MicroRNA-mediated regulation of glucose and lipid metabolism

Pancreatic β cell microRNA-26a alleviates type 2 diabetes by improving peripheral insulin sensitivity and preserving β cell function

(2020) Haixia Xu et al.   PLOS BIOLOGY

Obesity-induced overexpression of miR-802 impairs insulin transcription and secretion

(2020) Fangfang Zhang et al.   Nature Communications

Circulating MicroRNA-15a Associates With Retinal Damage in Patients With Early Stage Type 2 Diabetes

(2020) Elena Sangalli et al.   Frontiers in Endocrinology

A MicroRNA Linking Human Positive Selection and Metabolic Disorders

(2020) Lifeng Wang et al.   CELL

Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise

(2020) Bruna B. Brandão et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptomic Analysis of Single Isolated Myofibers Identifies miR-27a-3p and miR-142-3p as Regulators of Metabolism in Skeletal Muscle

(2019) Francesco Chemello et al.   Cell Reports

Obesity: global epidemiology and pathogenesis

(2019) Matthias Blüher   Nature Reviews Endocrinology

Specific Disruption of Abca1 Targeting Largely Mimics the Effects of miR-33 Knockout on Macrophage Cholesterol Efflux and Atherosclerotic Plaque Development

(2019) Nathan L. Price et al.   CIRCULATION RESEARCH

Repressive Gene Regulation Synchronizes Development with Cellular Metabolism

(2019) Justin J. Cassidy et al.   CELL

515-P: Mitochondrial AKT1 in Renal Tubules Is a Novel Modulator for the Development of Glomerulosclerosis and Subsequent Renal Failure

(2019) HUGO YOU-HSIEN LIN et al.   DIABETES

Whole genome sequencing of canids reveals genomic regions under selection and variants influencing morphology

(2019) Jocelyn Plassais et al.   Nature Communications

MicroRNA-27a/b Negatively Regulates Hepatic Gluconeogenesis by Targeting FOXO1

(2019) Shuyue Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Early Diagnosis of Gestational Diabetes Mellitus Using Circulating MicroRNAs

(2019) Liron Yoffe et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Extracellular miRNAs: From Biomarkers to Mediators of Physiology and Disease

(2019) Marcelo A. Mori et al.   Cell Metabolism

MirGeneDB 2.0: the metazoan microRNA complement

(2019) Bastian Fromm et al.   NUCLEIC ACIDS RESEARCH

Circulating miRNAs as Biomarkers of Obesity and Obesity-Associated Comorbidities in Children and Adolescents: A Systematic Review

(2019) Maddi Oses et al.   Nutrients

MicroRNA-144 Silencing Protects Against Atherosclerosis in Male, but Not Female Mice

(2019) Joan Cheng et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

MicroRNA miR-7 Regulates Secretion of Insulin-Like Peptides

(2019) Pamela Agbu et al.   ENDOCRINOLOGY

Metazoan MicroRNAs

(2018) David P. Bartel   CELL

MicroRNA 122, Regulated by GRLH2, Protects Livers of Mice and Patients From Ethanol-Induced Liver Disease

(2018) Abhishek Satishchandran et al.   GASTROENTEROLOGY

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men

(2018) Patrik Rorsman et al.   PHYSIOLOGICAL REVIEWS

MicroRNA-7 mediates cross-talk between metabolic signaling pathways in the liver

(2018) Ragunath Singaravelu et al.   Scientific Reports

Genetic Ablation of miR-33 Increases Food Intake, Enhances Adipose Tissue Expansion, and Promotes Obesity and Insulin Resistance

(2018) Nathan L. Price et al.   Cell Reports

Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology

(2018) Cai Zhang et al.   Nature Communications

miRBase: from microRNA sequences to function

(2018) Ana Kozomara et al.   NUCLEIC ACIDS RESEARCH

Obesity-associated exosomal miRNAs modulate glucose and lipid metabolism in mice

(2018) Carlos Castaño et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An ‘alpha-beta’ of pancreatic islet microribonucleotides

(2017) Louise Torp Dalgaard et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

microRNA-30c reduces plasma cholesterol in homozygous familial hypercholesterolemic and type 2 diabetic mouse models

(2017) Sara Irani et al.   JOURNAL OF LIPID RESEARCH

Adipose-derived circulating miRNAs regulate gene expression in other tissues

(2017) Thomas Thomou et al.   NATURE

Biochemical and cellular properties of insulin receptor signalling

(2017) Rebecca A. Haeusler et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Rfam 13.0: shifting to a genome-centric resource for non-coding RNA families

(2017) Ioanna Kalvari et al.   NUCLEIC ACIDS RESEARCH

MicroRNA-27a regulates hepatic lipid metabolism and alleviates NAFLD via repressing FAS and SCD1

(2017) Meiyuan Zhang et al.   Scientific Reports

Genetic Dissection of the Impact of miR-33a and miR-33b during the Progression of Atherosclerosis

(2017) Nathan L. Price et al.   Cell Reports

Elevated miR-130a/miR130b/miR-152 expression reduces intracellular ATP levels in the pancreatic beta cell

(2017) Jones K. Ofori et al.   Scientific Reports

Paternal Psychological Stress Reprograms Hepatic Gluconeogenesis in Offspring

(2016) Ling Wu et al.   Cell Metabolism

MicroRNA-451 Negatively Regulates Hepatic Glucose Production and Glucose Homeostasis by Targeting Glycerol Kinase–Mediated Gluconeogenesis

(2016) Shu Zhuo et al.   DIABETES

Detection of human adaptation during the past 2000 years

(2016) Yair Field et al.   SCIENCE

The skeleton in the closet: actin cytoskeletal remodeling in β-cell function

(2015) Caroline Arous et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A Uniform System for the Annotation of Vertebrate microRNA Genes and the Evolution of the Human microRNAome

(2015) Bastian Fromm et al.   Annual Review of Genetics

Horizontal transfer of exosomal microRNAs transduce apoptotic signals between pancreatic beta-cells

(2015) Claudiane Guay et al.   Cell Communication and Signaling

MicroRNA-33–dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis

(2015) Mireille Ouimet et al.   JOURNAL OF CLINICAL INVESTIGATION

Obesity-induced miR-15b is linked causally to the development of insulin resistance through the repression of the insulin receptor in hepatocytes

(2015) Won-Mo Yang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels

(2015) Leigh Goedeke et al.   NATURE MEDICINE

The microRNA-200 family regulates pancreatic beta cell survival in type 2 diabetes

(2015) Bengt-Frederik Belgardt et al.   NATURE MEDICINE

Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis

(2015) Alexandre Wagschal et al.   NATURE MEDICINE

A metabolic stress-inducible miR-34a-HNF4α pathway regulates lipid and lipoprotein metabolism

(2015) Yang Xu et al.   Nature Communications

Effect of miR-34a in regulating steatosis by targeting PPARα expression in nonalcoholic fatty liver disease

(2015) Jiexia Ding et al.   Scientific Reports

MiR-19a regulates PTEN expression to mediate glycogen synthesis in hepatocytes

(2015) Lin Dou et al.   Scientific Reports

MicroRNA-124a is hyperexpressed in type 2 diabetic human pancreatic islets and negatively regulates insulin secretion

(2014) Guido Sebastiani et al.   ACTA DIABETOLOGICA

Regulation of miRNA strand selection: follow the leader?

(2014) Hedda A. Meijer et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Epigenetic Regulation of the DLK1-MEG3 MicroRNA Cluster in Human Type 2 Diabetic Islets

(2014) Vasumathi Kameswaran et al.   Cell Metabolism

Altered miRNA processing disrupts brown/white adipocyte determination and associates with lipodystrophy

(2014) Marcelo A. Mori et al.   JOURNAL OF CLINICAL INVESTIGATION

MicroRNA-7a regulates pancreatic β cell function

(2014) Mathieu Latreille et al.   JOURNAL OF CLINICAL INVESTIGATION

MicroRNA-223 coordinates cholesterol homeostasis

(2014) Kasey C. Vickers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepatic miR-378 targets p110α and controls glucose and lipid homeostasis by modulating hepatic insulin signalling

(2014) Wei Liu et al.   Nature Communications

MicroRNA-144 Regulates Hepatic ATP Binding Cassette Transporter A1 and Plasma High-Density Lipoprotein After Activation of the Nuclear Receptor Farnesoid X Receptor

(2013) Thomas Q. de Aguiar Vallim et al.   CIRCULATION RESEARCH

Control of Cholesterol Metabolism and Plasma High-Density Lipoprotein Levels by microRNA-144

(2013) Cristina M. Ramírez et al.   CIRCULATION RESEARCH

Increased expression of miR-187 in human islets from individuals with type 2 diabetes is associated with reduced glucose-stimulated insulin secretion

(2013) J. M. Locke et al.   DIABETOLOGIA

Regulation of cholesterol and bile acid homeostasis by the cholesterol 7α-hydroxylase/steroid response element-binding protein 2/microRNA-33a axis in mice

(2013) Tiangang Li et al.   HEPATOLOGY

A Regulatory Role for MicroRNA 33* in Controlling Lipid Metabolism Gene Expression

(2013) L. Goedeke et al.   MOLECULAR AND CELLULAR BIOLOGY

MicroRNA 33 Regulates Glucose Metabolism

(2013) C. M. Ramirez et al.   MOLECULAR AND CELLULAR BIOLOGY

MicroRNAs 185, 96, and 223 Repress Selective High-Density Lipoprotein Cholesterol Uptake through Posttranscriptional Inhibition

(2013) L. Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b

(2013) Jan-Wilhelm Kornfeld et al.   NATURE

MicroRNA-30c reduces hyperlipidemia and atherosclerosis in mice by decreasing lipid synthesis and lipoprotein secretion

(2013) James Soh et al.   NATURE MEDICINE

MicroRNAs in liver disease

(2013) Gyongyi Szabo et al.   Nature Reviews Gastroenterology & Hepatology

Pro-apoptotic miRNA-128-2 modulates ABCA1, ABCG1 and RXRα expression and cholesterol homeostasis

(2013) Y K Adlakha et al.   Cell Death & Disease

MicroRNA‐33 Deficiency Reduces the Progression of Atherosclerotic Plaque in ApoE −/− Mice

(2013) Takahiro Horie et al.   Journal of the American Heart Association

Roles for MicroRNAs in Conferring Robustness to Biological Processes

(2012) Margaret S. Ebert et al.   CELL

Pancreas-enriched miRNA refines endocrine cell differentiation

(2012) S. Kredo-Russo et al.   DEVELOPMENT

miR-33 controls the expression of biliary transporters, and mediates statin- and diet-induced hepatotoxicity

(2012) Ryan M. Allen et al.   EMBO Molecular Medicine

MicroRNA-27b is a regulatory hub in lipid metabolism and is altered in dyslipidemia

(2012) Kasey C. Vickers et al.   HEPATOLOGY

MicroRNA-29a-c decrease fasting blood glucose levels by negatively regulating hepatic gluconeogenesis

(2012) Jichao Liang et al.   JOURNAL OF HEPATOLOGY

The Lin28/let-7 Axis Regulates Glucose Metabolism

(2011) Hao Zhu et al.   CELL

miRNAs control insulin content in pancreatic β-cells via downregulation of transcriptional repressors

(2011) Tal Melkman-Zehavi et al.   EMBO JOURNAL

Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis

(2011) Katey J. Rayner et al.   JOURNAL OF CLINICAL INVESTIGATION

miR-29a and miR-29b Contribute to Pancreatic  -Cell-Specific Silencing of Monocarboxylate Transporter 1 (Mct1)

(2011) T. J. Pullen et al.   MOLECULAR AND CELLULAR BIOLOGY

MicroRNAs 103 and 107 regulate insulin sensitivity

(2011) Mirko Trajkovski et al.   NATURE

Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides

(2011) Katey J. Rayner et al.   NATURE

Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism

(2011) Sabine D. Jordan et al.   NATURE CELL BIOLOGY

MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins

(2011) Kasey C. Vickers et al.   NATURE CELL BIOLOGY

miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling

(2011) A. Davalos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian microRNAs: experimental evaluation of novel and previously annotated genes

(2010) H. R. Chiang et al.   GENES & DEVELOPMENT

Expression of miR-33 from anSREBP2Intron Inhibits Cholesterol Export and Fatty Acid Oxidation

(2010) Isabelle Gerin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNAs in skeletal muscle: their role and regulation in development, disease and function

(2010) Isabelle Güller et al.   JOURNAL OF PHYSIOLOGY-LONDON

Ancient animal microRNAs and the evolution of tissue identity

(2010) Foteini Christodoulou et al.   NATURE

Formation, regulation and evolution of Caenorhabditis elegans 3′UTRs

(2010) Calvin H. Jan et al.   NATURE

miR-33 links SREBP-2 induction to repression of sterol transporters

(2010) T. J. Marquart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein 2 (Srebp2) regulates HDL in vivo

(2010) T. Horie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-33 and the SREBP Host Genes Cooperate to Control Cholesterol Homeostasis

(2010) S. H. Najafi-Shoushtari et al.   SCIENCE

MiR-33 Contributes to the Regulation of Cholesterol Homeostasis

(2010) K. J. Rayner et al.   SCIENCE

A MicroRNA Imparts Robustness against Environmental Fluctuation during Development

(2009) Xin Li et al.   CELL

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Origins and Mechanisms of miRNAs and siRNAs

(2009) Richard W. Carthew et al.   CELL

MicroRNA control of muscle development and disease

(2009) Andrew H Williams et al.   CURRENT OPINION IN CELL BIOLOGY

European lactase persistence genotype shows evidence of association with increase in body mass index

(2009) J. Kettunen et al.   HUMAN MOLECULAR GENETICS

Mechanisms of biphasic insulin-granule exocytosis - roles of the cytoskeleton, small GTPases and SNARE proteins

(2009) Z. Wang et al.   JOURNAL OF CELL SCIENCE

Silencing by small RNAs is linked to endosomal trafficking

(2009) Young Sik Lee et al.   NATURE CELL BIOLOGY

Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity

(2009) Derrick J. Gibbings et al.   NATURE CELL BIOLOGY

Anti-Argonaute RIP-Chip shows that miRNA transfections alter global patterns of mRNA recruitment to microribonucleoprotein complexes

(2009) W.-X. Wang et al.   RNA

Genome-Wide Survey of SNP Variation Uncovers the Genetic Structure of Cattle Breeds

(2009) et al.   SCIENCE

Meta-regulation: microRNA regulation of glucose and lipid metabolism

(2009) Francis C. Lynn   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Glucose regulation of insulin gene expression in pancreatic β-cells

(2008) Sreenath S. Andrali et al.   BIOCHEMICAL JOURNAL

Why expression of some genes is disallowed in β-cells

(2008) Roel Quintens et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

HDL, ABC Transporters, and Cholesterol Efflux: Implications for the Treatment of Atherosclerosis

(2008) Alan R. Tall et al.   Cell Metabolism

The WNT signalling pathway and diabetes mellitus

(2008) T. Jin   DIABETOLOGIA

MicroRNA miR-7 is preferentially expressed in endocrine cells of the developing and adult human pancreas

(2008) Mayrin Correa-Medina et al.   GENE EXPRESSION PATTERNS

The impact of microRNAs on protein output

(2008) Daehyun Baek et al.   NATURE

Widespread changes in protein synthesis induced by microRNAs

(2008) Matthias Selbach et al.   NATURE

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY

Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

(2008) Witold Filipowicz et al.   NATURE REVIEWS GENETICS

Circulating microRNAs as stable blood-based markers for cancer detection

(2008) P. S. Mitchell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of glucose-regulated miRNAs from pancreatic   cells reveals a role for miR-30d in insulin transcription

(2008) X. Tang et al.   RNA