Design, Mechanism of Action, Bioavailability and Therapeutic Effects of Mn Porphyrin-Based Redox Modulators

Texaphyrins: Tumor Localizing Redox Active Expanded Porphyrins

(2012) Jonathan F. Arambula et al.   Anti-Cancer Agents in Medicinal Chemistry

A Combination of Two Antioxidants (An SOD Mimic and Ascorbate) Produces a Pro-Oxidative Effect Forcing Escherichia coli to Adapt Via Induction of oxyR Regulon

(2012) Ines Batinic-Haberle et al.   Anti-Cancer Agents in Medicinal Chemistry

Salen Mn Complexes Mitigate Radiation Injury in Normal Tissues

(2012) Rosalind A. Rosenthal et al.   Anti-Cancer Agents in Medicinal Chemistry

Effects of FP15, a peroxynitrite decomposition catalyst on cardiac and pulmonary function after cardiopulmonary bypass

(2012) T. Radovits et al.   EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

Manganese Porphyrin, MnTE-2-PyP5+, Acts as a Pro-Oxidant to Potentiate Glucocorticoid-Induced Apoptosis in Lymphoma Cells

(2012) Melba C. Jaramillo et al.   FREE RADICAL BIOLOGY AND MEDICINE

A new SOD mimic, Mn(III) ortho N-butoxyethylpyridylporphyrin, combines superb potency and lipophilicity with low toxicity

(2012) Zrinka Rajic et al.   FREE RADICAL BIOLOGY AND MEDICINE

A 12 Week, Open Label, Phase I/IIa Study Using Apatone® for the Treatment of Prostate Cancer Patients Who Have Failed Standard Therapy

(2012) Basir Tareen et al.   International Journal of Medical Sciences

Motor Deficits Are Triggered by Reperfusion-Reoxygenation Injury as Diagnosed by MRI and by a Mechanism Involving Oxidants

(2012) A. Drobyshevsky et al.   JOURNAL OF NEUROSCIENCE

Targeting the Overproduction of Peroxynitrite for the Prevention and Reversal of Paclitaxel-Induced Neuropathic Pain

(2012) T. Doyle et al.   JOURNAL OF NEUROSCIENCE

Metabolomics implicates altered sphingolipids in chronic pain of neuropathic origin

(2012) Gary J. Patti et al.   Nature Chemical Biology

Role of Reactive Oxygen and Nitrogen Species in Olfactory Epithelial Injury by the Sulfur Mustard Analogue 2-Chloroethyl Ethyl Sulfide

(2011) Heidi C. O'Neill et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Response to Rosenthal et al.

(2011) Ines Batinic-Haberle et al.   ANTIOXIDANTS & REDOX SIGNALING

Antioxidant therapies in traumatic brain and spinal cord injury

(2011) Mona Bains et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Manganese superoxide dismutase, MnSOD and its mimics

(2011) Sumitra Miriyala et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Overcoming biochemical pharmacologic mechanisms of platinum resistance with a texaphyrin–platinum conjugate

(2011) Jonathan F. Arambula et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Factors Affecting Protein Thiol Reactivity and Specificity in Peroxide Reduction

(2011) Gerardo Ferrer-Sueta et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Neuroprotective Actions of Flavonoids

(2011) C. Gutierrez-Merino et al.   CURRENT MEDICINAL CHEMISTRY

Methoxy-derivatization of alkyl chains increases the in vivo efficacy of cationic Mn porphyrins. Synthesis, characterization, SOD-like activity, and SOD-deficient E. coli study of meta Mn(iii) N-methoxyalkylpyridylporphyrins

(2011) Artak G. Tovmasyan et al.   DALTON TRANSACTIONS

Cytosolic, but not mitochondrial, oxidative stress is a likely contributor to cardiac hypertrophy resulting from cardiac specific GLUT4 deletion in mice

(2011) Yan Li et al.   FEBS Journal

Diverse functions of cationic Mn(III) N-substituted pyridylporphyrins, recognized as SOD mimics

(2011) Ines Batinic-Haberle et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lipophilicity of Mn(III) N-Alkylpyridylporphyrins Dominates Their Accumulation Within Mitochondria and Therefore in Vivo Efficacy: a Mouse Study

(2011) Ivan Spasojevic et al.   FREE RADICAL BIOLOGY AND MEDICINE

Clinical trials of antioxidants as cancer prevention agents: Past, present, and future

(2011) Michael Goodman et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mn(III) meso-tetrakis-(N-ethylpyridinium-2-yl) porphyrin mitigates total body irradiation-induced long-term bone marrow suppression

(2011) Hongliang Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cytotoxic effects of Mn(III)N-alkylpyridylporphyrins in the presence of cellular reductant, ascorbate

(2011) Xiaodong Ye et al.   FREE RADICAL RESEARCH

Mechanistic Studies on the Reactions of Cyanide with a Water-Soluble Fe(III) Porphyrin and Their Effect on the Binding of NO

(2011) Maria Oszajca et al.   INORGANIC CHEMISTRY

Dissection of the Mechanism of Manganese Porphyrin-Catalyzed Chlorine Dioxide Generation

(2011) Thomas P. Umile et al.   INORGANIC CHEMISTRY

Antiangiogenic cancer therapy: why do mouse and human patients respond in a different way to the same drug?

(2011) Yihai Cao   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Mitigation of radiation-induced lung injury by genistein and EUK-207

(2011) Javed Mahmood et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Towards the mechanisms involved in the antioxidant action of MnIII [meso-tetrakis(4-N-methyl pyridinium) porphyrin] in mitochondria

(2011) Juliana C. Araujo-Chaves et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Retooling Manganese(III) Porphyrin-Based Peroxynitrite Decomposition Catalysts for Selectivity and Oral Activity: A Potential New Strategy for Treating Chronic Pain

(2011) Smita Rausaria et al.   JOURNAL OF MEDICINAL CHEMISTRY

Neuroprotective Efficacy from a Lipophilic Redox-Modulating Mn(III) N-Hexylpyridylporphyrin, MnTnHex-2-PyP: Rodent Models of Ischemic Stroke and Subarachnoid Hemorrhage

(2011) H. Sheng et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Crown ether functionalized texaphyrin monomers and dimers

(2011) Christian Preihs et al.   JOURNAL OF PORPHYRINS AND PHTHALOCYANINES

Manganese(III) Complexes of Bis(hydroxyphenyl)dipyrromethenes Are Potent Orally Active Peroxynitrite Scavengers

(2011) Smita Rausaria et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

NADPH oxidase inhibition attenuates total body irradiation-induced haematopoietic genomic instability

(2011) S. K. Pazhanisamy et al.   MUTAGENESIS

Mitochondrial oxidative stress and epilepsy in SOD2 deficient mice: Attenuation by a lipophilic metalloporphyrin

(2011) Li-Ping Liang et al.   NEUROBIOLOGY OF DISEASE

Manganese superoxide dismutase is a mitochondrial fidelity protein that protects Polγ against UV-induced inactivation

(2011) V Bakthavatchalu et al.   ONCOGENE

2-Hydroxyglutarate Production, but Not Dominant Negative Function, Is Conferred by Glioma-Derived NADP+-Dependent Isocitrate Dehydrogenase Mutations

(2011) Genglin Jin et al.   PLoS One

Oxidative stress in spinal cord injury and antioxidant-based intervention

(2011) Z Jia et al.   SPINAL CORD

Mechanisms in cancer-chemotherapeutic drugs-induced peripheral neuropathy

(2011) Amteshwar Singh Jaggi et al.   TOXICOLOGY

Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities

(2010) Ines Batinic-Haberle et al.   AMINO ACIDS

Chlorite Dismutation to Chlorine Dioxide Catalyzed by a Water-Soluble Manganese Porphyrin

(2010) Scott D. Hicks et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Generation of Chlorine Dioxide from Chlorite Using a Water-Soluble Manganese Porphyrin

(2010) Thomas P. Umile et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Animal and human studies with the mitochondria-targeted antioxidant MitoQ

(2010) Robin A.J. Smith et al.   Annals of the New York Academy of Sciences

Superoxide Dismutase Mimics: Chemistry, Pharmacology, and Therapeutic Potential

(2010) Ines Batinić-Haberle et al.   ANTIOXIDANTS & REDOX SIGNALING

Exploring the molecular basis of human manganese superoxide dismutase inactivation mediated by tyrosine 34 nitration

(2010) Diego M. Moreno et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Natural Antioxidants and Hypertension: Promise and Challenges

(2010) Tinoy J. Kizhakekuttu et al.   Cardiovascular Therapeutics

Highly efficient catalase activity of metallocorroles

(2010) Atif Mahammed et al.   CHEMICAL COMMUNICATIONS

Lipid Peroxyl Radicals Mediate Tyrosine Dimerization and Nitration in Membranes

(2010) Silvina Bartesaghi et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Accumulation of Porphyrin-based SOD Mimics in Mitochondria is Proportional to Their Lipophilicity: S. cerevisiae Study of ortho Mn(III) N-alkylpyridylporphyrins

(2010) Ivan Spasojevic et al.   FREE RADICAL BIOLOGY AND MEDICINE

Early and late administration of MnTE-2-PyP5+ in mitigation and treatment of radiation-induced lung damage

(2010) Benjamin Gauter-Fleckenstein et al.   FREE RADICAL BIOLOGY AND MEDICINE

Treatment with the catalytic metalloporphyrin AEOL 10150 reduces inflammation and oxidative stress due to inhalation of the sulfur mustard analog 2-chloroethyl ethyl sulfide

(2010) Heidi C. O'Neill et al.   FREE RADICAL BIOLOGY AND MEDICINE

AEOL10150: A novel therapeutic for rescue treatment after toxic gas lung injury

(2010) Toby McGovern et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protective role ofortho-substituted Mn(III)N-alkylpyridylporphyrins against the oxidative injury induced bytert-butylhydroperoxide

(2010) Ana S. Fernandes et al.   FREE RADICAL RESEARCH

Natural and synthetic antioxidants: An updated overview

(2010) Agnieszka Augustyniak et al.   FREE RADICAL RESEARCH

Metalloporphyrin antioxidants ameliorate normal tissue radiation damage in rat brain

(2010) Robert D. Pearlstein et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Proteomic Analysis of Radiation-Induced Changes in Rat Lung: Modulation by the Superoxide Dismutase Mimetic MnTE-2-PyP5+

(2010) Vasily A. Yakovlev et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Neuroprotection against superoxide anion radical by metallocorroles in cellular and murine models of optic neuropathy

(2010) Akiyasu Kanamori et al.   JOURNAL OF NEUROCHEMISTRY

Peroxynitrite decomposition catalyst prevents matrix metalloproteinase activation and neurovascular injury after prolonged cerebral ischemia in rats

(2010) Yalikun Suofu et al.   JOURNAL OF NEUROCHEMISTRY

Metallocorroles as cytoprotective agents against oxidative and nitrative stress in cellular models of neurodegeneration

(2010) Lana Kupershmidt et al.   JOURNAL OF NEUROCHEMISTRY

Manganese Porphyrins Catalyze Selective C−H Bond Halogenations

(2010) Wei Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Natural Antioxidants: Fascinating or Mythical Biomolecules?

(2010) Ashwell Ndhlala et al.   MOLECULES

A Metalloporphyrin Antioxidant Alters Cytokine Responses after Irradiation in a Prostate Tumor Model

(2010) Adeola Y. Makinde et al.   RADIATION RESEARCH

Novel Synthetic SOD/Catalase Mimetics Can Mitigate Capillary Endothelial Cell Apoptosis Caused by Ionizing Radiation

(2010) Ekaterina Vorotnikova et al.   RADIATION RESEARCH

Increased Manganese Superoxide Dismutase Expression or Treatment with Manganese Porphyrin Potentiates Dexamethasone-Induced Apoptosis in Lymphoma Cells

(2009) Melba C. Jaramillo et al.   CANCER RESEARCH

Radioprotective Effect of a Metalloporphyrin Compound in Rat Eye Model

(2009) X. W. Mao et al.   CURRENT EYE RESEARCH

Superoxide dismutase activity of corrole metal complexes

(2009) Meital Eckshtain et al.   DALTON TRANSACTIONS

Radioprotective effects of manganese-containing superoxide dismutase mimics on ataxia–telangiectasia cells

(2009) Julianne M. Pollard et al.   FREE RADICAL BIOLOGY AND MEDICINE

Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP5+, via suppression of oxidative stress in a mouse model of breast tumor

(2009) Zahid N. Rabbani et al.   FREE RADICAL BIOLOGY AND MEDICINE

Long-term neuroprotection from a potent redox-modulating metalloporphyrin in the rat

(2009) Huaxin Sheng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lipophilicity of potent porphyrin-based antioxidants: Comparison of ortho and meta isomers of Mn(III) N-alkylpyridylporphyrins

(2009) Ivan Kos et al.   FREE RADICAL BIOLOGY AND MEDICINE

Losing and finding a way at C: New promise for pharmacologic ascorbate in cancer treatment

(2009) Mark Levine et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effect of lipophilicity of Mn (III)ortho N-alkylpyridyl- and diortho N,N′-diethylimidazolylporphyrins in twoin-vitromodels of oxygen and glucose deprivation-induced neuronal death

(2009) Lisa Wise-Faberowski et al.   FREE RADICAL RESEARCH

Effects of a metalloporphyrinic peroxynitrite decomposition catalyst, ww-85, in a mouse model of spinal cord injury

(2009) Tiziana Genovese et al.   FREE RADICAL RESEARCH

Orally available Mn porphyrins with superoxide dismutase and catalase activities

(2009) Rosalind A. Rosenthal et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

High Lipophilicity of meta Mn(III)N-Alkylpyridylporphyrin-Based Superoxide Dismutase Mimics Compensates for Their Lower Antioxidant Potency and Makes Them as Effective as Ortho Analogues in Protecting Superoxide Dismutase-DeficientEscherichia coli

(2009) Ivan Kos et al.   JOURNAL OF MEDICINAL CHEMISTRY

Determination of residual manganese in Mn porphyrin-based superoxide dismutase (SOD) and peroxynitrite reductase mimics

(2009) Júlio S. Rebouças et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Inhibition of Lipid Infusion–Induced Skeletal Muscle Insulin Resistance by Cotreatment With Tempol and Glutathione in Mice

(2009) Byung Seok Kim et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Protection from radiation-induced pneumonitis using cerium oxide nanoparticles

(2009) Jimmie Colon et al.   Nanomedicine-Nanotechnology Biology and Medicine

Natural Antioxidants Protect Neurons in Alzheimer’s Disease and Parkinson’s Disease

(2009) Baolu Zhao   NEUROCHEMICAL RESEARCH

Superoxide signaling in pain is independent of nitric oxide signaling

(2009) Hee Young Kim et al.   NEUROREPORT

Supraspinal inactivation of mitochondrial superoxide dismutase is a source of peroxynitrite in the development of morphine antinociceptive tolerance

(2009) T. Doyle et al.   NEUROSCIENCE

Neuroprotection against staurosporine by metalloporphyrins independent of antioxidant capability

(2009) Joseph S. Tauskela et al.   NEUROSCIENCE LETTERS

Blockade of Peroxynitrite-Induced Neural Stem Cell Death in the Acutely Injured Spinal Cord by Drug-Releasing Polymer

(2009) Dou Yu et al.   STEM CELLS

Crosstalk Between Calcium and Redox Signaling: From Molecular Mechanisms to Health Implications

(2008) Cecilia Hidalgo et al.   ANTIOXIDANTS & REDOX SIGNALING

Catalytic Antioxidants and Neurodegeneration

(2008) Tamara R. Golden et al.   ANTIOXIDANTS & REDOX SIGNALING

SOD-like activity of Mn(II) β-octabromo-meso-tetrakis(N-methylpyridinium-3-yl)porphyrin equals that of the enzyme itself

(2008) Gilson DeFreitas-Silva et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Increased levels of superoxide and H2O2mediate the differential susceptibility of cancer cells versus normal cells to glucose deprivation

(2008) Nùkhet Aykin-Burns et al.   BIOCHEMICAL JOURNAL

Honokiol is a potent scavenger of superoxide and peroxyl radicals

(2008) Sergey Dikalov et al.   BIOCHEMICAL PHARMACOLOGY

Targeting lipophilic cations to mitochondria

(2008) Michael P. Murphy   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Protein and lipid nitration: Role in redox signaling and injury

(2008) Homero Rubbo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Redox modulation of oxidative stress by Mn porphyrin-based therapeutics: The effect of charge distribution

(2008) Júlio S. Rebouças et al.   DALTON TRANSACTIONS

Impact of electrostatics in redox modulation of oxidative stress by Mn porphyrins: Protection of SOD-deficient Escherichia coli via alternative mechanism where Mn porphyrin acts as a Mn carrier

(2008) Júlio S. Rebouças et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pharmacokinetics of the potent redox-modulating manganese porphyrin, MnTE-2-PyP5+, in plasma and major organs of B6C3F1 mice

(2008) Ivan Spasojević et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lipophilicity is a critical parameter that dominates the efficacy of metalloporphyrins in blocking the development of morphine antinociceptive tolerance through peroxynitrite-mediated pathways

(2008) Ines Batinić-Haberle et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pure MnTBAP selectively scavenges peroxynitrite over superoxide: Comparison of pure and commercial MnTBAP samples to MnTE-2-PyP in two models of oxidative stress injury, an SOD-specific Escherichia coli model and carrageenan-induced pleurisy

(2008) Ines Batinić-Haberle et al.   FREE RADICAL BIOLOGY AND MEDICINE

An SOD mimic protects NADP+-dependent isocitrate dehydrogenase against oxidative inactivation

(2008) Ines Batinic-Haberle et al.   FREE RADICAL RESEARCH

Quality of potent Mn porphyrin-based SOD mimics and peroxynitrite scavengers for pre-clinical mechanistic/therapeutic purposes

(2008) Júlio S. Rebouças et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

INO-4885 [5,10,15,20-Tetra[N-(benzyl-4'-carboxylate)-2-pyridinium]-21H,23H-porphine Iron(III) Chloride], a Peroxynitrite Decomposition Catalyst, Protects the Heart against Reperfusion Injury in Mice

(2008) X.-Y. Jiao et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Kinetics of the Reaction between Nitroxide and Thiyl Radicals: Nitroxides as Antioxidants in the Presence of Thiols

(2008) Sara Goldstein et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Effects of a potent antioxidant, platinum nanoparticle, on the lifespan of Caenorhabditis elegans

(2008) Juewon Kim et al.   MECHANISMS OF AGEING AND DEVELOPMENT

A neuronal model of Alzheimer's disease: An insight into the mechanisms of oxidative stress–mediated mitochondrial injury

(2008) P. Sompol et al.   NEUROSCIENCE

Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice

(2008) Q. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparison of two Mn porphyrin-based mimics of superoxide dismutase in pulmonary radioprotection

(2007) Benjamin Gauter-Fleckenstein et al.   FREE RADICAL BIOLOGY AND MEDICINE