Elevated endothelial Sox2 causes lumen disruption and cerebral arteriovenous malformations

Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy

(2018) Lara Al-Olabi et al.   JOURNAL OF CLINICAL INVESTIGATION

Vascular endothelium plays a key role in directing pulmonary epithelial cell differentiation

(2017) Jiayi Yao et al.   JOURNAL OF CELL BIOLOGY

RASAL2, a RAS GTPase-activating protein, inhibits stemness and epithelial–mesenchymal transition via MAPK/SOX2 pathway in bladder cancer

(2017) Ke Hui et al.   Cell Death & Disease

A Network Model to Explore the Effect of the Micro-environment on Endothelial Cell Behavior during Angiogenesis

(2017) Nathan Weinstein et al.   Frontiers in Physiology

Endothelial-mesenchymal transition in atherosclerotic lesion calcification

(2016) Kristina I. Boström et al.   ATHEROSCLEROSIS

Endothelial-Mesenchymal Transition in Vascular Calcification of Ins2Akita/+ Mice

(2016) Pierre J. Guihard et al.   PLoS One

Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability

(2016) Solene M. Evrard et al.   Nature Communications

Matrix Gla protein regulates differentiation of endothelial cells derived from mouse embryonic stem cells

(2015) Jiayi Yao et al.   ANGIOGENESIS

Serine Protease Activation Essential for Endothelial–Mesenchymal Transition in Vascular CalcificationNovelty and Significance

(2015) Jiayi Yao et al.   CIRCULATION RESEARCH

SOX2 primes the epigenetic landscape in neural precursors enabling proper gene activation during hippocampal neurogenesis

(2015) Alejandro Amador-Arjona et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cell of origin and subtype of K-Ras-induced lung tumors are modified by Notch and Sox2

(2014) Xia Xu et al.   GENES & DEVELOPMENT

A three-dimensional human neural cell culture model of Alzheimer’s disease

(2014) Se Hoon Choi et al.   NATURE

Constitutively active Notch4 receptor elicits brain arteriovenous malformations through enlargement of capillary-like vessels

(2014) Patrick A. Murphy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

JMJD5 Regulates Cell Cycle and Pluripotency in Human Embryonic Stem Cells

(2014) Hui Zhu et al.   STEM CELLS

Sox2 acts as a rheostat of epithelial to mesenchymal transition during neural crest development

(2014) Nikolaos Mandalos et al.   Frontiers in Physiology

The Sox Family of Transcription Factors: Versatile Regulators of Stem and Progenitor Cell Fate

(2013) Abby Sarkar et al.   Cell Stem Cell

A Role for the Endothelium in Vascular Calcification

(2013) Yucheng Yao et al.   CIRCULATION RESEARCH

Transcriptional Regulation of Endothelial Cell and Vascular Development

(2013) Changwon Park et al.   CIRCULATION RESEARCH

RASA1Mutations and Associated Phenotypes in 68 Families with Capillary Malformation-Arteriovenous Malformation

(2013) Nicole Revencu et al.   HUMAN MUTATION

EndMT contributes to the onset and progression of cerebral cavernous malformations

(2013) Luigi Maddaluno et al.   NATURE

Embryonic Stem Cells Markers SOX2, OCT4 and Nanog Expression and Their Correlations with Epithelial-Mesenchymal Transition in Nasopharyngeal Carcinoma

(2013) Weiren Luo et al.   PLoS One

Reducing Jagged 1 and 2 levels prevents cerebral arteriovenous malformations in matrix Gla protein deficiency

(2013) Y. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Essential Role of Sox2 for the Establishment and Maintenance of the Germ Cell Line

(2013) Federica Campolo et al.   STEM CELLS

Crossveinless 2 regulates bone morphogenetic protein 9 in human and mouse vascular endothelium

(2012) Y. Yao et al.   BLOOD

Vascular lumen formation

(2012) Jennifer Axnick et al.   CURRENT OPINION IN HEMATOLOGY

Jmjd5, an H3K36me2 histone demethylase, modulates embryonic cell proliferation through the regulation of Cdkn1a expression

(2012) A. Ishimura et al.   DEVELOPMENT

Sox2 in the Dermal Papilla Niche Controls Hair Growth by Fine-Tuning BMP Signaling in Differentiating Hair Shaft Progenitors

(2012) Carlos Clavel et al.   DEVELOPMENTAL CELL

An integrin–ILK–microtubule network orients cell polarity and lumen formation in glandular epithelium

(2012) Nasreen Akhtar et al.   NATURE CELL BIOLOGY

Notch4 Normalization Reduces Blood Vessel Size in Arteriovenous Malformations

(2012) P. A. Murphy et al.   Science Translational Medicine

Blood Vessel Tubulogenesis Requires Rasip1 Regulation of GTPase Signaling

(2011) Ke Xu et al.   DEVELOPMENTAL CELL

Over-expression of Sox2 in C3H10T1/2 cells inhibits osteoblast differentiation through Wnt and MAPK signalling pathways

(2011) Daofang Ding et al.   INTERNATIONAL ORTHOPAEDICS

Matrix Gla protein deficiency causes arteriovenous malformations in mice

(2011) Yucheng Yao et al.   JOURNAL OF CLINICAL INVESTIGATION

Microvascular rarefaction

(2011) Michael S. Goligorsky   Organogenesis

Hereditary haemorrhagic telangiectasia: Pathophysiology, diagnosis and treatment

(2010) Claire L. Shovlin   BLOOD REVIEWS

The transcription factor Sox2 is required for osteoblast self-renewal

(2010) U Basu-Roy et al.   CELL DEATH AND DIFFERENTIATION

β1 Integrin Establishes Endothelial Cell Polarity and Arteriolar Lumen Formation via a Par3-Dependent Mechanism

(2010) Ann C. Zovein et al.   DEVELOPMENTAL CELL

Conversion of vascular endothelial cells into multipotent stem-like cells

(2010) Damian Medici et al.   NATURE MEDICINE

KDM8, a H3K36me2 histone demethylase that acts in the cyclin A1 coding region to regulate cancer cell proliferation

(2010) D. A. Hsia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rasip1 is required for endothelial cell motility, angiogenesis and vessel formation

(2009) Ke Xu et al.   DEVELOPMENTAL BIOLOGY

ABERRANT ANGIOGENIC CHARACTERISTICS OF HUMAN BRAIN ARTERIOVENOUS MALFORMATION ENDOTHELIAL CELLS

(2009) Mark N. Jabbour et al.   NEUROSURGERY

Proline and γ-Carboxylated Glutamate Residues in Matrix Gla Protein Are Critical for Binding of Bone Morphogenetic Protein-4

(2008) Yucheng Yao et al.   CIRCULATION RESEARCH

Zebrafish Sox7 and Sox18 function together to control arterial–venous identity

(2008) Hélène Pendeville et al.   DEVELOPMENTAL BIOLOGY

Endothelial Notch4 signaling induces hallmarks of brain arteriovenous malformations in mice

(2008) P. A. Murphy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Redundant Roles for Sox7 and Sox18 in Arteriovenous Specification in Zebrafish

(2007) Robert Herpers et al.   CIRCULATION RESEARCH