmjC domain-containing histone demethylase KDM3A is a positive regulator of the G1/S transition in cancer cells via transcriptional regulation of the HOXA1 gene

(2011) Hyun-Soo Cho et al.   INTERNATIONAL JOURNAL OF CANCER

Inactivating mutations of acetyltransferase genes in B-cell lymphoma

(2011) Laura Pasqualucci et al.   NATURE

Initial genome sequencing and analysis of multiple myeloma

(2011) Michael A. Chapman et al.   NATURE

The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset

(2011) Craig J. Ceol et al.   NATURE

H3K9 Histone Methyltransferase G9a Promotes Lung Cancer Invasion and Metastasis by Silencing the Cell Adhesion Molecule Ep-CAM

(2010) M.-W. Chen et al.   CANCER RESEARCH

A Temporarily Distinct Subpopulation of Slow-Cycling Melanoma Cells Is Required for Continuous Tumor Growth

(2010) Alexander Roesch et al.   CELL

Opposing Roles of Dnmt1 in Early- and Late-Stage Murine Prostate Cancer

(2010) S. R. Morey Kinney et al.   MOLECULAR AND CELLULAR BIOLOGY

TDRD3 Is an Effector Molecule for Arginine-Methylated Histone Marks

(2010) Yanzhong Yang et al.   MOLECULAR CELL

The histone variant macroH2A suppresses melanoma progression through regulation of CDK8

(2010) Avnish Kapoor et al.   NATURE

Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis

(2010) Rajnish A. Gupta et al.   NATURE

Epigenetic modifications and human disease

(2010) Anna Portela et al.   NATURE BIOTECHNOLOGY

Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes

(2010) M.-C. Tsai et al.   SCIENCE

Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX–DNMT3–DNMT3L domain

(2009) Junji Otani et al.   EMBO REPORTS

Emerging similarities in epigenetic gene silencing by long noncoding RNAs

(2009) Takashi Nagano et al.   MAMMALIAN GENOME

Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome

(2009) E. Lieberman-Aiden et al.   SCIENCE

BORIS, a paralogue of the transcription factor, CTCF, is aberrantly expressed in breast tumours

(2008) V D'Arcy et al.   BRITISH JOURNAL OF CANCER

Global Hypomethylation of Genomic DNA in Cancer-Associated Myofibroblasts

(2008) L. Jiang et al.   CANCER RESEARCH

Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions

(2008) Lars Guelen et al.   NATURE

Downregulation of EZH2 decreases growth of estrogen receptor-negative invasive breast carcinoma and requires BRCA1

(2008) M E Gonzalez et al.   ONCOGENE