Discovery of Small-Molecule Antagonists of the H3K9me3 Binding to UHRF1 Tandem Tudor Domain

Epigenetic modification in chromatin machinery and its deregulation in pediatric brain tumors: Insight into epigenetic therapies

(2017) Eleonore Maury et al.   Epigenetics

Regioselective Bromination of Thieno[2′,3′:4,5]pyrrolo[1,2-d][1,2,4]triazin-8(7H)-one and Sequential Suzuki Couplings

(2017) Chunliang Lu et al.   JOURNAL OF ORGANIC CHEMISTRY

The EED protein–protein interaction inhibitor A-395 inactivates the PRC2 complex

(2017) Yupeng He et al.   Nature Chemical Biology

UHRF1: The key regulator of epigenetics and molecular target for cancer therapeutics

(2017) Harsimran Sidhu et al.   TUMOR BIOLOGY

Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED

(2017) Ling Li et al.   PLoS One

Signalling pathways in UHRF1-dependent regulation of tumor suppressor genes in cancer

(2016) Mahmoud Alhosin et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1)

(2016) Matthäus Getlik et al.   JOURNAL OF MEDICINAL CHEMISTRY

Epigenetic modulators, modifiers and mediators in cancer aetiology and progression

(2016) Andrew P. Feinberg et al.   NATURE REVIEWS GENETICS

Targeting the cancer epigenome for therapy

(2016) Peter A. Jones et al.   NATURE REVIEWS GENETICS

Design of a fluorescent ligand targeting the S-adenosylmethionine binding site of the histone methyltransferase MLL1

(2016) Yepeng Luan et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition

(2016) Jian Fang et al.   Nature Communications

UHRF1 promotes proliferation of gastric cancer via mediating tumor suppressor gene hypermethylation

(2015) Lin Zhou et al.   CANCER BIOLOGY & THERAPY

Regulation of UHRF1 by microRNA-9 modulates colorectal cancer cell proliferation and apoptosis

(2015) Mingchen Zhu et al.   CANCER SCIENCE

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia

(2015) Florian Grebien et al.   Nature Chemical Biology

DNA methylation pathways and their crosstalk with histone methylation

(2015) Jiamu Du et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

An Allosteric Interaction Links USP7 to Deubiquitination and Chromatin Targeting of UHRF1

(2015) Zhi-Min Zhang et al.   Cell Reports

Methylation Profiling of Multiple Tumor Suppressor Genes in Hepatocellular Carcinoma and the Epigenetic Mechanism of 3OST2 Regulation

(2015) Haiyan Chen et al.   Journal of Cancer

UHRF1 Overexpression Drives DNA Hypomethylation and Hepatocellular Carcinoma

(2014) Raksha Mudbhary et al.   CANCER CELL

Accessibility of Different Histone H3-Binding Domains of UHRF1 Is Allosterically Regulated by Phosphatidylinositol 5-Phosphate

(2014) Kathy A. Gelato et al.   MOLECULAR CELL

Targeting bromodomains: epigenetic readers of lysine acetylation

(2014) Panagis Filippakopoulos et al.   NATURE REVIEWS DRUG DISCOVERY

Luteolin Induces Apoptosis in BE Colorectal Cancer Cells by Downregulating Calpain, UHRF1, and DNMT1 Expressions

(2014) Mounira Krifa et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Epigenetic targets and drug discovery

(2014) Yanli Liu et al.   PHARMACOLOGY & THERAPEUTICS

Bromodomain and Extraterminal Domain Inhibitors (BETi) for Cancer Therapy: Chemical Modulation of Chromatin Structure

(2014) J. Qi   Cold Spring Harbor Perspectives in Biology

Multivalent histone engagement by the linked tandem Tudor and PHD domains of UHRF1 is required for the epigenetic inheritance of DNA methylation

(2013) S. B. Rothbart et al.   GENES & DEVELOPMENT

Limoniastrum guyonianum aqueous gall extract induces apoptosis in human cervical cancer cells involving p16INK4A re-expression related to UHRF1 and DNMT1 down-regulation

(2013) Mounira Krifa et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Analysis of Biomolecular Solvation Sites by 3D-RISM Theory

(2013) Daniel J. Sindhikara et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain

(2013) Lindsey I James et al.   Nature Chemical Biology

UHRF1 targets DNMT1 for DNA methylation through cooperative binding of hemi-methylated DNA and methylated H3K9

(2013) Xiaoli Liu et al.   Nature Communications

Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5

(2012) Guillermo Senisterra et al.   BIOCHEMICAL JOURNAL

Structural Insight into Coordinated Recognition of Trimethylated Histone H3 Lysine 9 (H3K9me3) by the Plant Homeodomain (PHD) and Tandem Tudor Domain (TTD) of UHRF1 (Ubiquitin-like, Containing PHD and RING Finger Domains, 1) Protein

(2012) Jingdong Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigenetic protein families: a new frontier for drug discovery

(2012) Cheryl H. Arrowsmith et al.   NATURE REVIEWS DRUG DISCOVERY

UHRF1 coordinates peroxisome proliferator activated receptor gamma (PPARG) epigenetic silencing and mediates colorectal cancer progression

(2012) L Sabatino et al.   ONCOGENE

Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1

(2012) K. Arita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recognition of Multivalent Histone States Associated with Heterochromatin by UHRF1 Protein

(2011) Nataliya Nady et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular replacement withMOLREP

(2009) Alexei Vagin et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

UHRF1 is associated with epigenetic silencing of BRCA1 in sporadic breast cancer

(2009) Wei Jin et al.   BREAST CANCER RESEARCH AND TREATMENT

The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix

(2008) Hideharu Hashimoto et al.   NATURE

Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1

(2008) George V. Avvakumov et al.   NATURE