The Glioblastoma Microenvironment: Morphology, Metabolism, and Molecular Signature of Glial Dynamics to Discover Metabolic Rewiring Sequence

Neurons, Glia, Extracellular Matrix and Neurovascular Unit: A Systems Biology Approach to the Complexity of Synaptic Plasticity in Health and Disease

(2020) Ciro De Luca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Understanding the glioblastoma immune microenvironment as basis for the development of new immunotherapeutic strategies

(2020) Ana Rita Pombo Antunes et al.   eLife

Tumor Cell Invasion in Glioblastoma

(2020) Arabel Vollmann-Zwerenz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glioblastoma hijacks microglial gene expression to support tumor growth

(2020) Sybren L. N. Maas et al.   Journal of Neuroinflammation

Cell-specific metabolomic responses to injury: novel insights into blood-brain barrier modulation

(2020) Sheng-Fu Huang et al.   Scientific Reports

Systems metabolomics: from metabolomic snapshots to design principles

(2020) Chiara Damiani et al.   CURRENT OPINION IN BIOTECHNOLOGY

Intra-Tumor DNA Methylation Heterogeneity in Glioblastoma; Implications for DNA Methylation-Based Classification

(2019) Anna Wenger et al.   NEURO-ONCOLOGY

The Impact of Timing of Concurrent Chemoradiation in Patients With High-Grade Glioma in the Era of the Stupp Protocol

(2019) Kwanza T. Warren et al.   Frontiers in Oncology

Specific Expression of a New Bruton Tyrosine Kinase Isoform (p65BTK) in the Glioblastoma Gemistocytic Histotype

(2019) Luca Sala et al.   Frontiers in Molecular Neuroscience

Radiotherapy resistance acquisition in Glioblastoma. Role of SOCS1 and SOCS3

(2019) Maria Paz Ventero et al.   PLoS One

Targeting cancer cell metabolism in glioblastoma

(2019) Sarah Crunkhorn   NATURE REVIEWS DRUG DISCOVERY

Cell-of-origin susceptibility to glioblastoma formation declines with neural lineage restriction

(2019) Sheila Alcantara Llaguno et al.   NATURE NEUROSCIENCE

Metabolic Reprogramming in Astrocytes Distinguishes Region-Specific Neuronal Susceptibility in Huntington Mice

(2019) Aris A. Polyzos et al.   Cell Metabolism

The oncometabolite 2-hydroxyglutarate inhibits microglial activation via the AMPK/mTOR/NF-κB pathway

(2019) Chao-jun Han et al.   ACTA PHARMACOLOGICA SINICA

Molecular Profiling of the Tumor Microenvironment in glioblastoma patients: correlation of microglia/macrophage polarization state with metalloprotease expression profiles and survival

(2019) Marko Gjorgjevski et al.   BIOSCIENCE REPORTS

Impact of time to initiation of radiotherapy on survival after resection of newly diagnosed glioblastoma

(2019) Sotirios Katsigiannis et al.   Radiation Oncology

RelB acts as a molecular switch driving chronic inflammation in glioblastoma multiforme

(2019) Michael R. Waters et al.   Oncogenesis

Distinct Tumor Microenvironment at Tumor Edge as a Result of Astrocyte Activation Is Associated With Therapeutic Resistance for Brain Tumor

(2019) Chiu-Min Lin et al.   Frontiers in Oncology

Mesenchymal transition and increased therapy resistance of glioblastoma cells is related to astrocyte reactivity

(2019) Mia Niklasson et al.   JOURNAL OF PATHOLOGY

Tumor-associated reactive astrocytes aid the evolution of immunosuppressive environment in glioblastoma

(2019) Dieter Henrik Heiland et al.   Nature Communications

Astrocytes enhance glioblastoma growth

(2019) Alessandro Mega et al.   GLIA

Electrical and synaptic integration of glioma into neural circuits

(2019) Humsa S. Venkatesh et al.   NATURE

Glutamatergic synaptic input to glioma cells drives brain tumour progression

(2019) Varun Venkataramani et al.   NATURE

Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration

(2019) Amit U. Joshi et al.   NATURE NEUROSCIENCE

Astrogliosis Releases Pro-Oncogenic Chitinase 3-Like 1 Causing MAPK Signaling in Glioblastoma

(2019) Julian Wurm et al.   Cancers

Localized metabolomic gradients in patient-derived xenograft models of glioblastoma

(2019) Elizabeth C Randall et al.   CANCER RESEARCH

Pre-Clinical Drug Testing in 2D and 3D Human In Vitro Models of Glioblastoma Incorporating Non-Neoplastic Astrocytes: Tunneling Nano Tubules and Mitochondrial Transfer Modulates Cell Behavior and Therapeutic Respons

(2019) Prospero Civita et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Phospho-mTOR expression in human glioblastoma microglia-macrophage cells

(2019) Lucia Lisi et al.   NEUROCHEMISTRY INTERNATIONAL

Metabolic landscape of the tumor microenvironment at single cell resolution

(2019) Zhengtao Xiao et al.   Nature Communications

Capture at the single cell level of metabolic modules distinguishing aggressive and indolent glioblastoma cells

(2019) Mirca S. Saurty-Seerunghen et al.   Acta Neuropathologica Communications

Reciprocal Signaling between Glioblastoma Stem Cells and Differentiated Tumor Cells Promotes Malignant Progression

(2018) Xiuxing Wang et al.   Cell Stem Cell

When Immune Cells Turn Bad—Tumor-Associated Microglia/Macrophages in Glioma

(2018) Saskia Roesch et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondria: A master regulator in macrophage and T cell immunity

(2018) Pu-Ste Liu et al.   MITOCHONDRION

WHO 2016 Classification of gliomas

(2018) P. Wesseling et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

C6 glioma-derived microvesicles stimulate the proliferative and metastatic gene expression of normal astrocytes

(2018) Behnaz Taheri et al.   NEUROSCIENCE LETTERS

Microglia/Astrocytes–Glioblastoma Crosstalk: Crucial Molecular Mechanisms and Microenvironmental Factors

(2018) Diana Matias et al.   Frontiers in Cellular Neuroscience

Chemoresistance caused by the microenvironment of glioblastoma and the corresponding solutions

(2018) Xin Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Osteopontin mediates glioblastoma-associated macrophage infiltration and is a potential therapeutic target

(2018) Jun Wei et al.   JOURNAL OF CLINICAL INVESTIGATION

Extracellular Vesicles Released by Glioblastoma Cells Stimulate Normal Astrocytes to Acquire a Tumor-Supportive Phenotype Via p53 and MYC Signaling Pathways

(2018) S. Hallal et al.   MOLECULAR NEUROBIOLOGY

Neuro-Immune Hemostasis: Homeostasis and Diseases in the Central Nervous System

(2018) Ciro De Luca et al.   Frontiers in Cellular Neuroscience

Glioblastoma: Microenvironment and Niche Concept

(2018) Davide Schiffer et al.   Cancers

Regulation of mitochondrial dynamics in astrocytes: Mechanisms, consequences, and unknowns

(2017) Joshua G. Jackson et al.   GLIA

Reactive Astrocytes: Production, Function, and Therapeutic Potential

(2017) Shane A. Liddelow et al.   IMMUNITY

Metabolic Pathways of the Warburg Effect in Health and Disease: Perspectives of Choice, Chain or Chance

(2017) Jorge Burns et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Astrocytic tight junctions control inflammatory CNS lesion pathogenesis

(2017) Sam Horng et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of diverse astrocyte populations and their malignant analogs

(2017) Chia-Ching John Lin et al.   NATURE NEUROSCIENCE

Ultrastructural characterization of the Mitochondria-associated membranes abnormalities in human astrocytomas: Functional and therapeutics implications

(2017) Gabriel Arismendi-Morillo et al.   ULTRASTRUCTURAL PATHOLOGY

The reverse Warburg effect is likely to be an Achilles’ heel of cancer that can be exploited for cancer therapy

(2017) Yaojie Fu et al.   Oncotarget

The Anti-Warburg Effect Elicited by the cAMP-PGC1α Pathway Drives Differentiation of Glioblastoma Cells into Astrocytes

(2017) Fan Xing et al.   Cell Reports

Cerebral Gluconeogenesis and Diseases

(2017) James Yip et al.   Frontiers in Pharmacology

Remodeling the blood–brain barrier microenvironment by natural products for brain tumor therapy

(2017) Xiao Zhao et al.   Acta Pharmaceutica Sinica B

The Warburg effect as an adaptation of cancer cells to rapid fluctuations in energy demand

(2017) Tamir Epstein et al.   PLoS One

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

Evaluation of TgH(CX3CR1-EGFP) mice implanted with mCherry-GL261 cells as an in vivo model for morphometrical analysis of glioma-microglia interaction

(2016) Fernando F. B. Resende et al.   BMC CANCER

Comparing Alzheimer’s and Parkinson’s diseases networks using graph communities structure

(2016) Alberto Calderone et al.   BMC Systems Biology

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

(2016) Vicky Lampropoulou et al.   Cell Metabolism

Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress

(2016) De Huang et al.   CELL RESEARCH

The glial scar is more than just astrocytes

(2016) Jerry Silver   EXPERIMENTAL NEUROLOGY

Time lapsein vivomicroscopy reveals distinct dynamics of microglia-tumor environment interactions-a new role for the tumor perivascular space as highway for trafficking microglia

(2016) Simon Heinrich Bayerl et al.   GLIA

Transient Oxygen/Glucose Deprivation Causes a Delayed Loss of Mitochondria and Increases Spontaneous Calcium Signaling in Astrocytic Processes

(2016) J. C. O'Donnell et al.   JOURNAL OF NEUROSCIENCE

Metabolic and Inflammatory Adaptation of Reactive Astrocytes: Role of PPARs

(2016) José Iglesias et al.   MOLECULAR NEUROBIOLOGY

Origin, fate and dynamics of macrophages at central nervous system interfaces

(2016) Tobias Goldmann et al.   NATURE IMMUNOLOGY

The role of microglia and macrophages in glioma maintenance and progression

(2016) Dolores Hambardzumyan et al.   NATURE NEUROSCIENCE

Reactive astrocytes potentiate tumor aggressiveness in a murine glioma resection and recurrence model

(2016) Onyinyechukwu Okolie et al.   NEURO-ONCOLOGY

Fatty acid oxidation is required for the respiration and proliferation of malignant glioma cells

(2016) Hua Lin et al.   NEURO-ONCOLOGY

Metabolic response of glioblastoma cells associated with glucose withdrawal and pyruvate substitution as revealed by GC-MS

(2016) Henry Oppermann et al.   Nutrition & Metabolism

TSPO Finds NOX2 in Microglia for Redox Homeostasis

(2016) Tomás R. Guilarte et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Microglial M1/M2 polarization and metabolic states

(2015) Ruben Orihuela et al.   BRITISH JOURNAL OF PHARMACOLOGY

Metabolic therapy: A new paradigm for managing malignant brain cancer

(2015) Thomas N. Seyfried et al.   CANCER LETTERS

Macitentan, a Dual Endothelin Receptor Antagonist, in Combination with Temozolomide Leads to Glioblastoma Regression and Long-term Survival in Mice

(2015) S.-J. Kim et al.   CLINICAL CANCER RESEARCH

USP18 lack in microglia causes destructive interferonopathy of the mouse brain

(2015) T. Goldmann et al.   EMBO JOURNAL

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

(2015) Abhishek K. Jha et al.   IMMUNITY

Astrocytes protect glioma cells from chemotherapy and upregulate survival genes via gap junctional communication

(2015) QINGTANG LIN et al.   Molecular Medicine Reports

Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma

(2015) Saverio Tardito et al.   NATURE CELL BIOLOGY

The Dynamics of Interactions Among Immune and Glioblastoma Cells

(2015) Katalin Eder et al.   NEUROMOLECULAR MEDICINE

Impact of Timing of Concurrent Chemoradiation for Newly Diagnosed Glioblastoma

(2015) Seunggu J. Han et al.   NEUROSURGERY

Glioma-Associated Microglia/Macrophages Display an Expression Profile Different from M1 and M2 Polarization and Highly Express Gpnmb and Spp1

(2015) Frank Szulzewsky et al.   PLoS One

Transcriptomic Analysis of Human Polarized Macrophages: More than One Role of Alternative Activation?

(2015) Eleonora Derlindati et al.   PLoS One

The role of astrocytes in the progression of brain cancer: complicating the picture of the tumor microenvironment

(2015) Amanda L. Placone et al.   TUMOR BIOLOGY

Loss of CX3CR1 increases accumulation of inflammatory monocytes and promotes gliomagenesis

(2015) Xi Feng et al.   Oncotarget

Down-regulation of IKKβ expression in glioma-infiltrating microglia/macrophages is associated with defective inflammatory/immune gene responses in glioblastoma

(2015) Jakub Mieczkowski et al.   Oncotarget

Coculture with astrocytes reduces the radiosensitivity of glioblastoma stem-like cells and identifies additional targets for radiosensitization

(2015) Barbara H. Rath et al.   Cancer Medicine

Glycolysis and the significance of lactate in traumatic brain injury

(2015) Keri L. H. Carpenter et al.   Frontiers in Neuroscience

Hypoxia induces macrophage polarization and re-education toward an M2 phenotype in U87 and U251 glioblastoma models

(2015) Marine M Leblond et al.   OncoImmunology

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(2015) Elisabet Cuyàs et al.   Oncotarget

Redox regulation of NF-κB p50 and M1 polarization in microglia

(2014) Thomas Taetzsch et al.   GLIA

The mTOR kinase inhibitors polarize glioma-activated microglia to express a M1 phenotype

(2014) Lucia Lisi et al.   Journal of Neuroinflammation

Glucose pathways adaptation supports acquisition of activated microglia phenotype

(2014) J. Gimeno-Bayón et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Glioblastoma-associated stromal cells (GASCs) from histologically normal surgical margins have a myofibroblast phenotype and angiogenic properties

(2014) Anne Clavreul et al.   JOURNAL OF PATHOLOGY

Tibolone protects T98G cells from glucose deprivation

(2014) Marco Ávila Rodriguez et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

A co-culture model with brain tumor-specific bioluminescence demonstrates astrocyte-induced drug resistance in glioblastoma

(2014) Ning Yang et al.   Journal of Translational Medicine

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation

(2014) Bart Everts et al.   NATURE IMMUNOLOGY

Microglial and macrophage polarization—new prospects for brain repair

(2014) Xiaoming Hu et al.   Nature Reviews Neurology

Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease

(2014) Marco Prinz et al.   NATURE REVIEWS NEUROSCIENCE

Astrocyte–neuron interplay in maladaptive plasticity

(2014) Michele Papa et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth

(2014) Ubaldo E. Martinez-Outschoorn et al.   SEMINARS IN CANCER BIOLOGY

Epigenetic transcriptional activation of monocyte chemotactic protein 3 contributes to long-lasting neuropathic pain

(2013) Satoshi Imai et al.   BRAIN

Inflammation-Induced Alteration of Astrocyte Mitochondrial Dynamics Requires Autophagy for Mitochondrial Network Maintenance

(2013) Elisa Motori et al.   Cell Metabolism

The Controversial Role of Microglia in Malignant Gliomas

(2013) Jun Wei et al.   Clinical & Developmental Immunology

Inflammatory response of microglial BV-2 cells includes a glycolytic shift and is modulated by mitochondrial glucose-regulated protein 75/mortalin

(2013) Ludmila A. Voloboueva et al.   FEBS LETTERS

Molecular definition of the pro-tumorigenic phenotype of glioma-activated microglia

(2013) Aleksandra Ellert-Miklaszewska et al.   GLIA

Flux modules in metabolic networks

(2013) Arne C. Müller et al.   JOURNAL OF MATHEMATICAL BIOLOGY

Glial Scar Borders Are Formed by Newly Proliferated, Elongated Astrocytes That Interact to Corral Inflammatory and Fibrotic Cells via STAT3-Dependent Mechanisms after Spinal Cord Injury

(2013) I. B. Wanner et al.   JOURNAL OF NEUROSCIENCE

Chondroitin Sulfate Proteoglycans Potently Inhibit Invasion and Serve as a Central Organizer of the Brain Tumor Microenvironment

(2013) D. J. Silver et al.   JOURNAL OF NEUROSCIENCE

Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake

(2013) William A Flavahan et al.   NATURE NEUROSCIENCE

Therapeutic activation of macrophages and microglia to suppress brain tumor-initiating cells

(2013) Susobhan Sarkar et al.   NATURE NEUROSCIENCE

Unraveling the complex metabolic nature of astrocytes

(2013) Anne-Karine Bouzier-Sore et al.   Frontiers in Cellular Neuroscience

Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells

(2012) B. Everts et al.   BLOOD

Two-compartment tumor metabolism: Autophagy in the tumor microenvironment and oxidative mitochondrial metabolism (OXPHOS) in cancer cells

(2012) Ahmed F. Salem et al.   CELL CYCLE

The cellular origin for malignant glioma and prospects for clinical advancements

(2012) Hui Zong et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

Review: Activation patterns of microglia and their identification in the human brain

(2012) D. Boche et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Astrocyte-Specific Expression Patterns Associated with the PDGF-Induced Glioma Microenvironment

(2012) Amanda M. Katz et al.   PLoS One

Dedifferentiation of Neurons and Astrocytes by Oncogenes Can Induce Gliomas in Mice

(2012) D. Friedmann-Morvinski et al.   SCIENCE

Epigenetic regulation of macrophage polarization and function

(2012) Lionel B. Ivashkiv   TRENDS IN IMMUNOLOGY

Determinants of Brain Cell Metabolic Phenotypes and Energy Substrate Utilization Unraveled with a Modeling Approach

(2012) Aitana Neves et al.   PLoS Computational Biology

Why does the brain (not) have glycogen?

(2011) Mauro DiNuzzo et al.   BIOESSAYS

Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy

(2011) Gabriele D Maurer et al.   BMC CANCER

Minocycline reduces glioma expansion and invasion by attenuating microglial MT1-MMP expression

(2011) D.S. Markovic et al.   BRAIN BEHAVIOR AND IMMUNITY

Mosaic Analysis with Double Markers Reveals Tumor Cell of Origin in Glioma

(2011) Chong Liu et al.   CELL

Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission

(2011) O. Pascual et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Three-Layer Concentric Model of Glioblastoma: Cancer Stem Cells, Microenvironmental Regulation, and Therapeutic Implications

(2011) Luca Persano et al.   TheScientificWorldJOURNAL

Hypoxia Increases the Expression of Stem-Cell Markers and Promotes Clonogenicity in Glioblastoma Neurospheres

(2010) Eli E. Bar et al.   AMERICAN JOURNAL OF PATHOLOGY

Phosphorylation status of pyruvate dehydrogenase distinguishes metabolic phenotypes of cultured rat brain astrocytes and neurons

(2010) Nader D. Halim et al.   GLIA

The perivascular astroglial sheath provides a complete covering of the brain microvessels: An electron microscopic 3D reconstruction

(2010) Thomas Misje Mathiisen et al.   GLIA

Microglia/macrophages promote glioma progression

(2010) Haiyan Zhai et al.   GLIA

Substrate Fate in Activated Macrophages: A Comparison between Innate, Classic, and Alternative Activation

(2010) J.-C. Rodriguez-Prados et al.   JOURNAL OF IMMUNOLOGY

Predominant Enhancement of Glucose Uptake in Astrocytes versus Neurons during Activation of the Somatosensory Cortex

(2010) J. Chuquet et al.   JOURNAL OF NEUROSCIENCE

Expression of macrophage inflammatory protein-1α and monocyte chemoattractant protein-1 in glioma-infiltrating microglia: Involvement of ATP and P2X7 receptor

(2010) Kuan-Min Fang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Glioma cancer stem cells induce immunosuppressive macrophages/microglia

(2010) Adam Wu et al.   NEURO-ONCOLOGY

Dynamics of central and peripheral immunomodulation in a murine glioma model

(2009) Benjamin C Kennedy et al.   BMC IMMUNOLOGY

HIF-1: upstream and downstream of cancer metabolism

(2009) Gregg L Semenza   CURRENT OPINION IN GENETICS & DEVELOPMENT

The role of microglia in central nervous system immunity and glioma immunology

(2009) Isaac Yang et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Thein vivoneuron-to-astrocyte lactate shuttle in human brain: evidence from modeling of measured lactate levels during visual stimulation

(2009) Silvia Mangia et al.   JOURNAL OF NEUROCHEMISTRY

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

Glioma-astrocyte interaction modifies the astrocyte phenotype in a co-culture experimental model

(2009) Gagliano   ONCOLOGY REPORTS

Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion

(2009) D. S. Markovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

(2008) Pierre Sonveaux et al.   JOURNAL OF CLINICAL INVESTIGATION