Dual Roles of Microglia in the Basal Ganglia in Parkinson’s Disease

The Roles of High Mobility Group Box 1 in Cerebral Ischemic Injury

(2021) Xiaoyun Gou et al.   Frontiers in Cellular Neuroscience

Snapshot of microglial physiological functions

(2021) Alexei Verkhratsky et al.   NEUROCHEMISTRY INTERNATIONAL

The effect of aged microglia on synaptic impairment and its relevance in neurodegenerative diseases

(2021) Juan José Triviño et al.   NEUROCHEMISTRY INTERNATIONAL

Neuroendocrine, neuroinflammatory and pathological outcomes of chronic stress: A story of microglial remodeling

(2021) Katherine Picard et al.   NEUROCHEMISTRY INTERNATIONAL

Through Reducing ROS Production, IL-10 Suppresses Caspase-1-Dependent IL-1β Maturation, thereby Preventing Chronic Neuroinflammation and Neurodegeneration

(2020) Yun Gao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microglia mediate forgetting via complement-dependent synaptic elimination

(2020) Chao Wang et al.   SCIENCE

Molecular Signatures of Neuroinflammation Induced by αSynuclein Aggregates in Microglial Cells

(2020) Souvarish Sarkar et al.   Frontiers in Immunology

Impact of Aging on the 6-OHDA-Induced Rat Model of Parkinson’s Disease

(2020) Sandra Barata-Antunes et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

BDNF reverses aging-related microglial activation

(2020) Shih-Ying Wu et al.   Journal of Neuroinflammation

Microglia and Macrophages in the Pathological Central and Peripheral Nervous Systems

(2020) Naoki Abe et al.   Cells

Microglial metabolic disturbances and neuroinflammation in cerebral infarction

(2020) Haruna Takeda et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Involvement of microglia in disturbed fear memory regulation: Possible microglial contribution to the pathophysiology of posttraumatic stress disorder

(2020) Shingo Enomoto et al.   NEUROCHEMISTRY INTERNATIONAL

Synaptic elimination by microglia and disturbed higher brain functions

(2020) Kazuya Miyanishi et al.   NEUROCHEMISTRY INTERNATIONAL

Neuroinflammation and protein pathology in Parkinson’s disease dementia

(2020) Antonina Kouli et al.   Acta Neuropathologica Communications

A geroscience approach for Parkinson’s disease: Conceptual framework and design of PROPAG-AGEING project

(2020) Chiara Pirazzini et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Noradrenaline as a key neurotransmitter in modulating microglial activation in stress response

(2020) Shuei Sugama et al.   NEUROCHEMISTRY INTERNATIONAL

miR-let-7a suppresses α-Synuclein-induced microglia inflammation through targeting STAT3 in Parkinson's disease

(2019) Jianzhong Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NG2 glia are required for maintaining microglia homeostatic state

(2019) Yingjun Liu et al.   GLIA

Phagocytic elimination of synapses by microglia during sleep

(2019) Mohammed E. Choudhury et al.   GLIA

Sustained anti-inflammatory effects of TGF-β1 on microglia/macrophages

(2018) Afsana Islam et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Aging and Parkinson's Disease: Inflammaging, neuroinflammation and biological remodeling as key factors in pathogenesis

(2018) Vittorio Calabrese et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cx3cr1-deficiency exacerbates alpha-synuclein-A53T induced neuroinflammation and neurodegeneration in a mouse model of Parkinson's disease

(2018) Sara Castro-Sánchez et al.   GLIA

High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease

(2018) Dunja Mrdjen et al.   IMMUNITY

Aged Mouse Cortical Microglia Display an Activation Profile Suggesting Immunotolerogenic Functions

(2018) Tanja Zöller et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Modafinil alleviates levodopa-induced excessive nighttime sleepiness and restores monoaminergic systems in a nocturnal animal model of Parkinson's disease

(2018) Rina Ando et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Arginase: A Multifaceted Enzyme Important in Health and Disease

(2018) R. William Caldwell et al.   PHYSIOLOGICAL REVIEWS

Comparison of the detrimental features of microglia and infiltrated macrophages in traumatic brain injury: A study using a hypnotic bromovalerylurea

(2018) Naoki Abe et al.   GLIA

Diagnostic biomarkers for Parkinson’s disease at a glance: where are we?

(2018) Ilaria Cova et al.   JOURNAL OF NEURAL TRANSMISSION

Role of Toll-like receptor mediated signaling in traumatic brain injury

(2018) Hongjuan Shi et al.   NEUROPHARMACOLOGY

Microglial TREM2/DAP12 Signaling: A Double-Edged Sword in Neural Diseases

(2018) Hiroyuki Konishi et al.   Frontiers in Cellular Neuroscience

Microglial glutamate release evoked by α-synuclein aggregates is prevented by dopamine

(2018) Mauricio dos-Santos-Pereira et al.   GLIA

Behavioral tests predicting striatal dopamine level in a rat hemi-Parkinson's disease model

(2018) Kazuya Miyanishi et al.   NEUROCHEMISTRY INTERNATIONAL

Role of Microglia TLRs in Neurodegeneration

(2018) Bernd L. Fiebich et al.   Frontiers in Cellular Neuroscience

Forced turnover of aged microglia induces an intermediate phenotype but does not rebalance CNS environmental cues driving priming to immune challenge

(2018) Shane M. O’Neil et al.   Acta Neuropathologica Communications

Microglia may compensate for dopaminergic neuron loss in experimental Parkinsonism through selective elimination of glutamatergic synapses from the subthalamic nucleus

(2017) Hitomi Aono et al.   GLIA

Siglec-H is a microglia-specific marker that discriminates microglia from CNS-associated macrophages and CNS-infiltrating monocytes

(2017) Hiroyuki Konishi et al.   GLIA

Minocycline reduces microgliosis and improves subcortical white matter function in a model of cerebral vascular disease

(2017) Yasmina Manso et al.   GLIA

Microglia amplify inflammatory activation of astrocytes in manganese neurotoxicity

(2017) Kelly S. Kirkley et al.   Journal of Neuroinflammation

Effects of hypnotic bromovalerylurea on microglial BV2 cells

(2017) Shun Kawasaki et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Microglia in Health and Disease: A Double-Edged Sword

(2017) Ana Raquel Santiago et al.   MEDIATORS OF INFLAMMATION

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Transcriptomic analysis of purified human cortical microglia reveals age-associated changes

(2017) Thais F Galatro et al.   NATURE NEUROSCIENCE

Interleukin-4 Protects Dopaminergic Neurons In vitro but Is Dispensable for MPTP-Induced Neurodegeneration In vivo

(2017) Laura Hühner et al.   Frontiers in Molecular Neuroscience

Toll-like receptor 2 is increased in neurons in Parkinson’s disease brain and may contribute to alpha-synuclein pathology

(2016) Nicolas Dzamko et al.   ACTA NEUROPATHOLOGICA

Microglia show altered morphology and reduced arborization in human brain during aging and Alzheimer's disease

(2016) Danielle S. Davies et al.   BRAIN PATHOLOGY

Critical data-based re-evaluation of minocycline as a putative specific microglia inhibitor

(2016) Thomas Möller et al.   GLIA

A polarizing question: do M1 and M2 microglia exist?

(2016) Richard M Ransohoff   NATURE NEUROSCIENCE

The hypnotic bromovalerylurea ameliorates 6-hydroxydopamine-induced dopaminergic neuron loss while suppressing expression of interferon regulatory factors by microglia

(2016) Hiromi Higaki et al.   NEUROCHEMISTRY INTERNATIONAL

New tools for studying microglia in the mouse and human CNS

(2016) Mariko L. Bennett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Integrated Review of Psychological Stress in Parkinson’s Disease: Biological Mechanisms and Symptom and Health Outcomes

(2016) Kim Wieczorek Austin et al.   Parkinsons Disease

Age-dependent defects of alpha-synuclein oligomer uptake in microglia and monocytes

(2015) Corinna Bliederhaeuser et al.   ACTA NEUROPATHOLOGICA

The ameliorative effects of a hypnotic bromvalerylurea in sepsis

(2015) Satoshi Kikuchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NG2-glia and their functions in the central nervous system

(2015) L. Dimou et al.   GLIA

CD200+ and CD200− macrophages accumulated in ischemic lesions of rat brain: The two populations cannot be classified as either M1 or M2 macrophages

(2015) Shirabe Matsumoto et al.   JOURNAL OF NEUROIMMUNOLOGY

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Anti-inflammatory effects of noradrenaline on LPS-treated microglial cells: Suppression of NFκB nuclear translocation and subsequent STAT1 phosphorylation

(2015) Yurika Ishii et al.   NEUROCHEMISTRY INTERNATIONAL

TMEM119 marks a subset of microglia in the human brain

(2015) Jun-ichi Satoh et al.   NEUROPATHOLOGY

NG2 cells (polydendrocytes): Listeners to the neural network with diverse properties

(2014) Robert A. Hill et al.   GLIA

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

(2014) Jonathan D Cherry et al.   Journal of Neuroinflammation

Direct and indirect pathways of basal ganglia: a critical reappraisal

(2014) Paolo Calabresi et al.   NATURE NEUROSCIENCE

Microglial priming in neurodegenerative disease

(2014) V. Hugh Perry et al.   Nature Reviews Neurology

Microglial phagocytosis of live neurons

(2014) Guy C. Brown et al.   NATURE REVIEWS NEUROSCIENCE

Redundant dopaminergic activity may enable compensatory axonal sprouting in Parkinson disease

(2014) D. Arkadir et al.   NEUROLOGY

Human Umbilical Cord Mesenchymal Stem Cells Infected with Adenovirus ExpressingHGFPromote Regeneration of Damaged Neuron Cells in a Parkinson’s Disease Model

(2014) Xin-Shan Liu et al.   Biomed Research International

Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro

(2013) Vibol Chhor et al.   BRAIN BEHAVIOR AND IMMUNITY

Glutamate Receptors in Microglia

(2013) Madhuvika Murugan et al.   CNS & Neurological Disorders-Drug Targets

Rotenone induces neuronal death by microglial phagocytosis of neurons

(2013) Julius V. Emmrich et al.   FEBS Journal

Activated microglia in a rat stroke model express NG2 proteoglycan in peri-infarct tissue through the involvement of TGF-β1

(2013) Kana Sugimoto et al.   GLIA

Doxycycline restrains glia and confers neuroprotection in a 6-OHDA Parkinson model

(2013) Marcio Lazzarini et al.   GLIA

Expression of MCP-1 and fractalkine on endothelial cells and astrocytes may contribute to the invasion and migration of brain macrophages in ischemic rat brain lesions

(2013) Nari Tei et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Neurotransmitter signaling in the pathophysiology of microglia

(2013) María Domercq et al.   Frontiers in Cellular Neuroscience

Toll like receptor 4 mediates cell death in a mouse MPTP model of Parkinson disease

(2013) Carmen Noelker et al.   Scientific Reports

Reciprocal Regulation between Resting Microglial Dynamics and Neuronal Activity In Vivo

(2012) Ying Li et al.   DEVELOPMENTAL CELL

Zonisamide up-regulated the mRNAs encoding astrocytic anti-oxidative and neurotrophic factors

(2012) ME Choudhury et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Progressive degeneration of human neural stem cells caused by pathogenic LRRK2

(2012) Guang-Hui Liu et al.   NATURE

Microglia: actively surveying and shaping neuronal circuit structure and function

(2012) Hiroaki Wake et al.   TRENDS IN NEUROSCIENCES

Toll-Like Receptor 4 Promotes α-Synuclein Clearance and Survival of Nigral Dopaminergic Neurons

(2011) Nadia Stefanova et al.   AMERICAN JOURNAL OF PATHOLOGY

Age related changes in microglial phenotype vary between CNS regions: Grey versus white matter differences

(2011) Adam D. Hart et al.   BRAIN BEHAVIOR AND IMMUNITY

Subcutaneous injection containing IL-3 and GM-CSF ameliorates stab wound-induced brain injury in rats

(2011) Tasuku Nishihara et al.   EXPERIMENTAL NEUROLOGY

Stress, depression and Parkinson's disease

(2011) Ann M. Hemmerle et al.   EXPERIMENTAL NEUROLOGY

β2-Adrenergic Receptor Activation Prevents Rodent Dopaminergic Neurotoxicity by Inhibiting Microglia via a Novel Signaling Pathway

(2011) Li Qian et al.   JOURNAL OF IMMUNOLOGY

Concurrent hippocampal induction of MHC II pathway components and glial activation with advanced aging is not correlated with cognitive impairment

(2011) Heather D VanGuilder et al.   Journal of Neuroinflammation

NG2-glia as Multipotent Neural Stem Cells: Fact or Fantasy?

(2011) William D. Richardson et al.   NEURON

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Microglial Morphology and Dynamic Behavior Is Regulated by Ionotropic Glutamatergic and GABAergic Neurotransmission

(2011) Aurora M. Fontainhas et al.   PLoS One

A cytokine mixture of GM-CSF and IL-3 that induces a neuroprotective phenotype of microglia leading to amelioration of (6-OHDA)-induced Parkinsonism of rats

(2011) Mohammed Emamussalehin Choudhury et al.   Brain and Behavior

Age-specific progression of nigrostriatal dysfunction in Parkinson's disease

(2010) Raúl de la Fuente-Fernández et al.   ANNALS OF NEUROLOGY

Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3β phosphorylation

(2010) Zhongshu Tang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry

(2010) Alexxai V. Kravitz et al.   NATURE

Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine

(2010) M. T. Heneka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglial Interactions with Synapses Are Modulated by Visual Experience

(2010) Marie-Ève Tremblay et al.   PLOS BIOLOGY

Pretreatment with interferon-γ protects microglia from oxidative stress via up-regulation of Mn-SOD

(2009) Xia Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Iba1+/NG2+ Macrophage-Like Cells Expressing a Variety of Neuroprotective Factors Ameliorate Ischemic Damage of the Brain

(2009) Anna Smirkin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Relationship between microglial activation and dopaminergic neuronal loss in the substantia nigra: a time course study in a 6-hydroxydopamine model of Parkinson’s disease

(2009) Lilia Marinova-Mutafchieva et al.   JOURNAL OF NEUROCHEMISTRY

Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria

(2009) Dennis W Dickson et al.   LANCET NEUROLOGY

Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

(2009) Wataru Satake et al.   NATURE GENETICS

Genome-wide association study reveals genetic risk underlying Parkinson's disease

(2009) Javier Simón-Sánchez et al.   NATURE GENETICS

Chronic expression of low levels of tumor necrosis factor-α in the substantia nigra elicits progressive neurodegeneration, delayed motor symptoms and microglia/macrophage activation

(2009) Ana Laura De Lella Ezcurra et al.   NEUROBIOLOGY OF DISEASE

Incidence and remaining lifetime risk of Parkinson disease in advanced age

(2009) J. A. Driver et al.   NEUROLOGY

The influence of microglia on the pathogenesis of Parkinson's disease

(2009) Caitríona M. Long-Smith et al.   PROGRESS IN NEUROBIOLOGY

Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1β and anti-inflammatory IL-10 cytokines

(2008) Christopher J. Henry et al.   BRAIN BEHAVIOR AND IMMUNITY

A Pilot Clinical Trial of Creatine and Minocycline in Early Parkinson Disease

(2008)   CLINICAL NEUROPHARMACOLOGY

Pre-synaptic dopaminergic compensation after moderate nigrostriatal damage in non-human primates

(2008) Xiomara A. Perez et al.   JOURNAL OF NEUROCHEMISTRY

Parkinson's disease: clinical features and diagnosis

(2008) J Jankovic   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Neuroinflammation and Oxidation/Nitration of  -Synuclein Linked to Dopaminergic Neurodegeneration

(2008) H.-M. Gao et al.   JOURNAL OF NEUROSCIENCE

Neuropsychological and psychiatric changes after deep brain stimulation for Parkinson's disease: a randomised, multicentre study

(2008) Karsten Witt et al.   LANCET NEUROLOGY

Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

(2008) Daniel G Healy et al.   LANCET NEUROLOGY