Powering the Immune System: Mitochondria in Immune Function and Deficiency

Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development

(2014) David O’Sullivan et al.   IMMUNITY

Glucose-dependentde NovoLipogenesis in B Lymphocytes

(2014) Fay J. Dufort et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulator of Fatty Acid Metabolism, Acetyl Coenzyme A Carboxylase 1, Controls T Cell Immunity

(2014) J. Lee et al.   JOURNAL OF IMMUNOLOGY

Metabolic Reprogramming Is Required for Antibody Production That Is Suppressed in Anergic but Exaggerated in Chronically BAFF-Exposed B Cells

(2014) A. Caro-Maldonado et al.   JOURNAL OF IMMUNOLOGY

Nucleotide signalling during inflammation

(2014) Marco Idzko et al.   NATURE

Predisposition to infection and SIRS in mitochondrial disorders: 8 years' experience in an academic center

(2014) Melissa A. Walker et al.   Journal of Allergy and Clinical Immunology-In Practice

Barth syndrome

(2013) John L. Jefferies   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

Metabolic Regulation of T Lymphocytes

(2013) Nancie J. MacIver et al.   Annual Review of Immunology

Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function

(2013) Madhusudhanan Sukumar et al.   JOURNAL OF CLINICAL INVESTIGATION

Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells

(2013) Zhen Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Association of a Genetic Variant of Carnitine Palmitoyltransferase 1A with Infections in Alaska Native Children

(2013) Bradford D. Gessner et al.   JOURNAL OF PEDIATRICS

Steroid hormone synthesis in mitochondria

(2013) Walter L. Miller   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch

(2013) Patrick M Gubser et al.   NATURE IMMUNOLOGY

CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability

(2013) G. J. W. van der Windt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fueling Immunity: Insights into Metabolism and Lymphocyte Function

(2013) E. L. Pearce et al.   SCIENCE

Dependence of Immunoglobulin Class Switch Recombination in B Cells on Vesicular Release of ATP and CD73 Ectonucleotidase Activity

(2013) Francesca Schena et al.   Cell Reports

Heme metabolism and erythropoiesis

(2012) Jacky Chung et al.   CURRENT OPINION IN HEMATOLOGY

Metabolic switching and fuel choice during T-cell differentiation and memory development

(2012) Gerritje J. W. Windt et al.   IMMUNOLOGICAL REVIEWS

First reported case of Omenn syndrome in a patient with reticular dysgenesis

(2012) Lauren A. Henderson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mitochondrial disorders as windows into an ancient organelle

(2012) Scott B. Vafai et al.   NATURE

Mitochondria: master regulators of danger signalling

(2012) Lorenzo Galluzzi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Monogenic Mitochondrial Disorders

(2012) Werner J.H. Koopman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prospective study on central venous line associated bloodstream infections

(2011) M. Wagner et al.   ARCHIVES OF DISEASE IN CHILDHOOD

Clinical and genetic spectrum of mitochondrial neurogastrointestinal encephalomyopathy

(2011) Caterina Garone et al.   BRAIN

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

(2011) Eric V. Dang et al.   CELL

MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response

(2011) Fajian Hou et al.   CELL

Mitochondria: commanders of innate immunity and disease?

(2011) Suzanne M Cloonan et al.   CURRENT OPINION IN IMMUNOLOGY

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development

(2011) Gerritje J.W. van der Windt et al.   IMMUNITY

Reduced thymic output, cell cycle abnormalities, and increased apoptosis of T lymphocytes in patients with cartilage-hair hypoplasia

(2011) Miguel A. de la Fuente et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

(2011) R. D. Michalek et al.   JOURNAL OF IMMUNOLOGY

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

(2011) A. Phillip West et al.   NATURE

Estrogen-related receptor-  is a metabolic regulator of effector T-cell activation and differentiation

(2011) R. D. Michalek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATP Inhibits the Generation and Function of Regulatory T Cells Through the Activation of Purinergic P2X Receptors

(2011) U. Schenk et al.   Science Signaling

Pannexin-1 hemichannel-mediated ATP release together with P2X1 and P2X4 receptors regulate T-cell activation at the immune synapse

(2010) T. Woehrle et al.   BLOOD

Tom70 imports antiviral immunity to the mitochondria

(2010) Rongtuan Lin et al.   CELL RESEARCH

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Autocrine regulation of T-cell activation by ATP release and P2X7 receptors

(2009) Linda Yip et al.   FASEB JOURNAL

An N-terminal addressing sequence targets NLRX1 to the mitochondrial matrix

(2009) D. Arnoult et al.   JOURNAL OF CELL SCIENCE

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

(2009) Erika L. Pearce et al.   NATURE

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Nucleotide- and nucleoside-converting ectoenzymes: Important modulators of purinergic signalling cascade

(2008) Gennady G. Yegutkin   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology

(2008) David J. Pagliarini et al.   CELL

NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-κB and JNK pathways by inducing reactive oxygen species production

(2008) Ivan Tattoli et al.   EMBO REPORTS

Phagocyte-specific S100 proteins are released from affected mucosa and promote immune responses during inflammatory bowel disease

(2008) D Foell et al.   JOURNAL OF PATHOLOGY

NLRX1 is a regulator of mitochondrial antiviral immunity

(2008) Chris B. Moore et al.   NATURE

Large-scale chemical dissection of mitochondrial function

(2008) Bridget K Wagner et al.   NATURE BIOTECHNOLOGY

Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness

(2008) Chantal Lagresle-Peyrou et al.   NATURE GENETICS

Purinergic Control of T Cell Activation by ATP Released Through Pannexin-1 Hemichannels

(2008) U. Schenk et al.   Science Signaling