Constitutive BRCA1 Promoter Hypermethylation Can Be a Predisposing Event in Isolated Early-Onset Breast Cancer

Single CpG hypermethylation, allele methylation errors, and decreased expression of multiple tumor suppressor genes in normal body cells of mutation-negative early-onset and high-risk breast cancer patients

(2018) Julia Böck et al.   INTERNATIONAL JOURNAL OF CANCER

Comprehensive analysis of theMLH1promoter region in 480 patients with colorectal cancer and 1150 controls reveals new variants including one with a heritable constitutionalMLH1epimutation

(2018) Monika Morak et al.   JOURNAL OF MEDICAL GENETICS

Gene panel testing of 5589 BRCA1/2 -negative index patients with breast cancer in a routine diagnostic setting: results of the German Consortium for Hereditary Breast and Ovarian Cancer

(2018) Jan Hauke et al.   Cancer Medicine

A Dominantly Inherited 5′ UTR Variant Causing Methylation-Associated Silencing of BRCA1 as a Cause of Breast and Ovarian Cancer

(2018) D.Gareth R. Evans et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Characterization of multi-locus imprinting disturbances and underlying genetic defects in patients with chromosome 11p15.5 related imprinting disorders

(2018) L. Fontana et al.   Epigenetics

Cancer incidence and mortality among young adults aged 20–39 years worldwide in 2012: a population-based study

(2017) Miranda M Fidler et al.   LANCET ONCOLOGY

Association analysis identifies 65 new breast cancer risk loci

(2017) Kyriaki Michailidou et al.   NATURE

Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer

(2017) Roger L Milne et al.   NATURE GENETICS

Integrating liquid biopsies into the management of cancer

(2017) Giulia Siravegna et al.   Nature Reviews Clinical Oncology

Associations Between Cancer Predisposition Testing Panel Genes and Breast Cancer

(2017) Fergus J. Couch et al.   JAMA Oncology

Women at high risk of breast cancer: Molecular characteristics, clinical presentation and management

(2016) Zdenek Kleibl et al.   BREAST

Platinum-Based Chemotherapy Induces Methylation Changes in Blood DNA Associated with Overall Survival in Patients with Ovarian Cancer

(2016) James M. Flanagan et al.   CLINICAL CANCER RESEARCH

Mutation detection rates associated with specific selection criteria for BRCA1/2 testing in 1854 high-risk families: A monocentric Italian study

(2016) Jacopo Azzollini et al.   European Journal of Internal Medicine

Familial Risk and Heritability of Cancer Among Twins in Nordic Countries

(2016) Lorelei A. Mucci et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Frequency of Germline Mutations in 25 Cancer Susceptibility Genes in a Sequential Series of Patients With Breast Cancer

(2016) Nadine Tung et al.   JOURNAL OF CLINICAL ONCOLOGY

DNA methylation and healthy human aging

(2015) Meaghan J. Jones et al.   AGING CELL

Epigenetic alterations in cancer and personalized cancer treatment

(2015) Monica Miozzo et al.   Future Oncology

CDKN2A (p14ARF/p16INK4a) and ATM promoter methylation in patients with impalpable breast lesions

(2015) Lucas Delmonico et al.   HUMAN PATHOLOGY

Association of BRCA1 promoter methylation with sporadic breast cancers: Evidence from 40 studies

(2015) Li Zhang et al.   Scientific Reports

Environmental chemicals and DNA methylation in adults: a systematic review of the epidemiologic evidence

(2015) Adrian Ruiz-Hernandez et al.   Clinical Epigenetics

The molecular significance of methylated BRCA1 promoter in white blood cells of cancer-free females

(2014) Nisreen Al-Moghrabi et al.   BMC CANCER

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

(2014) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Altered RECQ Helicase Expression in Sporadic Primary Colorectal Cancers

(2014) Victoria Valinluck Lao et al.   Translational Oncology

Blood-Based Analyses of Cancer: Circulating Tumor Cells and Circulating Tumor DNA

(2014) D. A. Haber et al.   Cancer Discovery

Performance of BOADICEA and BRCAPRO genetic models and of empirical criteria based on cancer family history for predicting BRCA mutation carrier probabilities: A retrospective study in a sample of Italian cancer genetics clinics

(2013) L. Varesco et al.   BREAST

Aberrant DNA methylation status of DNA repair genes in breast cancer treated with neoadjuvant chemotherapy

(2013) Yoshiyuki Watanabe et al.   GENES TO CELLS

Methylation signature of lymph node metastases in breast cancer patients

(2012) Zeinab Barekati et al.   BMC CANCER

Detection of promoter methylation of tumor suppressor genes in serum DNA of breast cancer cases and benign breast disease controls

(2012) Susan R. Sturgeon et al.   Epigenetics

Monozygotic twins discordant for constitutiveBRCA1promoter methylation, childhood cancer and secondary cancer

(2012) Danuta Galetzka et al.   Epigenetics

Constitutive promoter methylation of BRCA1 and RAD51C in patients with familial ovarian cancer and early-onset sporadic breast cancer

(2012) T. Hansmann et al.   HUMAN MOLECULAR GENETICS

Cigarette smoking behaviors and time since quitting are associated with differential DNA methylation across the human genome

(2012) Emily S. Wan et al.   HUMAN MOLECULAR GENETICS

Prevalence of BRCA1/2 mutations in sporadic breast/ovarian cancer patients and identification of a novel de novo BRCA1 mutation in a patient diagnosed with late onset breast and ovarian cancer: implications for genetic testing

(2011) Kim De Leeneer et al.   BREAST CANCER RESEARCH AND TREATMENT

The Korean Hereditary Breast Cancer (KOHBRA) Study: Protocols and Interim Report

(2011) Sang Ah Han et al.   CLINICAL ONCOLOGY

Fanconi Anemia Core Complex Gene Promoters Harbor Conserved Transcription Regulatory Elements

(2011) Daniel Meier et al.   PLoS One

Constitutional Methylation of the BRCA1 Promoter Is Specifically Associated with BRCA1 Mutation-Associated Pathology in Early-Onset Breast Cancer

(2010) E. M. Wong et al.   Cancer Prevention Research

Methylation profile of TP53 regulatory pathway and mtDNA alterations in breast cancer patients lacking TP53 mutations

(2010) Zeinab Barekati et al.   HUMAN MOLECULAR GENETICS

Methylation not a frequent “second hit” in tumors with germline BRCA mutations

(2009) Amy M. Dworkin et al.   Familial Cancer

Gene-body hypermethylation of ATM in peripheral blood DNA of bilateral breast cancer patients

(2009) James M. Flanagan et al.   HUMAN MOLECULAR GENETICS

Methylation profiles of 22 candidate genes in breast cancer using high-throughput MALDI-TOF mass array

(2009) R Radpour et al.   ONCOGENE

Promoter Hypermethylation of the PALB2 Susceptibility Gene in Inherited and Sporadic Breast and Ovarian Cancer

(2008) A. Potapova et al.   CANCER RESEARCH

DNA methylation, epimutations and cancer predisposition

(2008) Alexander Dobrovic et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Epigenetics in Cancer

(2008) Manel Esteller   NEW ENGLAND JOURNAL OF MEDICINE