The molecular profile of adult T-cell acute lymphoblastic leukemia: Mutations inRUNX1andDNMT3Aare associated with poor prognosis in T-ALL

Prognostic Significance ofNOTCH1andFBXW7Mutations in Pediatric T-ALL

(2013) Yucel Erbilgin et al.   DISEASE MARKERS

A novel hierarchical prognostic model of AML solely based on molecular mutations

(2012) V. Grossmann et al.   BLOOD

EZH2 mutations and their association with PICALM-MLLT10 positive acute leukaemia

(2012) Vera Grossmann et al.   BRITISH JOURNAL OF HAEMATOLOGY

Clinical Impact ofNOTCH1and/orFBXW7Mutations,FLASHDeletion, andTCRStatus in Pediatric T-Cell Lymphoblastic Lymphoma

(2012) Celine Callens et al.   JOURNAL OF CLINICAL ONCOLOGY

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

(2012) Jinghui Zhang et al.   NATURE

Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia

(2012) Panagiotis Ntziachristos et al.   NATURE MEDICINE

Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL

(2012) Giusy Della Gatta et al.   NATURE MEDICINE

Prognostic Relevance of Integrated Genetic Profiling in Acute Myeloid Leukemia

(2012) Jay P. Patel et al.   NEW ENGLAND JOURNAL OF MEDICINE

R453Plus1Toolbox: an R/Bioconductor package for analyzing Roche 454 Sequencing data

(2011) Hans-Ulrich Klein et al.   BIOINFORMATICS

Whole transcriptome sequencing reveals recurrent NOTCH1 mutations in mantle cell lymphoma

(2011) R. Kridel et al.   BLOOD

PTPN2 negatively regulates oncogenic JAK1 in T-cell acute lymphoblastic leukemia

(2011) M. Kleppe et al.   BLOOD

Integrated Transcript and Genome Analyses Reveal NKX2-1 and MEF2C as Potential Oncogenes in T Cell Acute Lymphoblastic Leukemia

(2011) Irene Homminga et al.   CANCER CELL

EPHA7 , a new target gene for 6q deletion in T-cell lymphoblastic lymphomas

(2011) Pilar López-Nieva et al.   CARCINOGENESIS

Prognostic relevance of RUNX1 mutations in T-cell acute lymphoblastic leukemia

(2011) V. Grossmann et al.   HAEMATOLOGICA

Mutations of PHF6 are associated with mutations of NOTCH1, JAK1 and rearrangement of SET-NUP214 in T-cell acute lymphoblastic leukemia

(2011) Q. Wang et al.   HAEMATOLOGICA

RUNX1 Mutations in Acute Myeloid Leukemia: Results From a Comprehensive Genetic and Clinical Analysis From the AML Study Group

(2011) Verena I. Gaidzik et al.   JOURNAL OF CLINICAL ONCOLOGY

ETV6mutations in early immature human T cell leukemias

(2011) Pieter Van Vlierberghe et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Analysis of the chronic lymphocytic leukemia coding genome: role ofNOTCH1mutational activation

(2011) Giulia Fabbri et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Interlaboratory RObustness of Next-generation sequencing (IRON) study: a deep sequencing investigation of TET2, CBL and KRAS mutations by an international consortium involving 10 laboratories

(2011) A Kohlmann et al.   LEUKEMIA

Landscape of TET2 mutations in acute myeloid leukemia

(2011) S Weissmann et al.   LEUKEMIA

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

(2011) Xose S. Puente et al.   NATURE

Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutations

(2011) Brian J O'Roak et al.   NATURE GENETICS

CTCF is a DNA methylation-sensitive positive regulator of the INK/ARF locus

(2010) Carmen Rodriguez et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inactivation of LEF1 in T-cell acute lymphoblastic leukemia

(2010) A. Gutierrez et al.   BLOOD

RUNX1 mutations are frequent in de novo AML with noncomplex karyotype and confer an unfavorable prognosis

(2010) S. Schnittger et al.   BLOOD

Prognostic implications of mutations and expression of the Wilms tumor 1 (WT1) gene in adult acute T-lymphoblastic leukemia

(2010) S. Heesch et al.   HAEMATOLOGICA

The Genetic Basis of Myelodysplastic Syndromes

(2010) Rafael Bejar et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Interplay of transcription factors in T-cell differentiation and function: the role of Runx

(2010) Won Fen Wong et al.   IMMUNOLOGY

NOTCH mutations as prognostic markers in T-ALL

(2010) A Ferrando   LEUKEMIA

PHF6 mutations in adult acute myeloid leukemia

(2010) P Van Vlierberghe et al.   LEUKEMIA

NOTCH1 and FBXW7 mutations have a favorable impact on early response to treatment, but not on outcome, in children with T-cell acute lymphoblastic leukemia (T-ALL) treated on EORTC trials 58881 and 58951

(2010) E Clappier et al.   LEUKEMIA

PHF6 mutations in T-cell acute lymphoblastic leukemia

(2010) Pieter Van Vlierberghe et al.   NATURE GENETICS

Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia

(2010) Maria Kleppe et al.   NATURE GENETICS

Mutations in GRIN2A and GRIN2B encoding regulatory subunits of NMDA receptors cause variable neurodevelopmental phenotypes

(2010) Sabine Endele et al.   NATURE GENETICS

A method and server for predicting damaging missense mutations

(2010) Ivan A Adzhubei et al.   NATURE METHODS

DNMT3AMutations in Acute Myeloid Leukemia

(2010) Timothy J. Ley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Comparative Functional Genomics Analysis of NNK Tobacco-Carcinogen Induced Lung Adenocarcinoma Development in Gprc5a-Knockout Mice

(2010) Junya Fujimoto et al.   PLoS One

WT1 mutations in T-ALL

(2009) V. Tosello et al.   BLOOD

High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia

(2009) A. Gutierrez et al.   BLOOD

Negative prognostic impact of PTEN mutation in pediatric T-cell acute lymphoblastic leukemia

(2009) P Y Jotta et al.   LEUKEMIA

NOTCH1/FBXW7 mutation identifies a large subgroup with favorable outcome in adult T-cell acute lymphoblastic leukemia (T-ALL): a Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) study

(2008) V. Asnafi et al.   BLOOD

CTCF regulates cell cycle progression of αβ T cells in the thymus

(2008) Helen Heath et al.   EMBO JOURNAL

Somatically acquiredJAK1mutations in adult acute lymphoblastic leukemia

(2008) Elisabetta Flex et al.   JOURNAL OF EXPERIMENTAL MEDICINE

FBXW7 mutation in adult T-cell and B-cell acute lymphocytic leukemias

(2008) Jee Hoon Song et al.   LEUKEMIA RESEARCH