Coronavirus envelope protein: current knowledge

Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome

(2019) I-Yin Chen et al.   Frontiers in Microbiology

Post-translational modifications of coronavirus proteins: roles and function

(2018) To Sing Fung et al.   Future Virology

The stapled peptides derived from hepatitis B virus core protein hijack viral replication

(2018) J. Han et al.   JOURNAL OF HEPATOLOGY

Role of Severe Acute Respiratory Syndrome Coronavirus Viroporins E, 3a, and 8a in Replication and Pathogenesis

(2018) Carlos Castaño-Rodriguez et al.   mBio

Protein Palmitoylation and Its Role in Bacterial and Viral Infections

(2018) Justyna Sobocińska et al.   Frontiers in Immunology

Host-Virus Protein Interaction Network Reveals the Involvement of Multiple Host Processes in the Life Cycle of Hepatitis E Virus

(2018) Chandru Subramani et al.   mSystems

Mechanistic understanding ofN-glycosylation in Ebola virus glycoprotein maturation and function

(2017) Bin Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Coronavirus in the 2014 Winter Season as a Cause of Lower Respiratory Tract Infection

(2017) Kyu Yeun Kim et al.   YONSEI MEDICAL JOURNAL

The Rotavirus NSP4 Viroporin Domain is a Calcium-conducting Ion Channel

(2017) Thieng Pham et al.   Scientific Reports

Curvature Sensing by a Viral Scission Protein

(2016) Agnieszka Martyna et al.   BIOCHEMISTRY

Pre-fusion structure of a human coronavirus spike protein

(2016) Robert N. Kirchdoerfer et al.   NATURE

Coronaviruses — drug discovery and therapeutic options

(2016) Alimuddin Zumla et al.   NATURE REVIEWS DRUG DISCOVERY

Structural basis for the membrane association of ankyrinG via palmitoylation

(2016) Yuichiro Fujiwara et al.   Scientific Reports

Autophagy Negatively Regulates Transmissible Gastroenteritis Virus Replication

(2016) Longjun Guo et al.   Scientific Reports

Hydrocarbon Stapled Peptides as Modulators of Biological Function

(2015) Philipp M. Cromm et al.   ACS Chemical Biology

A Coronavirus E Protein Is Present in Two Distinct Pools with Different Effects on Assembly and the Secretory Pathway

(2015) Jason W. Westerbeck et al.   JOURNAL OF VIROLOGY

Severe Acute Respiratory Syndrome Coronaviruses with Mutations in the E Protein Are Attenuated and Promising Vaccine Candidates

(2015) Jose A. Regla-Nava et al.   JOURNAL OF VIROLOGY

Viroporin Activity of the Foot-and-Mouth Disease Virus Non-Structural 2B Protein

(2015) Da Ao et al.   PLoS One

Bat-to-human: spike features determining ‘host jump’ of coronaviruses SARS-CoV, MERS-CoV, and beyond

(2015) Guangwen Lu et al.   TRENDS IN MICROBIOLOGY

Viruses and the autophagy pathway

(2015) William T. Jackson   VIROLOGY

Coronavirus envelope (E) protein remains at the site of assembly

(2015) Pavithra Venkatagopalan et al.   VIROLOGY

Severe acute respiratory syndrome coronavirus E protein transports calcium ions and activates the NLRP3 inflammasome

(2015) Jose L. Nieto-Torres et al.   VIROLOGY

Porcine epidemic diarrhea virus: An emerging and re-emerging epizootic swine virus

(2015) Changhee Lee   Virology Journal

MERS coronavirus envelope protein has a single transmembrane domain that forms pentameric ion channels

(2015) Wahyu Surya et al.   VIRUS RESEARCH

Protein-Protein Interactions of Viroporins in Coronaviruses and Paramyxoviruses: New Targets for Antivirals?

(2015) Jaume Torres et al.   Viruses-Basel

Animal models for SARS and MERS coronaviruses

(2015) Lisa M Gretebeck et al.   Current Opinion in Virology

Identification of the Mechanisms Causing Reversion to Virulence in an Attenuated SARS-CoV for the Design of a Genetically Stable Vaccine

(2015) Jose M. Jimenez-Guardeño et al.   PLoS Pathogens

Progress and Challenges toward the Development of Vaccines against Avian Infectious Bronchitis

(2015) Faruku Bande et al.   Journal of Immunology Research

Pathophysiological Consequences of Calcium-Conducting Viroporins

(2015) Joseph M. Hyser et al.   Annual Review of Virology

Accessory proteins of SARS-CoV and other coronaviruses

(2014) Ding Xiang Liu et al.   ANTIVIRAL RESEARCH

Coronavirus Infection in Equines: A Review

(2014) K. Dhama et al.  

A LC3-Interacting Motif in the Influenza A Virus M2 Protein Is Required to Subvert Autophagy and Maintain Virion Stability

(2014) Rupert Beale et al.   Cell Host & Microbe

Structure of a Conserved Golgi Complex-targeting Signal in Coronavirus Envelope Proteins

(2014) Yan Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hydrocarbon-Stapled Peptides: Principles, Practice, and Progress

(2014) Loren D. Walensky et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of the Human Respiratory Syncytial Virus Small Hydrophobic Protein and Structural Variations in a Bicelle Environment

(2014) Y. Li et al.   JOURNAL OF VIROLOGY

Human Coronaviruses Associated with Upper Respiratory Tract Infections in Three Rural Areas of Ghana

(2014) Michael Owusu et al.   PLoS One

Current progress in antiviral strategies

(2014) Zhiyong Lou et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Membrane rearrangements mediated by coronavirus nonstructural proteins 3 and 4

(2014) Marne C. Hagemeijer et al.   VIROLOGY

Coronavirus virulence genes with main focus on SARS-CoV envelope gene

(2014) Marta L. DeDiego et al.   VIRUS RESEARCH

The Coronavirus Nucleocapsid Is a Multifunctional Protein

(2014) Ruth McBride et al.   Viruses-Basel

The PDZ-Binding Motif of Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Is a Determinant of Viral Pathogenesis

(2014) Jose M. Jimenez-Guardeño et al.   PLoS Pathogens

Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Ion Channel Activity Promotes Virus Fitness and Pathogenesis

(2014) Jose L. Nieto-Torres et al.   PLoS Pathogens

Coronavirus infection, ER stress, apoptosis and innate immunity

(2014) To S. Fung et al.   Frontiers in Microbiology

Viral Membrane Scission

(2013) Jeremy S. Rossman et al.   Annual Review of Cell and Developmental Biology

Cell-based antiviral screening against coronaviruses: Developing virus-specific and broad-spectrum inhibitors

(2013) Andy Kilianski et al.   ANTIVIRAL RESEARCH

Analysis of SARS-CoV E protein ion channel activity by tuning the protein and lipid charge

(2013) Carmina Verdiá-Báguena et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The ORF4a protein of human coronavirus 229E functions as a viroporin that regulates viral production

(2013) Ronghua Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Stapled peptide-based membrane fusion inhibitors of hepatitis C virus

(2013) Hong-Kui Cui et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Future directions for peptide therapeutics development

(2013) Allan A. Kaspar et al.   DRUG DISCOVERY TODAY

Inhibition of p38 Mitogen-activated Protein Kinase Impairs Influenza Virus-induced Primary and Secondary Host Gene Responses and Protects Mice from Lethal H5N1 Infection

(2013) Yvonne Börgeling et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complete Protection against Severe Acute Respiratory Syndrome Coronavirus-Mediated Lethal Respiratory Disease in Aged Mice by Immunization with a Mouse-Adapted Virus Lacking E Protein

(2013) C. Fett et al.   JOURNAL OF VIROLOGY

The Amphipathic Helix of Influenza A Virus M2 Protein Is Required for Filamentous Bud Formation and Scission of Filamentous and Spherical Particles

(2013) K. L. Roberts et al.   JOURNAL OF VIROLOGY

Host IQGAP1 and Ebola Virus VP40 Interactions Facilitate Virus-Like Particle Egress

(2013) J. Lu et al.   JOURNAL OF VIROLOGY

Assessing Activity and Inhibition of Middle East Respiratory Syndrome Coronavirus Papain-Like and 3C-Like Proteases Using Luciferase-Based Biosensors

(2013) A. Kilianski et al.   JOURNAL OF VIROLOGY

Role of the Spike Glycoprotein of Human Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Virus Entry and Syncytia Formation

(2013) Zhaohui Qian et al.   PLoS One

Dual-acting stapled peptides target both HIV-1 entry and assembly

(2013) Hongtao Zhang et al.   Retrovirology

Interspecies transmission and emergence of novel viruses: lessons from bats and birds

(2013) Jasper Fuk-Woo Chan et al.   TRENDS IN MICROBIOLOGY

Porcine reproductive and respiratory syndrome virus activates inflammasomes of porcine alveolar macrophages via its small envelope protein E

(2013) Kao Zhang et al.   VIROLOGY

Engineering a Replication-Competent, Propagation-Defective Middle East Respiratory Syndrome Coronavirus as a Vaccine Candidate

(2013) F. Almazan et al.   mBio

Severe Acute Respiratory Syndrome Coronavirus Nonstructural Proteins 3, 4, and 6 Induce Double-Membrane Vesicles

(2013) M. M. Angelini et al.   mBio

Porcine reproductive and respiratory syndrome virus induces autophagy to promote virus replication

(2012) Ming-Xia Sun et al.   Autophagy

The Future of Peptide-based Drugs

(2012) David J. Craik et al.   Chemical Biology & Drug Design

PEDV ORF3 encodes an ion channel protein and regulates virus production

(2012) Kai Wang et al.   FEBS LETTERS

Cysteine 70 of Ankyrin-G IsS-Palmitoylated and Is Required for Function of Ankyrin-G in Membrane Domain Assembly

(2012) Meng He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chikungunya virus–induced autophagy delays caspase-dependent cell death

(2012) Pierre-Emmanuel Joubert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Classical Swine Fever Virus p7 Protein Is a Viroporin Involved in Virulence in Swine

(2012) D. P. Gladue et al.   JOURNAL OF VIROLOGY

A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease

(2012) Rachel L Graham et al.   NATURE MEDICINE

Autophagy hijacked through viroporin-activated calcium/calmodulin-dependent kinase kinase-  signaling is required for rotavirus replication

(2012) S. E. Crawford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression and purification of coronavirus envelope proteins using a modified β-barrel construct

(2012) Krupakar Parthasarathy et al.   PROTEIN EXPRESSION AND PURIFICATION

Human respiratory syncytial virus viroporin SH: a viral recognition pathway used by the host to signal inflammasome activation

(2012) Kathy Triantafilou et al.   THORAX

Coronavirus E protein forms ion channels with functionally and structurally-involved membrane lipids

(2012) Carmina Verdiá-Báguena et al.   VIROLOGY

Ready, Set, Fuse! The Coronavirus Spike Protein and Acquisition of Fusion Competence

(2012) Taylor Heald-Sargent et al.   Viruses-Basel

The Coronavirus E Protein: Assembly and Beyond

(2012) Travis R. Ruch et al.   Viruses-Basel

The Role of Flexibility and Conformational Selection in the Binding Promiscuity of PDZ Domains

(2012) Márton Münz et al.   PLoS Computational Biology

A Single Polar Residue and Distinct Membrane Topologies Impact the Function of the Infectious Bronchitis Coronavirus E Protein

(2012) Travis R. Ruch et al.   PLoS Pathogens

Encephalomyocarditis Virus Viroporin 2B Activates NLRP3 Inflammasome

(2012) Minako Ito et al.   PLoS Pathogens

Design and Structure of Stapled Peptides Binding to Estrogen Receptors

(2011) Chris Phillips et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune Response

(2011) I. Glowacka et al.   JOURNAL OF VIROLOGY

Identification of a Golgi Complex-Targeting Signal in the Cytoplasmic Tail of the Severe Acute Respiratory Syndrome Coronavirus Envelope Protein

(2011) J. R. Cohen et al.   JOURNAL OF VIROLOGY

Emerging Theme: Cellular PDZ Proteins as Common Targets of Pathogenic Viruses

(2011) R. T. Javier et al.   JOURNAL OF VIROLOGY

Mobility and Interactions of Coronavirus Nonstructural Protein 4

(2011) M. C. Hagemeijer et al.   JOURNAL OF VIROLOGY

Subcellular location and topology of severe acute respiratory syndrome coronavirus envelope protein

(2011) Jose L. Nieto-Torres et al.   VIROLOGY

Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Regulates Cell Stress Response and Apoptosis

(2011) Marta L. DeDiego et al.   PLoS Pathogens

Membrane Potential Depolarization as a Triggering Mechanism for Vpu-Mediated HIV-1 Release

(2010) Kate Hsu et al.   BIOPHYSICAL JOURNAL

Influenza Virus M2 Protein Mediates ESCRT-Independent Membrane Scission

(2010) Jeremy S. Rossman et al.   CELL

Autophagy Protects against Sindbis Virus Infection of the Central Nervous System

(2010) Anthony Orvedahl et al.   Cell Host & Microbe

Qualitative and quantitative ultrastructural analysis of the membrane rearrangements induced by coronavirus

(2010) Mustafa Ulasli et al.   CELLULAR MICROBIOLOGY

Insights on the permeability of wide protein channels: measurement and interpretation of ion selectivity

(2010) Vicente M. Aguilella et al.   Integrative Biology

The Epstein-Barr Virus-encoded G Protein-coupled Receptor BILF1 Hetero-oligomerizes with Human CXCR4, Scavenges GαiProteins, and Constitutively Impairs CXCR4 Functioning

(2010) Saskia Nijmeijer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The intracellular dynamic of protein palmitoylation

(2010) Christine Salaun et al.   JOURNAL OF CELL BIOLOGY

The Hepatitis B Virus X Protein Disrupts Innate Immunity by Downregulating Mitochondrial Antiviral Signaling Protein

(2010) C. Wei et al.   JOURNAL OF IMMUNOLOGY

A structural analysis of M protein in coronavirus assembly and morphology

(2010) Benjamin W. Neuman et al.   JOURNAL OF STRUCTURAL BIOLOGY

The Hydrophobic Domain of Infectious Bronchitis Virus E Protein Alters the Host Secretory Pathway and Is Important for Release of Infectious Virus

(2010) T. R. Ruch et al.   JOURNAL OF VIROLOGY

A Conserved Domain in the Coronavirus Membrane Protein Tail Is Important for Virus Assembly

(2010) A. L. Arndt et al.   JOURNAL OF VIROLOGY

SARS coronavirus 8b reduces viral replication by down-regulating E via an ubiquitin-independent proteasome pathway

(2010) Choong-Tat Keng et al.   MICROBES AND INFECTION

The SARS Coronavirus E Protein Interacts with PALS1 and Alters Tight Junction Formation and Epithelial Morphogenesis

(2010) Kim-Tat Teoh et al.   MOLECULAR BIOLOGY OF THE CELL

The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer

(2010) Michelle L Stewart et al.   Nature Chemical Biology

Influenza virus activates inflammasomes via its intracellular M2 ion channel

(2010) Takeshi Ichinohe et al.   NATURE IMMUNOLOGY

Immunization with an attenuated severe acute respiratory syndrome coronavirus deleted in E protein protects against lethal respiratory disease

(2010) Jason Netland et al.   VIROLOGY

The envelope protein of severe acute respiratory syndrome coronavirus interacts with the non-structural protein 3 and is ubiquitinated

(2010) Enrique Álvarez et al.   VIROLOGY

Rotavirus Disrupts Calcium Homeostasis by NSP4 Viroporin Activity

(2010) J. M. Hyser et al.   mBio

Intracellular Proton Conductance of the Hepatitis C Virus p7 Protein and Its Contribution to Infectious Virus Production

(2010) Ann L. Wozniak et al.   PLoS Pathogens

The Human Polyoma JC Virus Agnoprotein Acts as a Viroporin

(2010) Tadaki Suzuki et al.   PLoS Pathogens

Transmembrane protein topology prediction using support vector machines

(2009) Timothy Nugent et al.   BMC BIOINFORMATICS

Ubiquitination, Ubiquitin-like Modifiers, and Deubiquitination in Viral Infection

(2009) Marisa K. Isaacson et al.   Cell Host & Microbe

Matrix Protein 2 of Influenza A Virus Blocks Autophagosome Fusion with Lysosomes

(2009) Monique Gannagé et al.   Cell Host & Microbe

Coronavirus Diversity, Phylogeny and Interspecies Jumping

(2009) Patrick C. Y. Woo et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Influenza virus M2 protein inhibits epithelial sodium channels by increasing reactive oxygen species

(2009) Ahmed Lazrak et al.   FASEB JOURNAL

Apolipoprotein E interacts with hepatitis C virus nonstructural protein 5A and determines assembly of infectious particles

(2009) Wagane J. A. Benga et al.   HEPATOLOGY

Respiratory Syncytial Virus Inhibits Lung Epithelial Na+Channels by Up-regulating Inducible Nitric-oxide Synthase

(2009) Weifeng Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Palmitoylation of Hepatitis C Virus Core Protein Is Important for Virion Production

(2009) Nathalie Majeau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages

(2009) George B. Kyei et al.   JOURNAL OF CELL BIOLOGY

Detection of four human coronaviruses in respiratory infections in children: A one-year study in Colorado

(2009) Samuel R. Dominguez et al.   JOURNAL OF MEDICAL VIROLOGY

Epstein-Barr Virus Nuclear Antigen 3C Augments Mdm2-Mediated p53 Ubiquitination and Degradation by Deubiquitinating Mdm2

(2009) A. Saha et al.   JOURNAL OF VIROLOGY

Influenza A Virus Lacking M2 Protein as a Live Attenuated Vaccine

(2009) S. Watanabe et al.   JOURNAL OF VIROLOGY

A Chimeric A2 Strain of Respiratory Syncytial Virus (RSV) with the Fusion Protein of RSV Strain Line 19 Exhibits Enhanced Viral Load, Mucus, and Airway Dysfunction

(2009) M. L. Moore et al.   JOURNAL OF VIROLOGY

Human host factors required for influenza virus replication

(2009) Renate König et al.   NATURE

The autophagy machinery is required to initiate hepatitis C virus replication

(2009) M. Dreux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of specificity and promiscuity of PDZ domain interactions through their dynamic behavior

(2009) Z. Nevin Gerek et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Myristoylation of the small envelope protein of porcine reproductive and respiratory syndrome virus is non-essential for virus infectivity but promotes its growth

(2009) Yijun Du et al.   VIRUS RESEARCH

Structure and Inhibition of the SARS Coronavirus Envelope Protein Ion Channel

(2009) Konstantin Pervushin et al.   PLoS Pathogens

Structural Flexibility of the Pentameric SARS Coronavirus Envelope Protein Ion Channel

(2008) Krupakar Parthasarathy et al.   BIOPHYSICAL JOURNAL

Hepatitis B virus X protein sensitizes cells to starvation-induced autophagy via up-regulation of beclin 1 expression

(2008) Hong Tang et al.   HEPATOLOGY

A Cell-penetrating Helical Peptide as a Potential HIV-1 Inhibitor

(2008) Hongtao Zhang et al.   JOURNAL OF MOLECULAR BIOLOGY

Importance of Conserved Cysteine Residues in the Coronavirus Envelope Protein

(2008) L. A. Lopez et al.   JOURNAL OF VIROLOGY

Envelope Protein Palmitoylations Are Crucial for Murine Coronavirus Assembly

(2008) J. A. Boscarino et al.   JOURNAL OF VIROLOGY

A Live Attenuated Severe Acute Respiratory Syndrome Coronavirus Is Immunogenic and Efficacious in Golden Syrian Hamsters

(2008) E. W. Lamirande et al.   JOURNAL OF VIROLOGY

The M, E, and N Structural Proteins of the Severe Acute Respiratory Syndrome Coronavirus Are Required for Efficient Assembly, Trafficking, and Release of Virus-Like Particles

(2008) Y. L. Siu et al.   JOURNAL OF VIROLOGY

Autophagosome Supports Coxsackievirus B3 Replication in Host Cells

(2008) J. Wong et al.   JOURNAL OF VIROLOGY

Structure and mechanism of the M2 proton channel of influenza A virus

(2008) Jason R. Schnell et al.   NATURE

Genome-Wide Analysis of Protein-Protein Interactions and Involvement of Viral Proteins in SARS-CoV Replication

(2008) Ji'An Pan et al.   PLoS One

Respiratory syncytial virus uses a Vps4-independent budding mechanism controlled by Rab11-FIP2

(2008) T. J. Utley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogenicity of severe acute respiratory coronavirus deletion mutants in hACE-2 transgenic mice

(2008) Marta L. DeDiego et al.   VIROLOGY

Human (non-severe acute respiratory syndrome) coronavirus infections in hospitalised children in France

(2007) Astrid Vabret et al.   JOURNAL OF PAEDIATRICS AND CHILD HEALTH