Endothelial Extracellular Vesicles: From Keepers of Health to Messengers of Disease

To be or not to be: endothelial cell plasticity in development, repair, and disease

(2021) Leah J. Greenspan et al.   ANGIOGENESIS

Circulating Exosomes Are Strongly Involved in SARS-CoV-2 Infection

(2021) Elettra Barberis et al.   Frontiers in Molecular Biosciences

Highlight article: Neural stem cell-derived exosomes facilitate spinal cord functional recovery after injury by promoting angiogenesis

(2020) Dong Zhong et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

ALIX- and ESCRT-III–dependent sorting of tetraspanins to exosomes

(2020) Jorge Larios et al.   JOURNAL OF CELL BIOLOGY

Direct comparison of optical and electron microscopy methods for structural characterization of extracellular vesicles

(2020) Jade M. Noble et al.   JOURNAL OF STRUCTURAL BIOLOGY

The Endocardium and Heart Valves

(2020) Bailey Dye et al.   Cold Spring Harbor Perspectives in Biology

Linagliptin and telmisartan induced effects on renal and urinary exosomal miRNA expression in rats with 5/6 nephrectomy

(2020) Denis Delić et al.   Scientific Reports

A comparison of methods for the isolation and separation of extracellular vesicles from protein and lipid particles in human serum

(2020) K. Brennan et al.   Scientific Reports

Endothelial heterogeneity across distinct vascular beds during homeostasis and inflammation

(2020) Ankit Jambusaria et al.   eLife

Endocytosis of Extracellular Vesicles and Release of Their Cargo from Endosomes

(2020) Bhagyashree S. Joshi et al.   ACS Nano

Cloaked Viruses and Viral Factors in Cutting Edge Exosome-Based Therapies

(2020) Christos Dogrammatzis et al.   Frontiers in Cell and Developmental Biology

Endothelial Cell Morphology Regulates Inflammatory Cells Through MicroRNA Transferred by Extracellular Vesicles

(2020) Jiaqi Liang et al.   Frontiers in Bioengineering and Biotechnology

Reporter mice for isolating and auditing cell type‐specific extracellular vesicles in vivo

(2020) James V. McCann et al.   GENESIS

Adenosine and Its Receptors: An Expected Tool for the Diagnosis and Treatment of Coronary Artery and Ischemic Heart Diseases

(2020) Marine Gaudry et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular vesicle‐enclosed miR‐486‐5p mediates wound healing with adipose‐derived stem cells by promoting angiogenesis

(2020) Yingjie Lu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Extracellular vesicles in diabetes mellitus induce alterations in endothelial cell morphology and migration

(2020) Sharon F. Wu et al.   Journal of Translational Medicine

Extracellular Vesicles as Delivery Vehicles of Specific Cellular Cargo

(2020) Bilal Mir et al.   Cells

Extracellular Matrix Mimicking Nanofibrous Scaffolds Modified With Mesenchymal Stem Cell-Derived Extracellular Vesicles for Improved Vascularization

(2020) Dake Hao et al.   Frontiers in Bioengineering and Biotechnology

Three-Dimensional Human Liver-Chip Emulating Premetastatic Niche Formation by Breast Cancer-Derived Extracellular Vesicles

(2020) Junyoung Kim et al.   ACS Nano

Microscopy approaches to study extracellular vesicles

(2020) Federico Colombo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Epigallocatechin gallate suppresses inflammation in human coronary artery endothelial cells by inhibiting NF-κB

(2020) Aravind T. Reddy et al.   LIFE SCIENCES

Do tumor exosome integrins alone determine organotropic metastasis?

(2020) E. S. Grigoryeva et al.   MOLECULAR BIOLOGY REPORTS

Cells of the adult human heart

(2020) Monika Litviňuková et al.   NATURE

Endothelial extracellular vesicles contain protective proteins and rescue ischemia-reperfusion injury in a human heart-on-chip

(2020) Moran Yadid et al.   Science Translational Medicine

Endothelial Cell Contributions to COVID-19

(2020) Alexandra E. Oxford et al.   Pathogens

Hypoxia and CD11b+ Cell Influx Are Strongly Associated With Lymph Node Metastasis of Oral Cancer

(2020) KEI SUGIURA et al.   ANTICANCER RESEARCH

Patients With COVID-19 Have Elevated Levels of Circulating Extracellular Vesicle Tissue Factor Activity That Is Associated With Severity and Mortality

(2020) Axel Rosell et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Tumor exposed-lymphatic endothelial cells promote primary tumor growth via IL6

(2020) Maureen Van de Velde et al.   CANCER LETTERS

The N-glycome regulates the endothelial-to-hematopoietic transition

(2020) Dionna M. Kasper et al.   SCIENCE

Venous identity requires BMP signalling through ALK3

(2019) Alice Neal et al.   Nature Communications

piRNA-823 delivered by multiple myeloma-derived extracellular vesicles promoted tumorigenesis through re-educating endothelial cells in the tumor environment

(2019) Beibei Li et al.   ONCOGENE

Regulation of Endothelial Cell Permeability by Platelet-Derived Extracellular Vesicles

(2019) Byron Miyazawa et al.   Journal of Trauma and Acute Care Surgery

Studying the Fate of Tumor Extracellular Vesicles at High Spatiotemporal Resolution Using the Zebrafish Embryo

(2019) Vincent Hyenne et al.   DEVELOPMENTAL CELL

Live Tracking of Inter-organ Communication by Endogenous Exosomes In Vivo

(2019) Frederik J. Verweij et al.   DEVELOPMENTAL CELL

Effective Visualization and Easy Tracking of Extracellular Vesicles in Glioma Cells

(2019) Abir Mondal et al.   BIOLOGICAL PROCEDURES ONLINE

Inflammatory adipocyte-derived extracellular vesicles promote leukocyte attachment to vascular endothelial cells

(2019) Rebecca M. Wadey et al.   ATHEROSCLEROSIS

Proinflammatory Effect of Endothelial Microparticles Is Mitochondria Mediated and Modulated Through MAPKAPK2 (MAPK-Activated Protein Kinase 2) Leading to Attenuation of Cardiac Hypertrophy

(2019) Dipti Tripathi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endothelial progenitor cell-derived exosomes facilitate vascular endothelial cell repair through shuttling miR-21-5p to modulate Thrombospondin-1 expression

(2019) Hui Hu et al.   CLINICAL SCIENCE

Biology and Role of Extracellular Vesicles (EVs) in the Pathogenesis of Thrombosis

(2019) Marta Zarà et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Elevated endothelial Sox2 causes lumen disruption and cerebral arteriovenous malformations

(2019) Jiayi Yao et al.   JOURNAL OF CLINICAL INVESTIGATION

Development of a quantitative method to measure EV uptake

(2019) Víctor Toribio et al.   Scientific Reports

The biology of extracellular vesicles: The known unknowns

(2019) Leonid Margolis et al.   PLOS BIOLOGY

Delivery of microRNAs by Extracellular Vesicles in Viral Infections: Could the News be Packaged?

(2019) Fabio Seiti Yamada Yoshikawa et al.   Cells

Tumor-Derived Extracellular Vesicles Breach the Intact Blood–Brain Barrier via Transcytosis

(2019) Golnaz Morad et al.   ACS Nano

Endothelial Cell Development and Its Application to Regenerative Medicine

(2019) Jingyao Qiu et al.   CIRCULATION RESEARCH

Extracellular vesicles with ubiquitinated adenosine A 2A receptor in plasma of patients with coronary artery disease

(2019) Jean Ruf et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Endothelial-to-Mesenchymal Transition in Human Adipose Tissue Vasculature Alters the Particulate Secretome and Induces Endothelial Dysfunction

(2019) Bronson A. Haynes et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

3D cell culture stimulates the secretion of in vivo like extracellular vesicles

(2019) Sirisha Thippabhotla et al.   Scientific Reports

Cancer-derived exosomes trigger endothelial to mesenchymal transition followed by the induction of cancer-associated fibroblasts

(2018) Ju Hun Yeon et al.   Acta Biomaterialia

Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise

(2018) Martin Whitham et al.   Cell Metabolism

Molecular and functional characterization of circulating extracellular vesicles from diabetic patients with and without retinopathy and healthy subjects

(2018) Aurora Mazzeo et al.   EXPERIMENTAL EYE RESEARCH

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Extracellular vesicles from oral squamous carcinoma cells display pro- and anti-angiogenic properties

(2018) ALDL de Andrade et al.   ORAL DISEASES

Monitoring Extracellular Vesicle Cargo Active Uptake by Imaging Flow Cytometry

(2018) Yifat Ofir-Birin et al.   Frontiers in Immunology

Distinct adipocyte progenitor cells are associated with regional phenotypes of perivascular aortic fat in mice

(2018) Khanh-Van Tran et al.   Molecular Metabolism

Vascular Bed Molecular Profiling by Differential Systemic Decellularization In Vivo

(2018) Aida Serra et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

EndMT: A promising and controversial field

(2018) Lei Hong et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Therapeutic Effects of Wenxin Keli in Cardiovascular Diseases: An Experimental and Mechanism Overview

(2018) Guihua Tian et al.   Frontiers in Pharmacology

Enhanced extracellular vesicle production and ethanol-mediated vascularization bioactivity via a 3D-printed scaffold-perfusion bioreactor system

(2018) Divya B. Patel et al.   Acta Biomaterialia

Extracellular vesicles of multiple myeloma cells utilize the proteasome inhibitor mechanism to moderate endothelial angiogenesis

(2018) Moran Zarfati et al.   ANGIOGENESIS

Rapid and accurate analysis of stem cell-derived extracellular vesicles with super resolution microscopy and live imaging

(2018) Zubair Nizamudeen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

An Endothelial-to-Adipocyte Extracellular Vesicle Axis Governed by Metabolic State

(2018) Clair Crewe et al.   CELL

Exosomal miR-155 Derived from Hepatocellular Carcinoma Cells Under Hypoxia Promotes Angiogenesis in Endothelial Cells

(2018) Yusuke Matsuura et al.   DIGESTIVE DISEASES AND SCIENCES

Endocytosis Pathways of Endothelial Cell Derived Exosomes

(2018) Anna B. Banizs et al.   MOLECULAR PHARMACEUTICS

Super-resolution microscopy demystified

(2018) Lothar Schermelleh et al.   NATURE CELL BIOLOGY

Extracellular Vesicles and Matrix Remodeling Enzymes: The Emerging Roles in Extracellular Matrix Remodeling, Progression of Diseases and Tissue Repair

(2018) Muhammad Nawaz et al.   Cells

Endothelial microparticles prevent lipid-induced endothelial damage via Akt/eNOS signaling and reduced oxidative stress

(2017) Ayman M. Mahmoud et al.   FASEB JOURNAL

Lymphangiogenesis guidance by paracrine and pericellular factors

(2017) Kari Vaahtomeri et al.   GENES & DEVELOPMENT

The Methods of Choice for Extracellular Vesicles (EVs) Characterization

(2017) Rafal Szatanek et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Vascular heterogeneity and specialization in development and disease

(2017) Michael Potente et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Markers and Biomarkers of Endothelium: When Something Is Rotten in the State

(2017) Nikolay V. Goncharov et al.   Oxidative Medicine and Cellular Longevity

Transcellular vesicular transport in epithelial and endothelial cells: Challenges and opportunities

(2017) Karen Y. Y. Fung et al.   TRAFFIC

A class of extracellular vesicles from breast cancer cells activates VEGF receptors and tumour angiogenesis

(2017) Qiyu Feng et al.   Nature Communications

Extracellular Vesicle-functionalized Decalcified Bone Matrix Scaffolds with Enhanced Pro-angiogenic and Pro-bone Regeneration Activities

(2017) Hui Xie et al.   Scientific Reports

Endothelial Extracellular Vesicles—Promises and Challenges

(2017) Carina Hromada et al.   Frontiers in Physiology

Recent advances to accelerate re-endothelialization for vascular stents

(2017) Tarek M Bedair et al.   Journal of Tissue Engineering

Microfluidic compartments with sensing microbeads for dynamic monitoring of cytokine and exosome release from single cells

(2016) Kyung Jin Son et al.   ANALYST

Radiolabeling of Extracellular Vesicles with99mTc for QuantitativeIn VivoImaging Studies

(2016) Zoltán Varga et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

(2016) Mercedes Tkach et al.   CELL

Akt1 promotes stimuli-induced endothelial-barrier protection through FoxO-mediated tight-junction protein turnover

(2016) Fei Gao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Endothelial fluid shear stress sensing in vascular health and disease

(2016) Nicolas Baeyens et al.   JOURNAL OF CLINICAL INVESTIGATION

Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification

(2016) Sven Reischauer et al.   NATURE

Angiocrine functions of organ-specific endothelial cells

(2016) Shahin Rafii et al.   NATURE

Human 'brite/beige' adipocytes develop from capillary networks and their implantation improves metabolic homeostasis in mice

(2016) So Yun Min et al.   NATURE MEDICINE

Modulation of tissue tropism and biological activity of exosomes and other extracellular vesicles: New nanotools for cancer treatment

(2016) Sander A.A. Kooijmans et al.   PHARMACOLOGICAL RESEARCH

From glioblastoma to endothelial cells through extracellular vesicles: messages for angiogenesis

(2016) Ilaria Giusti et al.   TUMOR BIOLOGY

Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges

(2016) Dinh Ha et al.   Acta Pharmaceutica Sinica B

Indications of lymphatic endothelial differentiation and endothelial progenitor cell activation in the pathology of proliferative diabetic retinopathy

(2015) Sirpa Loukovaara et al.   ACTA OPHTHALMOLOGICA

Ischemia-Reperfusion Injury Enhances Lymphatic Endothelial VEGFR3 and Rejection in Cardiac Allografts

(2015) A. Dashkevich et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Endothelial-to-mesenchymal transition contributes to fibro-proliferative vascular disease and is modulated by fluid shear stress

(2015) Jan-Renier A.J. Moonen et al.   CARDIOVASCULAR RESEARCH

New Molecular Targets of Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension

(2015) Christophe Guignabert et al.   CHEST

Serine Protease Activation Essential for Endothelial–Mesenchymal Transition in Vascular CalcificationNovelty and Significance

(2015) Jiayi Yao et al.   CIRCULATION RESEARCH

Endothelial Plasticity Drives Arterial Remodeling Within the Endocardium After Myocardial Infarction

(2015) L. Miquerol et al.   CIRCULATION RESEARCH

Induction of hematopoietic and endothelial cell program orchestrated by ETS transcription factor ER71/ETV2

(2015) F. Liu et al.   EMBO REPORTS

Extracellular vesicles as new pharmacological targets to treat atherosclerosis

(2015) Min Yin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Featured Article: Dexamethasone and rosiglitazone are sufficient and necessary for producing functional adipocytes from mesenchymal stem cells

(2015) David Contador et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Notch signaling regulates venous arterialization during zebrafish fin regeneration

(2015) Yoshiko Kametani et al.   GENES TO CELLS

Effect of exosomes derived from multipluripotent mesenchymal stromal cells on functional recovery and neurovascular plasticity in rats after traumatic brain injury

(2015) Yanlu Zhang et al.   JOURNAL OF NEUROSURGERY

Human definitive haemogenic endothelium and arterial vascular endothelium represent distinct lineages

(2015) Andrea Ditadi et al.   NATURE CELL BIOLOGY

The Blood–Brain Barrier

(2015) Richard Daneman et al.   Cold Spring Harbor Perspectives in Biology

The sinus venosus contributes to coronary vasculature through VEGFC-stimulated angiogenesis

(2014) H. I. Chen et al.   DEVELOPMENT

The Vascular Endothelium and Human Diseases

(2014) Peramaiyan Rajendran et al.   International Journal of Biological Sciences

A Gestational Profile of Placental Exosomes in Maternal Plasma and Their Effects on Endothelial Cell Migration

(2014) Carlos Salomon et al.   PLoS One

Extracellular Vesicles as Therapeutic Tools in Cardiovascular Diseases

(2014) Audrey Fleury et al.   Frontiers in Immunology

Thecis-acting signals that target proteins to exosomes and microvesicles

(2013) Jr-Ming Yang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Adipose tissue plasticity from WAT to BAT and in between

(2013) Yun-Hee Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Characterization of the adipocyte cellular lineage in vivo

(2013) Ryan Berry et al.   NATURE CELL BIOLOGY

Endothelial microparticles: Sophisticated vesicles modulating vascular function

(2013) Anne M Curtis et al.   VASCULAR MEDICINE

Sox17 is indispensable for acquisition and maintenance of arterial identity

(2013) Monica Corada et al.   Nature Communications

Ongoing activation of sphingosine 1-phosphate receptors mediates maturation of exosomal multivesicular endosomes

(2013) Taketoshi Kajimoto et al.   Nature Communications

Endothelial Microparticle Uptake in Target Cells Is Annexin I/Phosphatidylserine Receptor Dependent and Prevents Apoptosis

(2012) Felix Jansen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Zfp423 Expression Identifies Committed Preadipocytes and Localizes to Adipose Endothelial and Perivascular Cells

(2012) Rana K. Gupta et al.   Cell Metabolism

Toward tailored exosomes: The exosomal tetraspanin web contributes to target cell selection

(2012) Sanyukta Rana et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

ALIX binds a YPX3L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting

(2012) Michael R. Dores et al.   JOURNAL OF CELL BIOLOGY

Microparticles and microRNAs of endothelial progenitor cells ameliorate acute kidney injury

(2012) Markus Bitzer et al.   KIDNEY INTERNATIONAL

Circulating and platelet-derived microparticles in human blood enhance thrombosis on atherosclerotic plaques

(2012) Rosa Suades et al.   THROMBOSIS AND HAEMOSTASIS

Microparticles in Angiogenesis

(2011) M. Carmen Martinez et al.   CIRCULATION RESEARCH

Microparticles in Hemostasis and Thrombosis

(2011) A. Phillip Owens et al.   CIRCULATION RESEARCH

Biogenesis of the Posterior Pole Is Mediated by the Exosome/Microvesicle Protein-sorting Pathway

(2011) Beiyi Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Circulating Microparticles from Pulmonary Hypertensive Rats Induce Endothelial Dysfunction

(2010) Simon Tual-Chalot et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Wnt/β-Catenin Pathway Modulates Vascular Remodeling and Specification by Upregulating Dll4/Notch Signaling

(2010) Monica Corada et al.   DEVELOPMENTAL CELL

Circulating CD31+/Annexin V+ microparticles correlate with cardiovascular outcomes

(2010) J.-M. Sinning et al.   EUROPEAN HEART JOURNAL

Transcriptional control of preadipocyte determination by Zfp423

(2010) Rana K. Gupta et al.   NATURE

Endothelial-derived microparticles: Biological conveyors at the crossroad of inflammation, thrombosis and angiogenesis

(2010) Aurélie Leroyer et al.   THROMBOSIS AND HAEMOSTASIS

Mechanism of cytokine modulation of epithelial tight junction barrier

(2009) Rana Al-Sadi   Frontiers in Bioscience-Landmark

Significance of a Multiple Biomarkers Strategy Including Endothelial Dysfunction to Improve Risk Stratification for Cardiovascular Events in Patients at High Risk for Coronary Heart Disease

(2009) Toshimitsu Nozaki et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cellular and Molecular Basis of Pulmonary Arterial Hypertension

(2009) Nicholas W. Morrell et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

p38 mitogen-activated protein kinase targets the production of proinflammatory endothelial microparticles

(2009) A. M. CURTIS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Vascular Smooth Muscle Modulates Endothelial Control of Vasoreactivity via Reactive Oxygen Species Production through Myoendothelial Communications

(2009) Marie Billaud et al.   PLoS One

Circulating Endothelial Microparticle Levels Predict Hemodynamic Severity of Pulmonary Hypertension

(2008) Nicolas Amabile et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

HIF1α Induces the Recruitment of Bone Marrow-Derived Vascular Modulatory Cells to Regulate Tumor Angiogenesis and Invasion

(2008) Rose Du et al.   CANCER CELL

Brief Secondhand Smoke Exposure Depresses Endothelial Progenitor Cells Activity and Endothelial Function

(2008) Christian Heiss et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Detection of microRNA Expression in Human Peripheral Blood Microvesicles

(2008) Melissa Piper Hunter et al.   PLoS One

Phospholipid composition of in vitro endothelial microparticles and their in vivo thrombogenic properties

(2007) M.N. Abid Hussein et al.   THROMBOSIS RESEARCH