HDAC8 cooperates with SMAD3/4 complex to suppress SIRT7 and promote cell survival and migration

SIRT7-mediated ATM deacetylation is essential for its deactivation and DNA damage repair

(2019) Ming Tang et al.   Science Advances

SIRT7 suppresses the epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis by promoting SMAD4 deacetylation

(2018) Wenlu Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

A SIRT1-centered circuitry regulates breast cancer stemness and metastasis

(2018) Lei Shi et al.   ONCOGENE

Advances in Cellular Characterization of the Sirtuin Isoform, SIRT7

(2018) Di Wu et al.   Frontiers in Endocrinology

Histone deacetylase 8 triggers the migration of triple negative breast cancer cells via regulation of YAP signals

(2018) Panpan An et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

SIRT7 antagonizes TGF-β signaling and inhibits breast cancer metastasis

(2017) Xiaolong Tang et al.   Nature Communications

Downregulation of SIRT7 by 5-fluorouracil induces radiosensitivity in human colorectal cancer

(2017) Ming Tang et al.   Theranostics

Regulation of Serine-Threonine Kinase Akt Activation by NAD + -Dependent Deacetylase SIRT7

(2017) Jia Yu et al.   Cell Reports

C/EBPα negatively regulates SIRT7 expression via recruiting HDAC3 to the upstream-promoter of hepatocellular carcinoma cells

(2016) Gui-fen Liu et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Histone deacetylase inhibitors suppress mutant p53 transcription via HDAC8/YY1 signals in triple negative breast cancer cells

(2016) Zhao-Tong Wang et al.   CELLULAR SIGNALLING

SIRT7 promotes genome integrity and modulates non‐homologous end joining DNA repair

(2016) Berta N Vazquez et al.   EMBO JOURNAL

MicroRNA-3666-induced suppression of SIRT7 inhibits the growth of non-small cell lung cancer cells

(2016) Hongyang Shi et al.   ONCOLOGY REPORTS

Transcriptional Control by the SMADs

(2016) Caroline S. Hill   Cold Spring Harbor Perspectives in Biology

Regulation of energy homeostasis by the ubiquitin-independent REGγ proteasome

(2016) Lianhui Sun et al.   Nature Communications

Sirtuin 7 in cell proliferation, stress and disease: Rise of the Seventh Sirtuin!

(2015) Shashi Kiran et al.   CELLULAR SIGNALLING

Age-Related Changes in Sirtuin 7 Expression in Calorie-Restricted and Refed Rats

(2015) Agata Wronska et al.   GERONTOLOGY

Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis

(2015) Katrin Palumbo-Zerr et al.   NATURE MEDICINE

A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging

(2015) M. Mohrin et al.   SCIENCE

Non-epigenetic function of HDAC8 in regulating breast cancer stem cells by maintaining Notch1 protein stability

(2015) Min-Wu Chao et al.   Oncotarget

MiR-93 Controls Adiposity via Inhibition of Sirt7 and Tbx3

(2015) Michele Cioffi et al.   Cell Reports

SIRT7 Controls Hepatic Lipid Metabolism by Regulating the Ubiquitin-Proteasome Pathway

(2014) Tatsuya Yoshizawa et al.   Cell Metabolism

Sustained activation of SMAD3/SMAD4 by FOXM1 promotes TGF-β–dependent cancer metastasis

(2014) Jianfei Xue et al.   JOURNAL OF CLINICAL INVESTIGATION

DEC1 Coordinates with HDAC8 to Differentially Regulate TAp73 and ΔNp73 Expression

(2014) Yingjuan Qian et al.   PLoS One

Hsa-miR-125b suppresses bladder cancer development by down-regulating oncogene SIRT7 and oncogenic long non-coding RNA MALAT1

(2013) Yonghua Han et al.   FEBS LETTERS

TGF-β inhibition enhances chemotherapy action against triple-negative breast cancer

(2013) Neil E. Bhola et al.   JOURNAL OF CLINICAL INVESTIGATION

Sirtuin 7 Plays a Role in Ribosome Biogenesis and Protein Synthesis

(2013) Yuan-Chin Tsai et al.   MOLECULAR & CELLULAR PROTEOMICS

Effects of hyperglycemia and aging on nuclear sirtuins and DNA damage of mouse hepatocytes

(2013) Flávia Gerelli Ghiraldini et al.   MOLECULAR BIOLOGY OF THE CELL

Repression of RNA Polymerase I upon Stress Is Caused by Inhibition of RNA-Dependent Deacetylation of PAF53 by SIRT7

(2013) Sifan Chen et al.   MOLECULAR CELL

SIRT1 Suppresses the Epithelial-to-Mesenchymal Transition in Cancer Metastasis and Organ Fibrosis

(2013) Petra Simic et al.   Cell Reports

SIRT7 Represses Myc Activity to Suppress ER Stress and Prevent Fatty Liver Disease

(2013) Jiyung Shin et al.   Cell Reports

Targeting class I histone deacetylases in cancer therapy

(2012) Geneviève P Delcuve et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Sirtuin7 oncogenic potential in human hepatocellular carcinoma and its regulation by the tumor suppressors MiR-125a-5p and MiR-125b

(2012) Jeong Kyu Kim et al.   HEPATOLOGY

Targeting the TGFβ signalling pathway in disease

(2012) Rosemary J. Akhurst et al.   NATURE REVIEWS DRUG DISCOVERY

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ChIPBase: a database for decoding the transcriptional regulation of long non-coding RNA and microRNA genes from ChIP-Seq data

(2012) Jian-Hua Yang et al.   NUCLEIC ACIDS RESEARCH

An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients

(2009) Balazs Györffy et al.   BREAST CANCER RESEARCH AND TREATMENT

Involvement of SIRT7 in resumption of rDNA transcription at the exit from mitosis

(2009) A. Grob et al.   JOURNAL OF CELL SCIENCE

Response to Neoadjuvant Therapy and Long-Term Survival in Patients With Triple-Negative Breast Cancer

(2008) Cornelia Liedtke et al.   JOURNAL OF CLINICAL ONCOLOGY

Intrinsic Resistance of Tumorigenic Breast Cancer Cells to Chemotherapy

(2008) X. Li et al.   JNCI-Journal of the National Cancer Institute

A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas

(2008) S Balasubramanian et al.   LEUKEMIA