Article
Immunology
Huijuan Ma, Qi Shu, Zhiming Li, Xiaodong Song, Huan Xu
Summary: Formaldehyde exacerbates inflammatory responses in allergic contact dermatitis by facilitating NLRP3 inflammasome activation in macrophages. These findings not only demonstrate that formaldehyde can aggravate inflammatory responses by promoting NLRP3 inflammasome activation in macrophages, but also suggest that NLRP3 may be a therapeutic target for alleviating formaldehyde-induced inflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Krunoslav Ilic, Nikolina Kalcec, Lucija Krce, Ivica Aviani, Petra Turcic, Ivan Pavicic, Ivana Vinkovic Vrcek
Summary: The use of nano-enabled products has many benefits, but it also raises concerns about the release of nanoparticles into the environment. This study evaluated the combined effect of silver (AgNP) and polystyrene nanoparticles (PSNP) on human macrophages, and the results showed increased negative effects such as apoptosis, oxidative stress, and mitochondrial dysfunction when the two types of nanoparticles were combined.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Review
Immunology
Stefan Schuelke, Stefanie Gilles, Adan C. Jirmo, Johannes U. Mayer
Summary: Antigen-presenting cells (APCs) play a critical role in bridging innate and adaptive immune responses by presenting antigens to T cells. In allergies, APCs drive immune responses against harmless antigens. Different types of APCs contribute differently to tissue-specific immune tolerance, allergen sensitization, and allergic inflammation.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Infectious Diseases
Dumizulu Tembo, Visopo Harawa, Tam C. Tran, Louise Afran, Malcolm E. Molyneux, Terrie E. Taylor, Karl B. Seydel, Tonney Nyirenda, David G. Russell, Wilson Mandala
Summary: Pro-inflammatory cytokines are increased during severe malaria, but IL-10 can suppress excessive inflammation. Acute cerebral malaria is characterized by elevated plasma levels of pro-inflammatory cytokines, which normalize during convalescence.
Article
Pharmacology & Pharmacy
Huiling Chen, Yanchao Zhang, Xing Li, Wei Zhang, Haoqi He, Bohai Du, Tianlan Li, Huanwen Tang, Yungang Liu, Li Li, Ming Shi
Summary: This study explores the in vitro toxicity of BPF on RAW264.7 macrophages. The results showed that a high concentration of BPF significantly reduced the survival rate of the macrophages, while a medium concentration caused apoptosis. Differential transcription analysis revealed changes in gene expression related to cell cycle, phagosome, lysosome, and antigen processing and presentation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemical Research Methods
Mahmoud Elsabahy, Karen L. Wooley, Amy Hendricksen, Kenneth Oh
Summary: A robust data mining algorithm is presented as a critical solution to managing data from multiplexing techniques, allowing simultaneous detection of multiple biomarkers in a single sample. This algorithm has been successfully applied as a diagnostic and therapeutic monitoring tool in managing breast cancer.
Article
Environmental Sciences
Ping Zhang, Yandi Li, Wenping Xu, Jiagao Cheng, Cheng Zhang, Jufang Gao, Zhong Li, Liming Tao, Yang Zhang
Summary: Ivermectin is widely used as a biopesticide in animal husbandry and agriculture, but its immunotoxicity has received little attention. Research shows that Ivermectin can induce immunotoxicity through the induction of cytotoxicity and immune dysfunction.
Review
Oncology
Geetha Shanmugam, Sumana Das, Sambuddha Paul, Sudeshna Rakshit, Koustav Sarkar
Summary: Lung cancer remains the leading cause of death globally, with poor survival rates for advanced-stage patients. Understanding immune cells is crucial for utilizing immune response mechanisms in lung cancer treatment. Professional antigen-presenting cells like dendritic cells and tumor-associated macrophages are being extensively studied for immunotherapy in lung cancer.
Article
Food Science & Technology
Jian Wu, Jian Ding, Yi Shi, Yong Fang, Peng Li, Fengjiao Fan, Ermin Zhao, Xinyang Sun, Xinchun Shen, Qiuhui Hu
Summary: Previous studies have shown that Selenium-enriched rice protein hydrolysates (SPHs) can alleviate Pb2+-induced apoptosis in RAW264.7 macrophages. The current study indicates that SPHs-2 effectively attenuate inflammatory response and inhibit the immunotoxicity of Pb2+ on RAW264.7 macrophages via regulating NF-kappa B/MAPK signaling pathways.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sara Coletta, Greta Battaggia, Chiara Della Bella, Matteo Furlani, Martina Hauke, Larissa Faass, Mario M. D'Elios, Christine Josenhans, Marina de Bernard
Summary: Helicobacter pylori persists in the human gastric mucosa by compromising the antigen presentation ability of macrophages through the utilization of ADP-heptose, which ultimately allows the bacterium to establish its survival niche despite the immune defense in the gastric mucosa.
Review
Engineering, Biomedical
Doudou Hu, Wei Zhang, Jianbin Tang, Zhuxian Zhou, Xiangrui Liu, Youqing Shen
Summary: Breakthroughs in molecular mechanisms underlying immune-suppressive tumor microenvironment and paradigm shifts in cancer-immunity response cycle have changed cancer immunotherapy landscape. Addressing serious side effects from systemic autoimmunity and autoinflammatory responses is a challenge, with bioengineering and delivery technologies providing potential solutions. Developing immunotoxicity-related animal models is also deemed significant.
Article
Chemistry, Medicinal
Nimsi Campos-Xolalpa, Ana Laura Esquivel-Campos, Rubria Marlen Martinez-Casares, Salud Perez-Gutierrez, Julia Perez-Ramos, Ernesto Sanchez-Mendoza
Summary: The study found that piquerol isolated from Piqueria trinervia has anti-inflammatory activity, can reduce ear edema and act by inhibiting pro-inflammatory mediators. Piquerol also has a protective effect on erythrocyte membrane.
Article
Environmental Sciences
Tingting Wei, Ting Zhang, Meng Tang
Summary: This review summarizes the immunotoxic effects caused by quantum dots (QDs) and their underlying mechanisms. It highlights the modulation of immune cell maturation and differentiation by QDs, as well as the variations in cytokines and activation of the complement system. Furthermore, it discusses how QDs disrupt the immune response through regulating oxidative stress levels, autophagy formation, and expressions of pro-inflammatory mediators, and highlights the involvement of key signaling pathways.
ENVIRONMENTAL POLLUTION
(2022)
Article
Environmental Sciences
Paolo Cocci, Serena Gabrielli, Genny Pastore, Marco Minicucci, Gilberto Mosconi, Francesco Alessandro Palermo
Summary: There is evidence that microplastic ingestion affects the gastrointestinal tract of marine species. This study investigates the presence of microplastics and their potential immunotoxic effects in the digestive tract of red mullet and European hake. The study finds a positive correlation between microplastic abundance and the expression of proinflammatory cytokines and antioxidant enzymes, suggesting the activation of cytokine-dependent signaling pathways and immune cell infiltration in the gut.
Article
Immunology
Kavita Mathi, Yael Rosenberg-Hasson, Holden Maecker, Dennis J. Carlo, Ronald B. Moss
Summary: Pre-treatment with the antioxidant Tempol significantly decreased cytokine secretion from activated peripheral blood cells of both COVID-19 patients and uninfected donors in vitro, suggesting its potential for COVID-19 treatment.
CLINICAL IMMUNOLOGY
(2021)
Article
Food Science & Technology
Lingyan Ma, Aqian Zheng, Liyang Ni, Lianxin Wu, Luting Hu, Yufeng Zhao, Zhengwei Fu, Yinhua Ni
Summary: The longevity-promoting probiotic strain LKM512 shows potential in improving hepatic lipid accumulation, reducing inflammation, and enhancing insulin sensitivity in high-fat diet-induced obese mice. It also has an impact on the composition and function of gut microbiota in these mice.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Review
Geriatrics & Gerontology
Xiaoxian Xie, Ruonan Shu, Chunan Yu, Zhengwei Fu, Zezhi Li
Summary: Mitochondrial dysfunction plays a crucial role in various diseases, and AKT, as a serine/threonine kinase, exerts important roles in cell metabolism and oxidative state regulation through modulating different mechanisms related to mitochondria.
Article
Agriculture, Multidisciplinary
Yinhua Ni, Yating Hu, Xiaoyi Lou, Nianke Rong, Fang Liu, Congrong Yang, Aqian Zheng, Song Yang, Jianfeng Bao, Zhengwei Fu
Summary: Spermidine may improve NASH partly through regulating the THRSP signaling pathway and gut microbiota-mediated bile acid metabolism.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Engineering, Environmental
Xiaoxian Xie, Jiafeng Zhou, Luting Hu, Ruonan Shu, Mengya Zhang, Lei Sun, Fengchun Wu, Zhengwei Fu, Zezhi Li
Summary: This study investigated the toxicological effects of Hexafluoropropylene oxide trimer acid (HFPO-TA) on mitochondrial function and biogenesis. Results showed that exposure to HFPO-TA induced adverse physiological changes in mice and was associated with disrupted mitochondrial energy metabolism.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Oncology
Mingcang Chen, Chunyu Wu, Zhengwei Fu, Sheng Liu
Summary: Bone-related events caused by breast cancer bone metastasis significantly impact patients' survival and quality of life. ICAM1, highly expressed in TNBC, correlates with prognosis in TNBC patients. ICAM1 interacts with integrins to activate signaling pathways, enhancing cell invasiveness, providing a rationale for ICAM1-targeted therapy.
Article
Endocrinology & Metabolism
Yinhua Ni, Fen Zhuge, Liyang Ni, Naoto Nagata, Tatsuya Yamashita, Naofumi Mukaida, Shuichi Kaneko, Tsuguhito Ota, Mayumi Nagashimada
Summary: This study investigates the roles of CX3CL1/CX3CR1 in macrophage migration and polarization in the livers of NASH mice. It is found that CX3CL1 and CX3CR1 expression is upregulated in NASH mice livers, and CX3CR1 is predominantly expressed by F4/80+ macrophages. CX3CR1 deficiency leads to increased inflammatory monocyte/macrophage infiltration and a shift towards M1 dominant macrophages, exacerbating NASH progression. Deletion of CCL2 in CX3CR1-deficient mice alleviates NASH progression by reducing macrophage infiltration and inducing a shift towards M2 dominant macrophages.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Food Science & Technology
Yinhua Ni, Kexin Zhou, Liqian Zhang, Sujie Nan, Zhengwei Fu
Summary: Hydrolyzed chicken meat extract (HCE) and its bioactive components (BC) can enhance phagocytic activity and attenuate oxidative stress in cells. They also affect macrophage activation through the modulation of specific pathways. Therefore, HCE and BC may serve as potential immunoregulatory agents.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Nutrition & Dietetics
Yinhua Ni, Aqian Zheng, Yating Hu, Nianke Rong, Qianpeng Zhang, Wenmin Long, Song Yang, Sujie Nan, Liqian Zhang, Kexin Zhou, Tianxing Wu, Zhengwei Fu
Summary: Dietary intervention with a low glycemic index and full nutritional support, such as the novel compound dietary fiber and high-grade protein diet (CFP), can effectively improve glycemic control, insulin resistance, and diabetes-related metabolic syndromes. CFP treatment enhances gut barrier function and alters gut microbiota composition and function, leading to a wider range of protection against diabetes compared to liraglutide.
FRONTIERS IN NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Yinhua Ni, Liujie Zheng, Sujie Nan, Lehui Ke, Zhengwei Fu, Juan Jin
Summary: The role of gut-kidney crosstalk in the progression of diabetic nephropathy is of increasing concern. Renal dysfunction increases circulating uremic toxins and affects the gut microbiota, while intestinal dysbiosis destroys the epithelial barrier, leading to increased exposure to endotoxins, and exacerbating kidney damage through systemic inflammation. Dietary interventions and novel diabetic agents targeting the gut microbiota may be potential therapies for diabetic nephropathy.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Article
Environmental Sciences
Luting Hu, Lei Sun, Jiafeng Zhou, Fengchun Wu, Zhengwei Fu, Xiaoxian Xie
Summary: HFPO-TA exposure results in imbalances and alterations in gut microbiota, as well as changes in metabolic pathways.
Article
Biochemistry & Molecular Biology
Chunlei Yang, Xiangfei Deng, Linjun Wu, Tianrui Jiang, Zhengwei Fu, Jinjun Li
Summary: This study investigated the efficacy of Morus root bark extract Morusin on ruminal epithelial cells (RECs) against pathogenic stimulus. The results showed that Morusin did not affect cell viability and exerted anti-inflammatory effects in a concentration-dependent manner. Transcriptome analysis revealed the regulation of cell signaling by Morusin, demonstrating its protective role in inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
You Weng, Ting Xu, Caihong Wang, Yuanxiang Jin
Summary: Epoxiconazole, a triazole fungicide widely used in agriculture, has been found to increase health risks and potentially harm mammals. In a study on mice, exposure to EPX resulted in altered liver and colon function, changes in gut microbiota composition, and disruption of lipid metabolism.
Article
Agriculture, Dairy & Animal Science
Chunlei Yang, Xiangfei Deng, Peter Lund, Haixia Liu, Xingwang Ding, Zhengwei Fu, Naifeng Zhang, Jinjun Li, Lifeng Dong
Summary: Developing alternatives to antibiotics for prevention of gastrointestinal dysbiosis in early-weaning farmed animals is urgently needed. This study explored the potential effects of trans-10, cis-12 conjugated linoleic acid (CLA) on maintaining ruminal homeostasis of young ruminants during the weaning transition period. Results showed that CLA supplementation enhanced the ruminal microbiota-driven transcriptional regulation and alleviated early-weaning stress in young ruminants.
Article
Environmental Sciences
Xiaofang Wang, Lingyu Hu, Caiyun Wang, Bingnan He, Zhengwei Fu, Cuiyuan Jin, Yuanxiang Jin
Summary: A recent study found that pregnant women had high levels of IMZ due to dietary exposure. In a mouse experiment, exposure to IMZ during gestation and lactation periods resulted in significant changes in growth phenotypes, carnitine levels, and gut microbiota in the offspring. Maternal IMZ exposure also affected carnitine absorption and disrupted gut microbiota balance.
Article
Materials Science, Biomaterials
Qinglian Hu, Chao He, Zhuoting Lu, Ying He, Hui Xie, Jingyu Li, Zhengwei Fu, Bing Guo
Summary: Sub-cellular targeted mild photothermal therapy (PTT) has the potential to improve therapeutic efficacy and minimize damage to healthy tissues. Mitochondria-targeted nanoparticles (M-TD1 NPs) constructed using small organic molecules (TD1) exhibit excellent photothermal performance, leading to apoptosis and autophagy of cancer cells, thus achieving antitumor and metastasis inhibition effects.
BIOMATERIALS SCIENCE
(2022)
