Histone deacetylase 6 regulates the immunosuppressive properties of cancer-associated fibroblasts in breast cancer through the STAT3–COX2-dependent pathway

The extracellular matrix in myocardial injury, repair, and remodeling

(2017) Nikolaos G. Frangogiannis   JOURNAL OF CLINICAL INVESTIGATION

Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages

(2017) Jennifer L. Guerriero et al.   NATURE

Fibroblasts drive an immunosuppressive and growth-promoting microenvironment in breast cancer via secretion of Chitinase 3-like 1

(2017) N Cohen et al.   ONCOGENE

Metabolic Interactions in the Tumor Microenvironment

(2017) Costas A. Lyssiotis et al.   TRENDS IN CELL BIOLOGY

Dysregulation of miRNA Expression in Cancer Associated Fibroblasts (CAFs) and Its Consequences on the Tumor Microenvironment

(2017) Maren Schoepp et al.   Cancers

CCL2 Produced by the Glioma Microenvironment Is Essential for the Recruitment of Regulatory T Cells and Myeloid-Derived Suppressor Cells

(2016) Alan L. Chang et al.   CANCER RESEARCH

Incipient Melanoma Brain Metastases Instigate Astrogliosis and Neuroinflammation

(2016) H. Schwartz et al.   CANCER RESEARCH

FAP Promotes Immunosuppression by Cancer-Associated Fibroblasts in the Tumor Microenvironment via STAT3–CCL2 Signaling

(2016) Xuguang Yang et al.   CANCER RESEARCH

HDAC Inhibitors Enhance T-Cell Chemokine Expression and Augment Response to PD-1 Immunotherapy in Lung Adenocarcinoma

(2016) Hong Zheng et al.   CLINICAL CANCER RESEARCH

Molecular Pathways: Maintaining MAPK Inhibitor Sensitivity by Targeting Nonmutational Tolerance

(2016) M. P. Smith et al.   CLINICAL CANCER RESEARCH

Stromal COX-2 signaling are correlated with colorectal cancer: A review

(2016) Chen-Wei Su et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

COX-2 inhibitors: a novel strategy in the management of breast cancer

(2016) Miłosz Regulski et al.   DRUG DISCOVERY TODAY

Epigenetic modifiers in immunotherapy: a focus on checkpoint inhibitors

(2016) Manuela Terranova-Barberio et al.   Immunotherapy

The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment

(2016) Vinit Kumar et al.   TRENDS IN IMMUNOLOGY

Tumor-Derived Osteopontin Reprograms Normal Mammary Fibroblasts to Promote Inflammation and Tumor Growth in Breast Cancer

(2015) Y. Sharon et al.   CANCER RESEARCH

HDAC6 mediates HIV-1 tat-induced proinflammatory responses by regulating MAPK-NF-kappaB/AP-1 pathways in astrocytes

(2015) Gi Soo Youn et al.   GLIA

Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy

(2015) Shabnam Shalapour et al.   NATURE

Deacetylation of tumor-suppressor MST1 in Hippo pathway induces its degradation through HBXIP-elevated HDAC6 in promotion of breast cancer growth

(2015) L Li et al.   ONCOGENE

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

The Reprogramming of Tumor Stroma by HSF1 Is a Potent Enabler of Malignancy

(2014) Ruth Scherz-Shouval et al.   CELL

A Novel Role for Histone Deacetylase 6 in the Regulation of the Tolerogenic STAT3/IL-10 Pathway in APCs

(2014) Fengdong Cheng et al.   JOURNAL OF IMMUNOLOGY

Targeting cardiac fibroblasts to treat fibrosis of the heart: Focus on HDACs

(2014) Katherine B. Schuetze et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Divergent roles of histone deacetylase 6 (HDAC6) and histone deacetylase 11 (HDAC11) on the transcriptional regulation of IL10 in antigen presenting cells

(2014) Fengdong Cheng et al.   MOLECULAR IMMUNOLOGY

Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells

(2014) K. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer

(2013) C. Feig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

COX2 regulation of breast cancer bone metastasis

(2013) John Karavitis et al.   OncoImmunology

Fibroblasts as architects of cancer pathogenesis

(2012) Timothy Marsh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

(2012) Paolo P. Provenzano et al.   CANCER CELL

Imaging Tumor-Stroma Interactions during Chemotherapy Reveals Contributions of the Microenvironment to Resistance

(2012) Elizabeth S. Nakasone et al.   CANCER CELL

Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer

(2012) Michael A Jacobetz et al.   GUT

Prostaglandin E2 EP receptors as therapeutic targets in breast cancer

(2011) Jocelyn Reader et al.   CANCER AND METASTASIS REVIEWS

Bone morphogenetic protein (BMP) signaling regulates mitotic checkpoint protein levels in human breast cancer cells

(2011) Hualong Yan et al.   CELLULAR SIGNALLING

NF-κB Signaling Pathway, Inflammation and Colorectal Cancer

(2010) Soly Wang et al.   Cellular & Molecular Immunology

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE