A DNMT3A PWWP mutation leads to methylation of bivalent chromatin and growth retardation in mice

Gain-of-function mutations in DNMT3A in patients with paraganglioma

(2018) Laura Remacha et al.   GENETICS IN MEDICINE

MLL2 conveys transcription-independent H3K4 trimethylation in oocytes

(2018) Courtney W. Hanna et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MLL2 conveys transcription-independent H3K4 trimethylation in oocytes

(2018) Courtney W. Hanna et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Gain-of-function DNMT3A mutations cause microcephalic dwarfism and hypermethylation of Polycomb-regulated regions

(2018) Patricia Heyn et al.   NATURE GENETICS

Targets and genomic constraints of ectopic Dnmt3b expression

(2018) Yingying Zhang et al.   eLife

Molecular Processes Connecting DNA Methylation Patterns with DNA Methyltransferases and Histone Modifications in Mammalian Genomes

(2018) Albert Jeltsch et al.   Genes

Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer

(2017) Zachary D. Smith et al.   NATURE

Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA

(2017) Xueyin Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Impact of cytosine methylation on DNA binding specificities of human transcription factors

(2017) Yimeng Yin et al.   SCIENCE

Application of dual reading domains as novel reagents in chromatin biology reveals a new H3K9me3 and H3K36me2/3 bivalent chromatin state

(2017) Rebekka Mauser et al.   Epigenetics & Chromatin

Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA

(2017) Xueyin Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

rahu is a mutant allele of Dnmt3c, encoding a DNA methyltransferase homolog required for meiosis and transposon repression in the mouse male germline

(2017) Devanshi Jain et al.   PLoS Genetics

Effects of ghrelin in energy balance and body weight homeostasis

(2016) Laura Mihalache et al.   Hormones-International Journal of Endocrinology and Metabolism

Structural basis for recognition of histone H3K36me3 nucleosome by human de novo DNA methyltransferases 3A and 3B

(2016) Grégoire Rondelet et al.   JOURNAL OF STRUCTURAL BIOLOGY

Regulation of Energy Balance via BDNF Expressed in Nonparaventricular Hypothalamic Neurons

(2016) Haili Yang et al.   MOLECULAR ENDOCRINOLOGY

Transient transcription in the early embryo sets an epigenetic state that programs postnatal growth

(2016) Maxim V C Greenberg et al.   NATURE GENETICS

The DNA methyltransferase DNMT3C protects male germ cells from transposon activity

(2016) Joan Barau et al.   SCIENCE

60 YEARS OF NEUROENDOCRINOLOGY: The hypothalamo-pituitary–gonadal axis

(2015) Tony M Plant   JOURNAL OF ENDOCRINOLOGY

Genomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation

(2015) Tuncay Baubec et al.   NATURE

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

In vivo targeting of de novo DNA methylation by histone modifications in yeast and mouse

(2015) Marco Morselli et al.   eLife

Application of histone modification-specific interaction domains as an alternative to antibodies

(2014) Goran Kungulovski et al.   GENOME RESEARCH

Cooperative DNA Binding and Protein/DNA Fiber Formation Increases the Activity of the Dnmt3a DNA Methyltransferase

(2014) Max Emperle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural insight into autoinhibition and histone H3-induced activation of DNMT3A

(2014) Xue Guo et al.   NATURE

Mutations in the DNA methyltransferase gene DNMT3A cause an overgrowth syndrome with intellectual disability

(2014) Katrina Tatton-Brown et al.   NATURE GENETICS

Structure and function of the nucleosome-binding PWWP domain

(2014) Su Qin et al.   TRENDS IN BIOCHEMICAL SCIENCES

CART in the regulation of appetite and energy homeostasis

(2014) Jackie Lau et al.   Frontiers in Neuroscience

Dynamic DNA methylation across diverse human cell lines and tissues

(2013) K. E. Varley et al.   GENOME RESEARCH

Major epigenetic development distinguishing neuronal and non-neuronal cells occurs postnatally in the murine hypothalamus

(2013) Ge Li et al.   HUMAN MOLECULAR GENETICS

Charting a dynamic DNA methylation landscape of the human genome

(2013) Michael J. Ziller et al.   NATURE

Large conserved domains of low DNA methylation maintained by Dnmt3a

(2013) Mira Jeong et al.   NATURE GENETICS

DNA methylation: roles in mammalian development

(2013) Zachary D. Smith et al.   NATURE REVIEWS GENETICS

Single-molecule analysis of combinatorial epigenomic states in normal and tumor cells

(2013) P. J. Murphy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global Epigenomic Reconfiguration During Mammalian Brain Development

(2013) R. Lister et al.   SCIENCE

SIRT1 and energy metabolism

(2012) X. Li   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Base-Resolution Analyses of Sequence and Parent-of-Origin Dependent DNA Methylation in the Mouse Genome

(2012) Wei Xie et al.   CELL

Bisulfite sequencing of chromatin immunoprecipitated DNA (BisChIP-seq) directly informs methylation status of histone-modified DNA

(2012) Aaron L. Statham et al.   GENOME RESEARCH

Sequential ChIP-bisulfite sequencing enables direct genome-scale investigation of chromatin and DNA methylation cross-talk

(2012) Arie B. Brinkman et al.   GENOME RESEARCH

A unique regulatory phase of DNA methylation in the early mammalian embryo

(2012) Zachary D. Smith et al.   NATURE

Functions of DNA methylation: islands, start sites, gene bodies and beyond

(2012) Peter A. Jones   NATURE REVIEWS GENETICS

Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications

(2011) Felix Krueger et al.   BIOINFORMATICS

Application of Celluspots peptide arrays for the analysis of the binding specificity of epigenetic reading domains to modified histone tails

(2011) Ina Bock et al.   BMC BIOCHEMISTRY

Histone tails regulate DNA methylation by allosterically activating de novo methyltransferase

(2011) Bin-Zhong Li et al.   CELL RESEARCH

Temporal uncoupling of the DNA methylome and transcriptional repression during embryogenesis

(2011) Ozren Bogdanović et al.   GENOME RESEARCH

Nucleosome-Interacting Proteins Regulated by DNA and Histone Methylation

(2010) Till Bartke et al.   CELL

Genetic evidence for Dnmt3a-dependent imprinting during oocyte growth obtained by conditional knockout withZp3-Cre and complete exclusion of Dnmt3b by chimera formation

(2010) Masahiro Kaneda et al.   GENES TO CELLS

The Dnmt3a PWWP Domain Reads Histone 3 Lysine 36 Trimethylation and Guides DNA Methylation

(2010) Arunkumar Dhayalan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targets and dynamics of promoter DNA methylation during early mouse development

(2010) Julie Borgel et al.   NATURE GENETICS

Chromatin methylation activity of Dnmt3a and Dnmt3a/3L is guided by interaction of the ADD domain with the histone H3 tail

(2010) Yingying Zhang et al.   NUCLEIC ACIDS RESEARCH

Orphan CpG Islands Identify Numerous Conserved Promoters in the Mammalian Genome

(2010) Robert S. Illingworth et al.   PLoS Genetics

DNMT3L Modulates Significant and Distinct Flanking Sequence Preference for DNA Methylation by DNMT3A and DNMT3B In Vivo

(2010) Bethany L. Wienholz et al.   PLoS Genetics

Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX–DNMT3–DNMT3L domain

(2009) Junji Otani et al.   EMBO REPORTS

Molecular physiology of weight regulation in mice and humans

(2009) R L Leibel   INTERNATIONAL JOURNAL OF OBESITY

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

(2009) Ben Langmead et al.   GENOME BIOLOGY

Brain circuits regulating energy homeostasis

(2008) Alfonso Abizaid et al.   REGULATORY PEPTIDES

Antagonism between DNA and H3K27 Methylation at the Imprinted Rasgrf1 Locus

(2008) Anders M. Lindroth et al.   PLoS Genetics