Atomic structures of closed and open influenza B M2 proton channel reveal the conduction mechanism

Elucidating Relayed Proton Transfer through a his-Trp-his Triad of a Transmembrane Proton Channel by Solid-State NMR

(2019) Byungsu Kwon et al.   JOURNAL OF MOLECULAR BIOLOGY

Hemagglutinin Cleavability, Acid Stability, and Temperature Dependence Optimize Influenza B Virus for Replication in Human Airways

(2019) Manon Laporte et al.   JOURNAL OF VIROLOGY

Functional studies reveal the similarities and differences between AM2 and BM2 proton channels from influenza viruses

(2018) Chunlong Ma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Rapid measurement of long-range distances in proteins by multidimensional 13C–19F REDOR NMR under fast magic-angle spinning

(2018) Alexander A. Shcherbakov et al.   JOURNAL OF BIOMOLECULAR NMR

Transport-Relevant Protein Conformational Dynamics and Water Dynamics on Multiple Time Scales in an Archetypal Proton Channel: Insights from Solid-State NMR

(2018) Venkata S. Mandala et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Influenza Hemagglutinin Protein Stability, Activation, and Pandemic Risk

(2018) Charles J. Russell et al.   TRENDS IN MICROBIOLOGY

Chemical synthesis of membrane proteins: a model study on the influenza virus B proton channel

(2018) A. C. Baumruck et al.   Chemical Science

Protonation equilibria and pore-opening structure of the dual-histidine influenza B virus M2 transmembrane proton channel from solid-state NMR

(2017) Jonathan K. Williams et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A fully automated flow-based approach for accelerated peptide synthesis

(2017) Alexander J Mijalis et al.   Nature Chemical Biology

Cholesterol-binding site of the influenza M2 protein in lipid bilayers from solid-state NMR

(2017) Matthew R. Elkins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Solid-State NMR Investigation of the Conformation, Proton Conduction, and Hydration of the Influenza B Virus M2 Transmembrane Proton Channel

(2016) Jonathan K. Williams et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Acid activation mechanism of the influenza A M2 proton channel

(2016) Ruibin Liang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and Mechanism of the Influenza A M218–60 Dimer of Dimers

(2015) Loren B. Andreas et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

High-resolution structures of the M2 channel from influenza A virus reveal dynamic pathways for proton stabilization and transduction

(2015) Jessica L. Thomaston et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accurate secondary structure prediction and fold recognition for circular dichroism spectroscopy

(2015) András Micsonai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Probing membrane protein structure using water polarization transfer solid-state NMR

(2014) Jonathan K. Williams et al.   JOURNAL OF MAGNETIC RESONANCE

Effect of Cytosolic pH on Inward Currents Reveals Structural Characteristics of the Proton Transport Cycle in the Influenza A Protein M2 in Cell-Free Membrane Patches of Xenopus oocytes

(2014) Mattia L. DiFrancesco et al.   PLoS One

pH-Dependent Conformation, Dynamics, and Aromatic Interaction of the Gating Tryptophan Residue of the Influenza M2 Proton Channel from Solid-State NMR

(2013) Jonathan K. Williams et al.   BIOPHYSICAL JOURNAL

Efficient resonance assignment of proteins in MAS NMR by simultaneous intra- and inter-residue 3D correlation spectroscopy

(2013) Eugenio Daviso et al.   JOURNAL OF BIOMOLECULAR NMR

Nmrglue: an open source Python package for the analysis of multidimensional NMR data

(2013) Jonathan J. Helmus et al.   JOURNAL OF BIOMOLECULAR NMR

Protein backbone and sidechain torsion angles predicted from NMR chemical shifts using artificial neural networks

(2013) Yang Shen et al.   JOURNAL OF BIOMOLECULAR NMR

Broadband homonuclear correlation spectroscopy driven by combined R2nv sequences under fast magic angle spinning for NMR structural analysis of organic and biological solids

(2013) Guangjin Hou et al.   JOURNAL OF MAGNETIC RESONANCE

Asp44 Stabilizes the Trp41 Gate of the M2 Proton Channel of Influenza A Virus

(2013) Chunlong Ma et al.   STRUCTURE

NMR Determination of Protein Partitioning into Membrane Domains with Different Curvatures and Application to the Influenza M2 Peptide

(2012) Tuo Wang et al.   BIOPHYSICAL JOURNAL

Hydrogen-Bonding Partner of the Proton-Conducting Histidine in the Influenza M2 Proton Channel Revealed From 1H Chemical Shifts

(2012) Mei Hong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Kinetics of Proton Transport into Influenza Virions by the Viral M2 Channel

(2012) Tijana Ivanovic et al.   PLoS One

Structural basis for proton conduction and inhibition by the influenza M2 protein

(2012) Mei Hong et al.   PROTEIN SCIENCE

NMR Detection of pH-Dependent Histidine–Water Proton Exchange Reveals the Conduction Mechanism of a Transmembrane Proton Channel

(2011) Fanghao Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The structural basis of secondary active transport mechanisms

(2010) Lucy R. Forrest et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Conformational plasticity of the influenza A M2 transmembrane helix in lipid bilayers under varying pH, drug binding, and membrane thickness

(2010) Fanghao Hu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Influenza Virus M2 Protein Mediates ESCRT-Independent Membrane Scission

(2010) Jeremy S. Rossman et al.   CELL

Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers

(2010) Sarah D. Cady et al.   NATURE

Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus

(2010) R. Acharya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insight into the Mechanism of the Influenza A Proton Channel from a Structure in a Lipid Bilayer

(2010) M. Sharma et al.   SCIENCE

Mechanisms of Proton Conduction and Gating in Influenza M2 Proton Channels from Solid-State NMR

(2010) F. Hu et al.   SCIENCE

Functional Studies and Modeling of Pore-Lining Residue Mutants of the Influenza A Virus M2 Ion Channel

(2009) Victoria Balannik et al.   BIOCHEMISTRY

3D 13C–13C–13C correlation NMR for de novo distance determination of solid proteins and application to a human α-defensin

(2009) Shenhui Li et al.   JOURNAL OF MAGNETIC RESONANCE

Ion channels versus ion pumps: the principal difference, in principle

(2009) David C. Gadsby   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Solution structure and functional analysis of the influenza B proton channel

(2009) Junfeng Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular dynamics calculations suggest a conduction mechanism for the M2 proton channel from influenza A virus

(2009) E. Khurana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of the Pore-lining Residues of the BM2 Ion Channel Protein of Influenza B Virus

(2008) Chunlong Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis for the function and inhibition of an influenza virus proton channel

(2008) Amanda L. Stouffer et al.   NATURE

Further conventions for NMR shielding and chemical shifts (IUPAC Recommendations 2008)

(2008) Robin K. Harris et al.   PURE AND APPLIED CHEMISTRY