Article
Biochemistry & Molecular Biology
Long Xu, Jian Wang, Buhan Liu, Jiaying Fu, Yuanxin Zhao, Sihang Yu, Luyan Shen, Xiaoyu Yan, Jing Su
Summary: Epithelial ovarian cancer has the highest mortality rate among gynecological malignant tumors, largely due to metastasis. This study found that HDAC9 plays different roles in different histological subtypes of ovarian cancer and may be a potential target for personalized treatment.
Article
Cell Biology
Weijia Li, Xibo Zhao, Rujian Zhang, Jiabin Xie, Guangmei Zhang
Summary: This study aims to investigate the role of NLRP3 in cisplatin resistance in ovarian cancer. It was found that NLRP3 is overexpressed in ovarian cancer and is associated with poor survival. Silencing NLRP3 gene can inhibit the malignant process of cisplatin-resistant ovarian cancer cells.
MEDIATORS OF INFLAMMATION
(2023)
Article
Biochemistry & Molecular Biology
Iason Psilopatis, Jule Ida Schaefer, Dimitrios Arsenakis, Dimitrios Bolovis, Georgia Levidou
Summary: This study provides preliminary evidence suggesting that overexpression of SOX11 might promote EMT in metastatic serous ovarian cancer, thereby enhancing tumor metastasis.
Article
Cell Biology
Piera Tocci, Celia Roman, Rosanna Sestito, Valeriana Di Castro, Andrea Sacconi, Ivan Molineris, Francesca Paolini, Mariantonia Carosi, Giovanni Tonon, Giovanni Blandino, Anna Bagnato
Summary: PARP inhibitors have changed the treatment paradigm of HG-SOC, but their efficacy is limited in patients with high TP53 mutation rates. The overexpression of the ET-1/ET1R axis in HG-SOC is associated with poor prognosis and inhibits the DNA damage response induced by PARP inhibitors. The ET-1R antagonist macitentan, in combination with olaparib, shows promising results in suppressing metastatic progression in HG-SOC patient-derived xenografts.
CELL DEATH & DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Nicole E. James, Morgan Woodman, Jennifer R. Ribeiro
Summary: EOC patients have low response rates to immunotherapies, but evidence suggests ovarian tumors are immunogenic and immune-related genomic profiles can serve as prognostic markers. Specific research areas that need to be addressed include developing immune-based prognostic signatures and driving advancements in this field.
Article
Oncology
Robert L. Hollis, Ian Croy, Michael Churchman, Clare Bartos, Tzyvia Rye, Charlie Gourley, C. Simon Herrington
Summary: Ovarian carcinosarcoma is a rare and highly aggressive type of ovarian cancer that requires new treatment strategies urgently. Histological subclassification does not identify patient subgroups with distinct survival.
BRITISH JOURNAL OF CANCER
(2022)
Editorial Material
Oncology
Rachel N. N. Grisham, Beryl L. L. Manning-Geist, M. Herman Chui
Summary: Estrogen receptor immunohistochemistry is not reliable for assessing response to antihormonal therapy; further research is needed for prognostic value of progesterone receptor immunohistochemistry. Multigene assays have the potential to serve as a diagnostic tool to identify patients who are less likely to respond to single-agent endocrine therapy and determine optimal combination strategies.
Article
Oncology
Xiaoli He, Li Wei, Rui Li, Shuang Jing, Linlin Jia, Danwei Ji, Yali Li, Yue Wang, Yongxia Zhu
Summary: IDS plus dense HIPEC with cisplatin in Chinese patients with FIGO stage III serous EOC is associated with improved survival and is reasonably well tolerated by patients.
Article
Biochemistry & Molecular Biology
Justin W. Gorski, Zhuwei Zhang, J. Robert McCorkle, Jodi M. DeJohn, Chi Wang, Rachel W. Miller, Holly H. Gallion, Charles S. Dietrich, Frederick R. Ueland, Jill M. Kolesar
Summary: The development of patient-derived tumor organoids from epithelial ovarian cancer has the potential to contribute significantly to precision medicine by testing chemotherapy sensitivity and investigating genetic drivers of drug resistance. This study identified one organoid line resistant to carboplatin, leading to a shorter progression-free survival and platinum-resistant recurrence. Gene expression analysis revealed interconnected pathways related to NF-kB, cellular differentiation, and B-cell receptor signaling in the context of carboplatin resistance.
Article
Oncology
Xue Lu, Yaowu He, Rebecca L. Johnston, Devathri Nanayakarra, Sivanandhini Sankarasubramanian, J. Alejandro Lopez, Michael Friedlander, Murugan Kalimutho, John D. Hooper, Prahlad V. Raninga, Kum Kum Khanna
Summary: This study demonstrates that inhibition of SSRP1 using CBL0137 shows significant anti-growth activity against HGSC cell lines and patient-derived tumor cells. Additionally, CBL0137 sensitizes HR-proficient HGSC cell lines and patient-derived tumor cells to PARP inhibitors and enhances the efficacy of platinum-based chemotherapy. This suggests that combination therapy with CBL0137 and PARP inhibitors could be a promising strategy for the treatment of HR-proficient HGSCs.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Multidisciplinary Sciences
Jesus Gonzalez Bosquet, Eric J. Devor, Andreea M. Newtson, Brian J. Smith, David P. Bender, Michael J. Goodheart, Megan E. McDonald, Terry A. Braun, Kristina W. Thiel, Kimberly K. Leslie
Summary: This study aims to create and validate accurate prediction models for treatment response in HGSC by integrating comprehensive clinical and genomic data. The models achieved prediction performances of over 95% in AUC by integrating clinical and genomic variables. Most performances in the validation set did not differ from the training set, but models with DNA methylation or lncRNA underperformed in the validation set.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Xinlu Zhan, Qi Zuo, Genhua Huang, Zhanghua Qi, Yufan Wang, Sihong Zhu, Yanying Zhong, Yifei Xiong, Tingtao Chen, Buzhen Tan
Summary: This study demonstrates that Tripterygium glycosides (GTW) combined with cisplatin (DDP) is more effective in inhibiting the growth of epithelial ovarian cancer (EOC) compared to DDP alone. GTW not only enhances the tumor suppressive effect but also offers gastrointestinal protection by reducing pathological damage. Furthermore, this study suggests that gut microbiota play an important role in the anticancer effect of GTW.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Oncology
Caroline H. Hemmingsen, Susanne K. Kjaer, Ane Katrine Kaer Bennetsen, Christian Dehlendorff, Louise Baandrup
Summary: Reproductive factors have a significant impact on the risk of ovarian cancer, with parity, infertility, and oral contraceptive use showing different effects on the risk of different types of ovarian cancer.
GYNECOLOGIC ONCOLOGY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Sofia Amante, Filipa Santos, Teresa Margarida Cunha
Summary: Low-grade serous carcinoma (LGSC) is a rare subtype of ovarian cancer, accounting for 5% of epithelial neoplasms, with distinct molecular features, pathogenesis, and clinical behavior compared to high-grade serous carcinoma (HGSC). LGSC typically presents as mixed lesions with different proportions of papillary projections and solid components, distinguishable from other ovarian serous tumors, and imaging plays a crucial role in differentiation and diagnosis.
INSIGHTS INTO IMAGING
(2021)
Article
Medicine, General & Internal
Karina Biskup, Caroline Stellmach, Elena Ioana Braicu, Jalid Sehouli, Veronique Blanchard
Summary: The modification of glycosaminoglycans in tissues surrounding malignant cells may contribute to tumor progression and metastasis in various types of cancers. A novel GAG-based score, CS-bio, was proposed as a potential biomarker for primary epithelial ovarian cancer, showing better sensitivity and specificity than the clinically used CA125 in identifying early-stage patients.
Meeting Abstract
Oncology
Dominic C. Grimberg, Scott P. Campbell, Wiguins Etienne, Fan Ping, Paolo F. Maccarini, Ivan Spasojevic, Rohith Arcot, Ankeet Shah, Brant Allen Inman
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Neurosciences
Zhuoran Wang, Xuan Li, Ivan Spasojevic, Liping Lu, Yuntian Shen, Xingguang Qu, Ulrike Hoffmann, David S. Warner, Wulf Paschen, Huaxin Sheng, Wei Yang
Summary: Our study established the neuroprotective role of XBP1s in ischemic stroke, linked to O-GlcNAcylation, and the therapeutic potential of targeting this axis, particularly in the aged brain. We discovered a novel mechanism involving compromised UDP-GlcNAc availability in the aged brain, contributing to impaired O-GlcNAcylation activation after ischemia. Furthermore, we confirmed the therapeutic effects of glucosamine treatment in both young and aged animals in stroke models, supporting the promise of increasing O-GlcNAcylation in stroke therapy.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Dermatology
Melodi Javid Whitley, Jutamas Suwanpradid, Chester Lai, Simon W. Jiang, Jonathan L. Cook, Daniel E. Zelac, Ross Rudolph, David L. Corcoran, Simone Degan, Ivan Spasojevic, Howard Levinson, Detlev Erdmann, Claire Reid, Jennifer Y. Zhang, Simon C. Robson, Eugene Healy, Wendy L. Havran, Amanda S. Macleod
Summary: This study demonstrates that ENTPD1 expression on T cells within cutaneous squamous cell carcinomas (cSCCs) is increased, leading to elevated levels of extracellular adenosine in tumors compared to normal skin. Furthermore, higher ENTPD1 expression is associated with metastatic cSCCs. The findings suggest that ENTPD1 regulates DNA damage repair through purinergic signaling, contributing to skin carcinogenesis and metastasis.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Review
Cell Biology
Ines Batinic-Haberle, Artak Tovmasyan, Zhiqing Huang, Weina Duan, Li Du, Sharareh Siamakpour-Reihani, Zhipeng Cao, Huaxin Sheng, Ivan Spasojevic, Angeles Alvarez Secord
Summary: MnPs were initially developed as SOD mimics but later found to react with various reactive species and modify protein activities through oxidation, affecting both normal and cancer cells. Lead Mn porphyrins have been tested in various injury and cancer models, with some progressing to clinical trials for glioma, head and neck cancer, anal cancer, and other conditions.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Oncology
Takuya Osada, Erika J. Crosby, Kensuke Kaneko, Joshua C. Snyder, Joshua D. Ginzel, Chaitanya R. Acharya, Xiao-Yi Yang, Thomas J. Polascik, Ivan Spasojevic, Rendon C. Nelson, Amy Hobeika, Zachary C. Hartman, Leonard M. Neckers, Andre Rogatko, Philip F. Hughes, Jiaoti Huang, Michael A. Morse, Timothy Haystead, H. Kim Lyerly
Summary: A noninvasive test utilizing the activity of Hsp90 has been developed to differentiate aggressive prostate cancer from less harmful types. In a human study, systemically administered HS196 was able to detect malignant nodules and showed greater uptake in secretory cells.
MOLECULAR CANCER THERAPEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Qingyu Zhou, Justin Doherty, Antonina Akk, Luke E. Springer, Ping Fan, Ivan Spasojevic, Ganesh V. Halade, Huanghe Yang, Christine T. N. Pham, Samuel A. Wickline, Hua Pan
Summary: In this study, the potential of rapamycin perfluorocarbon (PFC) nanoparticles to mitigate cisplatin-induced acute kidney injury was demonstrated with a single preventative dose. The pharmacokinetics and biodistribution of rapamycin were improved by the PFC nanoparticle delivery system. The safety of rapamycin PFC nanoparticles was also confirmed in both in vitro and in vivo experiments.
Article
Cell Biology
Luksana Chaiswing, Chontida Yarana, William St Clair, Artak Tovmasyan, Ines Batinic-Haberle, Ivan Spasojevic, Daret St Clair
Summary: This study used a redox-active MnP compound to investigate the redox status of ovarian cancer cells. The results showed that chemotherapy-resistant cells were under higher oxidative stress and had increased glycolysis activity and mitochondrial respiration. Altering the redox state could effectively inhibit the growth and metabolic activity of these cells.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Endocrinology & Metabolism
Tian Zhang, Julie Kephart, Elizabeth Bronson, Monika Anand, Christine Daly, Ivan Spasojevic, Subha Bakthavatsalam, Katherine Franz, Hannah Berg, Georgia S. Karachaliou, Olga G. James, Lauren Howard, Susan Halabi, Michael R. Harrison, Andrew J. Armstrong, Daniel J. George
Summary: In a phase 1b clinical trial, concurrent administration of disulfiram (DSF) with copper (Cu) was assessed in patients with metastatic castration-resistant prostate cancer (mCRPC). The trial showed that oral DSF as monotherapy was not effective in treating mCRPC due to rapid metabolism into an inactive metabolite, Me-DDC.
Article
Chemistry, Multidisciplinary
Soumen Saha, Samagya Banskota, Jianqiao Liu, Nikita Zakharov, Michael Dzuricky, Xinghai Li, Ping Fan, Sonal Deshpande, Ivan Spasojevic, Kedar Sharma, Mario Juan Borgnia, Jeffrey L. Schaal, Ashutosh Raman, Sarah Kim, Jayanta Bhattacharyya, Ashutosh Chilkoti
Summary: Loading Pt(IV) into genetically engineered nanoparticles can enhance the therapeutic efficacy of platinum drugs, potentially yielding more effective platinum-drug nanoformulations.
Article
Biology
Peng Wang, Ying Li, Baihui Yan, Zhong Yang, Litao Li, Zhipeng Cao, Xuan Li, Ines Batinic-Haberle, Ivan Spasojevic, David S. Warner, Huaxin Sheng
Summary: The study showed that the Mn porphyrin compound, MnTnBuOE-2-PyP5+, improves survival, neurologic function recovery, and behavioral performance in animals suffering from cardiac arrest. This suggests the potential of Mn porphyrin-based therapeutics for the treatment of heart failure and cardiac arrest.
Article
Microbiology
Isabelle S. Byers, Nicholas A. Turner, Nicole L. Levine, Alexander L. Lazarides, Daniel R. Evans, Ivan Spasojevic, Ping Fan, Sin-Ho Jung, Junheng Gao, Julia D. Visgauss, Brian E. Brigman, William C. Eward
Summary: In orthopedic oncology, the use of megaprosthetic devices is a common practice for large-scale tumor resections. However, infection remains a major concern. This study aimed to evaluate the effectiveness of current prophylactic strategies for megaprosthetic reconstructions and found that extending postoperative antibiotics did not reduce infection risk.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Neurosciences
P. J. Nicholls, Thomas F. Pack, Nikhil M. Urs, Sunil Kumar, Yang Zhou, Gabriel Ichim, Joshua D. Ginzel, Gabor Turu, Evan Calabrese, Wendy L. Roberts, Ping Fan, Valeriy G. Ostapchenko, Monica S. Guzman Lenis, Flavio Beraldo, Jiri Hatina, Vania F. Prado, Marco A. M. Prado, Ivan Spasojevic, Joshua C. Snyder, Kafui Dzirasa, G. Allan Johnson, Marc G. Caron
Summary: In this study, a transgenic mouse was generated as a tool to map and quantify nonapoptotic caspase activity. It was found that nonapoptotic caspase activity influences neurophysiology and exhibits persistent elevation in response to restraint stress.
Article
Biochemistry & Molecular Biology
Rita B. Soares, Rita Manguinhas, Joao G. Costa, Nuno Saraiva, Nuno Gil, Rafael Rosell, Sergio P. Camoes, Ines Batinic-Haberle, Ivan Spasojevic, Matilde Castro, Joana P. Miranda, Filipa Amaro, Joana Pinto, Ana S. Fernandes, Paula Guedes de Pinho, Nuno G. Oliveira
Summary: The study investigates the effects of MnTnHex in non-small cell lung cancer (NSCLC) cells. The results show that MnTnHex can significantly reduce cell viability, alter cell cycle distribution, induce cell death, enhance the cytotoxicity of cisplatin, and reduce cell migration. Metabolomics study also reveals an increase in oxidative stress-related compounds in MnTnHex-treated cells.
Article
Engineering, Biomedical
Imran Ozer, Anna Slezak, Parul Sirohi, Xinghai Li, Nikita Zakharov, Yunxin Yao, Jeffrey I. Everitt, Ivan Spasojevic, Stephen L. Craig, Joel H. Collier, Jonathan E. Campbell, David A. D'Alessio, Ashutosh Chilkoti
Summary: In order to solve the problem of the short half-life of biologics, researchers developed an injectable PEG-like conjugate that forms a subcutaneous depot, providing sustained delivery of the drugs. This conjugate showed better pharmacokinetic and pharmacodynamic properties compared to PEG conjugates and branched PEG, and it also remained effective and safe for long-term management of type 2 diabetes without causing an immune response.
Article
Cell Biology
Jinshi Zhao, C. Skyler Cochrane, Javaria Najeeb, David Gooden, Carly Sciandra, Ping Fan, Nadine Lemaitre, Kate Newns, Robert A. Nicholas, Ziqiang Guan, Joshua T. Thaden, Vance G. G. Fowler Jr, Ivan Spasojevic, Florent Sebbane, Eric J. Toone, Clayton Duncan, Richard Gammans, Pei Zhou
Summary: This article reports the preclinical characterization of a slow, tight-binding LpxC inhibitor, LPC-233, with low picomolar affinity. The compound is a rapid bactericidal antibiotic, unaffected by established resistance mechanisms to commercial antibiotics, and displays outstanding activity against a wide range of Gram-negative clinical isolates in vitro. It is orally bioavailable and efficiently eliminates infections caused by susceptible and multidrug-resistant Gram-negative bacterial pathogens in murine soft tissue, sepsis, and urinary tract infection models.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
