The role of Nrf2 transcription factor in viral infection

Respiratory syncytial virus induces NRF2 degradation through a promyelocytic leukemia protein ‐ ring finger protein 4 dependent pathway

(2017) Narayana Komaravelli et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of viruses in gastrointestinal cancer

(2017) Habibollah Mirzaei et al.   JOURNAL OF CELLULAR PHYSIOLOGY

HIV-1 decreases Nrf2/ARE activity and phagocytic function in alveolar macrophages

(2017) Bashar S. Staitieh et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Nrf2-dependent induction of innate host defense via heme oxygenase-1 inhibits Zika virus replication

(2017) Hanxia Huang et al.   VIROLOGY

Nonstructural Protein 1 of Tick-Borne Encephalitis Virus Induces Oxidative Stress and Activates Antioxidant Defense by the Nrf2/ARE Pathway

(2016) Yulia V. Kuzmenko et al.   INTERVIROLOGY

Dimerization Controls Marburg Virus VP24-dependent Modulation of Host Antioxidative Stress Responses

(2016) Britney Johnson et al.   JOURNAL OF MOLECULAR BIOLOGY

Oxidative Stress during HIV Infection: Mechanisms and Consequences

(2016) Alexander V. Ivanov et al.   Oxidative Medicine and Cellular Longevity

HIV-Tat Induces the Nrf2/ARE Pathway through NMDA Receptor-Elicited Spermine Oxidase Activation in Human Neuroblastoma Cells

(2016) Roberta Mastrantonio et al.   PLoS One

Influence of glutathione availability on cell damage induced by human immunodeficiency virus type 1 viral protein R

(2016) Noemí Monroy et al.   VIRUS RESEARCH

Apocynin and ebselen reduce influenza A virus-induced lung inflammation in cigarette smoke-exposed mice

(2016) L. C. Oostwoud et al.   Scientific Reports

Nrf2 Induces IL-17D to Mediate Tumor and Virus Surveillance

(2016) Robert Saddawi-Konefka et al.   Cell Reports

Activation of Nrf2 by the dengue virus causes an increase in CLEC5A, which enhances TNF-α production by mononuclear phagocytes

(2016) Yi-Lin Cheng et al.   Scientific Reports

p62 links autophagy and Nrf2 signaling

(2015) Tao Jiang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Respiratory syncytial virus infection down-regulates antioxidant enzyme expression by triggering deacetylation-proteasomal degradation of Nrf2

(2015) Narayana Komaravelli et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dimethyl fumarate suppresses Theiler’s murine encephalomyelitis virus-induced demyelinating disease by modifying the Nrf2-Keap1 pathway

(2015) Kunitoshi Kobayashi et al.   INTERNATIONAL IMMUNOLOGY

Bakuchiol Is a Phenolic Isoprenoid with Novel Enantiomer-selective Anti-influenza A Virus Activity Involving Nrf2 Activation

(2015) Masaki Shoji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Marburg Virus VP24 Protein Relieves Suppression of the NF–κB Pathway Through Interaction With Kelch-like ECH-Associated Protein 1

(2015) Megan R. Edwards et al.   JOURNAL OF INFECTIOUS DISEASES

Induction of Heme Oxygenase-1 Deficiency and Associated Glutamate-Mediated Neurotoxicity Is a Highly Conserved HIV Phenotype of Chronic Macrophage Infection That Is Resistant to Antiretroviral Therapy

(2015) Alexander J. Gill et al.   JOURNAL OF VIROLOGY

Activated Nrf2 Interacts with Kaposi's Sarcoma-Associated Herpesvirus Latency Protein LANA-1 and Host Protein KAP1 To Mediate Global Lytic Gene Repression

(2015) Olsi Gjyshi et al.   JOURNAL OF VIROLOGY

Hepatitis B virus stimulates G6PD expression through HBx-mediated Nrf2 activation

(2015) B Liu et al.   Cell Death & Disease

Functional Role of NRF2 in Cervical Carcinogenesis

(2015) Jun-Qi Ma et al.   PLoS One

Kaposi's Sarcoma-Associated Herpesvirus Induces Nrf2 Activation in Latently Infected Endothelial Cells through SQSTM1 Phosphorylation and Interaction with Polyubiquitinated Keap1

(2014) Olsi Gjyshi et al.   JOURNAL OF VIROLOGY

Marburgvirus Hijacks Nrf2-Dependent Pathway by Targeting Nrf2-Negative Regulator Keap1

(2014) Audrey Page et al.   Cell Reports

The Marburg Virus VP24 Protein Interacts with Keap1 to Activate the Cytoprotective Antioxidant Response Pathway

(2014) Megan R. Edwards et al.   Cell Reports

Cellular Oxidative Stress Response Controls the Antiviral and Apoptotic Programs in Dengue Virus-Infected Dendritic Cells

(2014) David Olagnier et al.   PLoS Pathogens

Kaposi's Sarcoma-Associated Herpesvirus Induces Nrf2 during De Novo Infection of Endothelial Cells to Create a Microenvironment Conducive to Infection

(2014) Olsi Gjyshi et al.   PLoS Pathogens

Genotype analysis of the NRF2 gene mutation in lung cancer

(2013) HIDEFUMI SASAKI et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Upregulation of Nrf2 expression by human cytomegalovirus infection protects host cells from oxidative stress

(2013) J. Lee et al.   JOURNAL OF GENERAL VIROLOGY

Extracellular HIV-1 viral protein R affects astrocytic glyceraldehyde 3-phosphate dehydrogenase activity and neuronal survival

(2013) Adriano Ferrucci et al.   JOURNAL OF NEUROVIROLOGY

Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy

(2013) Yoshinobu Ichimura et al.   MOLECULAR CELL

Oxidative Stress and HPV Carcinogenesis

(2013) Federico De Marco   Viruses-Basel

HCV and Oxidative Stress in the Liver

(2013) Alexander Ivanov et al.   Viruses-Basel

Oxidative stress induced by HIV-1 reverse transcriptase modulates the enzyme’s performance in gene immunization

(2013) Maria Isaguliants et al.   Human Vaccines & Immunotherapeutics

A Role for Virally Induced Reactive Oxygen Species in Kaposi's Sarcoma Herpesvirus Tumorigenesis

(2012) Qi Ma et al.   ANTIOXIDANTS & REDOX SIGNALING

Methylation of the KEAP1 gene promoter region in human colorectal cancer

(2012) Naoyuki Hanada et al.   BMC CANCER

Nrf2-induced antiapoptotic Bcl-xL protein enhances cell survival and drug resistance

(2012) Suryakant K. Niture et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2 Protein Up-regulates Antiapoptotic Protein Bcl-2 and Prevents Cellular Apoptosis

(2012) Suryakant K. Niture et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Nuclear Factor Erythroid 2-Related Factor 2 Exacerbates HIV-1 gp120-Induced Oxidative and Inflammatory Response: Role in HIV Associated Neurocognitive Disorder

(2012) Pichili Vijaya Bhaskar Reddy et al.   NEUROCHEMICAL RESEARCH

Nrf2 protects human alveolar epithelial cells against injury induced by influenza A virus

(2012) Beata Kosmider et al.   RESPIRATORY RESEARCH

Forty-Five Years of Marburg Virus Research

(2012) Kristina Brauburger et al.   Viruses-Basel

The Keap1–Nrf2 system in cancers: stress response and anabolic metabolism

(2012) Yoichiro Mitsuishi et al.   Frontiers in Oncology

N-acetyl-l-cysteine (NAC) inhibit mucin synthesis and pro-inflammatory mediators in alveolar type II epithelial cells infected with influenza virus A and B and with respiratory syncytial virus (RSV)

(2011) Manuel Mata et al.   BIOCHEMICAL PHARMACOLOGY

Frequent epigenetics inactivation of KEAP1 gene in non-small cell lung cancer

(2011) Lucia Anna Muscarella et al.   Epigenetics

Nrf2 expression modifies influenza A entry and replication in nasal epithelial cells

(2011) Matthew J. Kesic et al.   FREE RADICAL BIOLOGY AND MEDICINE

Clinical aspects of Marburg hemorrhagic fever

(2011) Masfique Mehedi et al.   Future Virology

Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution

(2011) Keiko Taguchi et al.   GENES TO CELLS

Hepatitis C Virus Impairs the Induction of Cytoprotective Nrf2 Target Genes by Delocalization of Small Maf Proteins

(2011) Monica Carvajal-Yepes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of MDL-1 (CLEC5A) on immature myeloid cells triggers lethal shock in mice

(2011) Ricky Cheung et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of Nrf2 in Host Defense against Influenza Virus in Cigarette Smoke-Exposed Mice

(2011) Y. Yageta et al.   JOURNAL OF VIROLOGY

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

Crosstalk in NF-κB signaling pathways

(2011) Andrea Oeckinghaus et al.   NATURE IMMUNOLOGY

Hepatitis C Virus Proteins Activate NRF2/ARE Pathway by Distinct ROS-Dependent and Independent Mechanisms in HUH7 Cells

(2011) Alexander V. Ivanov et al.   PLoS One

Cancer Chemoprevention Mechanisms Mediated Through the Keap1–Nrf2 Pathway

(2010) John D. Hayes et al.   ANTIOXIDANTS & REDOX SIGNALING

High Levels of Nrf2 Determine Chemoresistance in Type II Endometrial Cancer

(2010) T. Jiang et al.   CANCER RESEARCH

INrf2 (Keap1) targets Bcl-2 degradation and controls cellular apoptosis

(2010) S K Niture et al.   CELL DEATH AND DIFFERENTIATION

Suppression of NF-κB signaling by KEAP1 regulation of IKKβ activity through autophagic degradation and inhibition of phosphorylation

(2010) Jeong-Eun Kim et al.   CELLULAR SIGNALLING

Nrf2 and Keap1 Abnormalities in Non-Small Cell Lung Carcinoma and Association with Clinicopathologic Features

(2010) L. M. Solis et al.   CLINICAL CANCER RESEARCH

Coinfection with hepatitis C virus, oxidative stress and antioxidant status in HIV-positive drug users in Miami*

(2010) MK Baum et al.   HIV MEDICINE

Loss of Kelch-Like ECH-Associated Protein 1 Function in Prostate Cancer Cells Causes Chemoresistance and Radioresistance and Promotes Tumor Growth

(2010) P. Zhang et al.   MOLECULAR CANCER THERAPEUTICS

The many roles of NOX2 NADPH oxidase-derived ROS in immunity

(2010) Grace Y. Lam et al.   Seminars in Immunopathology

Bortezomib Inhibits Hepatitis B Virus Replication in Transgenic Mice

(2009) P. Bandi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Potential Factors Induced by Filoviruses that Lead to Immune Supression

(2009) Mansour Mohamadzadeh   CURRENT MOLECULAR MEDICINE

Nrf2 is involved in inhibiting Tat-induced HIV-1 long terminal repeat transactivation

(2009) Hong-Sheng Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress

(2009) Truyen Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of transcription factor Nrf2 by hepatitis C virus induces the cell-survival pathway

(2009) D. Burdette et al.   JOURNAL OF GENERAL VIROLOGY

Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin

(2009) Yoo Ri Kim et al.   JOURNAL OF PATHOLOGY

Ebolavirus VP24 Binding to Karyopherins Is Required for Inhibition of Interferon Signaling

(2009) M. Mateo et al.   JOURNAL OF VIROLOGY

The proteasomal system

(2009) Tobias Jung et al.   MOLECULAR ASPECTS OF MEDICINE

KEAP1 E3 Ligase-Mediated Downregulation of NF-κB Signaling by Targeting IKKβ

(2009) Dung-Fang Lee et al.   MOLECULAR CELL

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Antiviral Activity of Nrf2 in a Murine Model of Respiratory Syncytial Virus Disease

(2008) Hye-Youn Cho et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Pathology of Influenza Virus Infections

(2008) Jeffery K. Taubenberger et al.   Annual Review of Pathology-Mechanisms of Disease

Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

(2008) X.-J. Wang et al.   CARCINOGENESIS

Covalent Modification at Cys151 Dissociates the Electrophile Sensor Keap1 from the Ubiquitin Ligase CUL3

(2008) Girish Rachakonda et al.   CHEMICAL RESEARCH IN TOXICOLOGY

HIV/AIDS: Epidemiology, Pathophysiology, and Treatment of Kaposi Sarcoma–Associated Herpesvirus Disease: Kaposi Sarcoma, Primary Effusion Lymphoma, and Multicentric Castleman Disease

(2008) Ryan J. Sullivan et al.   CLINICAL INFECTIOUS DISEASES

Brick by brick: metabolism and tumor cell growth

(2008) Ralph J DeBerardinis et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Lung epithelial apoptosis in influenza virus pneumonia: the role of macrophage-expressed TNF-related apoptosis-inducing ligand

(2008) Susanne Herold et al.   JOURNAL OF EXPERIMENTAL MEDICINE

HIV-1 viral envelope glycoprotein gp120 produces oxidative stress and regulates the functional expression of multidrug resistance protein-1 (Mrp1) in glial cells

(2008) Patrick T. Ronaldson et al.   JOURNAL OF NEUROCHEMISTRY

CLEC5A is critical for dengue-virus-induced lethal disease

(2008) Szu-Ting Chen et al.   NATURE

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

(2008) T. Shibata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA