Article
Oncology
Carryn M. Anderson, Christopher M. Lee, Deborah Saunders, Amarinthia E. Curtis, Neal E. Dunlap, Chaitali Nangia, Arielle S. Lee, Philip Kovoor, Voichita Bar-Ad, Abhinand V. Pedadda, Jon Holmlund, Matt Downs, Stephen T. Sonis
Summary: Avasopasem manganese does not significantly improve tumor control outcomes when used concurrently with cisplatin and radiation therapy for head and neck cancer. Additionally, it does not have a detectable effect on trismus or xerostomia.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
Sachin R. Jhawar, Marcelo Bonomi, Paul M. Harari
Summary: The Oncology Grand Rounds series aims to help readers apply the results of key studies in clinical practice, using case presentations, literature reviews, and treatment recommendations to enhance understanding of the latest developments in oncology.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Mariana Inri de Carvalho, Marina Gatti, Renata Ligia Vieira Guedes, Renata Camilla Favarin Froes, Danila Rodrigues Costa, Jhonatan da Silva Vitor, Paulo Sergio da Silva Santos, Giedre Berretin-Felix
Summary: This study investigated the relationship between swallowing function, nutritional status, and salivary flow in patients after head and neck cancer treatment. Results showed that appropriate protein intake influences muscle activity during swallowing in head and neck cancer survivors.
SCIENTIFIC REPORTS
(2021)
Review
Otorhinolaryngology
Lisia D. B. Alves, Ana C. S. Menezes, Debora L. Pereira, Marco T. C. Santos, Heliton S. Antunes
Summary: Intraoral stents used in radiotherapy for head and neck cancers can reduce oral complications such as mucositis and trismus, as well as decrease the dose to healthy structures. Despite limited scientific evidence, multiple benefits have been reported.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Nutrition & Dietetics
Giuseppe Fanetti, Jerry Polesel, Elisabetta Fratta, Elena Muraro, Valentina Lupato, Salvatore Alfieri, Carlo Gobitti, Emilio Minatel, Fabio Matrone, Angela Caroli, Alberto Revelant, Marco Lionello, Viviana Zammattio Polentin, Andrea Ferretti, Roberto Guerrieri, Paola Chiovati, Andy Bertolin, Vittorio Giacomarra, Antonino De Paoli, Emanuela Vaccher, Giovanna Sartor, Agostino Steffan, Giovanni Franchin
Summary: The study found that PNI is an important parameter related to toxicity in head and neck cancer treatment, with low PNI levels associated with increased risk of weight loss and late toxicity. PNI plays a significant role in identifying high-risk head and neck cancer patients for acute and late toxicity.
Article
Oncology
Ghanyah Al-Qadami, Joanne Bowen, Ysabella Van Sebille, Kate Secombe, Mohsen Dorraki, Johan Verjans, Hannah Wardill, Hien Le
Summary: This study aimed to uncover associations between an individual's pre-therapy gut microbiota and the severity of radiotherapy-induced oral mucositis (OM) as well as recurrence risk in patients with head and neck cancer (HNC). The results showed that the composition of the gut microbiota was associated with the severity of OM and the risk of HNC recurrence.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Oncology
Elena Fasanaro, Paola Del Bianco, Elena Groff, Antonella Riva, Giovanna Petrangolini, Fabio Busato, Paola Stritoni, Giovanni Scarzello, Lucio Loreggian, Gian Luca De Salvo
Summary: This study aimed to evaluate the role of SAMITAL in reducing the incidence of severe mucositis induced by concurrent chemo-radiotherapy. The results showed that although SAMITAL did not significantly reduce the incidence of severe mucositis, the lower rate of mucositis and significantly better quality of life suggested a potential clinical benefit, which needs further research for validation.
Article
Oncology
Elisa Kauark-Fontes, Cesar Augusto Migliorati, Joel B. Epstein, Nathaniel Simon Treister, Carolina Guimaraes Bonfim Alves, Karina Morais Faria, Natalia Rangel Palmier, Leticia Rodrigues-Oliveira, Mariana de Pauli Paglioni, Luiz Alcino Monteiro Gueiros, Karina G. M. da Conceicao Vasconcelos, Gilberto de Castro Jr, Adriana Franco Paes Leme, Marcio Ajudarte Lopes, Ana Carolina Prado-Ribeiro, Thais Bianca Brandao, Alan Roger Santos-Silva
Summary: Prophylactic extraoral PBM can delay onset of OM, reduce pain, and decrease the need for analgesics and anti-inflammatory medications, leading to improved quality of life. However, there was no evidence of PBM impacting oncological outcomes during 1 year of follow-up.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Otorhinolaryngology
Diego Antonio Costa Arantes, Artur Christian Garcia da Silva, Nilceana Maya Aires Freitas, Eliana Martins Lima, Aline Carlos de Oliveira, Ricardo Neves Marreto, Elismauro Francisco Mendonca, Marize Campos Valadares
Summary: This study demonstrated that FITOPROT is safe and effective in preventing and treating oral mucositis. It reduces the severity of the condition and controls the levels of inflammatory mediators.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Medicine, General & Internal
Iwona Homa-Mlak, Anna Brzozowska, Radoslaw Mlak, Aneta Szudy-Szczyrek, Teresa Malecka-Massalska
Summary: The study revealed a positive correlation between NLR and the severity of OM, with higher NLR values associated with an increased risk of more severe OM. Additionally, higher TNM stage and NLR values were identified as independent prognostic factors for survival.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Y. Tao, J. Biau, X. S. Sun, C. Sire, L. Martin, M. Alfonsi, J. B. Prevost, A. Modesto, C. Lafond, J. M. Tourani, J. Miroir, M. C. Kaminsky, A. Coutte, X. Liem, E. Chautard, E. Vauleon, F. Drouet, A. Ruffer, J. F. Ramee, G. Waksi, A. Pechery, M. Wanneveich, J. Guigay, A. Auperin, J. Bourhis
Summary: This study aimed to evaluate the potential synergistic effect of pembrolizumab with radiotherapy compared with a standard-of-care cetuximab-radiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN). The results showed that pembrolizumab concomitant with radiotherapy did not improve tumor control and survival compared with cetuximab-radiotherapy, but it appeared to be less toxic in unfit patients with LA-SCCHN.
ANNALS OF ONCOLOGY
(2023)
Article
Oncology
Atsushi Musha, Chika Hirai, Yoko Kitada, Anna Tsunoda, Hirofumi Shimada, Nobuteru Kubo, Hidemasa Kawamura, Naoko Okano, Hiro Sato, Kohei Okada, Akiko Adachi, Satoshi Yokoo, Kazuaki Chikamatsu, Tatsuya Ohno
Summary: This study aimed to investigate the relationship between oral bacterial counts and oral mucositis during carbon ion radiotherapy in patients with head and neck cancer. The study found that oral bacterial counts gradually increased during carbon ion radiotherapy and peaked at 16 fractions. Patients with higher bacterial counts tended to experience faster-onset mucositis and slower healing.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Li-Ting Liu, Huai Liu, Ying Huang, Jin-Hao Yang, Si-Yi Xie, Yuan-Yuan Li, Shan-Shan Guo, Bin Qi, Xiao-Yun Li, Dong-Ping Chen, Feng Jin, Xue-Song Sun, Zhen-Chong Yang, Sai-Lan Liu, Dong-Hua Luo, Ji-Bin Li, Qing Liu, Pan Wang, Ling Guo, Hao-Yuan Mo, Fang Qiu, Qi Yang, Yu-Jing Liang, Guo-Dong Jia, Dong-Xiang Wen, Jin-Jie Yan, Chong Zhao, Qiu-Yan Chen, Rui Sun, Lin-Quan Tang, Hai-Qiang Mai
Summary: The efficacy and safety of concurrent adjuvant cisplatin-gemcitabine were compared with cisplatin-fluorouracil in N2-3 nasopharyngeal carcinoma. The 3-year progression-free survival was significantly higher in the cisplatin-gemcitabine group (83.9%) compared to the cisplatin-fluorouracil group (71.5%). The adverse events were similar between the two groups. Therefore, cisplatin-gemcitabine could be considered as an adjuvant therapy option for patients with N2-3 nasopharyngeal carcinoma.
Article
Oncology
Michela Buglione, Daniela Alterio, Marta Maddalo, Diana Greco, Marianna Alessandra Gerardi, Davide Tomasini, Ludovica Pegurri, Matteo Augugliaro, Giulia Marvaso, Irene Turturici, Andrea Guerini, Mohssen Ansarin, Luigi Spiazzi, Loredana Costa, Maria Cossu Rocca, Stefano Maria Magrini, Barbara Alicja Jereczek-Fossa
Summary: This study compared the effects of different dosing schedules of CDDP on patients with H&N squamous cell cancer. The results showed that while patients in the 3w-CDDP group had certain advantages, overall, the two schedules had similar impacts on acute toxicity and survival rates.
RADIATION ONCOLOGY
(2021)
Article
Integrative & Complementary Medicine
Hui-Ping Chang, Meng-Chuan Huang, Yen-Ping Lei, Yu-Ju Chuang, Chun-Wei Wang, Lee-Yan Sheen
Summary: This study evaluated the effect of phytochemical-rich vegetable and fruit juice (VFJ) consumption in preventing concurrent chemoradiotherapy (CCRT)-induced oral mucositis (OM). The results showed that consuming VFJ rich in total polyphenols and carotenoids effectively alleviates the severity of OM caused by CCRT.
JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE
(2022)
Article
Oncology
Haley K. Perlow, Michael Siedow, Yevgeniya Gokun, Joseph McElroy, Jennifer Matsui, Wesley Zoller, Sasha Beyer, Andrea Arnett, Dukagjin Blakaj, Daniel Boulter, Joel Fritz, Eric Miller, Raju Raval, Christopher Kleefishch, Joseph Bovi, Joshua D. Palmer
Summary: The use of Ga-68-DOTATATE PET imaging may assist radiation oncologists in creating more precise radiation treatment volumes by identifying undetected areas of disease that are not visible on MRI.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Medicine, General & Internal
David A. P. Dunkerley, Daniel E. Hyer, Jeffrey E. Snyder, Joel J. St-Aubin, Carryn M. Anderson, Joseph M. Caster, Mark C. Smith, John M. Buatti, Sridhar Yaddanapudi
Summary: MRgART provides benefits for cancer patients through enhanced imaging technology during treatment, but also faces challenges. This paper presents an institution's experience in developing a MRgART program and provides considerations for treating patients at different anatomical sites.
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Oncology
Geraldine M. Jacobson, Gopal K. Bajaj, John M. Buatti, Laura Dawson, Curtiland Deville, Thomas J. Eichler, Beth Erickson, Eric Ford, Iris C. Gibbs, Constantine Mantz, Brian Marples, Jeff M. Michalski, Howard Sandler, Benjamin Smith, Neha Vapiwala, Catheryn Yashar
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
Maura L. Gillison, Robert L. Ferris, Jonathan Harris, A. Dimitrios Colevas, Loren K. Mell, Christina Kong, Richard C. Jordan, Kevin L. Moore, Minh-Tam Truong, Claudia Kirsch, Arnab Chakravarti, Dukagjin M. Blakaj, David A. Clump, James P. Ohr, John F. Deeken, Michael F. Gensheimer, Nabil F. Saba, Jennifer A. Dorth, David I. Rosenthal, Rom S. Leidner, Randall J. Kimple, Mitchell Machtay, Walter J. Curran, Pedro Torres-Saavedra, Quynh Thu Le
Summary: A study found that the concurrent administration of nivolumab with (chemo)radiation is safe and effective for newly diagnosed patients with intermediate and high-risk head and neck squamous cell carcinoma (HNSCC).
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Oncology
Marcelo Bonomi, Dukagjin M. Blakaj, Rafi Kabarriti, Kyle Colvett, Vinita Takiar, Matthew Biagioli, Voichita Bar -Ad, Sharad Goyal, Brian Muzyka, Kenneth Niermann, Nacer Abrouk, Bryan Oronsky, Tony Reid, Scott Caroen, Stephen Sonis, David J. Sher
Summary: This study demonstrates the safety and feasibility of using RRx-001 as an intervention to mitigate oral mucositis in patients with head and neck cancer. Further studies are planned to confirm its efficacy.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lanchun Lu, Xiangyu Yang, Brian Raterman, Xia Jiang, Matthew Meineke, John Grecula, Dukagjin Blakaj, Joshua Palmer, Raju Raval, Evan Thomas, David Hintenlang, Nilendu Gupta
Summary: The magnitude of MRI image distortion was investigated based on 6 consecutive years of quality assurances/measurements on 14 MRI scanners. This study provides evidence for including additional margin for treatment planning. Results showed that MRI image distortion increases with the distance from the imaging isocenter, highlighting the importance of proper patient alignment. Regular distortion checks are recommended.
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2023)
Article
Virology
Sujith Baliga, Darrion Mitchell, Vedat O. Yildiz, Emile Gogineni, David J. Konieczkowski, John Grecula, Dukagjin M. Blakaj, Xuefeng Liu, Mauricio E. Gamez
Summary: This study aimed to determine if Black patients with HPV-OPSCC have a similar favorable prognosis to the White population. A retrospective cohort study of HNSCC patients from 2010 to 2016 found that Black patients with HPV-OPSCC have a poor prognosis and OS similar to HPV-negative White patients, which may be partly due to socioeconomic barriers.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Oncology
Sujith Baliga, Brett Klamer, Joshua D. Palmer, Sharla Wells-Di Gregirio, Sachin S. Kale, Marcelo Bonomi, Matthew O. Old, James W. Rocco, Dukagjin M. Blakaj
Summary: The purpose of this study was to determine the proportion of Emergency Department visits in cancer patients associated with a mental and substance use disorder (MSUD) and the subsequent healthcare costs. The study found that approximately 22% of ED visits in cancer patients were associated with MSUD. Among these MSUD-related visits, the patients were more likely to be female, younger, have Medicaid insurance, and be discharged home. Alcohol-related disorders, anxiety disorders, and depressive disorders were the most common MSUD diagnoses among cancer patients.
Article
Oncology
Ashley J. Cetnar, Michael Degnan, Joseph Pichler, Sagarika Jain, Samantha Morelli, Evan Thomas, J. Bradley Elder, Thomas J. Scharschmidt, Joshua D. Palmer, Dukagjin M. Blakaj
Summary: The aim of this study was to investigate the application of triggered kilovoltage (kV) imaging for spine stereotactic radiotherapy (SRT) patients with hardware. The results showed that using kV imaging during treatment is an effective method of assessing intrafraction motion (IM) without increasing treatment time for SRT spine patients with hardware.
PHYSICS & IMAGING IN RADIATION ONCOLOGY
(2023)
Article
Oncology
Haley K. Perlow, Cindy Ho, Jennifer K. Matsui, Rahul N. Prasad, Brett G. Klamer, Joshua Wang, Mark Damante, Rituraj Upadhyay, Evan Thomas, Dukagjin M. Blakaj, Sasha Beyer, Russell Lonser, Douglas Hardesty, Raju R. Raval, Roshan Prabhu, James B. Elder, Joshua D. Palmer
Summary: The standard treatment for large brain metastases is surgical resection followed by stereotactic radiosurgery (SRS). However, post-operative SRS is associated with high rates of local failure and complications. Pre-operative fractionated stereotactic radiation therapy (FSRT) may have less toxicity and better outcomes.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2023)
Editorial Material
Oncology
John M. Buatti, Ronald D. Ennis, Ana P. Kiess, Jeff M. Michalski
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Oncology
Sujith Baliga, Vedat O. Yildiz, Jose Bazan, Joshua D. Palmer, Sachin R. Jhawar, David J. Konieczkowski, John Grecula, Dukagjin M. Blakaj, Darrion Mitchell, Christina Henson, Kenneth Hu, Kosj Yamoah, Mauricio E. Gamez
Summary: This retrospective study examined the clinical and treatment-related survival outcomes in different racial and ethnic groups with head and neck cancers. It was found that Black race was associated with worse overall survival rates. Black patients had more advanced disease stage and longer treatment times compared to White patients. Further research is needed to better understand the biological basis behind these disparities.
Article
Oncology
Jennifer K. Matsui, Haley K. Perlow, Rituraj Upadhyay, Aliah McCalla, Raju R. Raval, Evan M. Thomas, Dukagjin M. Blakaj, Sasha J. Beyer, Joshua D. Palmer
SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA
(2023)
Article
Oncology
Maria C. Cuitino, Jessica L. Fleming, Sagarika Jain, Ashley Cetnar, Ahmet S. Ayan, Jeffrey Woollard, Heather Manring, Wei Meng, Joseph P. Mcelroy, Dukagjin M. Blakaj, Nilendu Gupta, Arnab Chakravarti
Summary: The purpose of this study was to assess whether ultra-high-dose-rate radiation therapy can reduce toxicity to healthy gonads in mice compared to conventional radiation therapy. The results showed that ultra-high-dose-rate radiation therapy had similar toxic effects on mouse reproductive organs compared to conventional radiation therapy.
ADVANCES IN RADIATION ONCOLOGY
(2023)
Letter
Oncology
Carryn M. Anderson
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)