Flame Retardants-Mediated Interferon Signaling in the Pathogenesis of Nonalcoholic Fatty Liver Disease

Comprehensive analysis of organophosphorus flame retardant-induced mitochondrial abnormalities: potential role in lipid accumulation

(2021) Yifei Le et al.   ENVIRONMENTAL POLLUTION

Evaluation of hepatotoxicity induced by 2-ethylhexyldiphenyl phosphate based on transcriptomics and its potential metabolism pathway in human hepatocytes

(2021) Lingfei Zhu et al.   JOURNAL OF HAZARDOUS MATERIALS

IFN-γ contributes to the hepatic inflammation in HFD-induced nonalcoholic steatohepatitis by STAT1β/TLR2 signaling pathway

(2021) Jing Li et al.   MOLECULAR IMMUNOLOGY

MAFLD: A consensus-driven proposed nomenclature for metabolic associated fatty liver disease

(2020) Mohammed Eslam et al.   GASTROENTEROLOGY

Remdesivir attenuates high fat diet (HFD)-induced NAFLD by regulating hepatocyte dyslipidemia and inflammation via the suppression of STING

(2020) Yan-Ni Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondrial DNA in inflammation and immunity

(2020) Joel S Riley et al.   EMBO REPORTS

Gut microbiota and human NAFLD: disentangling microbial signatures from metabolic disorders

(2020) Judith Aron-Wisnewsky et al.   Nature Reviews Gastroenterology & Hepatology

In vitro oxidative stress, mitochondrial impairment and G1 phase cell cycle arrest induced by alkyl-phosphorus-containing flame retardants

(2020) Shengwu Yuan et al.   CHEMOSPHERE

Exposure to PBDE47 affects mouse oocyte quality via mitochondria dysfunction-induced oxidative stress and apoptosis

(2020) Ming-Hong Sun et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

In Vitro Immunotoxicity of Organophosphate Flame Retardants in Human THP-1-Derived Macrophages

(2020) Xinyan Li et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Multiple Parallel Hits Hypothesis in NAFLD – Revisited After a Decade

(2020) Herbert Tilg et al.   HEPATOLOGY

Sex- and age-dependent effects of maternal organophosphate flame-retardant exposure on neonatal hypothalamic and hepatic gene expression

(2020) Samantha Adams et al.   REPRODUCTIVE TOXICOLOGY

Regulation of lipid metabolism in pancreatic beta cells by interferon gamma: A link to anti-viral function

(2020) Nguyen T.T. Truong et al.   CYTOKINE

Cytotoxic Screening and Transcriptomics Reveal Insights into the Molecular Mechanisms of Trihexyl Phosphate-Triggered Hepatotoxicity

(2020) Zhenhua Li et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Hypothyroidism-Induced Nonalcoholic Fatty Liver Disease (HIN): Mechanisms and Emerging Therapeutic Options

(2020) Daniela Maria Tanase et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Maternal organophosphate flame‐retardant exposure alters offspring energy and glucose homeostasis in a sexually dimorphic manner in mice

(2020) Sabrina N. Walley et al.   JOURNAL OF APPLIED TOXICOLOGY

Environmental pollutants and the immune response

(2020) Takafumi Suzuki et al.   NATURE IMMUNOLOGY

Picking up a Fight: Fine Tuning Mitochondrial Innate Immune Defenses Against RNA Viruses

(2020) Sourav Dutta et al.   Frontiers in Microbiology

Tetrachlorobisphenol A induced immunosuppression and uterine injury in mice

(2020) Yinan Wang et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Exposure to organophosphate ester flame retardants and plasticizers during pregnancy: Thyroid endocrine disruption and mediation role of oxidative stress

(2020) Yiming Yao et al.   ENVIRONMENT INTERNATIONAL

Tris(2-chloroethyl) Phosphate (TCEP) Elicits Hepatotoxicity by Activating Human Cancer Pathway Genes in HepG2 Cells

(2020) Abdullah M. Al-Salem et al.   Toxics

A review on contaminants of emerging concern in European raptors (2002−2020)

(2020) Soledad González-Rubio et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Prioritization of hazards of novel flame retardants using the mechanistic toxicology information from ToxCast and Adverse Outcome Pathways

(2019) Lola Bajard et al.   Environmental Sciences Europe

Endocrine Disrupting Chemicals: An Occult Mediator of Metabolic Disease

(2019) Olga Papalou et al.   Frontiers in Endocrinology

Elevated Urinary Bisphenol A Levels are Associated with Nonalcoholic Fatty Liver Disease among Adults in the United States

(2019) Donghee Kim et al.   LIVER INTERNATIONAL

Interferon-alpha 2 but not Interferon-gamma serum levels are associated with intramuscular fat in obese patients with nonalcoholic fatty liver disease

(2019) Giovanni Tarantino et al.   Journal of Translational Medicine

Regulation of TBBPA-induced oxidative stress on mitochondrial apoptosis in L02 cells through the Nrf2 signaling pathway

(2019) Yunchao Zhang et al.   CHEMOSPHERE

Mitochondrial Dysfunction in C. elegans Activates Mitochondrial Relocalization and Nuclear Hormone Receptor-Dependent Detoxification Genes

(2019) Kai Mao et al.   Cell Metabolism

Assessment of Occupational Exposure to Organic Flame Retardants: A Systematic Review

(2019) Sabrina Gravel et al.   Annals of Work Exposures and Health

Organophosphorus Flame Retardants Impair Intracellular Lipid Metabolic Function in Human Hepatocellular Cells

(2019) Zhengliang Hao et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Concentrations of brominated and phosphorous flame retardants in Finnish house dust and insights into children's exposure

(2019) Panu Rantakokko et al.   CHEMOSPHERE

The effects of decabromodiphenyl ether on glycolipid metabolism and related signaling pathways in mice

(2019) Yupeng Zhu et al.   CHEMOSPHERE

Cardiovascular toxicity of decabrominated diphenyl ethers (BDE-209) and decabromodiphenyl ethane (DBDPE) in rats

(2019) Li Jing et al.   CHEMOSPHERE

The cGAS-cGAMP-STING Pathway: A Molecular Link Between Immunity and Metabolism

(2019) Juli Bai et al.   DIABETES

Past, present and future perspectives in nonalcoholic fatty liver disease

(2019) Arun J. Sanyal   Nature Reviews Gastroenterology & Hepatology

1H NMR-based metabolomic analysis of nine organophosphate flame retardants metabolic disturbance in Hep G2 cell line

(2019) Jinping Gu et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Maternal exposure to low dose BDE209 and Pb mixture induced neurobehavioral anomalies in C57BL/6 male offspring

(2019) Yuanhong Chen et al.   TOXICOLOGY

A Review of a Class of Emerging Contaminants: The Classification, Distribution, Intensity of Consumption, Synthesis Routes, Environmental Effects and Expectation of Pollution Abatement to Organophosphate Flame Retardants (OPFRs)

(2019) Jiawen Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The role of pro-inflammatory cytokines in lipid metabolism of metabolic diseases

(2019) Yan Chen et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Association of Aryl Organophosphate Flame Retardants Triphenyl Phosphate and 2-Ethylhexyl Diphenyl Phosphate with Human Blood Triglyceride and Total Cholesterol Levels

(2019) Fanrong Zhao et al.   Environmental Science & Technology Letters

Tetrabromoethylcyclohexane (TBECH) exhibits immunotoxicity in murine macrophages

(2019) Xia Wang et al.   ENVIRONMENTAL TOXICOLOGY

Chronic exposure to tetrabromodiphenyl ether (BDE-47) aggravates hepatic steatosis and liver fibrosis in diet-induced obese mice

(2019) Chunxue Yang et al.   JOURNAL OF HAZARDOUS MATERIALS

What’s new in NAFLD pathogenesis, biomarkers and treatment?

(2019) Christopher D. Byrne et al.   Nature Reviews Gastroenterology & Hepatology

Hepatotoxicity of decabromodiphenyl ethane (DBDPE) and decabromodiphenyl ether (BDE-209) in 28-day exposed Sprague-Dawley rats

(2019) Yanmin Sun et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Chlorinated phosphorus flame retardants exert oxidative damage to SMMC-7721 human hepatocarcinoma cells

(2019) Ming Guo et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Organophosphate Ester Flame Retardants: Are They a Regrettable Substitution for Polybrominated Diphenyl Ethers?

(2019) Arlene Blum et al.   Environmental Science & Technology Letters

Worker exposure to flame retardants in manufacturing, construction and service industries

(2019) Cheryl Fairfield Estill et al.   ENVIRONMENT INTERNATIONAL

An exploratory analysis of urinary organophosphate ester metabolites and oxidative stress among pregnant women in Puerto Rico

(2019) Mary E. Ingle et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Hepatic Transcriptomic Patterns in the Neonatal Rat After Pentabromodiphenyl Ether Exposure

(2019) June K. Dunnick et al.   TOXICOLOGIC PATHOLOGY

Oxidative stress, cell cycle arrest, DNA damage and apoptosis in adult zebrafish ( Danio rerio ) induced by tris(1,3-dichloro-2-propyl) phosphate

(2018) Hanyan Chen et al.   AQUATIC TOXICOLOGY

Flame retardants, hexabromocyclododecane (HCBD) and tetrabromobisphenol a (TBBPA), alter secretion of tumor necrosis factor alpha (TNFα) from human immune cells

(2018) Sharia Yasmin et al.   ARCHIVES OF TOXICOLOGY

In utero and lactational exposure to BDE-47 promotes obesity development in mouse offspring fed a high-fat diet: impaired lipid metabolism and intestinal dysbiosis

(2018) Dezhen Wang et al.   ARCHIVES OF TOXICOLOGY

Mitochondrial damage and apoptosis: Key features in BDE-153-induced hepatotoxicity

(2018) Lilian Cristina Pereira et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Polybrominated diphenyl ether (PBDE) exposures and thyroid hormones in children at age 3 years

(2018) Ann M. Vuong et al.   ENVIRONMENT INTERNATIONAL

Polybrominated diphenyl ethers (PBDEs) and hydroxylated PBDE metabolites (OH-PBDEs) in maternal and fetal tissues, and associations with fetal cytochrome P450 gene expression

(2018) Ami R. Zota et al.   ENVIRONMENT INTERNATIONAL

Bisphenol a increases risk for presumed non-alcoholic fatty liver disease in Hispanic adolescents in NHANES 2003–2010

(2018) Sofia G. Verstraete et al.   Environmental Health

Neonatal triphenyl phosphate and its metabolite diphenyl phosphate exposure induce sex- and dose-dependent metabolic disruptions in adult mice

(2018) Dezhen Wang et al.   ENVIRONMENTAL POLLUTION

Adipose tissue levels of polybrominated diphenyl ethers and breast cancer risk in Chinese women: A case–control study

(2018) Yuanfang He et al.   ENVIRONMENTAL RESEARCH

Disruption of adenosine 2A receptor exacerbates NAFLD through increasing inflammatory responses and SREBP1c activity

(2018) Yuli Cai et al.   HEPATOLOGY

Flame retardant exposure assessment: findings from a behavioral intervention study

(2018) Elizabeth A. Gibson et al.   Journal of Exposure Science and Environmental Epidemiology

Activation of the STING-IRF3 pathway promotes hepatocyte inflammation, apoptosis and induces metabolic disorders in nonalcoholic fatty liver disease

(2018) J.T. Qiao et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Direct effects of thyroid hormones on hepatic lipid metabolism

(2018) Rohit A. Sinha et al.   Nature Reviews Endocrinology

Triggering and resolution of inflammation in NASH

(2018) Susanne Schuster et al.   Nature Reviews Gastroenterology & Hepatology

Pathogenesis of non-alcoholic fatty liver disease in children and adolescence: From “two hit theory” to “multiple hit model”

(2018) Yan-Lan Fang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Transcriptome profiling of HepG2 cells exposed to the flame retardant 9,10-dihydro-9-oxa-10-phosphaphenanthrene 10-oxide (DOPO)

(2018) Boris V. Krivoshiev et al.   Toxicology Research

Toll-Like Receptor-7 Signaling Promotes Nonalcoholic Steatohepatitis by Inhibiting Regulatory T Cells in Mice

(2018) Yoon Seok Roh et al.   AMERICAN JOURNAL OF PATHOLOGY

Recent biomonitoring reports on phosphate ester flame retardants: a short review

(2018) Anne-Marie Saillenfait et al.   ARCHIVES OF TOXICOLOGY

Association of non-alcoholic fatty liver disease with thyroid function: A systematic review and meta-analysis

(2018) Zeqi Guo et al.   DIGESTIVE AND LIVER DISEASE

Decabromodiphenyl ether (BDE-209) enhances foam cell formation in human macrophages via augmenting Toll-like receptor 4-dependent lipid uptake

(2018) Hui Zhi et al.   FOOD AND CHEMICAL TOXICOLOGY

Tetrabromobisphenol-A Promotes Early Adipogenesis and Lipogenesis in 3T3-L1 Cells

(2018) Vesna A Chappell et al.   TOXICOLOGICAL SCIENCES

Role of Innate Immune Signaling in Non-Alcoholic Fatty Liver Disease

(2018) Jingjing Cai et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Targeting respiratory chain by toxicants: Beyond the toxicities on mitochondrial morphology

(2018) Ping-Kun Zhou et al.   Toxicology Research

Developmental Exposure to 2,2′,4,4′-Tetrabromodiphenyl Ether Permanently Alters Blood-Liver Balance of Lipids in Male Mice

(2018) Ahmed Khalil et al.   Frontiers in Endocrinology

Metabolic Mechanism of Aryl Phosphorus Flame Retardants by Cytochromes P450: A Combined Experimental and Computational Study on Triphenyl Phosphate

(2018) Quan Zhang et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Hepatic transcriptional dose-response analysis of male and female Fischer rats exposed to hexabromocyclododecane

(2018) Reza Farmahin et al.   FOOD AND CHEMICAL TOXICOLOGY

Expression of STING Is Increased in Liver Tissues From Patients With NAFLD and Promotes Macrophage-Mediated Hepatic Inflammation and Fibrosis in Mice

(2018) Xianjun Luo et al.   GASTROENTEROLOGY

STING-mediated inflammation in Kupffer cells contributes to progression of nonalcoholic steatohepatitis

(2018) Yongsheng Yu et al.   JOURNAL OF CLINICAL INVESTIGATION

Obesity and nonalcoholic fatty liver disease: From pathophysiology to therapeutics

(2018) Stergios A. Polyzos et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Dietary exposure to brominated flame retardants and risk of type 2 diabetes in the French E3N cohort

(2018) Jeanne Sandrine Ongono et al.   ENVIRONMENT INTERNATIONAL

A Human Mixture Risk Assessment for Neurodevelopmental Toxicity Associated with Polybrominated Diphenyl Ethers Used as Flame Retardants

(2017) Olwenn V. Martin et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Aryl- and alkyl-phosphorus-containing flame retardants induced mitochondrial impairment and cell death in Chinese hamster ovary (CHO-k1) cells

(2017) Chao Huang et al.   ENVIRONMENTAL POLLUTION

Organophosphorus Flame Retardants in Pregnant Women and Their Transfer to Chorionic Villi

(2017) Fanrong Zhao et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Effect of E-waste Recycling on Urinary Metabolites of Organophosphate Flame Retardants and Plasticizers and Their Association with Oxidative Stress

(2017) Shao-you Lu et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Biological effects of new-generation dialkyl phosphinate flame retardants and their hydrolysates in BALB/C mice

(2017) Jieqing Bao et al.   ENVIRONMENTAL TOXICOLOGY

Overexpression of pregnane X and glucocorticoid receptors and the regulation of cytochrome P450 in human epileptic brain endothelial cells

(2017) Chaitali Ghosh et al.   EPILEPSIA

Dietary intake of phosphorus flame retardants (PFRs) using Swedish food market basket estimations

(2017) Giulia Poma et al.   FOOD AND CHEMICAL TOXICOLOGY

Curcumin ameliorates liver damage and progression of NASH in NASH-HCC mouse model possibly by modulating HMGB1-NF-κB translocation

(2017) Rejina Afrin et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Altered expression of the Olr59 , Ethe1 , and Slc10a2 genes in the liver of F344 rats by neonatal thyroid hormone disruption

(2017) Kana Matsubara et al.   JOURNAL OF APPLIED TOXICOLOGY

Exposure to decabromodiphenyl ether (BDE-209) produces mitochondrial dysfunction in rat liver and cell death

(2017) Lilian C Pereira et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Time-course microarrays reveal early activation of the immune transcriptome in a choline-deficient mouse model of liver injury

(2017) Koji Mitsumoto et al.   LIFE SCIENCES

Endocrine-disrupting chemicals and fatty liver disease

(2017) Charles E. Foulds et al.   Nature Reviews Endocrinology

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

(2017) Zobair Younossi et al.   Nature Reviews Gastroenterology & Hepatology

Metabolism disrupting chemicals and metabolic disorders

(2017) Jerrold J. Heindel et al.   REPRODUCTIVE TOXICOLOGY

Serum polybrominated diphenyl ether (PBDE) concentrations in relation to biomarkers of oxidative stress and inflammation: The National Health and Nutrition Examination Survey 2003–2004

(2017) Ye Yuan et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Clinical effects of chemical exposures on mitochondrial function

(2017) Zarazuela Zolkipli-Cunningham et al.   TOXICOLOGY

Tetrabromobisphenol A activates the hepatic interferon pathway in rats

(2017) J.K. Dunnick et al.   TOXICOLOGY LETTERS

Nuclear receptors and nonalcoholic fatty liver disease 1 1This article is part of a Special Issue entitled: Xenobiotic nuclear receptors: New Tricks for An Old Dog, edited by Dr. Wen Xie.

(2016) Matthew C. Cave et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Toxicological responses following short-term exposure through gavage feeding or water-borne exposure to Dechlorane Plus in zebrafish (Danio rerio)

(2016) Habyeong Kang et al.   CHEMOSPHERE

Inhalation a significant exposure route for chlorinated organophosphate flame retardants

(2016) Erika D. Schreder et al.   CHEMOSPHERE

Innate Immunity and Inflammation in NAFLD/NASH

(2016) Marco Arrese et al.   DIGESTIVE DISEASES AND SCIENCES

Thyroid hormone-disrupting activity and ecological risk assessment of phosphorus-containing flame retardants by in vitro , in vivo and in silico approaches

(2016) Quan Zhang et al.   ENVIRONMENTAL POLLUTION

Analysis of human hair to assess exposure to organophosphate flame retardants: Influence of hair segments and gender differences

(2016) Lin Qiao et al.   ENVIRONMENTAL RESEARCH

Consumer Product Chemicals in Indoor Dust: A Quantitative Meta-analysis of U.S. Studies

(2016) Susanna D. Mitro et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Adipose type I interferon signalling protects against metabolic dysfunction

(2016) Verena Wieser et al.   GUT

The economic and clinical burden of nonalcoholic fatty liver disease in the United States and Europe

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Involvement of oxidative stress in tri-ortho–cresyl phosphate-induced liver injury in male mice

(2016) LL Xu et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9

(2016) Irma Garcia-Martinez et al.   JOURNAL OF CLINICAL INVESTIGATION

IRF3 promotes adipose inflammation and insulin resistance and represses browning

(2016) Manju Kumari et al.   JOURNAL OF CLINICAL INVESTIGATION

Hazards of low dose flame-retardants (BDE-47 and BDE-32): Influence on transcriptome regulation and cell death in human liver cells

(2016) Quaiser Saquib et al.   JOURNAL OF HAZARDOUS MATERIALS

The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)

(2016) Elena Buzzetti et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

(2016) Qi Chen et al.   NATURE IMMUNOLOGY

Organophosphate ester flame retardants and plasticizers in human placenta in Eastern China

(2016) Jinjian Ding et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Tipping the Balance: Hepatotoxicity and the 4 Apical Key Events of Hepatic Steatosis

(2016) Michelle M. Angrish et al.   TOXICOLOGICAL SCIENCES

Brominated flame retardants, hexabromocyclododecane and tetrabromobisphenol A, affect proinflammatory protein expression in human bronchial epithelial cells via disruption of intracellular signaling

(2016) Eiko Koike et al.   TOXICOLOGY IN VITRO

Effects of primary metabolites of organophosphate flame retardants on transcriptional activity via human nuclear receptors

(2016) Hiroyuki Kojima et al.   TOXICOLOGY LETTERS

Mitochondrial DNA from hepatocytes as a ligand for TLR9: Drivers of nonalcoholic steatohepatitis?

(2016) Priya Handa et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Effects of the Commercial Flame Retardant Mixture DE-71 on Cytokine Production by Human Immune Cells

(2016) Thit Mynster Kronborg et al.   PLoS One

TPhP exposure disturbs carbohydrate metabolism, lipid metabolism, and the DNA damage repair system in zebrafish liver

(2016) Zhongkun Du et al.   Scientific Reports

Acute Exposure to Tris(1,3-dichloro-2-propyl) Phosphate (TDCIPP) Causes Hepatic Inflammation and Leads to Hepatotoxicity in Zebrafish

(2016) Chunsheng Liu et al.   Scientific Reports

Environmental exposure to BDE47 is associated with increased diabetes prevalence: Evidence from community-based case-control studies and an animal experiment

(2016) Zhan Zhang et al.   Scientific Reports

Hepatic Deletion of Janus Kinase 2 Counteracts Oxidative Stress in Mice

(2016) Madeleine Themanns et al.   Scientific Reports

Hepatic TLR4 signaling in obese NAFLD

(2015) Torfay Sharifnia et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Hexabromocyclododecane and tetrabromobisphenol A alter secretion of interferon gamma (IFN-γ) from human immune cells

(2015) Haifa Almughamsi et al.   ARCHIVES OF TOXICOLOGY

Adverse Outcome Pathways and Drug-Induced Liver Injury Testing

(2015) Mathieu Vinken   CHEMICAL RESEARCH IN TOXICOLOGY

EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals

(2015) A. C. Gore et al.   ENDOCRINE REVIEWS

Polybrominated Diphenyl Ether Exposure and Thyroid Function Tests in North American Adults

(2015) Colleen M. Makey et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Occurrence and spatial distribution of organophosphate ester flame retardants and plasticizers in 40 rivers draining into the Bohai Sea, north China

(2015) Runmei Wang et al.   ENVIRONMENTAL POLLUTION

Exposure of male mice to two kinds of organophosphate flame retardants (OPFRs) induced oxidative stress and endocrine disruption

(2015) Guanliang Chen et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage

(2015) Anannya Bhattacharya et al.   IMMUNITY

Mitochondria in the Regulation of Innate and Adaptive Immunity

(2015) Samuel E. Weinberg et al.   IMMUNITY

Troxerutin protects against 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47)-induced liver inflammation by attenuating oxidative stress-mediated NAD+-depletion

(2015) Zi-Feng Zhang et al.   JOURNAL OF HAZARDOUS MATERIALS

Thyroid-stimulating hormone regulates hepatic bile acid homeostasis via SREBP-2/HNF-4α/CYP7A1 axis

(2015) Yongfeng Song et al.   JOURNAL OF HEPATOLOGY

Progression from Nonalcoholic Fatty Liver to Nonalcoholic Steatohepatitis Is Marked by a Higher Frequency of Th17 Cells in the Liver and an Increased Th17/Resting Regulatory T Cell Ratio in Peripheral Blood and in the Liver

(2015) Monika Rau et al.   JOURNAL OF IMMUNOLOGY

Down-regulation of miR-144 elicits proinflammatory cytokine production by targeting toll-like receptor 2 in nonalcoholic steatohepatitis of high-fat-diet-induced metabolic syndrome E3 rats

(2015) Dongmin Li et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Guarding the frontiers: the biology of type III interferons

(2015) Andreas Wack et al.   NATURE IMMUNOLOGY

Organophosphorus flame retardants (PFRs) in human breast milk from several Asian countries

(2014) Joon-Woo Kim et al.   CHEMOSPHERE

Exposures, mechanisms, and impacts of endocrine-active flame retardants

(2014) Laura V Dishaw et al.   CURRENT OPINION IN PHARMACOLOGY

Impaired Lipid and Glucose Homeostasis in Hexabromocyclododecane-Exposed Mice Fed a High-Fat Diet

(2014) Rie Yanagisawa et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Urinary Biomonitoring of Phosphate Flame Retardants: Levels in California Adults and Recommendations for Future Studies

(2014) Robin E. Dodson et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Adding to the STING

(2014) Hong-Bing Shu et al.   IMMUNITY

Selected oxidative stress parameters after single and repeated administration of octabromodiphenyl ether to rats

(2014) Elżbieta Bruchajzer et al.   International Journal of Occupational Medicine and Environmental Health

Thyrotropin increases hepatic triglyceride content through upregulation of SREBP-1c activity

(2014) Fang Yan et al.   JOURNAL OF HEPATOLOGY

Cytosolic-DNA-Mediated, STING-Dependent Proinflammatory Gene Induction Necessitates Canonical NF- B Activation through TBK1

(2014) T. Abe et al.   JOURNAL OF VIROLOGY

Thyroid Hormone Regulation of Metabolism

(2014) Rashmi Mullur et al.   PHYSIOLOGICAL REVIEWS

IL-1 Signaling in Obesity-Induced Hepatic Lipogenesis and Steatosis

(2014) Kimberly A. Negrin et al.   PLoS One

Tris(1,3-dichloro-2-propyl) phosphate perturbs the expression of genes involved in immune response and lipid and steroid metabolism in chicken embryos

(2014) Amani Farhat et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Powering the Immune System: Mitochondria in Immune Function and Deficiency

(2014) Melissa A. Walker et al.   Journal of Immunology Research

Regulation of the effects of CYP2E1-induced oxidative stress by JNK signaling

(2014) Jörn M. Schattenberg et al.   Redox Biology

IFN-γ induces lipogenesis in mouse mesangial cells via the JAK2/STAT1 pathway

(2013) Jun Hao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Interferon regulatory factor 7 deficiency prevents diet-induced obesity and insulin resistance

(2013) Xin-An Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

IFN-γ deficiency attenuates hepatic inflammation and fibrosis in a steatohepatitis model induced by a methionine- and choline-deficient high-fat diet

(2013) Xiao-Yu Luo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Insulin Resistance and Environmental Pollutants: Experimental Evidence and Future Perspectives

(2013) Tine L.M. Hectors et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Immune and inflammatory pathways in NASH

(2013) Michal Ganz et al.   Hepatology International

Linagliptin alleviates hepatic steatosis and inflammation in a mouse model of non-alcoholic steatohepatitis

(2013) Thomas Klein et al.   Medical Molecular Morphology

From NAFLD to NASH to cirrhosis—new insights into disease mechanisms

(2013) Alexander Wree et al.   Nature Reviews Gastroenterology & Hepatology

Associations between brominated flame retardants in house dust and hormone levels in men

(2013) Paula I. Johnson et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Perinatal Exposure to BDE-99 Causes Decreased Protein Levels of Cyclin D1 via GSK3β Activation and Increased ROS Production in Rat Pup Livers

(2013) Jordi Blanco et al.   TOXICOLOGICAL SCIENCES

Mitochondria as a Target of Environmental Toxicants

(2013) Joel N. Meyer et al.   TOXICOLOGICAL SCIENCES

Involvement of reactive oxygen species in brominated diphenyl ether-47-induced inflammatory cytokine release from human extravillous trophoblasts in vitro

(2013) Hae-Ryung Park et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A mechanistic view of polybrominated diphenyl ether (PBDE) developmental neurotoxicity

(2013) Lucio G. Costa et al.   TOXICOLOGY LETTERS

The Scap/SREBP Pathway Is Essential for Developing Diabetic Fatty Liver and Carbohydrate-Induced Hypertriglyceridemia in Animals

(2012) Young-Ah Moon et al.   Cell Metabolism

Phosphorus flame retardants: Properties, production, environmental occurrence, toxicity and analysis

(2012) Ike van der Veen et al.   CHEMOSPHERE

Responses of Mouse Liver to Dechlorane Plus Exposure by Integrative Transcriptomic and Metabonomic Studies

(2012) Bing Wu et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Putative Mechanisms of Environmental Chemical–Induced Steatosis

(2012) J. Phillip Kaiser et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

Accumulation and Endocrine Disrupting Effects of the Flame Retardant Mixture Firemaster®550 in Rats: An Exploratory Assessment

(2012) Heather B. Patisaul et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Hepatocyte-specific Deletion of Janus Kinase 2 (JAK2) Protects against Diet-induced Steatohepatitis and Glucose Intolerance

(2012) Sally Yu Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of Innate Cells Is Coupled to a Th1-Polarized Immune Response in Pediatric Nonalcoholic Steatohepatitis

(2012) Nazarena E. Ferreyra Solari et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Characterization of Polybrominated Diphenyl Ether Toxicity in Wistar Han Rats and Use of Liver Microarray Data for Predicting Disease Susceptibilities

(2012) J. K. Dunnick et al.   TOXICOLOGIC PATHOLOGY

Toxicant-associated Steatohepatitis

(2012) Banrida Wahlang et al.   TOXICOLOGIC PATHOLOGY

Both type I and II IFN induce insulin resistance by inducing different isoforms of SOCS expression in 3T3-L1 adipocytes

(2011) Tsutomu Wada et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Interleukin-17 exacerbates hepatic steatosis and inflammation in non-alcoholic fatty liver disease

(2011) Y. Tang et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Toxicologic and immunologic effects of perinatal exposure to the brominated diphenyl ether (BDE) mixture DE-71 in the Sprague-Dawley rat

(2011) Genevieve S. Bondy et al.   ENVIRONMENTAL TOXICOLOGY

The mechanistic basis for the induction of hepatic steatosis by xenobiotics

(2011) David E Amacher   Expert Opinion on Drug Metabolism & Toxicology

Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2

(2011) Brandon C. Sos et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatic FXR: key regulator of whole-body energy metabolism

(2011) João Soeiro Teodoro et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Increased expression of cytochrome P450 2E1 in nonalcoholic fatty liver disease: Mechanisms and pathophysiological role

(2011) J. Aubert et al.   Clinics and Research in Hepatology and Gastroenterology

Significantly Higher Polybrominated Diphenyl Ether Levels in Young U.S. Children than in Their Mothers

(2010) Sonya Lunder et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Indoor Contamination with Hexabromocyclododecanes, Polybrominated Diphenyl Ethers, and Perfluoroalkyl Compounds: An Important Exposure Pathway for People?

(2010) Stuart Harrad et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Oxidative stress and the etiology of insulin resistance and type 2 diabetes

(2010) Erik J. Henriksen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

(2010) Herbert Tilg et al.   HEPATOLOGY

The effect of short-term intoxication of rats with pentabromodiphenyl ether (in mixture mimic commercial products)

(2010) Elżbieta Bruchajzer et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Anabolic-androgenic steroids: a possible new risk factor of toxicant-associated fatty liver disease

(2010) Paulo Adriano Schwingel et al.   LIVER INTERNATIONAL

Toxic effect of PBDE-47 on thyroid development, learning, and memory, and the interaction between PBDE-47 and PCB153 that enhances toxicity in rats

(2010) Ping He et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

Toxicity of penta- and decabromodiphenyl ethers after repeated administration to rats: a comparative study

(2009) Elżbieta Bruchajzer et al.   ARCHIVES OF TOXICOLOGY

Depletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance

(2009) W. Huang et al.   DIABETES

Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement

(2009) Evanthia Diamanti-Kandarakis et al.   ENDOCRINE REVIEWS

Polybrominated Diphenyl Ethers Induce Developmental Neurotoxicity in a Human in Vitro Model: Evidence for Endocrine Disruption

(2009) Timm Schreiber et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Global Gene Expression Analysis in the Livers of Rat Offspring Perinatally Exposed to Low Doses of 2,2′,4,4′-Tetrabromodiphenyl Ether

(2009) Alexander Suvorov et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Respiratory and Dermal Exposure to Organophosphorus Flame Retardants and Tetrabromobisphenol A at Five Work Environments

(2009) Maija S. E. Mäkinen et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Immature myeloid cells induced by a high-fat diet contribute to liver inflammation

(2009) Zhong-bin Deng et al.   HEPATOLOGY

Kupffer cells promote hepatic steatosis via interleukin-1β-dependent suppression of peroxisome proliferator-activated receptor α activity

(2009) Rinke Stienstra et al.   HEPATOLOGY

Toxicant-associated steatohepatitis in vinyl chloride workers

(2009) Matt Cave et al.   HEPATOLOGY

The role of interleukins in insulin resistance and type 2 diabetes mellitus

(2009) Bruno Fève et al.   Nature Reviews Endocrinology

Technical pentabromodiphenyl ether and hexabromocyclododecane as activators of the pregnane-X-receptor (PXR)

(2009) Yvonne Fery et al.   TOXICOLOGY

Thyroid hormone crosstalk with nuclear receptor signaling in metabolic regulation

(2009) Yan-Yun Liu et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Selective versus Total Insulin Resistance: A Pathogenic Paradox

(2008) Michael S. Brown et al.   Cell Metabolism

Association of Brominated Flame Retardants With Diabetes and Metabolic Syndrome in the U.S. Population, 2003-2004

(2008) J.-S. Lim et al.   DIABETES CARE

Hormone Disruption by PBDEs in Adult Male Sport Fish Consumers

(2008) Mary E. Turyk et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Birth Delivery Mode Modifies the Associations between Prenatal Polychlorinated Biphenyl (PCB) and Polybrominated Diphenyl Ether (PBDE) and Neonatal Thyroid Hormone Levels

(2008) Julie B. Herbstman et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Effects of decabrominated diphenyl ether (DBDE) on developmental immunotoxicity in offspring mice

(2008) Wataru Watanabe et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Characterization of liver toxicity in F344/N rats and B6C3F1 mice after exposure to a flame retardant containing lower molecular weight polybrominated diphenyl ethers

(2008) June K. Dunnick et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE

Effects of Perinatal PBDE Exposure on Hepatic Phase I, Phase II, Phase III, and Deiodinase 1 Gene Expression Involved in Thyroid Hormone Metabolism in Male Rat Pups

(2008) David T. Szabo et al.   TOXICOLOGICAL SCIENCES

Nonalcoholic fatty liver disease and mitochondrial dysfunction

(2008) Yongzhong Wei et al.   WORLD JOURNAL OF GASTROENTEROLOGY

A 28-day oral dose toxicity study enhanced to detect endocrine effects of a purified technical pentabromodiphenyl ether (pentaBDE) mixture in Wistar rats

(2007) Leo T.M. van der Ven et al.   TOXICOLOGY