Involvement of microglia in disturbed fear memory regulation: Possible microglial contribution to the pathophysiology of posttraumatic stress disorder

Neurobiology of BDNF in fear memory, sensitivity to stress, and stress-related disorders

(2020) Michael Notaras et al.   MOLECULAR PSYCHIATRY

Microglia mediate forgetting via complement-dependent synaptic elimination

(2020) Chao Wang et al.   SCIENCE

Microglial Function in the Effects of Early-Life Stress on Brain and Behavioral Development

(2020) Clarissa Catale et al.   Journal of Clinical Medicine

Acute stress induces chronic neuroinflammatory, microglial and behavioral priming: A role for potentiated NLRP3 inflammasome activation

(2020) Matthew G. Frank et al.   BRAIN BEHAVIOR AND IMMUNITY

Regulation of microglia by neuromodulators: Modulations in major and minor modes

(2020) G. Albertini et al.   NEUROSCIENCE LETTERS

Stress-induced impairment in fear discrimination is causally related to increased kynurenic acid formation in the prefrontal cortex

(2020) Alex D. Klausing et al.   PSYCHOPHARMACOLOGY

PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies

(2020) Shivani Bhatt et al.   Nature Communications

Stress-induced NLRP3 inflammasome activation negatively regulates fear memory in mice

(2020) Yuan Dong et al.   Journal of Neuroinflammation

Inflammation and posttraumatic stress disorder

(2019) Hiroaki Hori et al.   PSYCHIATRY AND CLINICAL NEUROSCIENCES

Microglia: Neuroimmune-sensors of stress

(2019) Matthew G. Frank et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Neurobiology of Fear Generalization

(2019) Arun Asok et al.   Frontiers in Behavioral Neuroscience

Norepinephrine Induces PTSD-Like Memory Impairments via Regulation of the β-Adrenoceptor-cAMP/PKA and CaMK II/PKC Systems in the Basolateral Amygdala

(2019) Xiang-Hui Liu et al.   Frontiers in Behavioral Neuroscience

Suicide and Microglia: Recent Findings and Future Perspectives Based on Human Studies

(2019) Hisaomi Suzuki et al.   Frontiers in Cellular Neuroscience

Deficiencies of microglia and TNFα in the mPFC-mediated cognitive inflexibility induced by social stress during adolescence

(2019) Yu Zhang et al.   BRAIN BEHAVIOR AND IMMUNITY

Early life stress by repeated maternal separation induces long-term neuroinflammatory response in glial cells of male rats

(2019) María Banqueri et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Glucocorticoid receptor antagonism prevents microglia-mediated neuronal remodeling and behavioral despair following chronic unpredictable stress

(2019) Matthew J. Horchar et al.   BRAIN BEHAVIOR AND IMMUNITY

Minocycline inhibits microglial activation and alleviates depressive-like behaviors in male adolescent mice subjected to maternal separation

(2019) Yue Han et al.   PSYCHONEUROENDOCRINOLOGY

Transient upregulation of immune activity induced by adolescent social stress is involved in cognitive deficit in adult male mice and early intervention with minocycline

(2019) Yu Zhang et al.   BEHAVIOURAL BRAIN RESEARCH

Microglia Biology: One Century of Evolving Concepts

(2019) Marco Prinz et al.   CELL

Role of BDNF in the pathophysiology and treatment of depression: Activity‐dependent effects distinguish rapid‐acting antidepressants

(2019) Ronald S. Duman et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The effects of eicosapentaenoic acid dietary supplementation on behavioral parameters and expression of hippocampal brain-derived neurotrophic factor in an animal model of post-traumatic stress disorder

(2019) Masaaki Tanichi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Stress-induced microglial activation occurs through β-adrenergic receptor: noradrenaline as a key neurotransmitter in microglial activation

(2019) Shuei Sugama et al.   Journal of Neuroinflammation

Antidepressant effect of the translocator protein antagonist ONO-2952 on mouse behaviors under chronic social defeat stress

(2019) Kanako Nozaki et al.   NEUROPHARMACOLOGY

Stress-Induced Neuronal Colony Stimulating Factor 1 Provokes Microglia-Mediated Neuronal Remodeling and Depressive-like Behavior

(2018) Eric S. Wohleb et al.   BIOLOGICAL PSYCHIATRY

Persistent Increase in Microglial RAGE Contributes to Chronic Stress–Induced Priming of Depressive-like Behavior

(2018) Tina C. Franklin et al.   BIOLOGICAL PSYCHIATRY

Enhanced fear and altered neuronal activation in forebrain limbic regions of CX3CR1-deficient mice

(2018) Inga Schubert et al.   BRAIN BEHAVIOR AND IMMUNITY

Glycyrrhizin Treatment Facilitates Extinction of Conditioned Fear Responses After a Single Prolonged Stress Exposure in Rats

(2018) Shuhua Lai et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Tryptophan-kynurenine and lipid related metabolites as blood biomarkers for first-episode drug-naïve patients with major depressive disorder: An exploratory pilot case-control study

(2018) Nobuki Kuwano et al.   JOURNAL OF AFFECTIVE DISORDERS

Immune memory in the brain

(2018) Alexi Nott et al.   NATURE

The Innate Immune Receptors TLR2/4 Mediate Repeated Social Defeat Stress-Induced Social Avoidance through Prefrontal Microglial Activation

(2018) Xiang Nie et al.   NEURON

Dynamic changes in hippocampal microglia contribute to depressive-like behavior induced by early social isolation

(2018) Yu Gong et al.   NEUROPHARMACOLOGY

The role of the medial prefrontal cortex in the generalization of conditioned fear.

(2018) Kelsey N. Spalding   NEUROPSYCHOLOGY

Repeated social defeat-induced neuroinflammation, anxiety-like behavior and resistance to fear extinction were attenuated by the cannabinoid receptor agonist WIN55,212-2

(2018) Sabrina Francesca Lisboa et al.   NEUROPSYCHOPHARMACOLOGY

A neuronal basis for fear discrimination in the lateral amygdala

(2018) Anna Grosso et al.   Nature Communications

Noradrenergic Modulation of Fear Conditioning and Extinction

(2018) Thomas F. Giustino et al.   Frontiers in Behavioral Neuroscience

Propranolol can induce PTSD-like memory impairments in rats

(2018) Rong-Ting Zhu et al.   Brain and Behavior

Regulatory and Mechanistic Actions of Glucocorticoids on T and Inflammatory Cells

(2018) Ana C. Liberman et al.   Frontiers in Endocrinology

The effects of early life stress on context fear generalization in adult rats.

(2018) Nathalie D. Elliott et al.   BEHAVIORAL NEUROSCIENCE

Mechanisms of fear learning and extinction: synaptic plasticity–fear memory connection

(2018) Natalia V. Luchkina et al.   PSYCHOPHARMACOLOGY

Synaptic encoding of fear memories in the amygdala

(2018) Reed L Ressler et al.   CURRENT OPINION IN NEUROBIOLOGY

Pro-inflammatory activation of primary microglia and macrophages increases 18 kDa translocator protein expression in rodents but not humans

(2017) David R Owen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Heroes of the Engram

(2017) Sheena A. Josselyn et al.   JOURNAL OF NEUROSCIENCE

BDNF at the synapse: why location matters

(2017) M Song et al.   MOLECULAR PSYCHIATRY

The Biology of Forgetting—A Perspective

(2017) Ronald L. Davis et al.   NEURON

Forgetting of what was once learned: Exploring the role of postsynaptic ionotropic glutamate receptors on memory formation, maintenance, and decay

(2017) Ricardo Marcelo Sachser et al.   NEUROPHARMACOLOGY

Stress-altered synaptic plasticity and DAMP signaling in the hippocampus-PFC axis; elucidating the significance of IGF-1/IGF-1R/CaMKIIα expression in neural changes associated with a prolonged exposure therapy

(2017) Olalekan M. Ogundele et al.   NEUROSCIENCE

Differences in hippocampal serotonergic activity in a mouse single prolonged stress paradigm impact discriminant fear acquisition and retention

(2017) Deane E. Aikins et al.   NEUROSCIENCE LETTERS

Driving and regulating temporal association learning coordinated by entorhinal-hippocampal network

(2017) Takashi Kitamura   NEUROSCIENCE RESEARCH

Modulation of Aversive Memory by Adult Hippocampal Neurogenesis

(2017) Michael R. Drew et al.   Neurotherapeutics

Risk of relapse after antidepressant discontinuation in anxiety disorders, obsessive-compulsive disorder, and post-traumatic stress disorder: systematic review and meta-analysis of relapse prevention trials

(2017) Neeltje M Batelaan et al.   BMJ-British Medical Journal

Risk of relapse after antidepressant discontinuation in anxiety disorders, obsessive-compulsive disorder, and post-traumatic stress disorder: systematic review and meta-analysis of relapse prevention trials

(2017) Neeltje M Batelaan et al.   BMJ-British Medical Journal

Microglial depletion and activation: A [11C]PBR28 PET study in nonhuman primates

(2017) Ansel T. Hillmer et al.   EJNMMI Research

TNF-α from hippocampal microglia induces working memory deficits by acute stress in mice

(2016) Masahiro Ohgidani et al.   BRAIN BEHAVIOR AND IMMUNITY

Fractalkine receptor deficiency impairs microglial and neuronal responsiveness to chronic stress

(2016) Giampaolo Milior et al.   BRAIN BEHAVIOR AND IMMUNITY

Stress, glucocorticoids and memory: implications for treating fear-related disorders

(2016) Dominique de Quervain et al.   NATURE REVIEWS NEUROSCIENCE

Neural circuits and mechanisms involved in fear generalization: Implications for the pathophysiology and treatment of posttraumatic stress disorder

(2016) Dora Lopresto et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Hippocampal neurogenesis enhancers promote forgetting of remote fear memory after hippocampal reactivation by retrieval

(2016) Rie Ishikawa et al.   eLife

Neuron–Microglia Interactions in Mental Health Disorders: “For Better, and For Worse”

(2016) Eric S. Wohleb   Frontiers in Immunology

Cecal Ligation and Puncture Results in Long-Term Central Nervous System Myeloid Inflammation

(2016) Benjamin H. Singer et al.   PLoS One

Plasma Metabolites Predict Severity of Depression and Suicidal Ideation in Psychiatric Patients-A Multicenter Pilot Analysis

(2016) Daiki Setoyama et al.   PLoS One

Abnormal Fear Memory as a Model for Posttraumatic Stress Disorder

(2015) Aline Desmedt et al.   BIOLOGICAL PSYCHIATRY

Molecular mechanisms regulating NLRP3 inflammasome activation

(2015) Eun-Kyeong Jo et al.   Cellular & Molecular Immunology

GABAergic mechanisms regulated by miR-33 encode state-dependent fear

(2015) Vladimir Jovasevic et al.   NATURE NEUROSCIENCE

Neuronal circuits for fear and anxiety

(2015) Philip Tovote et al.   NATURE REVIEWS NEUROSCIENCE

Stress and Fear Extinction

(2015) Stephen Maren et al.   NEUROPSYCHOPHARMACOLOGY

Microglia activation regulates GluR1 phosphorylation in chronic unpredictable stress-induced cognitive dysfunction

(2015) Mingchao Liu et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Fear renewal preferentially activates ventral hippocampal neurons projecting to both amygdala and prefrontal cortex in rats

(2015) Jingji Jin et al.   Scientific Reports

Glucocorticoids Increase Excitotoxic Injury and Inflammation in the Hippocampus of Adult Male Rats

(2014) Shawn F. Sorrells et al.   NEUROENDOCRINOLOGY

Hippocampal Neurogenesis Regulates Forgetting During Adulthood and Infancy

(2014) K. G. Akers et al.   SCIENCE

Stem Cells of the Apical Papilla Regulate Trigeminal Neurite Outgrowth and Targeting through a BDNF-Dependent Mechanism

(2014) Jose Flavio A. de Almeida et al.   TISSUE ENGINEERING PART A

Association of trauma exposure with proinflammatory activity: a transdiagnostic meta-analysis

(2014) M Tursich et al.   Translational Psychiatry

Minocycline, a Microglial Inhibitor, Diminishes Terminal Patients' Delirium?

(2013) Kohei Hayakawa et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

Potent and multiple regulatory actions of microglial glucocorticoid receptors during CNS inflammation

(2013) M Á Carrillo-de Sauvage et al.   CELL DEATH AND DIFFERENTIATION

Geranylgeranyltransferase I mediates BDNF-induced synaptogenesis

(2013) Zhengwei Li et al.   JOURNAL OF NEUROCHEMISTRY

A Genetic Polymorphism for Translocator Protein 18 Kda Affects both in Vitro and in Vivo Radioligand Binding in Human Brain to this Putative Biomarker of Neuroinflammation

(2012) William C Kreisl et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Single prolonged stress disrupts retention of extinguished fear in rats

(2012) D. Knox et al.   LEARNING & MEMORY

Optogenetic stimulation of a hippocampal engram activates fear memory recall

(2012) Xu Liu et al.   NATURE

Minocycline Modulates Human Social Decision-Making: Possible Impact of Microglia on Personality-Oriented Social Behaviors

(2012) Takahiro A. Kato et al.   PLoS One

Glucocorticoids Can Induce PTSD-Like Memory Impairments in Mice

(2012) N. Kaouane et al.   SCIENCE

Stress-enhanced fear learning in rats is resistant to the effects of immediate massed extinction

(2012) Virginia A. Long et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

The Nature and Significance of Memory Disturbance in Posttraumatic Stress Disorder

(2011) Chris R. Brewin   Annual Review of Clinical Psychology

Increased peripheral NF-κB pathway activity in women with childhood abuse-related posttraumatic stress disorder

(2011) Thaddeus W.W. Pace et al.   BRAIN BEHAVIOR AND IMMUNITY

Molecular Mechanisms of Fear Learning and Memory

(2011) Joshua P. Johansen et al.   CELL

Between-systems memory interference during retrieval

(2011) Fraser T. Sparks et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

High-mobility group box-1 impairs memory in mice through both toll-like receptor 4 and Receptor for Advanced Glycation End Products

(2011) Andréy Mazarati et al.   EXPERIMENTAL NEUROLOGY

The Role of Microglia in the Healthy Brain

(2011) M.-E. Tremblay et al.   JOURNAL OF NEUROSCIENCE

Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation

(2011) Amar Sahay et al.   NATURE

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

CX3CR1 deficiency alters hippocampal-dependent plasticity phenomena blunting the effects of enriched environment

(2011) Laura Maggi   Frontiers in Cellular Neuroscience

Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis

(2010) Amanda Sierra et al.   Cell Stem Cell

Inflammation-associated depression: From serotonin to kynurenine

(2010) Robert Dantzer et al.   PSYCHONEUROENDOCRINOLOGY

Changing Face of Microglia

(2010) M. B. Graeber   SCIENCE

Microglial Physiology: Unique Stimuli, Specialized Responses

(2009) Richard M. Ransohoff et al.   Annual Review of Immunology

Microglia in ALS: The Good, The Bad, and The Resting

(2009) Jenny S. Henkel et al.   Journal of Neuroimmune Pharmacology

Resting Microglia Directly Monitor the Functional State of Synapses In Vivo and Determine the Fate of Ischemic Terminals

(2009) H. Wake et al.   JOURNAL OF NEUROSCIENCE

Association of posttraumatic stress disorder with low-grade elevation of C-reactive protein: Evidence from the general population

(2009) Carsten Spitzer et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Fractalkine and CX3CR1 regulate hippocampal neurogenesis in adult and aged rats

(2009) Adam D. Bachstetter et al.   NEUROBIOLOGY OF AGING

Steroid hormone receptor expression and function in microglia

(2008) Amanda Sierra et al.   GLIA

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE