Tumor Cell Invasion in Glioblastoma

Integrating microarray-based spatial transcriptomics and single-cell RNA-seq reveals tissue architecture in pancreatic ductal adenocarcinomas

(2020) Reuben Moncada et al.   NATURE BIOTECHNOLOGY

Understanding the glioblastoma immune microenvironment as basis for the development of new immunotherapeutic strategies

(2020) Ana Rita Pombo Antunes et al.   eLife

Phenotypic Plasticity of Invasive Edge Glioma Stem-like Cells in Response to Ionizing Radiation

(2019) Mutsuko Minata et al.   Cell Reports

Modeling Patient-Derived Glioblastoma with Cerebral Organoids

(2019) Amanda Linkous et al.   Cell Reports

Intravital imaging of glioma border morphology reveals distinctive cellular dynamics and contribution to tumor cell invasion

(2019) Maria Alieva et al.   Scientific Reports

Deciphering the complex role of thrombospondin-1 in glioblastoma development

(2019) Thomas Daubon et al.   Nature Communications

Identification of UGP2 as a progression marker that promotes cell growth and motility in human glioma

(2019) Chun Zeng et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Glioblastoma heterogeneity and the tumour microenvironment: implications for preclinical research and development of new treatments

(2019) Sally L. Perrin et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Characterizing tumor invasiveness of glioblastoma using multiparametric magnetic resonance imaging

(2019) Chao Li et al.   JOURNAL OF NEUROSURGERY

Survivin is a prognostic indicator in glioblastoma and may be a target of microRNA‑218

(2019) Xuezhi Tong et al.   Oncology Letters

Radiomics in Glioblastoma: Current Status and Challenges Facing Clinical Implementation

(2019) Ahmad Chaddad et al.   Frontiers in Oncology

An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma

(2019) Cyril Neftel et al.   CELL

HOXB13 promotes proliferation, migration, and invasion of glioblastoma through transcriptional upregulation of lncRNA HOXC‐AS3

(2019) Xi Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Single-Cell RNA Sequencing in Cancer: Lessons Learned and Emerging Challenges

(2019) Mario L. Suvà et al.   MOLECULAR CELL

Myosin IIA suppresses glioblastoma development in a mechanically sensitive manner

(2019) Hannah S. Picariello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multicenter study demonstrates radiomic features derived from magnetic resonance perfusion images identify pseudoprogression in glioblastoma

(2019) Nabil Elshafeey et al.   Nature Communications

Glutamatergic synaptic input to glioma cells drives brain tumour progression

(2019) Varun Venkataramani et al.   NATURE

High-definition spatial transcriptomics for in situ tissue profiling

(2019) Sanja Vickovic et al.   NATURE METHODS

Feature-Guided Deep Radiomics for Glioblastoma Patient Survival Prediction

(2019) Zeina A. Shboul et al.   Frontiers in Neuroscience

Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization

(2019) Chiara Baccin et al.   NATURE CELL BIOLOGY

Computational modeling demonstrates that glioblastoma cells can survive spatial environmental challenges through exploratory adaptation

(2019) Orieta Celiku et al.   Nature Communications

Exploring inflammatory signatures in arthritic joint biopsies with Spatial Transcriptomics

(2019) Konstantin Carlberg et al.   Scientific Reports

A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment

(2018) Amelie Griveau et al.   CANCER CELL

Multiclonal Invasion in Breast Tumors Identified by Topographic Single Cell Sequencing

(2018) Anna K. Casasent et al.   CELL

SYK inhibition blocks proliferation and migration of glioma cells and modifies the tumor microenvironment

(2018) Gerald Moncayo et al.   NEURO-ONCOLOGY

An anatomic transcriptional atlas of human glioblastoma

(2018) Ralph B. Puchalski et al.   SCIENCE

Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity

(2018) Emelie Berglund et al.   Nature Communications

Simultaneous miRNA and mRNA transcriptome profiling of glioblastoma samples reveals a novel set of OncomiR candidates and their target genes

(2018) Sukru Gulluoglu et al.   BRAIN RESEARCH

Spatially resolved transcriptomics enables dissection of genetic heterogeneity in stage III cutaneous malignant melanoma

(2018) Kim Thrane et al.   CANCER RESEARCH

Single-cell transcriptome analysis of lineage diversity in high-grade glioma

(2018) Jinzhou Yuan et al.   Genome Medicine

Transcriptome profiling reveals PDZ binding kinase as a novel biomarker in peritumoral brain zone of glioblastoma

(2018) Banavathy S. Kruthika et al.   JOURNAL OF NEURO-ONCOLOGY

Phenotypic and Expressional Heterogeneity in the Invasive Glioma Cells

(2018) Artem Fayzullin et al.   Translational Oncology

Mitochondrial enzyme GLUD2 plays a critical role in glioblastoma progression

(2018) Sara Franceschi et al.   EBioMedicine

Glioblastoma: Microenvironment and Niche Concept

(2018) Davide Schiffer et al.   Cancers

The STAT3/Slug Axis Enhances Radiation-Induced Tumor Invasion and Cancer Stem-like Properties in Radioresistant Glioblastoma

(2018) Jang-Chun Lin et al.   Cancers

Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma

(2017) Roger Stupp et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Clinical implications of in silico mathematical modeling for glioblastoma: a critical review

(2017) Maria Protopapa et al.   JOURNAL OF NEURO-ONCOLOGY

The biology and mathematical modelling of glioma invasion: a review

(2017) J. C. L. Alfonso et al.   Journal of the Royal Society Interface

Comparative Analysis of Single-Cell RNA Sequencing Methods

(2017) Christoph Ziegenhain et al.   MOLECULAR CELL

Dissecting human gliomas by single-cell RNA sequencing

(2017) Itay Tirosh et al.   NEURO-ONCOLOGY

Fibroblast growth factor 13 regulates glioma cell invasion and is important for bevacizumab-induced glioma invasion

(2017) Y Otani et al.   ONCOGENE

Single-Cell Multiomics: Multiple Measurements from Single Cells

(2017) Iain C. Macaulay et al.   TRENDS IN GENETICS

Snail homolog 1 is involved in epithelial-mesenchymal transition-like processes in human glioblastoma cells

(2017) Caspar D. Kühnöl et al.   Oncology Letters

Preventing inflammation inhibits biopsy-mediated changes in tumor cell behavior

(2017) Maria Alieva et al.   Scientific Reports

Single-Cell RNA-Seq Analysis of Infiltrating Neoplastic Cells at the Migrating Front of Human Glioblastoma

(2017) Spyros Darmanis et al.   Cell Reports

Tumor microenvironment in treatment of glioma

(2017) Guijie Li et al.   Open Medicine

Molecular and Microenvironmental Determinants of Glioma Stem-Like Cell Survival and Invasion

(2017) Alison Roos et al.   Frontiers in Oncology

Acidosis Acts through HSP90 in a PHD/VHL-Independent Manner to Promote HIF Function and Stem Cell Maintenance in Glioma

(2016) Alina Filatova et al.   CANCER RESEARCH

A Three-Dimensional Organoid Culture System Derived from Human Glioblastomas Recapitulates the Hypoxic Gradients and Cancer Stem Cell Heterogeneity of Tumors Found In Vivo

(2016) Christopher G. Hubert et al.   CANCER RESEARCH

EMT: 2016

(2016) M. Angela Nieto et al.   CELL

Silencing of PROS1 induces apoptosis and inhibits migration and invasion of glioblastoma multiforme cells

(2016) Mohd Firdaus Che Mat et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Glioma Stem Cells but Not Bulk Glioma Cells Upregulate IL-6 Secretion in Microglia/Brain Macrophages via Toll-like Receptor 4 Signaling

(2016) Omar Dildar a Dzaye et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Clonal evolution of glioblastoma under therapy

(2016) Jiguang Wang et al.   NATURE GENETICS

The role of microglia and macrophages in glioma maintenance and progression

(2016) Dolores Hambardzumyan et al.   NATURE NEUROSCIENCE

Single-cell genome sequencing: current state of the science

(2016) Charles Gawad et al.   NATURE REVIEWS GENETICS

Radiogenomics to characterize regional genetic heterogeneity in glioblastoma

(2016) Leland S. Hu et al.   NEURO-ONCOLOGY

Big data visualization identifies the multidimensional molecular landscape of human gliomas

(2016) Hamid Bolouri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stattic and metformin inhibit brain tumor initiating cells by reducing STAT3-phosphorylation

(2016) Verena Leidgens et al.   Oncotarget

Clonal Variation in Drug and Radiation Response among Glioma-Initiating Cells Is Linked to Proneural-Mesenchymal Transition

(2016) Anna Segerman et al.   Cell Reports

Glioblastoma Stem-Like Cells: Characteristics, Microenvironment, and Therapy

(2016) Yang Yi et al.   Frontiers in Pharmacology

Spatiotemporal Evolution of the Primary Glioblastoma Genome

(2015) Jinkuk Kim et al.   CANCER CELL

Brain tumour cells interconnect to a functional and resistant network

(2015) Matthias Osswald et al.   NATURE

Single-cell epigenomics: techniques and emerging applications

(2015) Omer Schwartzman et al.   NATURE REVIEWS GENETICS

Organotypic brain slice cultures: A review

(2015) C. Humpel   NEUROSCIENCE

Pleiotrophin promotes vascular abnormalization in gliomas and correlates with poor survival in patients with astrocytomas

(2015) Lei Zhang et al.   Science Signaling

Microenvironmental regulation of therapeutic response in cancer

(2015) Florian Klemm et al.   TRENDS IN CELL BIOLOGY

The role of astrocytes in the progression of brain cancer: complicating the picture of the tumor microenvironment

(2015) Amanda L. Placone et al.   TUMOR BIOLOGY

CD151-α3β1 integrin complexes are prognostic markers of glioblastoma and cooperate with EGFR to drive tumor cell motility and invasion

(2015) Pengcheng Zhou et al.   Oncotarget

Pleiotrophin promotes vascular abnormalization in gliomas and correlates with poor survival in patients with astrocytomas

(2015) Lei Zhang et al.   Science Signaling

Spherical Cancer Models in Tumor Biology

(2015) Louis-Bastien Weiswald et al.   NEOPLASIA

Microglia Activate Migration of Glioma Cells through a Pyk2 Intracellular Pathway

(2015) Kimberleve Rolón-Reyes et al.   PLoS One

Tie2/TEK Modulates the Interaction of Glioma and Brain Tumor Stem Cells with Endothelial Cells and Promotes an Invasive Phenotype

(2015)   Oncotarget

Transcriptional profiling of GBM invasion genes identifies effective inhibitors of the LIM kinase-Cofilin pathway

(2015) Jun-Bum Park et al.   Oncotarget

Invasive Glioblastoma Cells Acquire Stemness and Increased Akt Activation

(2015) Jennifer R. Molina et al.   NEOPLASIA

Engineering strategies to mimic the glioblastoma microenvironment

(2014) Andrew Rape et al.   ADVANCED DRUG DELIVERY REVIEWS

Cell jamming: Collective invasion of mesenchymal tumor cells imposed by tissue confinement

(2014) Anna Haeger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Imaging genomic mapping of an invasive MRI phenotype predicts patient outcome and metabolic dysfunction: a TCGA glioma phenotype research group project

(2014) Rivka R Colen et al.   BMC Medical Genomics

Guanine nucleotide exchange factor Dock7 mediates HGF-induced glioblastoma cell invasion via Rac activation

(2014) D W Murray et al.   BRITISH JOURNAL OF CANCER

Upregulation of NHE1 protein expression enables glioblastoma cells to escape TMZ-mediated toxicity via increased H+extrusion, cell migration and survival

(2014) Damin Cong et al.   CARCINOGENESIS

Osteopontin-CD44 Signaling in the Glioma Perivascular Niche Enhances Cancer Stem Cell Phenotypes and Promotes Aggressive Tumor Growth

(2014) Alexander Pietras et al.   Cell Stem Cell

Versican isoform V1 regulates proliferation and migration in high-grade gliomas

(2014) Julia Onken et al.   JOURNAL OF NEURO-ONCOLOGY

A neurocentric perspective on glioma invasion

(2014) Vishnu Anand Cuddapah et al.   NATURE REVIEWS NEUROSCIENCE

JAK2/STAT3 targeted therapy suppresses tumor invasion via disruption of the EGFRvIII/JAK2/STAT3 axis and associated focal adhesion in EGFRvIII-expressing glioblastoma

(2014) Q. Zheng et al.   NEURO-ONCOLOGY

Identification of Molecular Pathways Facilitating Glioma Cell Invasion In Situ

(2014) Ido Nevo et al.   PLoS One

In vivo radiation response of proneural glioma characterized by protective p53 transcriptional program and proneural-mesenchymal shift

(2014) J. Halliday et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

(2014) A. P. Patel et al.   SCIENCE

Disruption of astrocyte–vascular coupling and the blood–brain barrier by invading glioma cells

(2014) Stacey Watkins et al.   Nature Communications

Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma

(2013) Krishna P.L. Bhat et al.   CANCER CELL

Collective Invasion in Breast Cancer Requires a Conserved Basal Epithelial Program

(2013) Kevin J. Cheung et al.   CELL

Dynamic Regulation of the Structure and Functions of Integrin Adhesions

(2013) Haguy Wolfenson et al.   DEVELOPMENTAL CELL

The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance

(2013) Florian A. Siebzehnrubl et al.   EMBO Molecular Medicine

Cancer stem cells: The challenges ahead

(2013) Jan Paul Medema   NATURE CELL BIOLOGY

Pathophysiology of the brain extracellular matrix: a new target for remyelination

(2013) Lorraine W. Lau et al.   NATURE REVIEWS NEUROSCIENCE

NFAT1 Is Highly Expressed in, and Regulates the Invasion of, Glioblastoma Multiforme Cells

(2013) Xinxin Tie et al.   PLoS One

Reciprocal Activation of Transcription Factors Underlies the Dichotomy between Proliferation and Invasion of Glioma Cells

(2013) Harshil D. Dhruv et al.   PLoS One

Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics

(2013) A. Sottoriva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic Reprogramming in Cancer

(2013) M. L. Suva et al.   SCIENCE

The regulation of cysteine cathepsins and cystatins in human gliomas

(2012) Boris Gole et al.   INTERNATIONAL JOURNAL OF CANCER

Tumor-Associated Microglia/Macrophages Enhance the Invasion of Glioma Stem-like Cells via TGF- 1 Signaling Pathway

(2012) X.-z. Ye et al.   JOURNAL OF IMMUNOLOGY

Galectin-1, a gene preferentially expressed at the tumor margin, promotes glioblastoma cell invasion

(2012) L Toussaint et al.   Molecular Cancer

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(2012) Salvatore Coniglio et al.   MOLECULAR MEDICINE

Classifying collective cancer cell invasion

(2012) Peter Friedl et al.   NATURE CELL BIOLOGY

A Radial Glia Gene Marker, Fatty Acid Binding Protein 7 (FABP7), Is Involved in Proliferation and Invasion of Glioblastoma Cells

(2012) Antonella De Rosa et al.   PLoS One

ECM microenvironment regulates collective migration and local dissemination in normal and malignant mammary epithelium

(2012) K.-V. Nguyen-Ngoc et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Addressing Diffuse Glioma as a Systemic Brain Disease With Single-Cell Analysis

(2011) David Capper   ARCHIVES OF NEUROLOGY

Cancer Invasion and the Microenvironment: Plasticity and Reciprocity

(2011) Peter Friedl et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Subventricular Zone-Derived Neuroblasts Use Vasculature as a Scaffold to Migrate Radially to the Cortex in Neonatal Mice

(2011) C. Le Magueresse et al.   CEREBRAL CORTEX

The transcriptional coactivator TAZ regulates mesenchymal differentiation in malignant glioma

(2011) K. P. L. Bhat et al.   GENES & DEVELOPMENT

Integrative, Multimodal Analysis of Glioblastoma Using TCGA Molecular Data, Pathology Images, and Clinical Outcomes

(2011) Jun Kong et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

p53 and its mutants in tumor cell migration and invasion

(2011) Patricia A. J. Muller et al.   JOURNAL OF CELL BIOLOGY

Hydrodynamic Cellular Volume Changes Enable Glioma Cell Invasion

(2011) S. Watkins et al.   JOURNAL OF NEUROSCIENCE

Bradykinin Promotes the Chemotactic Invasion of Primary Brain Tumors

(2011) V. Montana et al.   JOURNAL OF NEUROSCIENCE

The chemokine CXCL12 and its receptor CXCR4 promote glioma stem cell-mediated VEGF production and tumour angiogenesis via PI3K/AKT signalling

(2011) Yi-fang Ping et al.   JOURNAL OF PATHOLOGY

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions

(2011) Guo-li Ming et al.   NEURON

Radiogenomic Mapping of Edema/Cellular Invasion MRI-Phenotypes in Glioblastoma Multiforme

(2011) Pascal O. Zinn et al.   PLoS One

Cancer Stem Cells and Epithelial-to-Mesenchymal Transition (EMT)-Phenotypic Cells: Are They Cousins or Twins?

(2011) Dejuan Kong et al.   Cancers

SNAI2/Slug promotes growth and invasion in human gliomas

(2010) Hong Wei Yang et al.   BMC CANCER

Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma

(2010) Houtan Noushmehr et al.   CANCER CELL

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

The plasticity of cytoskeletal dynamics underlying neoplastic cell migration

(2010) Victoria Sanz-Moreno et al.   CURRENT OPINION IN CELL BIOLOGY

Cancer stem-like cells of glioblastoma characteristically express MMP-13 and display highly invasive activity

(2010) Takahashi   INTERNATIONAL JOURNAL OF ONCOLOGY

PINCH1 regulates Akt1 activation and enhances radioresistance by inhibiting PP1α

(2010) Iris Eke et al.   JOURNAL OF CLINICAL INVESTIGATION

Radiographic patterns of relapse in glioblastoma

(2010) Marc C. Chamberlain   JOURNAL OF NEURO-ONCOLOGY

TWIST1 promotes invasion through mesenchymal change in human glioblastoma

(2010) Svetlana A Mikheeva et al.   Molecular Cancer

EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

(2010) A Singh et al.   ONCOGENE

A New α5β1 Integrin-Dependent Survival Pathway Through GSK3β Activation in Leukemic Cells

(2010) Fabienne De Toni-Costes et al.   PLoS One

Role of hyaluronan in glioma invasion

(2010) Jong Bae Park et al.   Cell Adhesion & Migration

Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells

(2009) Zhizhong Li et al.   CANCER CELL

A Novel Splice Variant of GLI1 That Promotes Glioblastoma Cell Migration and Invasion

(2009) H.-W. Lo et al.   CANCER RESEARCH

Epithelial-Mesenchymal Transition and Cell Cooperativity in Metastasis

(2009) T. Tsuji et al.   CANCER RESEARCH

Imaging glioma cell invasionin vivoreveals mechanisms of dissemination and peritumoral angiogenesis

(2009) Frank Winkler et al.   GLIA

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY

Rembrandt: Helping Personalized Medicine Become a Reality through Integrative Translational Research

(2009) S. Madhavan et al.   MOLECULAR CANCER RESEARCH

The transcriptional network for mesenchymal transformation of brain tumours

(2009) Maria Stella Carro et al.   NATURE

The trip of the tip: understanding the growth cone machinery

(2009) Laura Anne Lowery et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Collective cell migration in morphogenesis, regeneration and cancer

(2009) Peter Friedl et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion

(2009) D. S. Markovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Extracellular Matrix: Not Just Pretty Fibrils

(2009) R. O. Hynes   SCIENCE

Glioma cells on the run – the migratory transcriptome of 10 human glioma cell lines

(2008) Tim Demuth et al.   BMC GENOMICS

Brain Extracellular Matrix in Neurodegeneration

(2008) Dafna Bonneh-Barkay et al.   BRAIN PATHOLOGY

Tube Travel: The Role of Proteases in Individual and Collective Cancer Cell Invasion

(2008) P. Friedl et al.   CANCER RESEARCH

Temozolomide Preferentially Depletes Cancer Stem Cells in Glioblastoma

(2008) D. Beier et al.   CANCER RESEARCH

Modular control of endothelial sheet migration

(2008) P. Vitorino et al.   GENES & DEVELOPMENT

Extracellular matrix of the central nervous system: from neglect to challenge

(2008) Dieter R. Zimmermann et al.   HISTOCHEMISTRY AND CELL BIOLOGY

The Role of Myosin II in Glioma Invasion of the Brain

(2008) Christopher Beadle et al.   MOLECULAR BIOLOGY OF THE CELL

Lactate promotes glioma migration by TGF-β2–dependent regulation of matrix metalloproteinase-2

(2008) Fusun Baumann et al.   NEURO-ONCOLOGY

Regulation of glioblastoma cell invasion by PKCι and RhoB

(2008) R M Baldwin et al.   ONCOGENE

Cancer stem cells and glioma

(2008) Sunit Das et al.   Nature clinical practice. Neurology