The cellular origin for malignant glioma and prospects for clinical advancements

Studying a Complex Tumor

(2012) Siyuan Zheng et al.   CANCER JOURNAL

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

(2012) Sevin Turcan et al.   NATURE

Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response

(2012) N. J. Szerlip et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mosaic Amplification of Multiple Receptor Tyrosine Kinase Genes in Glioblastoma

(2011) Matija Snuderl et al.   CANCER CELL

Cooperativity within and among Pten, p53, and Rb Pathways Induces High-Grade Astrocytoma in Adult Brain

(2011) Lionel M.L. Chow et al.   CANCER CELL

Mosaic Analysis with Double Markers Reveals Tumor Cell of Origin in Glioma

(2011) Chong Liu et al.   CELL

Evidence for Sequenced Molecular Evolution of IDH1 Mutant Glioblastoma From a Distinct Cell of Origin

(2011) Albert Lai et al.   JOURNAL OF CLINICAL ONCOLOGY

Glioblastoma Models Reveal the Connection between Adult Glial Progenitors and the Proneural Phenotype

(2011) Liang Lei et al.   PLoS One

Recruited Cells Can Become Transformed and Overtake PDGF-Induced Murine Gliomas In Vivo during Tumor Progression

(2011) Elena I. Fomchenko et al.   PLoS One

Increased Re-Entry into Cell Cycle Mitigates Age-Related Neurogenic Decline in the Murine Subventricular Zone

(2011) Elizabeth A. Stoll et al.   STEM CELLS

Temporal Dissection of Tumorigenesis in Primary Cancers

(2011) Steffen Durinck et al.   Cancer Discovery

Non-Stem Cell Origin for Oligodendroglioma

(2010) Anders I. Persson et al.   CANCER CELL

Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma

(2010) Houtan Noushmehr et al.   CANCER CELL

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

Subtypes of medulloblastoma have distinct developmental origins

(2010) Paul Gibson et al.   NATURE

Cross-species genomics matches driver mutations and cell compartments to model ependymoma

(2010) Robert A. Johnson et al.   NATURE

Magnetic Resonance Imaging Characteristics of Glioblastoma Multiforme: Implications for Understanding Glioma Ontogeny

(2010) Leif-Erik Bohman et al.   NEUROSURGERY

NG2+/Olig2+Cells are the Major Cycle-Related Cell Population of the Adult Human Normal Brain

(2009) Sameh Geha et al.   BRAIN PATHOLOGY

Malignant Astrocytomas Originate from Neural Stem/Progenitor Cells in a Somatic Tumor Suppressor Mouse Model

(2009) Sheila Alcantara Llaguno et al.   CANCER CELL

Unsupervised Analysis of Transcriptomic Profiles Reveals Six Glioma Subtypes

(2009) A. Li et al.   CANCER RESEARCH

Effects of developmental age, brain region, and time in culture on long-term proliferation and multipotency of neural stem cell populations

(2009) Angela Gritti et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Biology of glioma cancer stem cells

(2009) Deric M. Park et al.   MOLECULES AND CELLS

Identity crisis for adult periventricular neural stem cells: subventricular zone astrocytes, ependymal cells or both?

(2009) Andrew K. Chojnacki et al.   NATURE REVIEWS NEUROSCIENCE

Intratumoral patterns of clonal evolution in gliomas

(2009) Ana Luísa Vital et al.   NEUROGENETICS

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oligodendrocyte progenitor cells can act as cell of origin for experimental glioma

(2009) N Lindberg et al.   ONCOGENE

Glioblastoma Subclasses Can Be Defined by Activity among Signal Transduction Pathways and Associated Genomic Alterations

(2009) Cameron Brennan et al.   PLoS One

The interface between glial progenitors and gliomas

(2008) Peter Canoll et al.   ACTA NEUROPATHOLOGICA

Quantitative analysis of mitotic Olig2 cells in adult human brain and gliomas: Implications for glioma histogenesis and biology

(2008) Wootack Rhee et al.   GLIA

Stem Cell–Related “Self-Renewal” Signature and High Epidermal Growth Factor Receptor Expression Associated With Resistance to Concomitant Chemoradiotherapy in Glioblastoma

(2008) Anastasia Murat et al.   JOURNAL OF CLINICAL ONCOLOGY

A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function

(2008) J. D. Cahoy et al.   JOURNAL OF NEUROSCIENCE

p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation

(2008) Hongwu Zheng et al.   NATURE

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity

(2008) Akiko Nishiyama et al.   NATURE REVIEWS NEUROSCIENCE

Glioma Stem Cells: A Midterm Exam

(2008) Charles D. Stiles et al.   NEURON

Regenerative capacity of neural precursors in the adult mammalian brain is under the control of p53

(2007) Silvia Medrano et al.   NEUROBIOLOGY OF AGING