Review
Medicine, General & Internal
Lilly M. Wong, Guochun Jiang
Summary: HIV cure is hindered by the presence of quiescent yet replication competent HIV-1, but current research in NF-kappa B signaling pathways shows promise. Both canonical and noncanonical NF-kappa B signaling have been found to promote latency reversal and expression of HIV from reservoirs, offering new avenues for potential functional cure strategies.
Article
Multidisciplinary Sciences
Xiang-Hong Ran, Jia-Wu Zhu, Run-Ze Ni, Yong-Tang Zheng, Ya-Yun Chen, Wei-Hua Zheng, Dan Mu
Summary: Tripartite motif-containing protein 5 alpha (TRIM5 alpha) plays a crucial role in maintaining viral latency. Knockdown of TRIM5 alpha enhances the transcription of HIV-1, which can be reversed by shRNA-resistant TRIM5 alpha. TRIM5 alpha suppresses HIV-1 gene expression by binding to and enhancing the recruitment of histone deacetylase 1 (HDAC1) to NF-kappa B and Sp1.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Yuqi Zhu, Zhengtao Jiang, Lin Liu, Xinyi Yang, Min Li, Yipeng Cheng, Jianqing Xu, Chunhua Yin, Huanzhang Zhu
Summary: This study found that a compound called Scopoletin can reactivate latent HIV-1 infection and revealed its underlying mechanism. Using a Jurkat T cell model of HIV-1 latency, it was shown that Scopoletin can activate latent infection similarly to Prostratin in a dose- and time-dependent manner. The study also found that Scopoletin-induced HIV-1 reactivation involves the nuclear factor kappa B (NF-?B) signaling pathway. Overall, the findings suggest that Scopoletin has the potential to reactivate latent HIV-1 without causing global T-cell activation, making it a promising treatment option for anti-HIV-1 latency strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Laura L. Dickey, Laura J. Martins, Vicente Planelles, Timothy M. Hanley
Summary: Macrophages chronically infected with HIV-1 can enter a latent state resembling latency, characterized by decreased viral transcription and maintenance of a non-permissive state. This transition to viral latency is mediated by type I interferon signaling and requires the viral accessory protein Vpr. Understanding the mechanisms of HIV-1 latency in macrophages can lead to potential therapeutic targets for eliminating this important HIV-1 reservoir.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ma. Sheila M. de Jesus, Allan Patrick G. Macabeo, John Donnie A. Ramos, Von Novi O. de Leon, Kaori Asamitsu, Takashi Okamoto
Summary: The effects of spirobisindole alkaloids from the Philippine medicinal plant on HIV gene transcription were investigated, and it was found that one of the alkaloids showed inhibitory activity against viral replication. This alkaloid may serve as an inspiration for the discovery of new alkaloid-based anti-HIV derivatives.
Article
Evolutionary Biology
Michelle M. Leger, Nuria Ros-Rocher, Sebastian R. Najle, Inaki Ruiz-Trillo
Summary: The Rel/NF-kappa B transcription factor family plays diverse roles in immunity, development, and differentiation in animals. New research suggests that these proteins originated earlier than previously thought, in the last common ancestor of animals and fungi. The proteins in the sister group to fungi also contain elements necessary for subcellular regulation of Rel/NF-kappa B, similar to those found in animals.
GENOME BIOLOGY AND EVOLUTION
(2022)
Article
Biochemistry & Molecular Biology
Lei Xu, Yangfan Ye, Zeqiang Tao, Tian Wang, Yutian Wei, Wanzhi Cai, Xin Wan, Pengzhan Zhao, Wei Gu, Bin Gu, Liuchao Zhang, Yufei Tian, Ning Liu, Yiming Tu, Jing Ji
Summary: This study elucidated the role of MLPH in GBM radiation resistance, showing that MLPH promotes radiotherapy resistance by regulating the NF-kappa B pathway. Additionally, O-GlcNAcylation of MLPH protects it from degradation and stabilizes its presence in cells. These findings provide insights into a potential mechanism of GBM radiation resistance and suggest a therapeutic strategy for GBM treatment.
Editorial Material
Microbiology
Robert Z. Zhang, Melissa Kane
Summary: HIV-1 both inhibits and activates the NF-kappa B pathway, which is important for the viral life cycle. The viral protein U has contrasting effects on beta-TrCP1 and beta-TrCP2, leading to dysregulation of the NF-kappa B pathways. These findings enhance our understanding of how the NF-kappa B pathway functions during viral infection.
Article
Biology
Nicholas Sim, Yinghui Li
Summary: p52-induced ETS1 overexpression in glioma cells remodels the genome-wide regulatory network of p52 and ETS1 to transcriptionally drive cancer progression. Chronic inflammation promotes glioma progression by activating NF-kappa B signalling, which promotes cancer cell invasion and angiogenesis. Non-canonical NF-kappa B activation directly regulates p52 at the ETS1 promoter, leading to its overexpression and impacting the genomic landscape of ETS1 in a glioma-specific manner.
COMMUNICATIONS BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Matthew Martin, Mengyao Sun, Aishat Motolani, Tao Lu
Summary: This article provides an overview of colorectal cancer (CRC) and its stages, types of biomarkers, signaling pathways related to CRC, and the significant role of NF-kappa B in CRC. The authors suggest that more ideal NF-kappa B inhibitors may be developed with the discovery of novel regulators of the pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Matthew Martin, Rasika Mundade, Antja-Voy Hartley, Guanglong Jiang, Jiamin Jin, Steven Sun, Ahmad Safa, George Sandusky, Yunlong Liu, Tao Lu
Summary: ARMC4 is identified as a novel negative regulator of NF-kappa B, and may serve as a potential therapeutic target in colorectal cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Kyle D. Pedro, Luis M. Agosto, Jared A. Sewell, Kimberly A. Eberenz, Xianbao He, Juan I. Fuxman Bass, Andrew J. Henderson
Summary: Through a high-throughput screen, researchers identified 42 human transcription factors and 85 protein-DNA interactions related to HIV-1 and HIV-2, shedding light on their roles in HIV replication, transcription, and latency. Experimental results confirmed that transcription factors like KLF2, KLF3, and PLAGL1 have different regulatory effects on the transcription of HIV-1 and HIV-2.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Fisheries
Linwei Yang, Zi-Ang Wang, Ran Geng, Shengwen Niu, Hongliang Zuo, Shaoping Weng, Jianguo He, Xiaopeng Xu
Summary: In this study, a protein called KLHDC2 was identified and investigated for its immune function in Pacific white shrimp. KLHDC2 was found to enhance the immune defense against Vibrio parahaemolyticus but inhibit that against white spot syndrome virus. It regulates the expression of immune effector genes and has a complex regulatory relationship with NF-kappa B family members.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Wanzhen Lu, Chan Yang, Xinfeng Xu, Chen Chen, Xuben Hou, Hao Fang, Shuwen Liu
Summary: The synthesized HDAC I inhibitor CC-4a was found to reactivate latent HIV-1 at the protein and gene levels with low cytotoxicity and induced apoptosis in HIV-1 infected cell models. CC-4a also showed a synergistic activation effect with prostratin without triggering global T cell activation and down-regulated the expressions of CCR5 and CD4. Furthermore, CC-4a together with antiviral drugs antagonized HIV-1 without mutual interference by enhancing histone acetylation and activating the NF-kappa B pathway.
Article
Cell Biology
Wenfei Pan, Limei Deng, Haitao Wang, Vivien Ya-Fan Wang
Summary: The NF-kappa B family of dimeric transcription factors regulate various biological functions. A study has revealed that the atypical I kappa B protein, Bcl3, plays a crucial role in enhancing the population of the p52:p52 homodimer within the NF-kappa B family. Bcl3 competes with other NF-kappa B subunits for efficient p52:p52 homodimer formation, leading to the upregulation of target genes involved in cell proliferation, migration, and inflammation. The aberrant activation of Bcl3 and p52 contributes to cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemical Research Methods
James C. Stroud
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
(2013)
Correction
Immunology
Hozefa S. Bandukwala, Yongqing Wu, Markus Feuerer, Yongheng Chen, Bianca Barboza, Srimoyee Ghosh, James C. Stroud, Christophe Benoist, Diane Mathis, Anjana Rao, Lin Chen
Article
Immunology
Hozefa S. Bandukwala, Yongqing Wu, Markus Feuerer, Yongheng Chen, Bianca Barboza, Srimoyee Ghosh, James C. Stroud, Christophe Benoist, Diane Mathis, Anjana Rao, Lin Chen
Article
Biochemistry & Molecular Biology
Cosma D. Dellisanti, Sonya M. Hanson, Lin Chen, Cynthia Czajkowski
JOURNAL OF BIOLOGICAL CHEMISTRY
(2011)
Article
Biochemistry & Molecular Biology
Lei Gu, Cong Liu, James C. Stroud, Sam Ngo, Lin Jiang, Zhefeng Guo
JOURNAL OF BIOLOGICAL CHEMISTRY
(2014)
Article
Biochemistry & Molecular Biology
Yongqing Wu, Raja Dey, Aidong Han, Nimanthi Jayathilaka, Michael Philips, Jun Ye, Lin Chen
JOURNAL OF MOLECULAR BIOLOGY
(2010)
Article
Neurosciences
Lin Chen
JOURNAL OF PHYSIOLOGY-LONDON
(2010)
Article
Neurosciences
Shu-Xing Li, Sun Huang, Nina Bren, Kaori Noridomi, Cosma D. Dellisanti, Steven M. Sine, Lin Chen
NATURE NEUROSCIENCE
(2011)
Article
Biochemistry & Molecular Biology
Ju He, Jun Ye, Yongfei Cai, Cecilia Riquelme, Jun O. Liu, Xuedong Liu, Aidong Han, Lin Chen
NUCLEIC ACIDS RESEARCH
(2011)
Article
Multidisciplinary Sciences
James C. Stroud, Cong Liu, Poh K. Teng, David Eisenberg
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2012)
Article
Multidisciplinary Sciences
Georg K. A. Hochberg, Heath Ecroyd, Cong Liu, Dezerae Cox, Duilio Cascio, Michael R. Sawaya, Miranda P. Collier, James Stroud, John A. Carver, Andrew J. Baldwin, Carol V. Robinson, David S. Eisenberg, Justin L. P. Benesch, Arthur Laganowsky
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2014)
Article
Biochemistry & Molecular Biology
Yongheng Chen, Raja Dey, Lin Chen
Meeting Abstract
Biochemistry & Molecular Biology
Georg Hochberg, Heath Ecroyd, Dezerea Cox, Michael Sawaya, Cong Liu, Duilio Cascio, Miranda Collier, James Stroud, John Carver, Andrew Baldwin, Carol Robinson, David Eisenberg, Justin Benesch, Arthur Laganowsky
Article
Biochemistry & Molecular Biology
Ankita Chadda, Alexander G. Kozlov, Binh Nguyen, Timothy M. Lohman, Eric A. Galburt
Summary: In this study, it was found that the DNA damage response in Mycobacterium tuberculosis differs from well-studied model bacteria. The DNA repair helicase UvrD1 in Mtb is activated through a redox-dependent process and is closely associated with the homo-dimeric Ku protein. Additionally, Ku protein is shown to stimulate the helicase activity of UvrD1.
JOURNAL OF MOLECULAR BIOLOGY
(2024)