Fibroblast-macrophage reciprocal interactions in health, fibrosis, and cancer

Does tissue imprinting restrict macrophage plasticity?

(2021) Martin Guilliams et al.   NATURE IMMUNOLOGY

Cross-tissue organization of the fibroblast lineage

(2021) Matthew B. Buechler et al.   NATURE

Transforming growth factor–β in tissue fibrosis

(2020) Nikolaos G. Frangogiannis   JOURNAL OF EXPERIMENTAL MEDICINE

Cancer-associated fibroblast heterogeneity in axillary lymph nodes drives metastases in breast cancer through complementary mechanisms

(2020) Floriane Pelon et al.   Nature Communications

Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer

(2020) Lei Zhang et al.   CELL

Establishment and Maintenance of the Macrophage Niche

(2020) Martin Guilliams et al.   IMMUNITY

Human chimeric antigen receptor macrophages for cancer immunotherapy

(2020) Michael Klichinsky et al.   NATURE BIOTECHNOLOGY

Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth

(2020) Sarah Davidson et al.   Cell Reports

Stromal cell diversity associated with immune evasion in human triple‐negative breast cancer

(2020) Sunny Z Wu et al.   EMBO JOURNAL

Determinants of Resident Tissue Macrophage Identity and Function

(2020) Camille Blériot et al.   IMMUNITY

Reticular Fibroblasts Expressing the Transcription Factor WT1 Define a Stromal Niche that Maintains and Replenishes Splenic Red Pulp Macrophages

(2020) Alicia Bellomo et al.   IMMUNITY

TGFβ biology in cancer progression and immunotherapy

(2020) Rik Derynck et al.   Nature Reviews Clinical Oncology

Concepts of extracellular matrix remodelling in tumour progression and metastasis

(2020) Juliane Winkler et al.   Nature Communications

Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression

(2020) Ori Maller et al.   NATURE MATERIALS

Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage

(2019) Dvir Aran et al.   NATURE IMMUNOLOGY

Cancer-associated fibroblasts enhance tumor-associated macrophages enrichment and suppress NK cells function in colorectal cancer

(2019) Rongsheng Zhang et al.   Cell Death & Disease

Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches

(2019) Svetoslav Chakarov et al.   SCIENCE

Hepatocytes direct the formation of a pro-metastatic niche in the liver

(2019) Jae W. Lee et al.   NATURE

A Macrophage-Pericyte Axis Directs Tissue Restoration via Amphiregulin-Induced Transforming Growth Factor Beta Activation

(2019) Carlos M. Minutti et al.   IMMUNITY

Disruption of tumour-associated macrophage trafficking by the osteopontin-induced colony-stimulating factor-1 signalling sensitises hepatocellular carcinoma to anti-PD-L1 blockade

(2019) Ying Zhu et al.   GUT

Platelet derived growth factor receptor alpha is essential for cardiac fibroblast survival

(2019) Malina J Ivey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage

(2019) Stefan Uderhardt et al.   CELL

Distinct fibroblast subsets drive inflammation and damage in arthritis

(2019) Adam P. Croft et al.   NATURE

A Stromal Niche Defined by Expression of the Transcription Factor WT1 Mediates Programming and Homeostasis of Cavity-Resident Macrophages

(2019) Matthew B. Buechler et al.   IMMUNITY

Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts

(2019) Ela Elyada et al.   Cancer Discovery

Targeting cardiac fibrosis with engineered T cells

(2019) Haig Aghajanian et al.   NATURE

Amphiregulin modulates murine lung recovery and fibroblast function following exposure to agriculture organic dust

(2019) Jill A. Poole et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Heterogeneity of human prostate carcinoma‐associated fibroblasts implicates a role for subpopulations in myeloid cell recruitment

(2019) Renee E. Vickman et al.   PROSTATE

Single-cell RNA sequencing reveals stromal evolution into LRRC15+ myofibroblasts as a determinant of patient response to cancer immunotherapy

(2019) Claudia X Dominguez et al.   Cancer Discovery

Evasion of apoptosis by myofibroblasts: a hallmark of fibrotic diseases

(2019) Boris Hinz et al.   Nature Reviews Rheumatology

Therapeutic interleukin-6 blockade reverses transforming growth factor-beta pathway activation in dermal fibroblasts: insights from the faSScinate clinical trial in systemic sclerosis

(2018) Christopher P Denton et al.   ANNALS OF THE RHEUMATIC DISEASES

Amphiregulin enhances cardiac fibrosis and aggravates cardiac dysfunction in mice with experimental myocardial infarction partly through activating EGFR-dependent pathway

(2018) Liang Liu et al.   BASIC RESEARCH IN CARDIOLOGY

Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer

(2018) Ana Costa et al.   CANCER CELL

Macrophage-derived granulin drives resistance to immune checkpoint inhibition in metastatic pancreatic cancer

(2018) Valeria Quaranta et al.   CANCER RESEARCH

Circuit Design Features of a Stable Two-Cell System

(2018) Xu Zhou et al.   CELL

Paracrine interactions of cancer-associated fibroblasts, macrophages and endothelial cells

(2018) Roberto Ronca et al.   CURRENT OPINION IN ONCOLOGY

CSF1R inhibition prevents radiation pulmonary fibrosis by depletion of interstitial macrophages

(2018) Lydia Meziani et al.   EUROPEAN RESPIRATORY JOURNAL

Understanding the tumor immune microenvironment (TIME) for effective therapy

(2018) Mikhail Binnewies et al.   NATURE MEDICINE

Phenotype molding of stromal cells in the lung tumor microenvironment

(2018) Diether Lambrechts et al.   NATURE MEDICINE

Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors

(2018) Magdolna Djurec et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti–PD-1 treatment

(2018) Elisa Peranzoni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T cell–induced CSF1 promotes melanoma resistance to PD1 blockade

(2018) Natalie J. Neubert et al.   Science Translational Medicine

A short field guide to fibroblast function in immunity

(2018) Matthew B. Buechler et al.   SEMINARS IN IMMUNOLOGY

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

(2018) Sanjeev Mariathasan et al.   NATURE

Interleukin-6 and Type-I Collagen Production by Systemic Sclerosis Fibroblasts Are Differentially Regulated by Interleukin-17A in the Presence of Transforming Growth Factor-Beta 1

(2018) Aleksandra Maria Dufour et al.   Frontiers in Immunology

Targeting macrophages: therapeutic approaches in cancer

(2018) Luca Cassetta et al.   NATURE REVIEWS DRUG DISCOVERY

Tissue-Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression

(2017) Yu Zhu et al.   IMMUNITY

Pulmonary fibrosis requires cell-autonomous mesenchymal fibroblast growth factor (FGF) signaling

(2017) Robert D. Guzy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An adaptive signaling network in melanoma inflammatory niches confers tolerance to MAPK signaling inhibition

(2017) Helen L. Young et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy

(2017) Michael A. Cannarile et al.   Journal for ImmunoTherapy of Cancer

Overexpression of OSM and IL-6 impacts the polarization of pro-fibrotic macrophages and the development of bleomycin-induced lung fibrosis

(2017) Ehab A. Ayaub et al.   Scientific Reports

FAP Promotes Immunosuppression by Cancer-Associated Fibroblasts in the Tumor Microenvironment via STAT3–CCL2 Signaling

(2016) Xuguang Yang et al.   CANCER RESEARCH

Tumor macrophages are pivotal constructors of tumor collagenous matrix

(2016) Ran Afik et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bone Marrow CD11c+Cell–Derived Amphiregulin Promotes Pulmonary Fibrosis

(2016) Lin Ding et al.   JOURNAL OF IMMUNOLOGY

Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis

(2016) Sebastian R. Nielsen et al.   NATURE CELL BIOLOGY

Tumor-associated fibroblasts predominantly come from local and not circulating precursors

(2016) Ainhoa Arina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

(2016) I. Tirosh et al.   SCIENCE

Cancer-associated fibroblast-secreted CXCL16 attracts monocytes to promote stroma activation in triple-negative breast cancers

(2016) Roni Allaoui et al.   Nature Communications

Stromal Cells in Chronic Inflammation and Tertiary Lymphoid Organ Formation

(2015) Christopher D. Buckley et al.   Annual Review of Immunology

Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy

(2015) Bryan W Miller et al.   EMBO Molecular Medicine

PDGFRα signaling drives adipose tissue fibrosis by targeting progenitor cell plasticity

(2015) Tomoaki Iwayama et al.   GENES & DEVELOPMENT

Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma

(2015) Yulong Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

(2015) Bruno Costa-Silva et al.   NATURE CELL BIOLOGY

Prostate Field Cancerization: Deregulated Expression of Macrophage Inhibitory Cytokine 1 (MIC-1) and Platelet Derived Growth Factor A (PDGF-A) in Tumor Adjacent Tissue

(2015) Anna C. Jones et al.   PLoS One

Identification and isolation of a dermal lineage with intrinsic fibrogenic potential

(2015) Y. Rinkevich et al.   SCIENCE

Macrophage IL-10 Blocks CD8+ T Cell-Dependent Responses to Chemotherapy by Suppressing IL-12 Expression in Intratumoral Dendritic Cells

(2014) Brian Ruffell et al.   CANCER CELL

Targeting Tumor-Associated Macrophages with Anti-CSF-1R Antibody Reveals a Strategy for Cancer Therapy

(2014) Carola H. Ries et al.   CANCER CELL

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

(2014) Yonit Lavin et al.   CELL

Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities

(2014) David Gosselin et al.   CELL

Heme-Mediated SPI-C Induction Promotes Monocyte Differentiation into Iron-Recycling Macrophages

(2014) Malay Haldar et al.   CELL

Always cleave up your mess: targeting collagen degradation to treat tissue fibrosis

(2013) William McKleroy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Fibrosis of two: Epithelial cell-fibroblast interactions in pulmonary fibrosis

(2013) Norihiko Sakai et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Impeding Macrophage Entry into Hypoxic Tumor Areas by Sema3A/Nrp1 Signaling Blockade Inhibits Angiogenesis and Restores Antitumor Immunity

(2013) Andrea Casazza et al.   CANCER CELL

Stromally Derived Lysyl Oxidase Promotes Metastasis of Transforming Growth Factor- -Deficient Mouse Mammary Carcinomas

(2013) M. W. Pickup et al.   CANCER RESEARCH

Targeting the PDGF signaling pathway in tumor treatment

(2013) Carl-Henrik Heldin   Cell Communication and Signaling

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

M-CSF instructs myeloid lineage fate in single haematopoietic stem cells

(2013) Noushine Mossadegh-Keller et al.   NATURE

Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer

(2013) C. Feig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical and pathological significance of interleukin 6 overexpression in systemic sclerosis

(2012) Korsa Khan et al.   ANNALS OF THE RHEUMATIC DISEASES

CCR2-Dependent Recruitment of Macrophages by Tumor-Educated Mesenchymal Stromal Cells Promotes Tumor Development and Is Mimicked by TNFα

(2012) Guangwen Ren et al.   Cell Stem Cell

Amphiregulin, an Epidermal Growth Factor Receptor Ligand, Plays an Essential Role in the Pathogenesis of Transforming Growth Factor-β-induced Pulmonary Fibrosis

(2012) Yang Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia

(2012) Yaming Wang et al.   NATURE IMMUNOLOGY

Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

(2012) Emmanuel L Gautier et al.   NATURE IMMUNOLOGY

Macrophage-Stimulated Cardiac Fibroblast Production of IL-6 Is Essential for TGF β/Smad Activation and Cardiac Fibrosis Induced by Angiotensin II

(2012) Feifei Ma et al.   PLoS One

Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice

(2011) Moshe Elkabets et al.   JOURNAL OF CLINICAL INVESTIGATION

An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue- and tumor-associated macrophages but does not inhibit inflammation

(2010) K. P. A. MacDonald et al.   BLOOD

Bleomycin and IL-1β–mediated pulmonary fibrosis is IL-17A dependent

(2010) Mark S. Wilson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Macrophages: Master Regulators of Inflammation and Fibrosis

(2010) Thomas Wynn et al.   SEMINARS IN LIVER DISEASE

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Increased PDGFRα Activation Disrupts Connective Tissue Development and Drives Systemic Fibrosis

(2009) Lorin E. Olson et al.   DEVELOPMENTAL CELL

Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages

(2009) Kamran Atabai et al.   JOURNAL OF CLINICAL INVESTIGATION

CXCL14 is an autocrine growth factor for fibroblasts and acts as a multi-modal stimulator of prostate tumor growth

(2009) M. Augsten et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The epidermal growth factor receptor ligand amphiregulin participates in the development of mouse liver fibrosis

(2008) Maria J. Perugorria et al.   HEPATOLOGY