Characterization of the SARS‐CoV ‐2 E Protein: Sequence, Structure, Viroporin, and Inhibitors

SARS-CoV-2 D614G spike mutation increases entry efficiency with enhanced ACE2-binding affinity

(2021) Seiya Ozono et al.   Nature Communications

Targeting C-terminal Helical bundle of NCOVID19 Envelope (E) protein

(2021) Shruti Mukherjee et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

COVID-19 and the cardiovascular system

(2020) Ying-Ying Zheng et al.   Nature Reviews Cardiology

Atomic structures of closed and open influenza B M2 proton channel reveal the conduction mechanism

(2020) Venkata S. Mandala et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Coronavirus: covid-19 has killed more people than SARS and MERS combined, despite lower case fatality rate

(2020) Elisabeth Mahase   BMJ-British Medical Journal

Regulation of the ER Stress Response by the Ion Channel Activity of the Infectious Bronchitis Coronavirus Envelope Protein Modulates Virion Release, Apoptosis, Viral Fitness, and Pathogenesis

(2020) Shumin Li et al.   Frontiers in Microbiology

Digestive Symptoms in COVID-19 Patients With Mild Disease Severity

(2020) Chaoqun Han et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

The Architecture of SARS-CoV-2 Transcriptome

(2020) Dongwan Kim et al.   CELL

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

Viroporins and inflammasomes: A key to understand virus-induced inflammation

(2020) N.S. Farag et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Management of COVID-19 Respiratory Distress

(2020) John J. Marini et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A computational prediction of SARS-CoV-2 structural protein inhibitors from Azadirachta indica (Neem)

(2020) Subhomoi Borkotoky et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Real estimates of mortality following COVID-19 infection

(2020) David Baud et al.   LANCET INFECTIOUS DISEASES

Immunoinformatic analysis of the SARS-CoV-2 envelope protein as a strategy to assess cross-protection against COVID-19

(2020) Bruno Tilocca et al.   MICROBES AND INFECTION

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

(2020) Jun Lan et al.   NATURE

Advances in COVID-19: the virus, the pathogenesis, and evidence-based control and therapeutic strategies

(2020) Guangbiao Zhou et al.   Frontiers of Medicine

COVID-19 and Diabetes Mellitus: May Old Anti-diabetic Agents Become the New Philosopher’s Stone?

(2020) Theano Penlioglou et al.   Diabetes Therapy

Coronavirus membrane fusion mechanism offers a potential target for antiviral development

(2020) Tiffany Tang et al.   ANTIVIRAL RESEARCH

Host-membrane interacting interface of the SARS coronavirus envelope protein: Immense functional potential of C-terminal domain

(2020) Shruti Mukherjee et al.   BIOPHYSICAL CHEMISTRY

Making Sense of Mutation: What D614G Means for the COVID-19 Pandemic Remains Unclear

(2020) Nathan D. Grubaugh et al.   CELL

Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus

(2020) Bette Korber et al.   CELL

The Novel Insight of SARS-CoV-2 Molecular Biology and Pathogenesis and Therapeutic Options

(2020) Arghavan Asghari et al.   DNA AND CELL BIOLOGY

Ligand and structure-based virtual screening applied to the SARS-CoV-2 main protease: an in silico repurposing study

(2020) Witor Ribeiro Ferraz et al.   Future Medicinal Chemistry

Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing

(2020) Laura Riva et al.   NATURE

Structural insight into the role of novel SARS-CoV-2 E protein: A potential target for vaccine development and other therapeutic strategies

(2020) Manish Sarkar et al.   PLoS One

Architecture and self‐assembly of the SARS‐CoV ‐2 nucleocapsid protein

(2020) Qiaozhen Ye et al.   PROTEIN SCIENCE

Functional Pangenome Analysis Shows Key Features of E Protein Are Preserved in SARS and SARS-CoV-2

(2020) Intikhab Alam et al.   Frontiers in Cellular and Infection Microbiology

Adamantanes might be protective from COVID-19 in patients with neurological diseases: multiple sclerosis, parkinsonism and cognitive impairment

(2020) Konrad Rejdak et al.   Multiple Sclerosis and Related Disorders

Targeting the NLRP3 Inflammasome in Severe COVID-19

(2020) Tracey L. Freeman et al.   Frontiers in Immunology

Construction of SARS-CoV-2 Virus-Like Particles by Mammalian Expression System

(2020) Ruodan Xu et al.   Frontiers in Bioengineering and Biotechnology

Doxycycline: From Ocular Rosacea to COVID-19 Anosmia. New Insight Into the Coronavirus Outbreak

(2020) Chiara Bonzano et al.   Frontiers in Medicine

Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant

(2020) Leonid Yurkovetskiy et al.   CELL

Molecular Architecture of the SARS-CoV-2 Virus

(2020) Hangping Yao et al.   CELL

Identification of potential inhibitors against SARS-CoV-2 by targeting proteins responsible for envelope formation and virion assembly using docking based virtual screening, and pharmacokinetics approaches

(2020) Deep Bhowmik et al.   INFECTION GENETICS AND EVOLUTION

Observational study of people infected with SARS-Cov-2, treated with amantadine

(2020) Gonzalo Emiliano Aranda-Abreu et al.   Pharmacological Reports

Comparative genome analysis of novel coronavirus (SARS-CoV-2) from different geographical locations and the effect of mutations on major target proteins: An in silico insight

(2020) Mohd Imran Khan et al.   PLoS One

Comparing the binding properties of peptides mimicking the Envelope protein of SARS‐CoV and SARS‐CoV ‐2 to the PDZ domain of the tight junction‐associated PALS1 protein

(2020) Angelo Toto et al.   PROTEIN SCIENCE

Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate

(2020) Sandhya Bangaru et al.   SCIENCE

Identification of a Membrane Binding Peptide in the Envelope Protein of MHV Coronavirus

(2020) Entedar A. J. Alsaadi et al.   Viruses-Basel

SARS-CoV-2 envelope protein topology in eukaryotic membranes

(2020) Gerard Duart et al.   Open Biology

Coronavirus Proteins as Ion Channels: Current and Potential Research

(2020) Conor McClenaghan et al.   Frontiers in Immunology

Memantine and Ibuprofen pretreatment exerts anti-inflammatory effect against streptozotocin-induced astroglial inflammation via modulation of NMDA receptor-associated downstream calcium ion signaling

(2020) Sandeep K. Mishra et al.   INFLAMMOPHARMACOLOGY

Prepare for the Future: Dissecting the Spike to Seek Broadly Neutralizing Antibodies and Universal Vaccine for Pandemic Coronaviruses

(2020) Luca Vangelista et al.   Frontiers in Molecular Biosciences

Determine the Potential Epitope Based Peptide Vaccine Against Novel SARS-CoV-2 Targeting Structural Proteins Using Immunoinformatics Approaches

(2020) Muhammad Waqas et al.   Frontiers in Molecular Biosciences

Abstract 15857: SARS-Cov-2 Genes Encode I to -like Potassium Channels: Linkage Between Viroporins and High Mortality Rate in COVID-19 Patients With Pre-existing Cardiovascular Diseases

(2020) Iuliia Polina et al.   CIRCULATION

In silico identification of Tretinoin as a SARS-CoV-2 envelope (E) protein ion channel inhibitor

(2020) Debajit Dey et al.   COMPUTERS IN BIOLOGY AND MEDICINE

Structural insights into SARS-CoV-2 proteins

(2020) Rimanshee Arya et al.   JOURNAL OF MOLECULAR BIOLOGY

Phosphoregulation of Phase Separation by the SARS-CoV-2 N Protein Suggests a Biophysical Basis for its Dual Functions

(2020) Christopher R. Carlson et al.   MOLECULAR CELL

Nucleocapsid protein of SARS-CoV-2 phase separates into RNA-rich polymerase-containing condensates

(2020) Adriana Savastano et al.   Nature Communications

Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome

(2019) I-Yin Chen et al.   Frontiers in Microbiology

The structure of a prokaryotic viral envelope protein expands the landscape of membrane fusion proteins

(2019) Kamel El Omari et al.   Nature Communications

Severe acute respiratory syndrome coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC

(2019) Kam-Leung Siu et al.   FASEB JOURNAL

N-Linked glycosylation of the membrane protein ectodomain regulates infectious bronchitis virus-induced ER stress response, apoptosis and pathogenesis

(2019) Jia Qi Liang et al.   VIROLOGY

Coronavirus envelope protein: current knowledge

(2019) Dewald Schoeman et al.   Virology Journal

The effect of amantadine on an ion channel protein from Chikungunya virus

(2019) Debajit Dey et al.   PLoS Neglected Tropical Diseases

Viroporins in the Influenza Virus

(2019) Janet To et al.   Cells

Prediction of ligands to universally conserved binding sites of the influenza a virus nuclear export protein

(2019) Hershna Patel et al.   VIROLOGY

Post-translational modifications of coronavirus proteins: roles and function

(2018) To Sing Fung et al.   Future Virology

Role of Severe Acute Respiratory Syndrome Coronavirus Viroporins E, 3a, and 8a in Replication and Pathogenesis

(2018) Carlos Castaño-Rodriguez et al.   mBio

Alkyl-imino sugars inhibit the pro-oncogenic ion channel function of human papillomavirus (HPV) E5

(2018) Laura F. Wetherill et al.   ANTIVIRAL RESEARCH

Memantine ameliorates pulmonary inflammation in a mice model of COPD induced by cigarette smoke combined with LPS

(2018) Qingmei Cheng et al.   BIOMEDICINE & PHARMACOTHERAPY

Mechanistic understanding ofN-glycosylation in Ebola virus glycoprotein maturation and function

(2017) Bin Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatitis E virus ORF3 is a functional ion channel required for release of infectious particles

(2017) Qiang Ding et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Self-assembling study of sarcolipin and its mutants in multiple molecular dynamic simulations

(2017) Yipeng Cao et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

The Rotavirus NSP4 Viroporin Domain is a Calcium-conducting Ion Channel

(2017) Thieng Pham et al.   Scientific Reports

Protein aggregation and membrane lipid modifications under lactic acid stress in wild type and OPI1 deleted Saccharomyces cerevisiae strains

(2016) Nadia Maria Berterame et al.   Microbial Cell Factories

Coronaviruses — drug discovery and therapeutic options

(2016) Alimuddin Zumla et al.   NATURE REVIEWS DRUG DISCOVERY

Exenatide (a GLP-1 agonist) expresses anti-inflammatory properties in cultured human monocytes/macrophages in a protein kinase A and B/Akt manner

(2016) Łukasz Bułdak et al.   Pharmacological Reports

Self-Assembly of a Nine-Residue Amyloid-Forming Peptide Fragment of SARS Corona Virus E-Protein: Mechanism of Self Aggregation and Amyloid-Inhibition of hIAPP

(2015) Anirban Ghosh et al.   BIOCHEMISTRY

Role of GxxxG Motifs in Transmembrane Domain Interactions

(2015) Mark G. Teese et al.   BIOCHEMISTRY

Polarization of Monocytic Myeloid-Derived Suppressor Cells by Hepatitis B Surface Antigen Is Mediated via ERK/IL-6/STAT3 Signaling Feedback and Restrains the Activation of T Cells in Chronic Hepatitis B Virus Infection

(2015) Zhong Fang et al.   JOURNAL OF IMMUNOLOGY

Coronavirus envelope (E) protein remains at the site of assembly

(2015) Pavithra Venkatagopalan et al.   VIROLOGY

Severe acute respiratory syndrome coronavirus E protein transports calcium ions and activates the NLRP3 inflammasome

(2015) Jose L. Nieto-Torres et al.   VIROLOGY

Incorporation of Spike and Membrane Glycoproteins into Coronavirus Virions

(2015) Makoto Ujike et al.   Viruses-Basel

Protein-Protein Interactions of Viroporins in Coronaviruses and Paramyxoviruses: New Targets for Antivirals?

(2015) Jaume Torres et al.   Viruses-Basel

Relevance of Viroporin Ion Channel Activity on Viral Replication and Pathogenesis

(2015) Jose Nieto-Torres et al.   Viruses-Basel

Structure of a Conserved Golgi Complex-targeting Signal in Coronavirus Envelope Proteins

(2014) Yan Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Constitutively Oxidized CXXC Motifs within the CD3 Heterodimeric Ectodomains of the T Cell Receptor Complex Enforce the Conformation of Juxtaposed Segments

(2014) Kristine N. Brazin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid charge regulation of non-specific biological ion channels

(2014) Vicente M. Aguilella et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Membrane rearrangements mediated by coronavirus nonstructural proteins 3 and 4

(2014) Marne C. Hagemeijer et al.   VIROLOGY

Inhibitory effect of doxycycline against dengue virus replication in vitro

(2013) Hussin A. Rothan et al.   ARCHIVES OF VIROLOGY

Identifying SARS-CoV Membrane Protein Amino Acid Residues Linked to Virus-Like Particle Assembly

(2013) Ying-Tzu Tseng et al.   PLoS One

Viroporin activity of the JC polyomavirus is regulated by interactions with the adaptor protein complex 3

(2013) T. Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Severe Acute Respiratory Syndrome Coronavirus Nonstructural Proteins 3, 4, and 6 Induce Double-Membrane Vesicles

(2013) M. M. Angelini et al.   mBio

Doxycycline treatment attenuates acute lung injury in mice infected with virulent influenza H3N2 virus: Involvement of matrix metalloproteinases

(2012) H.H. Ng et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

High-Risk Human Papillomavirus E5 Oncoprotein Displays Channel-Forming Activity Sensitive to Small-Molecule Inhibitors

(2012) L. F. Wetherill et al.   JOURNAL OF VIROLOGY

Viroporins: structure and biological functions

(2012) José Luis Nieva et al.   NATURE REVIEWS MICROBIOLOGY

Expression and purification of coronavirus envelope proteins using a modified β-barrel construct

(2012) Krupakar Parthasarathy et al.   PROTEIN EXPRESSION AND PURIFICATION

Structural basis for proton conduction and inhibition by the influenza M2 protein

(2012) Mei Hong et al.   PROTEIN SCIENCE

Coronavirus E protein forms ion channels with functionally and structurally-involved membrane lipids

(2012) Carmina Verdiá-Báguena et al.   VIROLOGY

The Coronavirus E Protein: Assembly and Beyond

(2012) Travis R. Ruch et al.   Viruses-Basel

Human Coronavirus EMC Does Not Require the SARS-Coronavirus Receptor and Maintains Broad Replicative Capability in Mammalian Cell Lines

(2012) M. A. Muller et al.   mBio

Subcellular location and topology of severe acute respiratory syndrome coronavirus envelope protein

(2011) Jose L. Nieto-Torres et al.   VIROLOGY

Self-assembly of Severe Acute Respiratory Syndrome Coronavirus Membrane Protein

(2010) Ying-Tzu Tseng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A structural analysis of M protein in coronavirus assembly and morphology

(2010) Benjamin W. Neuman et al.   JOURNAL OF STRUCTURAL BIOLOGY

The Hydrophobic Domain of Infectious Bronchitis Virus E Protein Alters the Host Secretory Pathway and Is Important for Release of Infectious Virus

(2010) T. R. Ruch et al.   JOURNAL OF VIROLOGY

The SARS Coronavirus E Protein Interacts with PALS1 and Alters Tight Junction Formation and Epithelial Morphogenesis

(2010) Kim-Tat Teoh et al.   MOLECULAR BIOLOGY OF THE CELL

Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers

(2010) Sarah D. Cady et al.   NATURE

α-Helical transmembrane peptides: A “Divide and Conquer” approach to membrane proteins

(2009) Natalie Bordag et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Solution structure and functional analysis of the influenza B proton channel

(2009) Junfeng Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure and Inhibition of the SARS Coronavirus Envelope Protein Ion Channel

(2009) Konstantin Pervushin et al.   PLoS Pathogens

Structural Flexibility of the Pentameric SARS Coronavirus Envelope Protein Ion Channel

(2008) Krupakar Parthasarathy et al.   BIOPHYSICAL JOURNAL

Importance of Conserved Cysteine Residues in the Coronavirus Envelope Protein

(2008) L. A. Lopez et al.   JOURNAL OF VIROLOGY

Comparative Analysis of Complete Genome Sequences of Three Avian Coronaviruses Reveals a Novel Group 3c Coronavirus

(2008) P. C. Y. Woo et al.   JOURNAL OF VIROLOGY