Viroporins in the Influenza Virus

Functional studies reveal the similarities and differences between AM2 and BM2 proton channels from influenza viruses

(2018) Chunlong Ma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Influenza D virus M2 protein exhibits ion channel activity in Xenopus laevis oocytes

(2018) Evan Kesinger et al.   PLoS One

Role of Severe Acute Respiratory Syndrome Coronavirus Viroporins E, 3a, and 8a in Replication and Pathogenesis

(2018) Carlos Castaño-Rodriguez et al.   mBio

The Antiviral Effects of Na,K-ATPase Inhibition: A Minireview

(2018) Luciano Amarelle et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibitors of the M2 Proton Channel Engage and Disrupt Transmembrane Networks of Hydrogen-Bonded Waters

(2018) Jessica L. Thomaston et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protonation equilibria and pore-opening structure of the dual-histidine influenza B virus M2 transmembrane proton channel from solid-state NMR

(2017) Jonathan K. Williams et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell Cycle-independent Role of Cyclin D3 in Host Restriction of Influenza Virus Infection

(2017) Ying Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for Asymmetric Conductance of the Influenza M2 Proton Channel Investigated by Solid-State NMR Spectroscopy

(2017) Venkata S. Mandala et al.   JOURNAL OF MOLECULAR BIOLOGY

XFEL structures of the influenza M2 proton channel: Room temperature water networks and insights into proton conduction

(2017) Jessica L. Thomaston et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparative influenza protein interactomes identify the role of plakophilin 2 in virus restriction

(2017) Lingyan Wang et al.   Nature Communications

Knowns and unknowns of influenza B viruses

(2016) Marios Koutsakos et al.   Future Microbiology

Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection

(2016) Nicholas S. Heaton et al.   IMMUNITY

Discovery of Highly Potent Inhibitors Targeting the Predominant Drug-Resistant S31N Mutant of the Influenza A Virus M2 Proton Channel

(2016) Fang Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Solid-State NMR Investigation of the Conformation, Proton Conduction, and Hydration of the Influenza B Virus M2 Transmembrane Proton Channel

(2016) Jonathan K. Williams et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pathogenesis of Influenza D Virus in Cattle

(2016) Lucas Ferguson et al.   JOURNAL OF VIROLOGY

Host Cellular Protein TRAPPC6AΔ Interacts with Influenza A Virus M2 Protein and Regulates Viral Propagation by Modulating M2 Trafficking

(2016) Pengyang Zhu et al.   JOURNAL OF VIROLOGY

Infrared and fluorescence assessment of the hydration status of the tryptophan gate in the influenza A M2 proton channel

(2016) Beatrice N. Markiewicz et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Acid activation mechanism of the influenza A M2 proton channel

(2016) Ruibin Liang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human mesenchymal stromal cells reduce influenza A H5N1-associated acute lung injury in vitro and in vivo

(2016) Michael C. W. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of the drug-resistant S31N influenza M2 proton channel

(2016) Jessica L. Thomaston et al.   PROTEIN SCIENCE

Antiviral Screening of Multiple Compounds against Ebola Virus

(2016) Stuart Dowall et al.   Viruses-Basel

Discovery of Potent Antivirals against Amantadine-Resistant Influenza A Viruses by Targeting the M2-S31N Proton Channel

(2016) Fang Li et al.   ACS Infectious Diseases

Meta- and Orthogonal Integration of Influenza “OMICs” Data Defines a Role for UBR4 in Virus Budding

(2015) Shashank Tripathi et al.   Cell Host & Microbe

The Influenza M2 Cytoplasmic Tail Changes the Proton-Exchange Equilibria and the Backbone Conformation of the Transmembrane Histidine Residue to Facilitate Proton Conduction

(2015) Shu Y. Liao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Domestic Pigs Are Susceptible to Infection with Influenza B Viruses

(2015) Zhiguang Ran et al.   JOURNAL OF VIROLOGY

M2 Proton Channel: Toward a Model of a Primitive Proton Pump

(2015) Chenyu Wei et al.   ORIGINS OF LIFE AND EVOLUTION OF BIOSPHERES

High-resolution structures of the M2 channel from influenza A virus reveal dynamic pathways for proton stabilization and transduction

(2015) Jessica L. Thomaston et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic Short Hydrogen Bonds in Histidine Tetrad of Full-Length M2 Proton Channel Reveal Tetrameric Structural Heterogeneity and Functional Mechanism

(2015) Yimin Miao et al.   STRUCTURE

Viroporins: Structures and functions beyond cell membrane permeabilization

(2015) José Nieva et al.   Viruses-Basel

Pathophysiological Consequences of Calcium-Conducting Viroporins

(2015) Joseph M. Hyser et al.   Annual Review of Virology

Adamantane-Resistant Influenza A Viruses in the World (1902–2013): Frequency and Distribution of M2 Gene Mutations

(2015) Guoying Dong et al.   PLoS One

Proton Association Constants of His 37 in the Influenza-A M218–60 Dimer-of-Dimers

(2014) Michael T. Colvin et al.   BIOCHEMISTRY

Influenza Virus-Host Interactome Screen as a Platform for Antiviral Drug Development

(2014) Tokiko Watanabe et al.   Cell Host & Microbe

A LC3-Interacting Motif in the Influenza A Virus M2 Protein Is Required to Subvert Autophagy and Maintain Virion Stability

(2014) Rupert Beale et al.   Cell Host & Microbe

Palmitoylation is required for intracellular trafficking of influenza B virus NB protein and efficient influenza B virus growth in vitro

(2014) A. Demers et al.   JOURNAL OF GENERAL VIROLOGY

Influenza Virus Reservoirs and Intermediate Hosts: Dogs, Horses, and New Possibilities for Influenza Virus Exposure of Humans

(2014) Colin R. Parrish et al.   JOURNAL OF VIROLOGY

Effect of Cytosolic pH on Inward Currents Reveals Structural Characteristics of the Proton Transport Cycle in the Influenza A Protein M2 in Cell-Free Membrane Patches of Xenopus oocytes

(2014) Mattia L. DiFrancesco et al.   PLoS One

Multiscale simulation reveals a multifaceted mechanism of proton permeation through the influenza A M2 proton channel

(2014) Ruibin Liang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of a Novel Influenza Virus in Cattle and Swine: Proposal for a New Genus in the Orthomyxoviridae Family

(2014) B. M. Hause et al.   mBio

Influenza matrix protein 2 alters CFTR expression and function through its ion channel activity

(2013) James D. Londino et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

pH-Dependent Conformation, Dynamics, and Aromatic Interaction of the Gating Tryptophan Residue of the Influenza M2 Proton Channel from Solid-State NMR

(2013) Jonathan K. Williams et al.   BIOPHYSICAL JOURNAL

Emerging Antiviral Strategies to Interfere with Influenza Virus Entry

(2013) Evelien Vanderlinden et al.   MEDICINAL RESEARCH REVIEWS

Effect of Cysteine Mutations in the Extracellular Domain of CM2 on the Influenza C Virus Replication

(2013) Yasushi Muraki et al.   PLoS One

Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus

(2013) Jun Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Asp44 Stabilizes the Trp41 Gate of the M2 Proton Channel of Influenza A Virus

(2013) Chunlong Ma et al.   STRUCTURE

Structural and energetic analysis of drug inhibition of the influenza A M2 proton channel

(2013) Ruo-Xu Gu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Activation of the NLRP3 Inflammasome by IAV Virulence Protein PB1-F2 Contributes to Severe Pathophysiology and Disease

(2013) Julie L. McAuley et al.   PLoS Pathogens

Isolation of a Novel Swine Influenza Virus from Oklahoma in 2011 Which Is Distantly Related to Human Influenza C Viruses

(2013) Ben M. Hause et al.   PLoS Pathogens

Recent progress in structure-based anti-influenza drug design

(2012) Juan Du et al.   DRUG DISCOVERY TODAY

Paramagnetic Cu(II) for Probing Membrane Protein Structure and Function: Inhibition Mechanism of the Influenza M2 Proton Channel

(2012) Yongchao Su et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Influenza Virus Protein PB1-F2 Inhibits the Induction of Type I Interferon by Binding to MAVS and Decreasing Mitochondrial Membrane Potential

(2012) Zsuzsanna T. Varga et al.   JOURNAL OF VIROLOGY

Mapping the Phosphoproteome of Influenza A and B Viruses by Mass Spectrometry

(2012) Edward C. Hutchinson et al.   PLoS Pathogens

A Theory for the Proton Transport of the Influenza Virus M2 Protein: Extensive Test against Conductance Data

(2011) Huan-Xiang Zhou   BIOPHYSICAL JOURNAL

Cystic Fibrosis Transmembrane Conductance Regulator Intracellular Processing, Trafficking, and Opportunities for Mutation-Specific Treatment

(2011) Mark P. Rogan et al.   CHEST

NMR Detection of pH-Dependent Histidine–Water Proton Exchange Reveals the Conduction Mechanism of a Transmembrane Proton Channel

(2011) Fanghao Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Influenza C Virus CM2 Protein Can Alter Intracellular pH, and Its Transmembrane Domain Can Substitute for That of the Influenza A Virus M2 Protein and Support Infectious Virus Production

(2011) S. M. Stewart et al.   JOURNAL OF VIROLOGY

Human Annexin A6 Interacts with Influenza A Virus Protein M2 and Negatively Modulates Infection

(2011) H. Ma et al.   JOURNAL OF VIROLOGY

Influenza A Virus Nucleoprotein Exploits Hsp40 to Inhibit PKR Activation

(2011) Kulbhushan Sharma et al.   PLoS One

Tidal surge in the M2 proton channel, sensed by 2D IR spectroscopy

(2011) A. Ghosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Investigation of Rimantadine Inhibition of the AM2-BM2 Chimera Channel of Influenza Viruses

(2011) Rafal M. Pielak et al.   STRUCTURE

Antiviral Inhibition of Enveloped Virus Release by Tetherin/BST-2: Action and Counteraction

(2011) Anna Le Tortorec et al.   Viruses-Basel

Influenza Virus M2 Protein Mediates ESCRT-Independent Membrane Scission

(2010) Jeremy S. Rossman et al.   CELL

Emerging Influenza Antiviral Resistance Threats

(2010) F. G. Hayden et al.   JOURNAL OF INFECTIOUS DISEASES

Kinetic Analysis of the M2 Proton Conduction of the Influenza Virus

(2010) Rafal M. Pielak et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Role of the CM2 Protein in the Influenza C Virus Replication Cycle

(2010) T. Furukawa et al.   JOURNAL OF VIROLOGY

The Rab11 Pathway Is Required for Influenza A Virus Budding and Filament Formation

(2010) E. A. Bruce et al.   JOURNAL OF VIROLOGY

Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers

(2010) Sarah D. Cady et al.   NATURE

Influenza virus activates inflammasomes via its intracellular M2 ion channel

(2010) Takeshi Ichinohe et al.   NATURE IMMUNOLOGY

The Proapoptotic Influenza A Virus Protein PB1-F2 Forms a Nonselective Ion Channel

(2010) Michael Henkel et al.   PLoS One

Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus

(2010) R. Acharya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insight into the Mechanism of the Influenza A Proton Channel from a Structure in a Lipid Bilayer

(2010) M. Sharma et al.   SCIENCE

Mechanisms of Proton Conduction and Gating in Influenza M2 Proton Channels from Solid-State NMR

(2010) F. Hu et al.   SCIENCE

Na+/K+-ATPase β1 subunit interacts with M2 proteins of influenza A and B viruses and affects the virus replication

(2010) ShuoFu Mi et al.   Science China-Life Sciences

Caveolin-1 influences human influenza A virus (H1N1) multiplication in cell culture

(2010) Lijing Sun et al.   Virology Journal

Interaction of Hsp40 with influenza virus M2 protein: implications for PKR signaling pathway

(2010) Zhenhong Guan et al.   Protein & Cell

Matrix Protein 2 of Influenza A Virus Blocks Autophagosome Fusion with Lysosomes

(2009) Monique Gannagé et al.   Cell Host & Microbe

Influenza virus M2 protein inhibits epithelial sodium channels by increasing reactive oxygen species

(2009) Ahmed Lazrak et al.   FASEB JOURNAL

Emergence and pandemic potential of swine-origin H1N1 influenza virus

(2009) Gabriele Neumann et al.   NATURE

Solution structure and functional analysis of the influenza B proton channel

(2009) Junfeng Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Conformational heterogeneity of the M2 proton channel and a structural model for channel activation

(2009) M. Yi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular dynamics calculations suggest a conduction mechanism for the M2 proton channel from influenza A virus

(2009) E. Khurana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of the functional core of the influenza A virus A/M2 proton-selective ion channel

(2009) C. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of influenza virus replication by alteration of sodium ion transport and protein kinase C activity

(2008) H HOFFMANN et al.   ANTIVIRAL RESEARCH

Identification of the Pore-lining Residues of the BM2 Ion Channel Protein of Influenza B Virus

(2008) Chunlong Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and mechanism of the M2 proton channel of influenza A virus

(2008) Jason R. Schnell et al.   NATURE

Structural basis for the function and inhibition of an influenza virus proton channel

(2008) Amanda L. Stouffer et al.   NATURE

Proton Transport through Influenza A Virus M2 Protein Reconstituted in Vesicles

(2007) J. Craig Moffat et al.   BIOPHYSICAL JOURNAL