Acute Myeloid Leukemia: Aging and Epigenetics

Cancer statistics, 2019

(2019) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Murine Models of Acute Myeloid Leukaemia

(2019) Marwa Almosailleakh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

L1 drives IFN in senescent cells and promotes age-associated inflammation

(2019) Marco De Cecco et al.   NATURE

Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML

(2019) Faisal Basheer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Epigenetic age is a cell-intrinsic property in transplanted human hematopoietic cells

(2019) Arne Søraas et al.   AGING CELL

Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan

(2019) Lei Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Losing Sense of Self and Surroundings: Hematopoietic Stem Cell Aging and Leukemic Transformation

(2019) Evgenia V. Verovskaya et al.   TRENDS IN MOLECULAR MEDICINE

Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to Leukemia

(2019) Emmalee R Adelman et al.   Cancer Discovery

Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging

(2019) Ya-Hsuan Ho et al.   Cell Stem Cell

The diverse roles of DNA methylation in mammalian development and disease

(2019) Maxim V. C. Greenberg et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing

(2019) Qian Zhang et al.   Genome Medicine

Haematopoietic stem cells in perisinusoidal niches are protected from ageing

(2019) Mehmet Saçma et al.   NATURE CELL BIOLOGY

Microenvironmental contributions to hematopoietic stem cell aging

(2019) Ya-Hsuan Ho et al.   HAEMATOLOGICA

Genetics of acute myeloid leukemia in the elderly: mutation spectrum and clinical impact in intensively treated patients aged ≥ 75 years

(2018) Victoria V. Prassek et al.   HAEMATOLOGICA

Clearance of Somatic Mutations at Remission and the Risk of Relapse in Acute Myeloid Leukemia

(2018) Kiyomi Morita et al.   JOURNAL OF CLINICAL ONCOLOGY

Persistence of pre-leukemic clones during first remission and risk of relapse in acute myeloid leukemia

(2018) Maja Rothenberg-Thurley et al.   LEUKEMIA

Short Telomere Syndromes in Clinical Practice: Bridging Bench and Bedside

(2018) Abhishek A. Mangaonkar et al.   MAYO CLINIC PROCEEDINGS

Clinical Implications of Clonal Hematopoiesis

(2018) David P. Steensma   MAYO CLINIC PROCEEDINGS

Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche

(2018) Maria Maryanovich et al.   NATURE MEDICINE

DNA methylation-based biomarkers and the epigenetic clock theory of ageing

(2018) Steve Horvath et al.   NATURE REVIEWS GENETICS

Enhancing the accuracy of next-generation sequencing for detecting rare and subclonal mutations

(2018) Jesse J. Salk et al.   NATURE REVIEWS GENETICS

Molecular Minimal Residual Disease in Acute Myeloid Leukemia

(2018) Mojca Jongen-Lavrencic et al.   NEW ENGLAND JOURNAL OF MEDICINE

Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers

(2018) Janeta Popovici-Muller et al.   ACS Medicinal Chemistry Letters

Genetics of acute myeloid leukemia in the elderly: mutation spectrum and clinical impact in intensively treated patients aged ≥ 75 years

(2018) Victoria V. Prassek et al.   HAEMATOLOGICA

Chromatin Architectural Changes during Cellular Senescence and Aging

(2018) Luyang Sun et al.   Genes

Glasdegib in combination with cytarabine and daunorubicin in patients with AML or high-risk MDS: Phase 2 study results

(2018) Jorge E. Cortes et al.   AMERICAN JOURNAL OF HEMATOLOGY

BCL-2 inhibition in AML: an unexpected bonus?

(2018) Marina Konopleva et al.   BLOOD

Mouse Models to Disentangle the Hallmarks of Human Aging

(2018) Alicia R. Folgueras et al.   CIRCULATION RESEARCH

Rational identification of a Cdc42 inhibitor presents a new regimen for long-term hematopoietic stem cell mobilization

(2018) Wei Liu et al.   LEUKEMIA

Prediction of acute myeloid leukaemia risk in healthy individuals

(2018) Sagi Abelson et al.   NATURE

Aging alters the epigenetic asymmetry of HSC division

(2018) M. Carolina Florian et al.   PLOS BIOLOGY

Venetoclax combined with decitabine or azacitidine in treatment-naive, elderly patients with acute myeloid leukemia

(2018) Courtney D. DiNardo et al.   BLOOD

Clinical impact of clonal hematopoiesis in acute myeloid leukemia patients receiving allogeneic transplantation

(2018) Juliane Grimm et al.   BONE MARROW TRANSPLANTATION

Randomized comparison of low dose cytarabine with or without glasdegib in patients with newly diagnosed acute myeloid leukemia or high-risk myelodysplastic syndrome

(2018) Jorge E. Cortes et al.   LEUKEMIA

Turning back time with emerging rejuvenation strategies

(2018) Salah Mahmoudi et al.   NATURE CELL BIOLOGY

Myelodysplastic syndrome progression to acute myeloid leukemia at the stem cell level

(2018) Jiahao Chen et al.   NATURE MEDICINE

Somatic Mutations Reveal Lineage Relationships and Age-Related Mutagenesis in Human Hematopoiesis

(2018) Fernando G. Osorio et al.   Cell Reports

Expression and Activity of the Small RhoGTPase Cdc42 in Blood Cells of Older Adults Are Associated With Age and Cardiovascular Disease

(2017) Maria Carolina Florian et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Acute myeloid leukemia in the elderly is characterized by a distinct genetic and epigenetic landscape

(2017) P Silva et al.   LEUKEMIA

Autophagy maintains the metabolism and function of young and old stem cells

(2017) Theodore T. Ho et al.   NATURE

Rejuvenation of aged hematopoietic stem cells

(2017) Novella Guidi et al.   SEMINARS IN HEMATOLOGY

Preclinical studies of gilteritinib, a next-generation FLT3 inhibitor

(2016) Lauren Y. Lee et al.   BLOOD

Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel

(2016) Hartmut Döhner et al.   BLOOD

MLL-AF9 Expression in Hematopoietic Stem Cells Drives a Highly Invasive AML Expressing EMT-Related Genes Linked to Poor Outcome

(2016) Vaia Stavropoulou et al.   CANCER CELL

Aging of hematopoietic stem cells: DNA damage and mutations?

(2016) Bettina M. Moehrle et al.   EXPERIMENTAL HEMATOLOGY

Isocitrate dehydrogenase mutations in myeloid malignancies

(2016) B C Medeiros et al.   LEUKEMIA

Age-dependent modulation of vascular niches for haematopoietic stem cells

(2016) Anjali P. Kusumbe et al.   NATURE

Tissue-specific mutation accumulation in human adult stem cells during life

(2016) Francis Blokzijl et al.   NATURE

Assessment of Minimal Residual Disease in Standard-Risk AML

(2016) Adam Ivey et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genomic Classification and Prognosis in Acute Myeloid Leukemia

(2016) Elli Papaemmanuil et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lateral Thinking: How Histone Modifications Regulate Gene Expression

(2016) Moyra Lawrence et al.   TRENDS IN GENETICS

Aging, Clonality, and Rejuvenation of Hematopoietic Stem Cells

(2016) Shailaja Akunuru et al.   TRENDS IN MOLECULAR MEDICINE

Leukaemia cell of origin identified by chromatin landscape of bulk tumour cells

(2016) Joshy George et al.   Nature Communications

Continued improvement in survival of acute myeloid leukemia patients: an application of the loss in expectation of life

(2016) H Bower et al.   Blood Cancer Journal

Age-Associated Decrease of the Histone Methyltransferase SUV39H1 in HSC Perturbs Heterochromatin and B Lymphoid Differentiation

(2016) Dounia Djeghloul et al.   Stem Cell Reports

Inflamm-Aging of Hematopoiesis, Hematopoietic Stem Cells, and the Bone Marrow Microenvironment

(2016) Larisa V. Kovtonyuk et al.   Frontiers in Immunology

Transposable elements become active and mobile in the genomes of aging mammalian somatic tissues

(2016) Marco De Cecco et al.   Aging-US

Survival of Patients with Acute Myeloid Leukemia Relapsing after Allogeneic Hematopoietic Cell Transplantation: A Center for International Blood and Marrow Transplant Research Study

(2015) Nelli Bejanyan et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Epigenetics and approaches to targeted epigenetic therapy in acute myeloid leukemia

(2015) B. J. Wouters et al.   BLOOD

Telomere Dysfunction Drives Aberrant Hematopoietic Differentiation and Myelodysplastic Syndrome

(2015) Simona Colla et al.   CANCER CELL

Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia

(2015) Jeffery M. Klco et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging

(2015) M. Mohrin et al.   SCIENCE

Aging as a driver of leukemogenesis

(2015) Thomas McKerrell et al.   Science Translational Medicine

Stem Cell-Specific Mechanisms Ensure Genomic Fidelity within HSCs and upon Aging of HSCs

(2015) Bettina M. Moehrle et al.   Cell Reports

Epigenomic Profiling of Young and Aged HSCs Reveals Concerted Changes during Aging that Reinforce Self-Renewal

(2014) Deqiang Sun et al.   Cell Stem Cell

Quiescent Hematopoietic Stem Cells Accumulate DNA Damage during Aging that Is Repaired upon Entry into Cell Cycle

(2014) Isabel Beerman et al.   Cell Stem Cell

Acute myeloid leukaemia: a paradigm for the clonal evolution of cancer?

(2014) C. S. Grove et al.   Disease Models & Mechanisms

Age-related epigenetic drift in the pathogenesis of MDS and AML

(2014) S. Maegawa et al.   GENOME RESEARCH

The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation

(2014) Hiba Ahmad Zahreddine et al.   NATURE

Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia

(2014) Liran I. Shlush et al.   NATURE

Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence

(2014) Giulio Genovese et al.   NEW ENGLAND JOURNAL OF MEDICINE

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

(2014) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission

(2014) M. R. Corces-Zimmerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The genetic basis of myelodysplasia and its clinical relevance

(2013) M. Cazzola et al.   BLOOD

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Xist RNA Is a Potent Suppressor of Hematologic Cancer in Mice

(2013) Eda Yildirim et al.   CELL

Proliferation-Dependent Alterations of the DNA Methylation Landscape Underlie Hematopoietic Stem Cell Aging

(2013) Isabel Beerman et al.   Cell Stem Cell

What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer

(2013) J.-A. Losman et al.   GENES & DEVELOPMENT

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

Selective BCL-2 Inhibition by ABT-199 Causes On-Target Cell Death in Acute Myeloid Leukemia

(2013) R. Pan et al.   Cancer Discovery

SIRT3 Reverses Aging-Associated Degeneration

(2013) Katharine Brown et al.   Cell Reports

The Origin and Evolution of Mutations in Acute Myeloid Leukemia

(2012) John S. Welch et al.   CELL

Cdc42 Activity Regulates Hematopoietic Stem Cell Aging and Rejuvenation

(2012) Maria Carolina Florian et al.   Cell Stem Cell

Global heterochromatin loss

(2012) Amy Tsurumi et al.   Epigenetics

Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates

(2012) Gregory Hannum et al.   MOLECULAR CELL

Clonal Evolution of Preleukemic Hematopoietic Stem Cells Precedes Human Acute Myeloid Leukemia

(2012) M. Jan et al.   Science Translational Medicine

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

Accumulating Mitochondrial DNA Mutations Drive Premature Hematopoietic Aging Phenotypes Distinct from Physiological Stem Cell Aging

(2011) Gudmundur L. Norddahl et al.   Cell Stem Cell

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

(2010) Maria E. Figueroa et al.   CANCER CELL

Isocitrate Dehydrogenase 1 and 2 Mutations in Cancer: Alterations at a Crossroads of Cellular Metabolism

(2010) Z. J. Reitman et al.   JNCI-Journal of the National Cancer Institute

Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome

(2009) Elaine R. Mardis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells

(2009) C. Chen et al.   Science Signaling

Malignant Transformation Initiated by Mll-AF9: Gene Dosage and Critical Target Cells

(2008) Weili Chen et al.   CANCER CELL

Stems Cells and the Pathways to Aging and Cancer

(2008) Derrick J. Rossi et al.   CELL

Age-Related Risk Profile and Chemotherapy Dose Response in Acute Myeloid Leukemia: A Study by the German Acute Myeloid Leukemia Cooperative Group

(2008) Thomas Büchner et al.   JOURNAL OF CLINICAL ONCOLOGY

Mutations and Treatment Outcome in Cytogenetically Normal Acute Myeloid Leukemia

(2008) Richard F. Schlenk et al.   NEW ENGLAND JOURNAL OF MEDICINE

Upsides and downsides to polarity and asymmetric cell division in leukemia

(2008) E D Hawkins et al.   ONCOGENE