Intracellular Redox-Modulated Pathways as Targets for Effective Approaches in the Treatment of Viral Infection

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Therapeutic options for the 2019 novel coronavirus (2019-nCoV)

(2020) Guangdi Li et al.   NATURE REVIEWS DRUG DISCOVERY

Oxidative Stress as Key Player in Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) Infection

(2020) Livan Delgado-Roche et al.   ARCHIVES OF MEDICAL RESEARCH

Disulfide isomerase ERp57 improves the stability and immunogenicity of H3N2 influenza virus hemagglutinin

(2020) Jialing Wu et al.   Virology Journal

COVID-19 cytokine storm: the interplay between inflammation and coagulation

(2020) Ricardo J Jose et al.   Lancet Respiratory Medicine

Endogenous Deficiency of Glutathione as the Most Likely Cause of Serious Manifestations and Death in COVID-19 Patients

(2020) Alexey Polonikov   ACS Infectious Diseases

I-152, a supplier of N-acetyl-cysteine and cysteamine, inhibits immunoglobulin secretion and plasma cell maturation in LP-BM5 murine leukemia retrovirus-infected mice by affecting the unfolded protein response

(2020) Fraternale Alessandra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Redox-Modulating Agents in the Treatment of Viral Infections

(2020) Paola Checconi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS)?

(2020) Bingwen Liu et al.   JOURNAL OF AUTOIMMUNITY

Small Molecule NF-κB Inhibitors as Immune Potentiators for Enhancement of Vaccine Adjuvants

(2020) Brittany A. Moser et al.   Frontiers in Immunology

Reductive stress promotes protein aggregation and impairs neurogenesis

(2020) Kishore Kumar S Narasimhan et al.   Redox Biology

Protein Disulfide Isomerase Inhibitor Suppresses Viral Replication and Production during Antibody-Dependent Enhancement of Dengue Virus Infection in Human Monocytic Cells

(2019) Nantapon Rawarak et al.   Viruses-Basel

Coronavirus envelope protein: current knowledge

(2019) Dewald Schoeman et al.   Virology Journal

Lung epithelial protein disulfide isomerase A3 (PDIA3) plays an important role in influenza infection, inflammation, and airway mechanics

(2019) Nicolas Chamberlain et al.   Redox Biology

Metabolic Responses to Reductive Stress

(2019) Wusheng Xiao et al.   ANTIOXIDANTS & REDOX SIGNALING

Boosting GSH Using the Co-Drug Approach: I-152, a Conjugate of N-acetyl-cysteine and β-mercaptoethylamine

(2019) Rita Crinelli et al.   Nutrients

The Metabolic Signature of Macrophage Responses

(2019) Antonella Viola et al.   Frontiers in Immunology

Single-cell RNA-sequencing of herpes simplex virus 1-infected cells connects NRF2 activation to an antiviral program

(2019) Emanuel Wyler et al.   Nature Communications

Pathological consequences of the unfolded protein response and downstream protein disulphide isomerases in pulmonary viral infection and disease

(2019) Nicolas Chamberlain et al.   JOURNAL OF BIOCHEMISTRY

N-Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why

(2018) Giancarlo Aldini et al.   FREE RADICAL RESEARCH

Post-translational modifications of coronavirus proteins: roles and function

(2018) To Sing Fung et al.   Future Virology

The glutathione cycle: Glutathione metabolism beyond the γ-glutamyl cycle

(2018) Anand Kumar Bachhawat et al.   IUBMB LIFE

The role of Nrf2 transcription factor in viral infection

(2018) Ali Ramezani et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

How Are Proteins Reduced in the Endoplasmic Reticulum?

(2018) Lars Ellgaard et al.   TRENDS IN BIOCHEMICAL SCIENCES

Oxidative stress, aging, and diseases

(2018) Ilaria Liguori et al.   Clinical Interventions in Aging

Metabolic Reprogramming in Modulating T Cell Reactive Oxygen Species Generation and Antioxidant Capacity

(2018) Josephin N. Rashida Gnanaprakasam et al.   Frontiers in Immunology

Redox Biology of Respiratory Viral Infections

(2018) Olga Khomich et al.   Viruses-Basel

Suppression of NF-κB Activity: A Viral Immune Evasion Mechanism

(2018) Liyao Deng et al.   Viruses-Basel

Nitazoxanide inhibits paramyxovirus replication by targeting the Fusion protein folding: role of glycoprotein-specific thiol oxidoreductase ERp57

(2018) Sara Piacentini et al.   Scientific Reports

Therapeutic Modulation of Virus-Induced Oxidative Stress via the Nrf2-Dependent Antioxidative Pathway

(2018) Choongho Lee   Oxidative Medicine and Cellular Longevity

Caught in the cROSsfire: GSH Controls T Cell Metabolic Reprogramming

(2017) Ramon I. Klein Geltink et al.   IMMUNITY

Reductive Stress in Inflammation-Associated Diseases and the Pro-Oxidant Effect of Antioxidant Agents

(2017) Israel Pérez-Torres et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

N-acetylcysteine induces apoptosis via the mitochondria-dependent pathway but not via endoplasmic reticulum stress in H9c2 cells

(2017) Yuyong Liu et al.   Molecular Medicine Reports

Host-directed therapies for bacterial and viral infections

(2017) Stefan H. E. Kaufmann et al.   NATURE REVIEWS DRUG DISCOVERY

Implications of oxidative stress on viral pathogenesis

(2016) Fernanda Caetano Camini et al.   ARCHIVES OF VIROLOGY

Inflammasomes and its importance in viral infections

(2016) Gaurav Shrivastava et al.   IMMUNOLOGIC RESEARCH

Glutathione Depletion Is Linked with Th2 Polarization in Mice with a Retrovirus-Induced Immunodeficiency Syndrome, Murine AIDS: Role of Proglutathione Molecules as Immunotherapeutics

(2016) Serena Brundu et al.   JOURNAL OF VIROLOGY

Opportunistic intruders: how viruses orchestrate ER functions to infect cells

(2016) Madhu Sudhan Ravindran et al.   NATURE REVIEWS MICROBIOLOGY

Immune Responses to Influenza Virus and Its Correlation to Age and Inherited Factors

(2016) Azadeh Bahadoran et al.   Frontiers in Microbiology

Reductive potential — A savior turns stressor in protein aggregation cardiomyopathy

(2015) Madhusudhanan Narasimhan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Reductive stress impairs myoblasts mitochondrial function and triggers mitochondrial hormesis

(2015) François Singh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Protein disulfide–isomerase, a folding catalyst and a redox-regulated chaperone

(2015) Lei Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Long-term treatment with oral N-acetylcysteine: Affects lung function but not sputum inflammation in cystic fibrosis subjects. A phase II randomized placebo-controlled trial

(2015) C. Conrad et al.   Journal of Cystic Fibrosis

Liposomal Glutathione Supplementation Restores TH1 Cytokine Response toMycobacterium tuberculosisInfection in HIV-Infected Individuals

(2015) Judy Ly et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Redox Proteomics of the Inflammatory Secretome Identifies a Common Set of Redoxins and Other Glutathionylated Proteins Released in Inflammation, Influenza Virus Infection and Oxidative Stress

(2015) Paola Checconi et al.   PLoS One

Combating emerging viral threats

(2015) E. Bekerman et al.   SCIENCE

The Virus-Host Interplay: Biogenesis of +RNA Replication Complexes

(2015) Colleen Reid et al.   Viruses-Basel

Recent advances on viral manipulation of NF-κB signaling pathway

(2015) Jun Zhao et al.   Current Opinion in Virology

Oxidative Protein Folding: Nature's Knotty Challenge

(2014) Chad R. Borges et al.   ANTIOXIDANTS & REDOX SIGNALING

The intricate interplay between RNA viruses and NF-κB

(2014) M. Lienhard Schmitz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Influenza virus replication in lung epithelial cells depends on redox-sensitive pathways activated by NOX4-derived ROS

(2014) Donatella Amatore et al.   CELLULAR MICROBIOLOGY

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

(2014) C. Franceschi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Effect of nitazoxanide in adults and adolescents with acute uncomplicated influenza: a double-blind, randomised, placebo-controlled, phase 2b/3 trial

(2014) Jason Haffizulla et al.   LANCET INFECTIOUS DISEASES

Effect of the N-butanoyl glutathione (GSH) derivative and acyclovir on HSV-1 replication and Th1 cytokine expression in human macrophages

(2014) Alessandra Fraternale et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Long-Time Treatment by Low-Dose N-Acetyl-L-Cysteine Enhances Proinflammatory Cytokine Expressions in LPS-Stimulated Macrophages

(2014) Tomokazu Ohnishi et al.   PLoS One

ERAD and how viruses exploit it

(2014) Hyewon Byun et al.   Frontiers in Microbiology

Curing a viral infection by targeting the host: The example of cyclophilin inhibitors

(2013) Kai Lin et al.   ANTIVIRAL RESEARCH

Development of cellular signaling pathway inhibitors as new antivirals against influenza

(2013) Oliver Planz   ANTIVIRAL RESEARCH

A Systems Analysis Identifies a Feedforward Inflammatory Circuit Leading to Lethal Influenza Infection

(2013) Marlène Brandes et al.   CELL

Human immunodeficiency virus type 1 viral protein R (Vpr) induces CCL5 expression in astrocytes via PI3K and MAPK signaling pathways

(2013) Mohitkumar R Gangwani et al.   Journal of Neuroinflammation

Inhibition of NF- B-Mediated Inflammation in Severe Acute Respiratory Syndrome Coronavirus-Infected Mice Increases Survival

(2013) M. L. DeDiego et al.   JOURNAL OF VIROLOGY

Molecules Altering the Intracellular Thiol Content Modulate NF-kB and STAT-1/IRF-1 Signalling Pathways and IL-12 p40 and IL-27 p28 Production in Murine Macrophages

(2013) Alessandra Fraternale et al.   PLoS One

Glutathione and infection

(2012) Devin Morris et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Into the Eye of the Cytokine Storm

(2012) J. R. Tisoncik et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

NF-κB as a potential therapeutic target in microbial diseases

(2012) Mariateresa Vitiello et al.   Molecular BioSystems

Recent Advances in the Treatment of Neurodegenerative Diseases Based on GSH Delivery Systems

(2012) Ivana Cacciatore et al.   Oxidative Medicine and Cellular Longevity

Redox Regulation of the Influenza Hemagglutinin Maturation Process: A New Cell-Mediated Strategy for Anti-Influenza Therapy

(2011) Rossella Sgarbanti et al.   ANTIOXIDANTS & REDOX SIGNALING

The Protein Disulfide Isomerase Family: Key Players in Health and Disease

(2011) Adam M. Benham   ANTIOXIDANTS & REDOX SIGNALING

N-acetyl-l-cysteine (NAC) inhibit mucin synthesis and pro-inflammatory mediators in alveolar type II epithelial cells infected with influenza virus A and B and with respiratory syncytial virus (RSV)

(2011) Manuel Mata et al.   BIOCHEMICAL PHARMACOLOGY

Viral interference with innate immunity by preventing NF-κB activity

(2011) Gaëlle Le Negrate   CELLULAR MICROBIOLOGY

Intracellular Redox Signaling as Therapeutic Target for Novel Antiviral Strategy

(2011) Lucia Nencioni et al.   CURRENT PHARMACEUTICAL DESIGN

Anti-inflammatory properties of N-acetylcysteine on lipopolysaccharide-activated macrophages

(2011) J. R. Palacio et al.   INFLAMMATION RESEARCH

Ampelopsin reduces endotoxic inflammation via repressing ROS-mediated activation of PI3K/Akt/NF-κB signaling pathways

(2011) Shimei Qi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Systematic Approaches towards the Development of Host-Directed Antiviral Therapeutics

(2011) Andrew Prussia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

N-acetylcysteine in Children with Dengue-associated Liver Failure: A Case Report

(2011) G. Lim et al.   JOURNAL OF TROPICAL PEDIATRICS

Population biological principles of drug-resistance evolution in infectious diseases

(2011) Pia Abel zur Wiesch et al.   LANCET INFECTIOUS DISEASES

Human immunodeficiency virus-1 Tat activates NF-κB via physical interaction with IκB-α and p65

(2011) Giuseppe Fiume et al.   NUCLEIC ACIDS RESEARCH

Cysteine: The Fun-Ke Nutraceutical

(2011) Robert A. McPherson et al.   NUTRITION

Modulation of Th1/Th2 immune responses to HIV-1 Tat by new pro-GSH molecules

(2011) Alessandra Fraternale et al.   VACCINE

Cell death regulation during influenza A virus infection by matrix (M1) protein: a model of viral control over the cellular survival pathway

(2011) U C Halder et al.   Cell Death & Disease

Codrug: An efficient approach for drug optimization

(2010) N. Das et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Glutathione-Redox Balance Regulates c-rel-Driven IL-12 Production in Macrophages: Possible Implications in Antituberculosis Immunotherapy

(2010) K. Alam et al.   JOURNAL OF IMMUNOLOGY

Prodrug Approach for Increasing Cellular Glutathione Levels

(2010) Ivana Cacciatore et al.   MOLECULES

The increase in intra-macrophage thiols induced by new pro-GSH molecules directs the Th1 skewing in ovalbumin immunized mice

(2010) Alessandra Fraternale et al.   VACCINE

N-acetyl-l-cysteine (NAC) inhibits virus replication and expression of pro-inflammatory molecules in A549 cells infected with highly pathogenic H5N1 influenza A virus

(2009) Janina Geiler et al.   BIOCHEMICAL PHARMACOLOGY

Thiazolides, a New Class of Anti-influenza Molecules Targeting Viral Hemagglutinin at the Post-translational Level

(2009) Jean François Rossignol et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bcl-2 Expression and p38MAPK Activity in Cells Infected with Influenza A Virus

(2009) Lucia Nencioni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis of HIV-1 Activation by NF-κB—A Higher-Order Complex of p50:RelA Bound to the HIV-1 LTR

(2009) James C. Stroud et al.   JOURNAL OF MOLECULAR BIOLOGY

Innate immune responses to influenza A H5N1: friend or foe?

(2009) Joseph Sriyal Malik Peiris et al.   TRENDS IN IMMUNOLOGY

N-acetylcysteine for antioxidant therapy: pharmacology and clinical utility

(2008) Seetal Dodd et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Improved Virologic Response in Chronic Hepatitis C Genotype 4 Treated With Nitazoxanide, Peginterferon, and Ribavirin

(2008) Jean–François Rossignol et al.   GASTROENTEROLOGY

Glucose‐6‐Phosphate Dehydrogenase Deficiency Enhances Human Coronavirus 229E Infection

(2008) Yi‐Hsuan Wu et al.   JOURNAL OF INFECTIOUS DISEASES

NF- B Signaling Differentially Regulates Influenza Virus RNA Synthesis

(2008) N. Kumar et al.   JOURNAL OF VIROLOGY

GSH and analogs in antiviral therapy

(2008) Alessandra Fraternale et al.   MOLECULAR ASPECTS OF MEDICINE

Regulation of glutathione synthesis

(2008) Shelly C. Lu   MOLECULAR ASPECTS OF MEDICINE

Influenza A Virus Inhibits Type I IFN Signaling via NF-κB-Dependent Induction of SOCS-3 Expression

(2008) Eva-K. Pauli et al.   PLoS Pathogens

Inhibition of murine AIDS by pro-glutathione (GSH) molecules

(2007) A. Fraternale et al.   ANTIVIRAL RESEARCH