Redox-Active Mn Porphyrin-based Potent SOD Mimic, MnTnBuOE-2-PyP5+, Enhances Carbenoxolone-Mediated TRAIL-Induced Apoptosis in Glioblastoma Multiforme

Mn Porphyrin-Based SOD Mimic and Vitamin C Enhance Radiation-Induced Tumor Growth Inhibition

(2015) Artak Tovmasyan et al.   FREE RADICAL BIOLOGY AND MEDICINE

A comprehensive evaluation of catalase-like activity of different classes of redox-active therapeutics

(2015) Artak Tovmasyan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Manganese (III) meso-tetrakis N-ethylpyridinium-2-yl porphyrin acts as a pro-oxidant to inhibit electron transport chain proteins, modulate bioenergetics, and enhance the response to chemotherapy in lymphoma cells

(2015) Melba C. Jaramillo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Novel Manganese-Porphyrin Superoxide Dismutase-Mimetic Widens the Therapeutic Margin in a Preclinical Head and Neck Cancer Model

(2015) Kathleen A. Ashcraft et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Glutathione-Garlic Sulfur Conjugates: Slow Hydrogen Sulfide Releasing Agents for Therapeutic Applications

(2015) Ashif Bhuiyan et al.   MOLECULES

A Phase IIb Trial Assessing the Addition of Disulfiram to Chemotherapy for the Treatment of Metastatic Non-Small Cell Lung Cancer

(2015) H. Nechushtan et al.   ONCOLOGIST

An educational overview of the chemistry, biochemistry and therapeutic aspects of Mn porphyrins – From superoxide dismutation to H 2 O 2 -driven pathways

(2015) Ines Batinic-Haberle et al.   Redox Biology

Manganese Superoxide Dismutase-Mediated Inside-Out Signaling in HaCaT Human Keratinocytes and SKH-1 Mouse Skin

(2014) Aaron K. Holley et al.   ANTIOXIDANTS & REDOX SIGNALING

Rational Design of Superoxide Dismutase (SOD) Mimics: The Evaluation of the Therapeutic Potential of New Cationic Mn Porphyrins with Linear and Cyclic Substituents

(2014) Artak Tovmasyan et al.   INORGANIC CHEMISTRY

Radioprotection of the Brain White Matter by Mn(III) N-Butoxyethylpyridylporphyrin-Based Superoxide Dismutase Mimic MnTnBuOE-2-PyP5+

(2014) D. H. Weitzel et al.   MOLECULAR CANCER THERAPEUTICS

Inhibition of Neuroinflammation and Mitochondrial Dysfunctions by Carbenoxolone in the Rotenone Model of Parkinson’s Disease

(2014) Poonam Thakur et al.   MOLECULAR NEUROBIOLOGY

NAC, Tiron and Trolox Impair Survival of Cell Cultures Containing Glioblastoma Tumorigenic Initiating Cells by Inhibition of Cell Cycle Progression

(2014) Massimiliano Monticone et al.   PLoS One

Human Wharton's Jelly Stem Cells, its Conditioned Medium and Cell-Free Lysate Inhibit the Growth of Human Lymphoma Cells

(2014) Hao Daniel Lin et al.   Stem Cell Reviews and Reports

Depolarization Controls TRAIL-Sensitization and Tumor-Selective Killing of Cancer Cells: Crosstalk with ROS

(2014) Yoshihiro Suzuki-Karasaki et al.   Frontiers in Oncology

A Distinct Reactive Oxygen Species Profile Confers Chemoresistance in Glioma-Propagating Cells and Associates with Patient Survival Outcome

(2013) Lynnette Wei-Hsien Koh et al.   ANTIOXIDANTS & REDOX SIGNALING

Simple Biological Systems for Assessing the Activity of Superoxide Dismutase Mimics

(2013) Artak Tovmasyan et al.   ANTIOXIDANTS & REDOX SIGNALING

SOD Therapeutics: Latest Insights into Their Structure-Activity Relationships and Impact on the Cellular Redox-Based Signaling Pathways

(2013) Ines Batinic-Haberle et al.   ANTIOXIDANTS & REDOX SIGNALING

Pharmacological ascorbate with gemcitabine for the control of metastatic and node-positive pancreatic cancer (PACMAN): results from a phase I clinical trial

(2013) J. L. Welsh et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Pharmacokinetics, Brain Hippocampus and Cortex, and Mitochondrial Accumulation of a New Generation of Lipophilic Redox-Active Therapeutic, Mn(III) Meso Tetrakis(N-n-butoxyethylpyridinium-2-yl)porphyrin, MnTnBuOE-2-PyP5+, in Comparison with its Ethyl and N-hexyl Analogs, MnTE-2-PyP5+ and MnTnHex-2-PyP5+

(2013) Ivan Spasojevic et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mn porphyrin in combination with ascorbate acts as a pro-oxidant and mediates caspase-independent cancer cell death

(2013) Myron K. Evans et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pivotal role for ROS activation of p38 MAPK in the control of differentiation and tumor-initiating capacity of glioma-initiating cells

(2013) Atsushi Sato et al.   Stem Cell Research

Carbenoxolone Enhances TRAIL-Induced Apoptosis Through the Upregulation of Death Receptor 5 and Inhibition of Gap Junction Intercellular Communication in Human Glioma

(2013) Yulyana Yulyana et al.   STEM CELLS AND DEVELOPMENT

Late administration of Mn porphyrin-based SOD mimic enhances diabetic complications

(2013) Dana K. Ali et al.   Redox Biology

Manganese Superoxide Dismutase (Sod2) and Redox-Control of Signaling Events That Drive Metastasis

(2012) Nadine Hempel et al.   Anti-Cancer Agents in Medicinal Chemistry

Lipoxygenase inhibitor MK886 potentiates TRAIL-induced apoptosis through CHOP- and p38 MAPK-mediated up-regulation of death receptor 5 in malignant glioma

(2012) Ji Sun Woo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Manganese Porphyrin, MnTE-2-PyP5+, Acts as a Pro-Oxidant to Potentiate Glucocorticoid-Induced Apoptosis in Lymphoma Cells

(2012) Melba C. Jaramillo et al.   FREE RADICAL BIOLOGY AND MEDICINE

A new SOD mimic, Mn(III) ortho N-butoxyethylpyridylporphyrin, combines superb potency and lipophilicity with low toxicity

(2012) Zrinka Rajic et al.   FREE RADICAL BIOLOGY AND MEDICINE

Histone deacetylase inhibitors sensitize glioblastoma cells to TRAIL-induced apoptosis by c-myc-mediated downregulation of cFLIP

(2012) A Bangert et al.   ONCOGENE

Phase I Evaluation of Intravenous Ascorbic Acid in Combination with Gemcitabine and Erlotinib in Patients with Metastatic Pancreatic Cancer

(2012) Daniel A. Monti et al.   PLoS One

Manganese superoxide dismutase, MnSOD and its mimics

(2011) Sumitra Miriyala et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Cytotoxic effects of Mn(III)N-alkylpyridylporphyrins in the presence of cellular reductant, ascorbate

(2011) Xiaodong Ye et al.   FREE RADICAL RESEARCH

Pro-oxidant and antioxidant effects of N-acetylcysteine regulate doxorubicin-induced NF-kappa B activity in leukemic cells

(2011) Nnenna Adimora Finn et al.   Molecular BioSystems

Calcium-induced permeability transition in rat brain mitochondria is promoted by carbenoxolone through targeting connexin43

(2010) Tamara Azarashvili et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities

(2010) Ines Batinic-Haberle et al.   AMINO ACIDS

Human Mesenchymal Stem Cells Efficiently Manage Oxidative Stress

(2010) Araceli Valle-Prieto et al.   STEM CELLS AND DEVELOPMENT

Increased Manganese Superoxide Dismutase Expression or Treatment with Manganese Porphyrin Potentiates Dexamethasone-Induced Apoptosis in Lymphoma Cells

(2009) Melba C. Jaramillo et al.   CANCER RESEARCH

Mesenchymal Stem Cell Delivery of TRAIL Can Eliminate Metastatic Cancer

(2009) M. R. Loebinger et al.   CANCER RESEARCH

HSV-1 amplicon viral vector-mediated gene transfer to human bone marrow-derived mesenchymal stem cells

(2008) I A W Ho et al.   CANCER GENE THERAPY

Gene Therapy Using TRAIL-Secreting Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells against Intracranial Glioma

(2008) S. M. Kim et al.   CANCER RESEARCH

Mesenchymal stem cells expressing TRAIL lead to tumour growth inhibition in an experimental lung cancer model

(2008) Andrea Mohr et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Targeting multiple pathways in gliomas with stem cell and viral delivered S-TRAIL and Temozolomide

(2008) S. Hingtgen et al.   MOLECULAR CANCER THERAPEUTICS

Evidence supporting antioxidant action of adipose-derived stem cells: Protection of human dermal fibroblasts from oxidative stress

(2007) Won-Serk Kim et al.   JOURNAL OF DERMATOLOGICAL SCIENCE