Overexpression of pregnane X and glucocorticoid receptors and the regulation of cytochrome P450 in human epileptic brain endothelial cells

Pathophysiological implications of neurovascular P450 in brain disorders

(2016) Chaitali Ghosh et al.   DRUG DISCOVERY TODAY

Lack of CAR impacts neuronal function and cerebrovascular integrity in vivo

(2016) Baddreddine Boussadia et al.   EXPERIMENTAL NEUROLOGY

Sertraline-induced potentiation of the CYP3A4-dependent neurotoxicity of carbamazepine: An in vitro study

(2015) Chaitali Ghosh et al.   EPILEPSIA

Pregnane X Receptor (PXR) at the Crossroads of Human Metabolism and Disease

(2013) Ioannis Koutsounas et al.   CURRENT DRUG METABOLISM

Expression and functional relevance of UGT1A4 in a cohort of human drug-resistant epileptic brains

(2013) Chaitali Ghosh et al.   EPILEPSIA

Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation

(2013) Ulrich M. Zanger et al.   PHARMACOLOGY & THERAPEUTICS

Polymorphic Cytochrome P450 Enzymes (CYPs) and Their Role in Personalized Therapy

(2013) Sarah C. Preissner et al.   PLoS One

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

(2012) Weiwei Yang et al.   NATURE CELL BIOLOGY

A pro-convulsive carbamazepine metabolite: Quinolinic acid in drug resistant epileptic human brain

(2012) Chaitali Ghosh et al.   NEUROBIOLOGY OF DISEASE

Cellular localization and functional significance of CYP3A4 in the human epileptic brain

(2011) Chaitali Ghosh et al.   EPILEPSIA

Regulation of P-glycoprotein by orphan nuclear receptors in human brain microvessel endothelial cells

(2011) Gary N. Y. Chan et al.   JOURNAL OF NEUROCHEMISTRY

Quantitative Prediction of Human Pregnane X Receptor and Cytochrome P450 3A4 Mediated Drug-Drug Interaction in a Novel Multiple Humanized Mouse Line

(2011) M. Hasegawa et al.   MOLECULAR PHARMACOLOGY

Pattern of P450 expression at the human blood-brain barrier: Roles of epileptic condition and laminar flow

(2010) Chaitali Ghosh et al.   EPILEPSIA

Aryl hydrocarbon receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrier

(2010) Xueqian Wang et al.   FASEB JOURNAL

Regulation of ABC Transporters at the Blood-Brain Barrier: New Targets for CNS Therapy

(2010) A. M. S. Hartz et al.   MOLECULAR INTERVENTIONS

Constitutive Androstane Receptor-Mediated Up-Regulation of ATP-Driven Xenobiotic Efflux Transporters at the Blood-Brain Barrier

(2010) X. Wang et al.   MOLECULAR PHARMACOLOGY

Genetic Polymorphism of Metabolic Enzymes P450 (CYP) as a Susceptibility Factor for Drug Response, Toxicity, and Cancer Risk

(2009) Nada Božina et al.   Arhiv za Higijenu Rada i Toksikologiju-Archives of Industrial Hygiene and Toxicology

Transporters in Drug-Refractory Epilepsy: Clinical Significance

(2009) N Marchi et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Polymorphism of human cytochrome P450 enzymes and its clinical impact

(2009) Shu-Feng Zhou et al.   DRUG METABOLISM REVIEWS

Management of the patient with medically refractory epilepsy

(2009) Tiziana Granata et al.   Expert Review of Neurotherapeutics

ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood-brain barrier

(2008) Sandrine Dauchy et al.   JOURNAL OF NEUROCHEMISTRY

Phthalate Induction of CYP3A4 is Dependent on Glucocorticoid Regulation of PXR Expression

(2008) Beth W. Cooper et al.   TOXICOLOGICAL SCIENCES

The Tangle of Nuclear Receptors that Controls Xenobiotic Metabolism and Transport: Crosstalk and Consequences

(2007) Jean-Marc Pascussi et al.   Annual Review of Pharmacology and Toxicology

Xenoreceptors CAR and PXR Activation and Consequences on Lipid Metabolism, Glucose Homeostasis, and Inflammatory Response

(2007) Amélie Moreau et al.   MOLECULAR PHARMACEUTICS