Post-translational modifications of coronavirus proteins: roles and function

Identification of N-linked glycosylation sites in the spike protein and their functional impact on the replication and infectivity of coronavirus infectious bronchitis virus in cell culture

(2018) Jie Zheng et al.   VIROLOGY

The coronavirus nucleocapsid protein is ADP-ribosylated

(2018) Matthew E. Grunewald et al.   VIROLOGY

Accessory proteins 8b and 8ab of severe acute respiratory syndrome coronavirus suppress the interferon signaling pathway by mediating ubiquitin-dependent rapid degradation of interferon regulatory factor 3

(2018) Hui Hui Wong et al.   VIROLOGY

Permissivity of Dipeptidyl Peptidase 4 Orthologs to Middle East Respiratory Syndrome Coronavirus Is Governed by Glycosylation and Other Complex Determinants

(2017) Kayla M. Peck et al.   JOURNAL OF VIROLOGY

The Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Inhibits Type I Interferon Production by Interfering with TRIM25-Mediated RIG-I Ubiquitination

(2017) Yong Hu et al.   JOURNAL OF VIROLOGY

Porcine Deltacoronavirus nsp5 Antagonizes Type I Interferon Signaling by Cleaving STAT2

(2017) Xinyu Zhu et al.   JOURNAL OF VIROLOGY

Cell attenuated porcine epidemic diarrhea virus strain Zhejiang08 provides effective immune protection attributed to dendritic cell stimulation

(2017) Yuchen Li et al.   VACCINE

Porcine deltacoronavirus nsp5 inhibits interferon-β production through the cleavage of NEMO

(2017) Xinyu Zhu et al.   VIROLOGY

Expression and Cleavage of Middle East Respiratory Syndrome Coronavirus nsp3-4 Polyprotein Induce the Formation of Double-Membrane Vesicles That Mimic Those Associated with Coronaviral RNA Replication

(2017) Diede Oudshoorn et al.   mBio

Channel-Inactivating Mutations and Their Revertant Mutants in the Envelope Protein of Infectious Bronchitis Virus

(2016) Janet To et al.   JOURNAL OF VIROLOGY

Recognition of Lys48-Linked Di-ubiquitin and Deubiquitinating Activities of the SARS Coronavirus Papain-like Protease

(2016) Miklós Békés et al.   MOLECULAR CELL

p53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PLprovia E3 ubiquitin ligase RCHY1

(2016) Yue Ma-Lauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

VHL negatively regulates SARS coronavirus replication by modulating nsp16 ubiquitination and stability

(2015) Xiao Yu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SARS hCoV papain-like protease is a unique Lys48linkage-specific di-distributive deubiquitinating enzyme

(2015) Miklós Békés et al.   BIOCHEMICAL JOURNAL

Glycosylation of Mouse DPP4 Plays a Role in Inhibiting Middle East Respiratory Syndrome Coronavirus Infection

(2015) Kayla M. Peck et al.   JOURNAL OF VIROLOGY

Decreased neutralizing antigenicity in IBV S1 protein expressed from mammalian cells

(2015) Kiyohiko Andoh et al.   VIRUS RESEARCH

Severe acute respiratory syndrome coronavirus protein 6 mediates ubiquitin-dependent proteosomal degradation of N-Myc (and STAT) interactor

(2015) Weijia Cheng et al.   VIROLOGICA SINICA

Accessory proteins of SARS-CoV and other coronaviruses

(2014) Ding Xiang Liu et al.   ANTIVIRAL RESEARCH

Coronavirus NSP6 restricts autophagosome expansion

(2014) Eleanor M Cottam et al.   Autophagy

Nucleocapsid Phosphorylation and RNA Helicase DDX1 Recruitment Enables Coronavirus Transition from Discontinuous to Continuous Transcription

(2014) Chia-Hsin Wu et al.   Cell Host & Microbe

Suppression of innate antiviral response by severe acute respiratory syndrome coronavirus M protein is mediated through the first transmembrane domain

(2014) Kam-Leung Siu et al.   Cellular & Molecular Immunology

Crystal Structure of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Papain-like Protease Bound to Ubiquitin Facilitates Targeted Disruption of Deubiquitinating Activity to Demonstrate Its Role in Innate Immune Suppression

(2014) Ben A. Bailey-Elkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SARS-Coronavirus Open Reading Frame-9b Suppresses Innate Immunity by Targeting Mitochondria and the MAVS/TRAF3/TRAF6 Signalosome

(2014) Chong-Shan Shi et al.   JOURNAL OF IMMUNOLOGY

The Endoplasmic Reticulum Stress Sensor IRE1  Protects Cells from Apoptosis Induced by the Coronavirus Infectious Bronchitis Virus

(2014) T. S. Fung et al.   JOURNAL OF VIROLOGY

Mutations across Murine Hepatitis Virus nsp4 Alter Virus Fitness and Membrane Modifications

(2014) Dia C. Beachboard et al.   JOURNAL OF VIROLOGY

Palmitoylation of the Alphacoronavirus TGEV spike protein S is essential for incorporation into virus-like particles but dispensable for S–M interaction

(2014) Sandra Gelhaus et al.   VIROLOGY

The SARS coronavirus papain like protease can inhibit IRF3 at a post activation step that requires deubiquitination activity

(2014) Krystal Matthews et al.   Virology Journal

Nidovirus papain-like proteases: Multifunctional enzymes with protease, deubiquitinating and deISGylating activities

(2014) Anna M. Mielech et al.   VIRUS RESEARCH

Structural Basis for the Ubiquitin-Linkage Specificity and deISGylating Activity of SARS-CoV Papain-Like Protease

(2014) Kiira Ratia et al.   PLoS Pathogens

SARS coronavirus papain-like protease inhibits the type I interferon signaling pathway through interaction with the STING-TRAF3-TBK1 complex

(2014) Xiaojuan Chen et al.   Protein & Cell

Proteolytic processing, deubiquitinase and interferon antagonist activities of Middle East respiratory syndrome coronavirus papain-like protease

(2013) X. Yang et al.   JOURNAL OF GENERAL VIROLOGY

Upregulation of CHOP/GADD153 during Coronavirus Infectious Bronchitis Virus Infection Modulates Apoptosis by Restricting Activation of the Extracellular Signal-Regulated Kinase Pathway

(2013) Y. Liao et al.   JOURNAL OF VIROLOGY

Middle East Respiratory Syndrome Coronavirus (MERS-CoV): Announcement of the Coronavirus Study Group

(2013) R. J. de Groot et al.   JOURNAL OF VIROLOGY

Identification of two ATR-dependent phosphorylation sites on coronavirus nucleocapsid protein with nonessential functions in viral replication and infectivity in cultured cells

(2013) Shouguo Fang et al.   VIROLOGY

MERS-CoV papain-like protease has deISGylating and deubiquitinating activities

(2013) Anna M. Mielech et al.   VIROLOGY

Severe Acute Respiratory Syndrome Coronavirus Nonstructural Proteins 3, 4, and 6 Induce Double-Membrane Vesicles

(2013) M. M. Angelini et al.   mBio

Yeast-expressed recombinant protein of the receptor-binding domain in SARS-CoV spike protein with deglycosylated forms as a SARS vaccine candidate

(2013) Wen-Hsiang Chen et al.   Human Vaccines & Immunotherapeutics

Monitoring of S Protein Maturation in the Endoplasmic Reticulum by Calnexin Is Important for the Infectivity of Severe Acute Respiratory Syndrome Coronavirus

(2012) M. Fukushi et al.   JOURNAL OF VIROLOGY

Discovery of Seven Novel Mammalian and Avian Coronaviruses in the Genus Deltacoronavirus Supports Bat Coronaviruses as the Gene Source of Alphacoronavirus and Betacoronavirus and Avian Coronaviruses as the Gene Source of Gammacoronavirus and Deltacoronavirus

(2012) P. C. Y. Woo et al.   JOURNAL OF VIROLOGY

Coronavirus Papain-like Proteases Negatively Regulate Antiviral Innate Immune Response through Disruption of STING-Mediated Signaling

(2012) Li Sun et al.   PLoS One

Replication of murine coronavirus requires multiple cysteines in the endodomain of spike protein

(2012) Jinhua Yang et al.   VIROLOGY

Coronavirus nsp6 proteins generate autophagosomes from the endoplasmic reticulum via an omegasome intermediate

(2011) Eleanor M. Cottam et al.   Autophagy

Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5

(2011) Roland Züst et al.   NATURE IMMUNOLOGY

PLP2 of Mouse Hepatitis Virus A59 (MHV-A59) Targets TBK1 to Negatively Regulate Cellular Type I Interferon Signaling Pathway

(2011) Gang Wang et al.   PLoS One

A Single Asparagine-Linked Glycosylation Site of the Severe Acute Respiratory Syndrome Coronavirus Spike Glycoprotein Facilitates Inhibition by Mannose-Binding Lectin through Multiple Mechanisms

(2010) Y. Zhou et al.   JOURNAL OF VIROLOGY

Deubiquitinating and Interferon Antagonism Activities of Coronavirus Papain-Like Proteases

(2010) M. A. Clementz et al.   JOURNAL OF VIROLOGY

Identification of N-linked carbohydrates from severe acute respiratory syndrome (SARS) spike glycoprotein

(2010) Gayle Ritchie et al.   VIROLOGY

Palmitoylation of SARS-CoV S protein is necessary for partitioning into detergent-resistant membranes and cell–cell fusion but not interaction with M protein

(2010) Corrin E. McBride et al.   VIROLOGY

Role of Spike Protein Endodomains in Regulating Coronavirus Entry

(2009) Ana Shulla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of In Vivo-Interacting Domains of the Murine Coronavirus Nucleocapsid Protein

(2009) K. R. Hurst et al.   JOURNAL OF VIROLOGY

Proteolytic Activation of the Spike Protein at a Novel RRRR/S Motif Is Implicated in Furin-Dependent Entry, Syncytium Formation, and Infectivity of Coronavirus Infectious Bronchitis Virus in Cultured Cells

(2009) Y. Yamada et al.   JOURNAL OF VIROLOGY

Severe Acute Respiratory Syndrome Coronavirus Papain-Like Protease Ubiquitin-Like Domain and Catalytic Domain Regulate Antagonism of IRF3 and NF- B Signaling

(2009) M. Frieman et al.   JOURNAL OF VIROLOGY

Murine Hepatitis Virus Nonstructural Protein 4 Regulates Virus-Induced Membrane Modifications and Replication Complex Function

(2009) M. J. Gadlage et al.   JOURNAL OF VIROLOGY

Detection of Nonstructural Protein 6 in Murine Coronavirus-Infected Cells and Analysis of the Transmembrane Topology by Using Bioinformatics and Molecular Approaches

(2009) S. Baliji et al.   JOURNAL OF VIROLOGY

Interaction of the Coronavirus Infectious Bronchitis Virus Membrane Protein with β-Actin and Its Implication in Virion Assembly and Budding

(2009) Jibin Wang et al.   PLoS One

Acquisition of Cell–Cell Fusion Activity by Amino Acid Substitutions in Spike Protein Determines the Infectivity of a Coronavirus in Cultured Cells

(2009) Yoshiyuki Yamada et al.   PLoS One

Genetic analysis of canine group 2 coronavirus in Korean dogs

(2009) Dong-Jun An et al.   VETERINARY MICROBIOLOGY

Dual effect of nitric oxide on SARS-CoV replication: Viral RNA production and palmitoylation of the S protein are affected

(2009) Sara Åkerström et al.   VIROLOGY

Studies on membrane topology, N-glycosylation and functionality of SARS-CoV membrane protein

(2009) Daniel Voß et al.   Virology Journal

Expression and membrane integration of SARS-CoV E protein and its interaction with M protein

(2009) Shih-Chi Chen et al.   VIRUS GENES

PLP2, a potent deubiquitinase from murine hepatitis virus, strongly inhibits cellular type I interferon production

(2008) Dahai Zheng et al.   CELL RESEARCH

Phosphorylation of the arginine/serine dipeptide-rich motif of the severe acute respiratory syndrome coronavirus nucleocapsid protein modulates its multimerization, translation inhibitory activity and cellular localization

(2008) Tsui-Yi Peng et al.   FEBS Journal

Glycogen Synthase Kinase-3 Regulates the Phosphorylation of Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Protein and Viral Replication

(2008) Chia-Hsin Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Variable Oligomerization Modes in Coronavirus Non-structural Protein 9

(2008) Rajesh Ponnusamy et al.   JOURNAL OF MOLECULAR BIOLOGY

Importance of Conserved Cysteine Residues in the Coronavirus Envelope Protein

(2008) L. A. Lopez et al.   JOURNAL OF VIROLOGY

Envelope Protein Palmitoylations Are Crucial for Murine Coronavirus Assembly

(2008) J. A. Boscarino et al.   JOURNAL OF VIROLOGY

Coronavirus Nonstructural Protein 16 Is a Cap-0 Binding Enzyme Possessing (Nucleoside-2'O)-Methyltransferase Activity

(2008) E. Decroly et al.   JOURNAL OF VIROLOGY

Topology and Membrane Anchoring of the Coronavirus Replication Complex: Not All Hydrophobic Domains of nsp3 and nsp6 Are Membrane Spanning

(2008) M. Oostra et al.   JOURNAL OF VIROLOGY

Mutation in murine coronavirus replication protein nsp4 alters assembly of double membrane vesicles

(2008) Mark A. Clementz et al.   VIROLOGY

Cell Type-Specific Cleavage of Nucleocapsid Protein by Effector Caspases during SARS Coronavirus Infection

(2007) Claudia Diemer et al.   JOURNAL OF MOLECULAR BIOLOGY

Role of phosphorylation clusters in the biology of the coronavirus infectious bronchitis virus nucleocapsid protein

(2007) Kelly-Anne Spencer et al.   VIROLOGY