Prioritization of hazards of novel flame retardants using the mechanistic toxicology information from ToxCast and Adverse Outcome Pathways

Tetrabromobisphenol A caused neurodevelopmental toxicity via disrupting thyroid hormones in zebrafish larvae

(2018) Biran Zhu et al.   CHEMOSPHERE

Paternal urinary concentrations of organophosphate flame retardant metabolites, fertility measures, and pregnancy outcomes among couples undergoing in vitro fertilization

(2018) Courtney C. Carignan et al.   ENVIRONMENT INTERNATIONAL

Neonatal triphenyl phosphate and its metabolite diphenyl phosphate exposure induce sex- and dose-dependent metabolic disruptions in adult mice

(2018) Dezhen Wang et al.   ENVIRONMENTAL POLLUTION

Mixed “Antiandrogenic” Chemicals at Low Individual Doses Produce Reproductive Tract Malformations in the Male Rat

(2018) Justin M Conley et al.   TOXICOLOGICAL SCIENCES

Organophosphate triesters and selected metabolites enhance binding of thyroxine to human transthyretin in vitro

(2018) Katie L. Hill et al.   TOXICOLOGY LETTERS

Recent biomonitoring reports on phosphate ester flame retardants: a short review

(2018) Anne-Marie Saillenfait et al.   ARCHIVES OF TOXICOLOGY

Cross-sectional study of social behaviors in preschool children and exposure to flame retardants

(2017) Shannon T. Lipscomb et al.   Environmental Health

Variability and predictors of urinary concentrations of organophosphate flame retardant metabolites among pregnant women in Rhode Island

(2017) Megan E. Romano et al.   Environmental Health

Adipogenic Effects and Gene Expression Profiling of Firemaster® 550 Components in Human Primary Preadipocytes

(2017) Emily W.Y. Tung et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

High dose tetrabromobisphenol A impairs hippocampal neurogenesis and memory retention

(2017) Ah Hyun Kim et al.   FOOD AND CHEMICAL TOXICOLOGY

Exposure to endocrine disrupting chemicals perturbs lipid metabolism and circadian rhythms

(2017) Renate Kopp et al.   JOURNAL OF ENVIRONMENTAL SCIENCES

PXR: More Than Just a Master Xenobiotic Receptor

(2017) Peter O. Oladimeji et al.   MOLECULAR PHARMACOLOGY

Triphenyl phosphate enhances adipogenic differentiation, glucose uptake and lipolysis via endocrine and noradrenergic mechanisms

(2017) German Cano-Sancho et al.   TOXICOLOGY IN VITRO

Development of an analytical method to quantify PBDEs, OH-BDEs, HBCDs, 2,4,6-TBP, EH-TBB, and BEH-TEBP in human serum

(2016) Craig M. Butt et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

A Review of Organophosphate Esters in the Environment from Biological Effects to Distribution and Fate

(2016) Alana K. Greaves et al.   BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY

Novel brominated flame retardants in food composites and human milk from the Chinese Total Diet Study in 2011: Concentrations and a dietary exposure assessment

(2016) Zhixiong Shi et al.   ENVIRONMENT INTERNATIONAL

Concentrations of polybrominated diphenyl ethers (PBDEs) and 2,4,6-tribromophenol in human placental tissues

(2016) Christopher Leonetti et al.   ENVIRONMENT INTERNATIONAL

Consumer Product Chemicals in Indoor Dust: A Quantitative Meta-analysis of U.S. Studies

(2016) Susanna D. Mitro et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Subchronic toxicology of tetrabromobisphenol A in rats

(2016) Thomas G Osimitz et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Whole-body aerosol exposure of cadmium chloride (CdCl 2 ) and tetrabromobisphenol A (TBBPA) induced hepatic changes in CD-1 male mice

(2016) Yuanhong Chen et al.   JOURNAL OF HAZARDOUS MATERIALS

Using ToxCast to Explore Chemical Activities and Hazard Traits: A Case Study WithOrtho-Phthalates

(2016) Nathalie Pham et al.   TOXICOLOGICAL SCIENCES

Editor's Highlight: Analysis of the Effects of Cell Stress and Cytotoxicity onIn VitroAssay Activity Across a Diverse Chemical and Assay Space

(2016) Richard Judson et al.   TOXICOLOGICAL SCIENCES

TBECH, 1,2-dibromo-4-(1,2 dibromoethyl) cyclohexane, alters androgen receptor regulation in response to mutations associated with prostate cancer

(2016) Joubert Banjop Kharlyngdoh et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Effects of primary metabolites of organophosphate flame retardants on transcriptional activity via human nuclear receptors

(2016) Hiroyuki Kojima et al.   TOXICOLOGY LETTERS

A brief history of the discovery of PXR and CAR as xenobiotic receptors

(2016) Jiong Yan et al.   Acta Pharmaceutica Sinica B

TPhP exposure disturbs carbohydrate metabolism, lipid metabolism, and the DNA damage repair system in zebrafish liver

(2016) Zhongkun Du et al.   Scientific Reports

Aryl organophosphate flame retardants induced cardiotoxicity during zebrafish embryogenesis: By disturbing expression of the transcriptional regulators

(2015) Zhongkun Du et al.   AQUATIC TOXICOLOGY

A Comparison of ToxCast Test Results with In Vivo and Other In Vitro Endpoints for Neuro, Endocrine, and Developmental Toxicities: A Case Study Using Endosulfan and Methidathion

(2015) M. Silva et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

Organophosphorus flame retardants and plasticizers: Sources, occurrence, toxicity and human exposure

(2015) Gao-Ling Wei et al.   ENVIRONMENTAL POLLUTION

Environmentally Relevant Concentrations of the Flame Retardant Tris(1,3-dichloro-2-propyl) Phosphate Inhibit Growth of Female Zebrafish and Decrease Fecundity

(2015) Ya Zhu et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Exposure of male mice to two kinds of organophosphate flame retardants (OPFRs) induced oxidative stress and endocrine disruption

(2015) Guanliang Chen et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Acute and developmental behavioral effects of flame retardants and related chemicals in zebrafish

(2015) Kimberly A. Jarema et al.   NEUROTOXICOLOGY AND TERATOLOGY

Use of alternative assays to identify and prioritize organophosphorus flame retardants for potential developmental and neurotoxicity

(2015) Mamta Behl et al.   NEUROTOXICOLOGY AND TERATOLOGY

Advanced Morphological — Behavioral Test Platform Reveals Neurodevelopmental Defects in Embryonic Zebrafish Exposed to Comprehensive Suite of Halogenated and Organophosphate Flame Retardants

(2015) Pamela D. Noyes et al.   TOXICOLOGICAL SCIENCES

The changing landscape in translocator protein (TSPO) function

(2015) Vimal Selvaraj et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Organophosphorus Flame Retardants Inhibit Specific Liver Carboxylesterases and Cause Serum Hypertriglyceridemia

(2014) Patrick J. Morris et al.   ACS Chemical Biology

Ligand Binding and Activation of PPAR γ by Firemaster ® 550: Effects on Adipogenesis and Osteogenesis in Vitro

(2014) Hari K. Pillai et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Urinary Biomonitoring of Phosphate Flame Retardants: Levels in California Adults and Recommendations for Future Studies

(2014) Robin E. Dodson et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Halogenated Bisphenol-A Analogs Act as Obesogens in Zebrafish Larvae (Danio rerio)

(2014) Anne Riu et al.   TOXICOLOGICAL SCIENCES

The brominated flame retardant TBECH activates the zebrafish (Danio rerio) androgen receptor, alters gene transcription and causes developmental disturbances

(2013) Ajay Pradhan et al.   AQUATIC TOXICOLOGY

PXR Ablation Alleviates Diet-Induced and Genetic Obesity and Insulin Resistance in Mice

(2013) J. He et al.   DIABETES

1,2-dibromo-4-(1,2 dibromoethyl) cyclohexane (TBECH)-mediated steroid hormone receptor activation and gene regulation in chicken LMH cells

(2013) Solomon Asnake et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Role of Pregnane X Receptor in Obesity and Glucose Homeostasis in Male Mice

(2013) Krisstonia Spruiell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vitro endocrine disruption potential of organophosphate flame retardants via human nuclear receptors

(2013) Hiroyuki Kojima et al.   TOXICOLOGY

Phosphorus flame retardants: Properties, production, environmental occurrence, toxicity and analysis

(2012) Ike van der Veen et al.   CHEMOSPHERE

Early Zebrafish Embryogenesis Is Susceptible to Developmental TDCPP Exposure

(2012) Sean P. McGee et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Effect of tetrabrombisphenol A on induction of apoptosis in the testes and changes in expression of selected testicular genes in CD1 mice

(2012) Eva Zatecka et al.   REPRODUCTIVE TOXICOLOGY

Peroxisome Proliferator-Activated Receptor γ Is a Target for Halogenated Analogs of Bisphenol A

(2011) Anne Riu et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Novel brominated flame retardants: A review of their analysis, environmental fate and behaviour

(2010) Adrian Covaci et al.   ENVIRONMENT INTERNATIONAL

Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

(2010) Gerald T. Ankley et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Diastereomers of the Brominated Flame Retardant 1,2-Dibromo-4-(1,2 dibromoethyl)cyclohexane Induce Androgen Receptor Activation in the HepG2 Hepatocellular Carcinoma Cell Line and the LNCaP Prostate Cancer Cell Line

(2009) Hazem Khalaf et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

In Vitro Screening of Environmental Chemicals for Targeted Testing Prioritization: The ToxCast Project

(2009) Richard S. Judson et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

House Dust Concentrations of Organophosphate Flame Retardants in Relation to Hormone Levels and Semen Quality Parameters

(2009) John D. Meeker et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Neurobehavioral effects of tetrabromobisphenol A, a brominated flame retardant, in mice

(2009) Akira Nakajima et al.   TOXICOLOGY LETTERS