The interplay between DNA and histone methylation: molecular mechanisms and disease implications
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Title
The interplay between DNA and histone methylation: molecular mechanisms and disease implications
Authors
Keywords
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Journal
EMBO REPORTS
Volume 22, Issue 5, Pages -
Publisher
EMBO
Online
2021-04-13
DOI
10.15252/embr.202051803
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Note: Only part of the references are listed.- Depletion of H3K36me2 recapitulates epigenomic and phenotypic changes induced by the H3.3K36M oncohistone mutation
- (2021) Kartik N. Rajagopalan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Chromatin dysregulation associated with NSD1 mutation in head and neck squamous cell carcinoma
- (2021) Nargess Farhangdoost et al. Cell Reports
- Delineation of a Human Mendelian Disorder of the DNA Demethylation Machinery: TET3 Deficiency
- (2020) David B. Beck et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Bivalent promoter hypermethylation in cancer is linked to the H327me3/H3K4me3 ratio in embryonic stem cells
- (2020) Donnchadh S. Dunican et al. BMC BIOLOGY
- Frameshift mutations at the C-terminus of HIST1H1E result in a specific DNA hypomethylation signature
- (2020) Andrea Ciolfi et al. Clinical Epigenetics
- DNA Methylation Signature for EZH2 Functionally Classifies Sequence Variants in Three PRC2 Complex Genes
- (2020) Sanaa Choufani et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Large DNA Methylation Nadirs Anchor Chromatin Loops Maintaining Hematopoietic Stem Cell Identity
- (2020) Xiaotian Zhang et al. MOLECULAR CELL
- Kinetics and mechanisms of mitotic inheritance of DNA methylation and their roles in aging-associated methylome deterioration
- (2020) Xuan Ming et al. CELL RESEARCH
- Spatiotemporal DNA methylome dynamics of the developing mouse fetus
- (2020) Yupeng He et al. NATURE
- Epigenetic Therapies for Cancer
- (2020) Susan E. Bates NEW ENGLAND JOURNAL OF MEDICINE
- Alternative splicing and allosteric regulation modulate the chromatin binding of UHRF1
- (2020) Maria Tauber et al. NUCLEIC ACIDS RESEARCH
- Direct readout of heterochromatic H3K9me3 regulates DNMT1-mediated maintenance DNA methylation
- (2020) Wendan Ren et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Nuclear interacting SET domain protein 1 inactivation impairs GATA1-regulated erythroid differentiation and causes erythroleukemia
- (2020) Katharina Leonards et al. Nature Communications
- Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms
- (2020) Linfeng Gao et al. Nature Communications
- Epigenetic switch-induced viral mimicry evasion in chemotherapy resistant breast cancer
- (2020) Genevieve Deblois et al. Cancer Discovery
- The inactive Dnmt3b3 isoform preferentially enhances Dnmt3b-mediated DNA methylation
- (2020) Yang Zeng et al. GENES & DEVELOPMENT
- Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B
- (2020) Ting-Hai Xu et al. NATURE
- NSD1-deposited H3K36me2 directs de novo methylation in the mouse male germline and counteracts Polycomb-associated silencing
- (2020) Kenjiro Shirane et al. NATURE GENETICS
- Complex DNA sequence readout mechanisms of the DNMT3B DNA methyltransferase
- (2020) Michael Dukatz et al. NUCLEIC ACIDS RESEARCH
- Flanking sequence preference modulates de novo DNA methylation in the mouse genome
- (2020) Izaskun Mallona et al. NUCLEIC ACIDS RESEARCH
- DNA Methylation Reprogramming during Mammalian Development
- (2019) Yang Zeng et al. Genes
- Epigenomic reordering induced by Polycomb loss drives oncogenesis but leads to therapeutic vulnerabilities in malignant peripheral nerve sheath tumors
- (2019) John B Wojcik et al. CANCER RESEARCH
- DNA Hypermethylation Encroachment at CpG Island Borders in Cancer Is Predisposed by H3K4 Monomethylation Patterns
- (2019) Ksenia Skvortsova et al. CANCER CELL
- Defining UHRF1 Domains that Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties
- (2019) Xiangqian Kong et al. CANCER CELL
- Profiling of Pluripotency Factors in Single Cells and Early Embryos
- (2019) Sarah J. Hainer et al. CELL
- PRC2 is high maintenance
- (2019) Jia-Ray Yu et al. GENES & DEVELOPMENT
- Molecular heterogeneity in peripheral T-cell lymphoma, not otherwise specified revealed by comprehensive genetic profiling
- (2019) Yosaku Watatani et al. LEUKEMIA
- SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development
- (2019) Qianhua Xu et al. NATURE GENETICS
- Histone H3 tail binds a unique sensing pocket in EZH2 to activate the PRC2 methyltransferase
- (2019) Krupa S. Jani et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A DNMT3A PWWP mutation leads to methylation of bivalent chromatin and growth retardation in mice
- (2019) Gintarė Sendžikaitė et al. Nature Communications
- Growth disrupting mutations in epigenetic regulatory molecules are associated with abnormalities of epigenetic aging
- (2019) Aaron R. Jeffries et al. GENOME RESEARCH
- Genome‐wide DNA methylation and RNA analyses enable reclassification of two variants of uncertain significance in a patient with clinical Kabuki syndrome
- (2019) Erfan Aref‐Eshghi et al. HUMAN MUTATION
- Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3
- (2019) Jark Böttcher et al. Nature Chemical Biology
- PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism
- (2019) Siddhant U. Jain et al. Nature Communications
- CUT&Tag for efficient epigenomic profiling of small samples and single cells
- (2019) Hatice S. Kaya-Okur et al. Nature Communications
- CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism
- (2019) Andrea Piunti et al. Science Advances
- PRC2 functions in development and congenital disorders
- (2019) Orla Deevy et al. DEVELOPMENT
- Interactions between core histone marks and DNA methyltransferases predict DNA methylation patterns observed in human cells and tissues
- (2019) Kai Fu et al. Epigenetics
- The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape
- (2019) Daniel N. Weinberg et al. NATURE
- Profiling chromatin states using single-cell itChIP-seq
- (2019) Shanshan Ai et al. NATURE CELL BIOLOGY
- Rare SUZ12 variants commonly cause an overgrowth phenotype
- (2019) Sharri S. Cyrus et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS
- The big picture of chromatin biology by cryo-EM
- (2019) Seongmin Jang et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells
- (2019) Roberta Ragazzini et al. Nature Communications
- Mapping histone modifications in low cell number and single cells using antibody-guided chromatin tagmentation (ACT-seq)
- (2019) Benjamin Carter et al. Nature Communications
- NSD2 overexpression drives clustered chromatin and transcriptional changes in a subset of insulated domains
- (2019) Priscillia Lhoumaud et al. Nature Communications
- DNA Methylation Directs Polycomb-Dependent 3D Genome Re-organization in Naive Pluripotency
- (2019) Katy McLaughlin et al. Cell Reports
- DNMT3A reads and connects histone H3K36me2 to DNA methylation
- (2019) Wenqi Xu et al. Protein & Cell
- H3K36me2/3 Binding and DNA Binding of the DNA Methyltransferase DNMT3A PWWP Domain Both Contribute to its Chromatin Interaction
- (2019) Michael Dukatz et al. JOURNAL OF MOLECULAR BIOLOGY
- Allelic H3K27me3 to allelic DNA methylation switch maintains noncanonical imprinting in extraembryonic cells
- (2019) Zhiyuan Chen et al. Science Advances
- Genomic DNA Methylation Signatures Enable Concurrent Diagnosis and Clinical Genetic Variant Classification in Neurodevelopmental Syndromes
- (2018) Erfan Aref-Eshghi et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Growth pattern of Rahman syndrome
- (2018) Toshiki Takenouchi et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART A
- Setd2 deficiency impairs hematopoietic stem cell self-renewal and causes malignant transformation
- (2018) Yuan-Liang Zhang et al. CELL RESEARCH
- Switching roles for DNA and histone methylation depend on evolutionary ages of human endogenous retroviruses
- (2018) Hitoshi Ohtani et al. GENOME RESEARCH
- Histone modifier gene mutations in peripheral T-cell lymphoma not otherwise specified
- (2018) Meng-Meng Ji et al. HAEMATOLOGICA
- Comparative methylome analysis of ICF patients identifies heterochromatin loci that require ZBTB24, CDCA7 and HELLS for their methylated state
- (2018) Guillaume Velasco et al. HUMAN MOLECULAR GENETICS
- Disruption ofNSD1in Head and Neck Cancer Promotes Favorable Chemotherapeutic Responses Linked to Hypomethylation
- (2018) Nam Bui et al. MOLECULAR CANCER THERAPEUTICS
- The H3K36me2 Methyltransferase Nsd1 Demarcates PRC2-Mediated H3K27me2 and H3K27me3 Domains in Embryonic Stem Cells
- (2018) Gundula Streubel et al. MOLECULAR CELL
- DNA methylation loss in late-replicating domains is linked to mitotic cell division
- (2018) Wanding Zhou et al. NATURE GENETICS
- MTF2 recruits Polycomb Repressive Complex 2 by helical-shape-selective DNA binding
- (2018) Matteo Perino et al. NATURE GENETICS
- Structural and mechanistic insights into UHRF1-mediated DNMT1 activation in the maintenance DNA methylation
- (2018) Tao Li et al. NUCLEIC ACIDS RESEARCH
- Single-Cell DNA Methylation Profiling: Technologies and Biological Applications
- (2018) Ino D. Karemaker et al. TRENDS IN BIOTECHNOLOGY
- Peripheral blood epi-signature of Claes-Jensen syndrome enables sensitive and specific identification of patients and healthy carriers with pathogenic mutations in KDM5C
- (2018) Laila C. Schenkel et al. Clinical Epigenetics
- Histone modifier gene mutations in peripheral T-cell lymphoma not otherwise specified
- (2018) Meng-Meng Ji et al. HAEMATOLOGICA
- Discovery of Small-Molecule Antagonists of the H3K9me3 Binding to UHRF1 Tandem Tudor Domain
- (2018) Guillermo Senisterra et al. SLAS Discovery
- Chromatin structure and its chemical modifications regulate the ubiquitin ligase substrate selectivity of UHRF1
- (2018) Robert M. Vaughan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Integrative Proteomic Profiling Reveals PRC2-Dependent Epigenetic Crosstalk Maintains Ground-State Pluripotency
- (2018) Guido van Mierlo et al. Cell Stem Cell
- BAH domains and a histone-like motif in DNA methyltransferase 1 (DNMT1) regulate de novo and maintenance methylation in vivo
- (2018) Olya Yarychkivska et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Bifunctional Role for the UHRF1 UBL Domain in the Control of Hemi-methylated DNA-Dependent Histone Ubiquitylation
- (2018) Paul A. DaRosa et al. MOLECULAR CELL
- Critical Role of the UBL Domain in Stimulating the E3 Ubiquitin Ligase Activity of UHRF1 toward Chromatin
- (2018) Benjamin M. Foster et al. MOLECULAR CELL
- Stella safeguards the oocyte methylome by preventing de novo methylation mediated by DNMT1
- (2018) Yingfeng Li et al. NATURE
- Gain-of-function DNMT3A mutations cause microcephalic dwarfism and hypermethylation of Polycomb-regulated regions
- (2018) Patricia Heyn et al. NATURE GENETICS
- Targets and genomic constraints of ectopic Dnmt3b expression
- (2018) Yingying Zhang et al. eLife
- Structural Basis of DNMT1 and DNMT3A-Mediated DNA Methylation
- (2018) Wendan Ren et al. Genes
- The defining DNA methylation signature of Kabuki syndrome enables functional assessment of genetic variants of unknown clinical significance
- (2017) Erfan Aref-Eshghi et al. Epigenetics
- Patients with a Kabuki syndrome phenotype demonstrate DNA methylation abnormalities
- (2017) Nara Sobreira et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Mutations in genes encoding polycomb repressive complex 2 subunits cause Weaver syndrome
- (2017) Eri Imagawa et al. HUMAN MUTATION
- Conformational dynamics of the TTD–PHD histone reader module of the UHRF1 epigenetic regulator reveals multiple histone-binding states, allosteric regulation, and druggability
- (2017) R. Scott Houliston et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structure of the Dnmt1 Reader Module Complexed with a Unique Two-Mono-Ubiquitin Mark on Histone H3 Reveals the Basis for DNA Methylation Maintenance
- (2017) Satoshi Ishiyama et al. MOLECULAR CELL
- Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation
- (2017) Laure Ferry et al. MOLECULAR CELL
- Intragenic DNA methylation prevents spurious transcription initiation
- (2017) Francesco Neri et al. NATURE
- Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas
- (2017) Simon Papillon-Cavanagh et al. NATURE GENETICS
- ICF-specific DNMT3B dysfunction interferes with intragenic regulation of mRNA transcription and alternative splicing
- (2017) Sole Gatto et al. NUCLEIC ACIDS RESEARCH
- Mechanisms Regulating PRC2 Recruitment and Enzymatic Activity
- (2017) Daniel Holoch et al. TRENDS IN BIOCHEMICAL SCIENCES
- The Arginine Methyltransferase PRMT6 Regulates DNA Methylation and Contributes to Global DNA Hypomethylation in Cancer
- (2017) Nicolas Veland et al. Cell Reports
- TET2 in Normal and Malignant Hematopoiesis
- (2017) Robert L. Bowman et al. Cold Spring Harbor Perspectives in Medicine
- NSD1 inactivation defines an immune cold, DNA hypomethylated subtype in squamous cell carcinoma
- (2017) Kevin Brennan et al. Scientific Reports
- Combining Epigenetic and Immunotherapy to Combat Cancer
- (2016) Katherine B. Chiappinelli et al. CANCER RESEARCH
- Dnmt3a and Dnmt3b Associate with Enhancers to Regulate Human Epidermal Stem Cell Homeostasis
- (2016) Lorenzo Rinaldi et al. Cell Stem Cell
- Weaver Syndrome-Associated EZH2 Protein Variants Show Impaired Histone Methyltransferase Function In Vitro
- (2016) Ana S.A. Cohen et al. HUMAN MUTATION
- A PWWP Domain of Histone-LysineN-Methyltransferase NSD2 Binds to Dimethylated Lys-36 of Histone H3 and Regulates NSD2 Function at Chromatin
- (2016) Saumya M. Sankaran et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- EED-associated overgrowth in a second male patient
- (2016) Ana SA Cohen et al. JOURNAL OF HUMAN GENETICS
- Structural basis for recognition of histone H3K36me3 nucleosome by human de novo DNA methyltransferases 3A and 3B
- (2016) Grégoire Rondelet et al. JOURNAL OF STRUCTURAL BIOLOGY
- Transcription factors as readers and effectors of DNA methylation
- (2016) Heng Zhu et al. NATURE REVIEWS GENETICS
- Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape
- (2016) C. Lu et al. SCIENCE
- Lowered H3K27me3 and DNA hypomethylation define poorly prognostic pediatric posterior fossa ependymomas
- (2016) J. Bayliss et al. Science Translational Medicine
- Epigenetic Determinants of Cancer
- (2016) Stephen B. Baylin et al. Cold Spring Harbor Perspectives in Biology
- DNMT3B isoforms without catalytic activity stimulate gene body methylation as accessory proteins in somatic cells
- (2016) Christopher E. Duymich et al. Nature Communications
- Dissecting the precise role of H3K9 methylation in crosstalk with DNA maintenance methylation in mammals
- (2016) Qian Zhao et al. Nature Communications
- Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition
- (2016) Jian Fang et al. Nature Communications
- Long noncoding RNAs in DNA methylation: new players stepping into the old game
- (2016) Yu Zhao et al. Cell and Bioscience
- Reversible Regulation of Promoter and Enhancer Histone Landscape by DNA Methylation in Mouse Embryonic Stem Cells
- (2016) Andrew D. King et al. Cell Reports
- Hemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1
- (2016) Joseph S Harrison et al. eLife
- Maternally provided LSD1/KDM1A enables the maternal-to-zygotic transition and prevents defects that manifest postnatally
- (2016) Jadiel A Wasson et al. eLife
- An epigenetic switch ensures transposon repression upon dynamic loss of DNA methylation in embryonic stem cells
- (2016) Marius Walter et al. eLife
- Application of the Protein Semisynthesis Strategy to the Generation of Modified Chromatin
- (2015) Matthew Holt et al. Annual Review of Biochemistry
- Non-CG Methylation in the Human Genome
- (2015) Yupeng He et al. Annual Review of Genomics and Human Genetics
- DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitination
- (2015) Weihua Qin et al. CELL RESEARCH
- Dynamic changes in histone modifications precede de novo DNA methylation in oocytes
- (2015) Kathleen R. Stewart et al. GENES & DEVELOPMENT
- EHMT2 directs DNA methylation for efficient gene silencing in mouse embryos
- (2015) Ghislain Auclair et al. GENOME RESEARCH
- Engineering of a Histone-Recognition Domain in Dnmt3a Alters the Epigenetic Landscape and Phenotypic Features of Mouse ESCs
- (2015) Kyung-Min Noh et al. MOLECULAR CELL
- Genomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation
- (2015) Tuncay Baubec et al. NATURE
- Genome-wide CpG island methylation and intergenic demethylation propensities vary among different tumor sites
- (2015) Seung-Tae Lee et al. NUCLEIC ACIDS RESEARCH
- NSD1 mutations generate a genome-wide DNA methylation signature
- (2015) S. Choufani et al. Nature Communications
- Dynamic reprogramming of DNA methylation in SETD2-deregulated renal cell carcinoma
- (2015) Rochelle L. Tiedemann et al. Oncotarget
- The Dnmt3L ADD Domain Controls Cytosine Methylation Establishment during Spermatogenesis
- (2015) Georgios Vlachogiannis et al. Cell Reports
- In vivo targeting of de novo DNA methylation by histone modifications in yeast and mouse
- (2015) Marco Morselli et al. eLife
- Germline mutations in the oncogene EZH2 cause Weaver syndrome and increased human height
- (2015) Katrina Tatton-Brown et al. Oncotarget
- Reversing DNA Methylation: Mechanisms, Genomics, and Biological Functions
- (2014) Hao Wu et al. CELL
- Mutations inSETD2cause a novel overgrowth condition
- (2014) Armelle Luscan et al. JOURNAL OF MEDICAL GENETICS
- Mutations in the DNA methyltransferase gene DNMT3A cause an overgrowth syndrome with intellectual disability
- (2014) Katrina Tatton-Brown et al. NATURE GENETICS
- Somatic RHOA mutation in angioimmunoblastic T cell lymphoma
- (2014) Mamiko Sakata-Yanagimoto et al. NATURE GENETICS
- Identification of functional cooperative mutations of SETD2 in human acute leukemia
- (2014) Xiaofan Zhu et al. NATURE GENETICS
- Regulation of DNA methylation turnover at LTR retrotransposons and imprinted loci by the histone methyltransferase Setdb1
- (2014) D. Leung et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Short sequences can efficiently recruit histone H3 lysine 27 trimethylation in the absence of enhancer activity and DNA methylation
- (2014) P. Jermann et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Synthetic CpG islands reveal DNA sequence determinants of chromatin structure
- (2014) Elisabeth Wachter et al. eLife
- The phenotypic spectrum of duplication 5q35.2-q35.3 encompassing NSD1 : Is it really a reversed sotos syndrome?
- (2013) Nicola Dikow et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART A
- Multilocus loss of DNA methylation in individuals with mutations in the histone H3 Lysine 4 Demethylase KDM5C
- (2013) Daria Grafodatskaya et al. BMC Medical Genomics
- Reduced H3K27me3 and DNA Hypomethylation Are Major Drivers of Gene Expression in K27M Mutant Pediatric High-Grade Gliomas
- (2013) Sebastian Bender et al. CANCER CELL
- Dnmt3L Antagonizes DNA Methylation at Bivalent Promoters and Favors DNA Methylation at Gene Bodies in ESCs
- (2013) Francesco Neri et al. CELL
- Epigenomic Analysis of Multilineage Differentiation of Human Embryonic Stem Cells
- (2013) Wei Xie et al. CELL
- De novo DNA methylation of endogenous retroviruses is shaped by KRAB-ZFPs/KAP1 and ESET
- (2013) H. M. Rowe et al. DEVELOPMENT
- Heterogeneous clinical presentation in ICF syndrome: correlation with underlying gene defects
- (2013) Corry MR Weemaes et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Multivalent histone engagement by the linked tandem Tudor and PHD domains of UHRF1 is required for the epigenetic inheritance of DNA methylation
- (2013) S. B. Rothbart et al. GENES & DEVELOPMENT
- The molecular profile of adult T-cell acute lymphoblastic leukemia: Mutations inRUNX1andDNMT3Aare associated with poor prognosis in T-ALL
- (2013) Vera Grossmann et al. GENES CHROMOSOMES & CANCER
- Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma
- (2013) F. Asmar et al. HAEMATOLOGICA
- Landscape of genetic lesions in 944 patients with myelodysplastic syndromes
- (2013) T Haferlach et al. LEUKEMIA
- Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication
- (2013) Atsuya Nishiyama et al. NATURE
- Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia
- (2013) Jacob D Jaffe et al. NATURE GENETICS
- Large conserved domains of low DNA methylation maintained by Dnmt3a
- (2013) Mira Jeong et al. NATURE GENETICS
- Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma
- (2013) P. W. Lewis et al. SCIENCE
- De Novo DNA Methylation in the Male Germ Line Occurs by Default but Is Excluded at Sites of H3K4 Methylation
- (2013) Purnima Singh et al. Cell Reports
- Redistribution of H3K27me3 upon DNA hypomethylation results in de-repression of Polycomb target genes
- (2013) James P Reddington et al. GENOME BIOLOGY
- Genome-wide analysis identifies a functional association of Tet1 and Polycomb repressive complex 2 in mouse embryonic stem cells
- (2013) Francesco Neri et al. GENOME BIOLOGY
- Recurrent TET2 mutations in peripheral T-cell lymphomas correlate with TFH-like features and adverse clinical parameters
- (2012) F. Lemonnier et al. BLOOD
- IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma
- (2012) R. A. Cairns et al. BLOOD
- Bisulfite sequencing of chromatin immunoprecipitated DNA (BisChIP-seq) directly informs methylation status of histone-modified DNA
- (2012) Aaron L. Statham et al. GENOME RESEARCH
- Sequential ChIP-bisulfite sequencing enables direct genome-scale investigation of chromatin and DNA methylation cross-talk
- (2012) Arie B. Brinkman et al. GENOME RESEARCH
- Mutations in DNMT1 cause autosomal dominant cerebellar ataxia, deafness and narcolepsy
- (2012) Juliane Winkelmann et al. HUMAN MOLECULAR GENETICS
- Structural Insight into Coordinated Recognition of Trimethylated Histone H3 Lysine 9 (H3K9me3) by the Plant Homeodomain (PHD) and Tandem Tudor Domain (TTD) of UHRF1 (Ubiquitin-like, Containing PHD and RING Finger Domains, 1) Protein
- (2012) Jingdong Cheng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- An H3K36 Methylation-Engaging Tudor Motif of Polycomb-like Proteins Mediates PRC2 Complex Targeting
- (2012) Ling Cai et al. MOLECULAR CELL
- IDH mutation impairs histone demethylation and results in a block to cell differentiation
- (2012) Chao Lu et al. NATURE
- Functions of DNA methylation: islands, start sites, gene bodies and beyond
- (2012) Peter A. Jones NATURE REVIEWS GENETICS
- Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity
- (2012) Cecilia Ballaré et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation
- (2012) Gerard L Brien et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation
- (2012) Scott B Rothbart et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1
- (2012) Catherine A Musselman et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- TET2andDNMT3AMutations in Human T-Cell Lymphoma
- (2012) Lucile Couronné et al. NEW ENGLAND JOURNAL OF MEDICINE
- Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1
- (2012) K. Arita et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Polycomb-Like 3 Promotes Polycomb Repressive Complex 2 Binding to CpG Islands and Embryonic Stem Cell Self-Renewal
- (2012) Julie Hunkapiller et al. PLoS Genetics
- Mutations in EZH2 Cause Weaver Syndrome
- (2011) William T. Gibson et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Deletion of KDM6A, a Histone Demethylase Interacting with MLL2, in Three Patients with Kabuki Syndrome
- (2011) Damien Lederer et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic stem cells
- (2011) M. Mochizuki-Kashio et al. BLOOD
- Structural basis for site-specific reading of unmodified R2 of histone H3 tail by UHRF1 PHD finger
- (2011) Chengkun Wang et al. CELL RESEARCH
- Crystal structure of PHD domain of UHRF1 and insights into recognition of unmodified histone H3 arginine residue 2
- (2011) Lulu Hu et al. CELL RESEARCH
- Histone tails regulate DNA methylation by allosterically activating de novo methyltransferase
- (2011) Bin-Zhong Li et al. CELL RESEARCH
- An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment
- (2011) Magnus D Lynch et al. EMBO JOURNAL
- Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer
- (2011) G. C. Hon et al. GENOME RESEARCH
- Comparative methylomics reveals gene-body H3K36me3 in Drosophila predicts DNA methylation and CpG landscapes in other invertebrates
- (2011) L. Nanty et al. GENOME RESEARCH
- Recognition of Multivalent Histone States Associated with Heterochromatin by UHRF1 Protein
- (2011) Nataliya Nady et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- H3K36 Methylation Antagonizes PRC2-mediated H3K27 Methylation
- (2011) Wen Yuan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- UHRF1 Double Tudor Domain and the Adjacent PHD Finger Act Together to Recognize K9me3-Containing Histone H3 Tail
- (2011) Si Xie et al. JOURNAL OF MOLECULAR BIOLOGY
- DNMT3A mutations in myeloproliferative neoplasms
- (2011) F Stegelmann et al. LEUKEMIA
- PHD Finger Recognition of Unmodified Histone H3R2 Links UHRF1 to Regulation of Euchromatic Gene Expression
- (2011) Eerappa Rajakumara et al. MOLECULAR CELL
- NSD2 Links Dimethylation of Histone H3 at Lysine 36 to Oncogenic Programming
- (2011) Alex J. Kuo et al. MOLECULAR CELL
- Histone Methylation by PRC2 Is Inhibited by Active Chromatin Marks
- (2011) Frank W. Schmitges et al. MOLECULAR CELL
- Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma
- (2011) Ryan D. Morin et al. NATURE
- Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss
- (2011) Christopher J Klein et al. NATURE GENETICS
- Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina–associated domains
- (2011) Benjamin P Berman et al. NATURE GENETICS
- Dnmt3a is essential for hematopoietic stem cell differentiation
- (2011) Grant A Challen et al. NATURE GENETICS
- Lysine methyltransferase G9a is required for de novo DNA methylation and the establishment, but not the maintenance, of proviral silencing
- (2011) D. C. Leung et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a
- (2011) Yanqi Chang et al. Nature Communications
- The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells
- (2010) E. Martinez-Garcia et al. BLOOD
- Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation
- (2010) Maria E. Figueroa et al. CANCER CELL
- The role of EZH2 and DNA methylation in the silencing of the tumour suppressor RUNX3 in colorectal cancer
- (2010) Liudmila L. Kodach et al. CARCINOGENESIS
- Nucleosome-Interacting Proteins Regulated by DNA and Histone Methylation
- (2010) Till Bartke et al. CELL
- LSH and G9a/GLP complex are required for developmentally programmed DNA methylation
- (2010) K. Myant et al. GENOME RESEARCH
- The Dnmt3a PWWP Domain Reads Histone 3 Lysine 36 Trimethylation and Guides DNA Methylation
- (2010) Arunkumar Dhayalan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- CpG Islands Recruit a Histone H3 Lysine 36 Demethylase
- (2010) Neil P. Blackledge et al. MOLECULAR CELL
- Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
- (2010) Ryan D Morin et al. NATURE GENETICS
- Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
- (2010) Thomas Ernst et al. NATURE GENETICS
- Exome sequencing identifies MLL2 mutations as a cause of Kabuki syndrome
- (2010) Sarah B Ng et al. NATURE GENETICS
- Molecular basis of histone H3K36me3 recognition by the PWWP domain of Brpf1
- (2010) Alessandro Vezzoli et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- DNMT3AMutations in Acute Myeloid Leukemia
- (2010) Timothy J. Ley et al. NEW ENGLAND JOURNAL OF MEDICINE
- Chromatin methylation activity of Dnmt3a and Dnmt3a/3L is guided by interaction of the ADD domain with the histone H3 tail
- (2010) Yingying Zhang et al. NUCLEIC ACIDS RESEARCH
- Dnmt3a-Dependent Nonpromoter DNA Methylation Facilitates Transcription of Neurogenic Genes
- (2010) H. Wu et al. SCIENCE
- Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies
- (2009) O. Abdel-Wahab et al. BLOOD
- Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX–DNMT3–DNMT3L domain
- (2009) Junji Otani et al. EMBO REPORTS
- Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells
- (2009) Daniela Meilinger et al. EMBO REPORTS
- KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints
- (2009) David N. Ciccone et al. NATURE
- Human DNA methylomes at base resolution show widespread epigenomic differences
- (2009) Ryan Lister et al. NATURE
- Rethinking how DNA methylation patterns are maintained
- (2009) Peter A. Jones et al. NATURE REVIEWS GENETICS
- Mutation inTET2in Myeloid Cancers
- (2009) François Delhommeau et al. NEW ENGLAND JOURNAL OF MEDICINE
- Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome
- (2009) Elaine R. Mardis et al. NEW ENGLAND JOURNAL OF MEDICINE
- The multi-domain protein Np95 connects DNA methylation and histone modification
- (2009) Andrea Rottach et al. NUCLEIC ACIDS RESEARCH
- The N-terminus of histone H3 is required for de novo DNA methylation in chromatin
- (2009) Jia-Lei Hu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Defining a Chromatin Pattern that Characterizes DNA-Hypermethylated Genes in Colon Cancer Cells
- (2008) K. M. McGarvey et al. CANCER RESEARCH
- DNA methylation in ES cells requires the lysine methyltransferase G9a but not its catalytic activity
- (2008) Kevin B Dong et al. EMBO JOURNAL
- G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription
- (2008) Makoto Tachibana et al. EMBO JOURNAL
- Lineage-Specific Polycomb Targets and De Novo DNA Methylation Define Restriction and Potential of Neuronal Progenitors
- (2008) Fabio Mohn et al. MOLECULAR CELL
- The ground state of embryonic stem cell self-renewal
- (2008) Qi-Long Ying et al. NATURE
- Genome-scale DNA methylation maps of pluripotent and differentiated cells
- (2008) Alexander Meissner et al. NATURE
- The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation
- (2008) Jing Wang et al. NATURE GENETICS
- Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation
- (2008) Yutaka Kondo et al. NATURE GENETICS
- DNA methylation landscapes: provocative insights from epigenomics
- (2008) Miho M. Suzuki et al. NATURE REVIEWS GENETICS
- De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes
- (2008) Silvina Epsztejn-Litman et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
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