Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology

Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling

(2017) Daniel A Giles et al.   NATURE MEDICINE

Acetate mediates a microbiome–brain–β-cell axis to promote metabolic syndrome

(2016) Rachel J. Perry et al.   NATURE

MicroRNA-130a and -130b enhance activation of hepatic stellate cells by suppressing PPARγ expression: A rat fibrosis model study

(2015) Le Lu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A possible link between hepatic mitochondrial dysfunction and diet-induced insulin resistance

(2015) Raffaella Crescenzo et al.   EUROPEAN JOURNAL OF NUTRITION

MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels

(2015) Leigh Goedeke et al.   NATURE MEDICINE

Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis

(2015) Alexandre Wagschal et al.   NATURE MEDICINE

MicroRNA regulatory networks in human adipose tissue and obesity

(2015) Peter Arner et al.   Nature Reviews Endocrinology

Towards a molecular understanding of microRNA-mediated gene silencing

(2015) Stefanie Jonas et al.   NATURE REVIEWS GENETICS

From guide to target: molecular insights into eukaryotic RNA-interference machinery

(2015) Jonathan J Ipsaro et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanistic insights on the Dicer-independent AGO2-mediated processing of AgoshRNAs

(2015) Ying Poi Liu et al.   RNA Biology

MicroRNA-130a can inhibit hepatitis B virus replication via targeting PGC1α and PPARγ

(2015) Jyun-Yuan Huang et al.   RNA

From guide to target: molecular insights into eukaryotic RNA-interference machinery

(2015) Jonathan J Ipsaro et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Emerging Role of microRNAs and Nutrition in Modulating Health and Disease

(2014) Sharon A. Ross et al.   Annual Review of Nutrition

Metformin: From Mechanisms of Action to Therapies

(2014) Marc Foretz et al.   Cell Metabolism

AMPK at the Nexus of Energetics and Aging

(2014) Kristopher Burkewitz et al.   Cell Metabolism

Thermoneutral housing is a critical factor for immune function and diet-induced obesity in C57BL/6 nude mice

(2014) K Stemmer et al.   INTERNATIONAL JOURNAL OF OBESITY

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

(2014) Anila K. Madiraju et al.   NATURE

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

(2014) Rachel J. Perry et al.   NATURE

Chronic enrichment of hepatic endoplasmic reticulum–mitochondria contact leads to mitochondrial dysfunction in obesity

(2014) Ana Paula Arruda et al.   NATURE MEDICINE

Regulation of microRNA biogenesis

(2014) Minju Ha et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ELAVL1 Modulates Transcriptome-wide miRNA Binding in Murine Macrophages

(2014) Yi-Chien Lu et al.   Cell Reports

Loss of Tumor Suppressor RPL5/RPL11 Does Not Induce Cell Cycle Arrest but Impedes Proliferation Due to Reduced Ribosome Content and Translation Capacity

(2013) T. Teng et al.   MOLECULAR AND CELLULAR BIOLOGY

Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b

(2013) Jan-Wilhelm Kornfeld et al.   NATURE

Argonaute proteins: functional insights and emerging roles

(2013) Gunter Meister   NATURE REVIEWS GENETICS

miRBase: annotating high confidence microRNAs using deep sequencing data

(2013) Ana Kozomara et al.   NUCLEIC ACIDS RESEARCH

The NHGRI GWAS Catalog, a curated resource of SNP-trait associations

(2013) Danielle Welter et al.   NUCLEIC ACIDS RESEARCH

Quantitative functions of Argonaute proteins in mammalian development

(2012) D. Wang et al.   GENES & DEVELOPMENT

CITED2 links hormonal signaling to PGC-1α acetylation in the regulation of gluconeogenesis

(2012) Mashito Sakai et al.   NATURE MEDICINE

Expression determinants of mammalian argonaute proteins in mediating gene silencing

(2012) Paul N. Valdmanis et al.   NUCLEIC ACIDS RESEARCH

Control of mitochondrial metabolism and systemic energy homeostasis by microRNAs 378 and 378

(2012) M. Carrer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polysome Profiling in Liver Identifies Dynamic Regulation of Endoplasmic Reticulum Translatome by Obesity and Fasting

(2012) Suneng Fu et al.   PLoS Genetics

Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways

(2011) Jessica L. Yecies et al.   Cell Metabolism

Dicer recognizes the 5′ end of RNA for efficient and accurate processing

(2011) Jong-Eun Park et al.   NATURE

MicroRNAs 103 and 107 regulate insulin sensitivity

(2011) Mirko Trajkovski et al.   NATURE

Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity

(2011) Suneng Fu et al.   NATURE

Nonalcoholic fatty liver disease and diabetes mellitus: pathogenesis and treatment

(2011) Briohny W. Smith et al.   Nature Reviews Endocrinology

Recognition of the pre-miRNA structure by Drosophila Dicer-1

(2011) Akihisa Tsutsumi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance

(2010) Ling Yang et al.   Cell Metabolism

A dicer-independent miRNA biogenesis pathway that requires Ago catalysis

(2010) Sihem Cheloufi et al.   NATURE

Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis

(2010) J.-S. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential expression analysis for sequence count data

(2010) Simon Anders et al.   GENOME BIOLOGY

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Essential and overlapping functions for mammalian Argonautes in microRNA silencing

(2009) H. Su et al.   GENES & DEVELOPMENT

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Many roads to maturity: microRNA biogenesis pathways and their regulation

(2009) Julia Winter et al.   NATURE CELL BIOLOGY

A novel high-affinity peptide antagonist to the insulin receptor

(2008) Lauge Schäffer et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dephosphorylation of Translation Initiation Factor 2α Enhances Glucose Tolerance and Attenuates Hepatosteatosis in Mice

(2008) Seiichi Oyadomari et al.   Cell Metabolism

Maternal Argonaute 2 Is Essential for Early Mouse Development at the Maternal-Zygotic Transition

(2008) Karin Lykke-Andersen et al.   MOLECULAR BIOLOGY OF THE CELL

miROrtho: computational survey of microRNA genes

(2008) D. Gerlach et al.   NUCLEIC ACIDS RESEARCH