PRC2 functions in development and congenital disorders

EZHIP / CXorf67 mimics K27M mutated oncohistones and functions as an intrinsic inhibitor of PRC2 function in aggressive posterior fossa ependymoma

(2019) Jens-Martin Hübner et al.   NEURO-ONCOLOGY

Three additional patients with EED-associated overgrowth: potential mutation hotspots identified?

(2019) Catherine J. Spellicy et al.   JOURNAL OF HUMAN GENETICS

Dangerous liaisons: interplay between SWI/SNF, NuRD, and Polycomb in chromatin regulation and cancer

(2019) Adrian P. Bracken et al.   GENES & DEVELOPMENT

PRC2 is high maintenance

(2019) Jia-Ray Yu et al.   GENES & DEVELOPMENT

Functional Landscape of PCGF Proteins Reveals Both RING1A/B-Dependent-and RING1A/B-Independent-Specific Activities

(2019) Andrea Scelfo et al.   MOLECULAR CELL

Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression

(2019) Nadezda A. Fursova et al.   MOLECULAR CELL

Molecular Mechanisms Directing PRC2 Recruitment and H3K27 Methylation

(2019) Anne Laugesen et al.   MOLECULAR CELL

SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development

(2019) Qianhua Xu et al.   NATURE GENETICS

Histone H3 tail binds a unique sensing pocket in EZH2 to activate the PRC2 methyltransferase

(2019) Krupa S. Jani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A DNMT3A PWWP mutation leads to methylation of bivalent chromatin and growth retardation in mice

(2019) Gintarė Sendžikaitė et al.   Nature Communications

Dissecting the role of H3K27 acetylation and methylation in PRC2 mediated control of cellular identity

(2019) Elisa Lavarone et al.   Nature Communications

PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism

(2019) Siddhant U. Jain et al.   Nature Communications

CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism

(2019) Andrea Piunti et al.   Science Advances

Non-core Subunits of the PRC2 Complex Are Collectively Required for Its Target-Site Specificity

(2019) Jonas Westergaard Højfeldt et al.   MOLECULAR CELL

PRC2.1 and PRC2.2 Synergize to Coordinate H3K27 Trimethylation

(2019) Evan Healy et al.   MOLECULAR CELL

The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape

(2019) Daniel N. Weinberg et al.   NATURE

The Complexity of PRC2 Subcomplexes

(2019) Guido van Mierlo et al.   TRENDS IN CELL BIOLOGY

EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells

(2019) Roberta Ragazzini et al.   Nature Communications

Novel SUZ12 mutations in Weaver-like syndrome

(2018) Eri Imagawa et al.   CLINICAL GENETICS

Live-cell imaging reveals the dynamics of PRC2 and recruitment to chromatin by SUZ12-associated subunits

(2018) Daniel T. Youmans et al.   GENES & DEVELOPMENT

Novel de novo mutation affecting two adjacent aminoacids in the EED gene in a patient with Weaver syndrome

(2018) Robert Smigiel et al.   JOURNAL OF HUMAN GENETICS

The H3K36me2 Methyltransferase Nsd1 Demarcates PRC2-Mediated H3K27me2 and H3K27me3 Domains in Embryonic Stem Cells

(2018) Gundula Streubel et al.   MOLECULAR CELL

A Family of Vertebrate-Specific Polycombs Encoded by the LCOR / LCORL Genes Balance PRC2 Subtype Activities

(2018) Eric Conway et al.   MOLECULAR CELL

Capturing the Onset of PRC2-Mediated Repressive Domain Formation

(2018) Ozgur Oksuz et al.   MOLECULAR CELL

MTF2 recruits Polycomb Repressive Complex 2 by helical-shape-selective DNA binding

(2018) Matteo Perino et al.   NATURE GENETICS

Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2

(2018) Jonas W. Højfeldt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

De novo mutation inRING1with epigenetic effects on neurodevelopment

(2018) Sarah B. Pierce et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2

(2018) Jonas W. Højfeldt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mtf2-PRC2 control of canonical Wnt signaling is required for definitive erythropoiesis

(2018) Janet L. Manias Rothberg et al.   Cell Discovery

Gain-of-function DNMT3A mutations cause microcephalic dwarfism and hypermethylation of Polycomb-regulated regions

(2018) Patricia Heyn et al.   NATURE GENETICS

Mutations in genes encoding polycomb repressive complex 2 subunits cause Weaver syndrome

(2017) Eri Imagawa et al.   HUMAN MUTATION

Ezh2 Mutations Found in the Weaver Overgrowth Syndrome Cause a Partial Loss of H3K27 Histone Methyltransferase Activity

(2017) Julian C Lui et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Polycomb Repressive Complex 1 Generates Discrete Compacted Domains that Change during Differentiation

(2017) Sharmistha Kundu et al.   MOLECULAR CELL

Polycomb-like proteins link the PRC2 complex to CpG islands

(2017) Haojie Li et al.   NATURE

Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA

(2017) Xueyin Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA binding by PHF1 prolongs PRC2 residence time on chromatin and thereby promotes H3K27 methylation

(2017) Jeongyoon Choi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PCGF3/5–PRC1 initiates Polycomb recruitment in X chromosome inactivation

(2017) Mafalda Almeida et al.   SCIENCE

Mechanisms Regulating PRC2 Recruitment and Enzymatic Activity

(2017) Daniel Holoch et al.   TRENDS IN BIOCHEMICAL SCIENCES

Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA

(2017) Xueyin Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA binding by PHF1 prolongs PRC2 residence time on chromatin and thereby promotes H3K27 methylation

(2017) Jeongyoon Choi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Role of Nuclear Receptor–Binding SET Domain Family Histone Lysine Methyltransferases in Cancer

(2017) Richard L. Bennett et al.   Cold Spring Harbor Perspectives in Medicine

Acute myeloid leukemia-associatedDNMT3Ap.Arg882His mutation in a patient with Tatton-Brown-Rahman overgrowth syndrome as a constitutional mutation

(2016) Rika Kosaki et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Tatton-Brown-Rahman syndrome due to 2p23 microdeletion

(2016) Nobuhiko Okamoto et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

NovelEEDmutation in patient with Weaver syndrome

(2016) Erin Cooney et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Functional analysis of AEBP2, a PRC2 Polycomb protein, reveals a Trithorax phenotype in embryonic development and in ESCs

(2016) Anne Grijzenhout et al.   DEVELOPMENT

Weaver Syndrome-Associated EZH2 Protein Variants Show Impaired Histone Methyltransferase Function In Vitro

(2016) Ana S.A. Cohen et al.   HUMAN MUTATION

EED-associated overgrowth in a second male patient

(2016) Ana SA Cohen et al.   JOURNAL OF HUMAN GENETICS

SETD2andDNMT3Ascreen in the Sotos-like syndrome French cohort

(2016) Camille Tlemsani et al.   JOURNAL OF MEDICAL GENETICS

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells

(2016) Giorgio Oliviero et al.   MOLECULAR & CELLULAR PROTEOMICS

EPOP Interacts with Elongin BC and USP7 to Modulate the Chromatin Landscape

(2016) Robert Liefke et al.   MOLECULAR CELL

EPOP Functionally Links Elongin and Polycomb in Pluripotent Stem Cells

(2016) Malte Beringer et al.   MOLECULAR CELL

Greater Than the Sum of Parts: Complexity of the Dynamic Epigenome

(2016) Alexey A. Soshnev et al.   MOLECULAR CELL

Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2

(2016) Sarah Cooper et al.   Nature Communications

Normal formation of a vertebrate body plan and loss of tissue maintenance in the absence of ezh2

(2016) Bilge San et al.   Scientific Reports

A High-Density Map for Navigating the Human Polycomb Complexome

(2016) Simon Hauri et al.   Cell Reports

Reversible Regulation of Promoter and Enhancer Histone Landscape by DNA Methylation in Mouse Embryonic Stem Cells

(2016) Andrew D. King et al.   Cell Reports

PRC2 mediated H3K27 methylations in cellular identity and cancer

(2015) Eric Conway et al.   CURRENT OPINION IN CELL BIOLOGY

A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence

(2015) Gerard L. Brien et al.   GENES & DEVELOPMENT

Genome-wide activities of Polycomb complexes control pervasive transcription

(2015) Hun-Goo Lee et al.   GENOME RESEARCH

A novel mutation in EED associated with overgrowth

(2015) Ana S A Cohen et al.   JOURNAL OF HUMAN GENETICS

Genomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation

(2015) Tuncay Baubec et al.   NATURE

NSD1 mutations generate a genome-wide DNA methylation signature

(2015) S. Choufani et al.   Nature Communications

Germline mutations in the oncogene EZH2 cause Weaver syndrome and increased human height

(2015) Katrina Tatton-Brown et al.   Oncotarget

Understanding the relationship between DNA methylation and histone lysine methylation

(2014) Nathan R. Rose et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation

(2014) Neil P. Blackledge et al.   CELL

Mutations inSETD2cause a novel overgrowth condition

(2014) Armelle Luscan et al.   JOURNAL OF MEDICAL GENETICS

Mammalian Polycomb-Like Pcl2/Mtf2 Is a Novel Regulatory Component of PRC2 That Can Differentially Modulate Polycomb Activity both at the Hox Gene Cluster and at Cdkn2a Genes

(2014) X. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Gene Silencing Triggers Polycomb Repressive Complex 2 Recruitment to CpG Islands Genome Wide

(2014) Eva Madi Riising et al.   MOLECULAR CELL

Jarid2 Is Implicated in the Initial Xist-Induced Targeting of PRC2 to the Inactive X Chromosome

(2014) Simão Teixeira da Rocha et al.   MOLECULAR CELL

Erratum: Corrigendum: Mutations in the DNA methyltransferase gene DNMT3A cause an overgrowth syndrome with intellectual disability

(2014) Katrina Tatton-Brown et al.   NATURE GENETICS

Reciprocal interactions of human C10orf12 and C17orf96 with PRC2 revealed by BioTAP-XL cross-linking and affinity purification

(2014) A. A. Alekseyenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The phenotypic spectrum of duplication 5q35.2-q35.3 encompassing NSD1 : Is it really a reversed sotos syndrome?

(2013) Nicola Dikow et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Weaver syndrome andEZH2mutations: Clarifying the clinical phenotype

(2013) Katrina Tatton-Brown et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

The NSD 1 and EZH 2 Overgrowth Genes, Similarities and Differences

(2013) KATRINA TATTON-BROWN et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

Variations on a theme: Polycomb group proteins in plants

(2013) Maria Derkacheva et al.   JOURNAL OF EXPERIMENTAL BOTANY

Fbxl10/Kdm2b Recruits Polycomb Repressive Complex 1 to CpG Islands and Regulates H2A Ubiquitylation

(2013) Xudong Wu et al.   MOLECULAR CELL

Polycomb-Dependent H3K27me1 and H3K27me2 Regulate Active Transcription and Enhancer Fidelity

(2013) Karin J. Ferrari et al.   MOLECULAR CELL

Coordinate Regulation of DNA Methylation and H3K27me3 in Mouse Embryonic Stem Cells

(2013) James A. Hagarman et al.   PLoS One

A Histone Mutant Reproduces the Phenotype Caused by Loss of Histone-Modifying Factor Polycomb

(2013) A. R. Pengelly et al.   SCIENCE

Redistribution of H3K27me3 upon DNA hypomethylation results in de-repression of Polycomb target genes

(2013) James P Reddington et al.   GENOME BIOLOGY

Polycomb Repressive Complex 2-Dependent and -Independent Functions of Jarid2 in Transcriptional Regulation in Drosophila

(2012) H.-M. Herz et al.   MOLECULAR AND CELLULAR BIOLOGY

Understanding the language of Lys36 methylation at histone H3

(2012) Eric J. Wagner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A dynamic and intricate regulatory network determines Pseudomonas aeruginosa virulence

(2012) Deepak Balasubramanian et al.   NUCLEIC ACIDS RESEARCH

Total kinetic analysis reveals how combinatorial methylation patterns are established on lysines 27 and 36 of histone H3

(2012) Y. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands

(2012) Anca M Farcas et al.   eLife

Mutations in EZH2 Cause Weaver Syndrome

(2011) William T. Gibson et al.   AMERICAN JOURNAL OF HUMAN GENETICS

An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment

(2011) Magnus D Lynch et al.   EMBO JOURNAL

CpG islands and the regulation of transcription

(2011) A. M. Deaton et al.   GENES & DEVELOPMENT

EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair

(2011) E. Ezhkova et al.   GENES & DEVELOPMENT

The Structure of NSD1 Reveals an Autoregulatory Mechanism Underlying Histone H3K36 Methylation

(2011) Qi Qiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

H3K36 Methylation Antagonizes PRC2-mediated H3K27 Methylation

(2011) Wen Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone Methylation by PRC2 Is Inhibited by Active Chromatin Marks

(2011) Frank W. Schmitges et al.   MOLECULAR CELL

The Polycomb complex PRC2 and its mark in life

(2011) Raphaël Margueron et al.   NATURE

Aebp2 as an Epigenetic Regulator for Neural Crest Cells

(2011) Hana Kim et al.   PLoS One

Nucleosome-Interacting Proteins Regulated by DNA and Histone Methylation

(2010) Till Bartke et al.   CELL

The Dnmt3a PWWP Domain Reads Histone 3 Lysine 36 Trimethylation and Guides DNA Methylation

(2010) Arunkumar Dhayalan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling

(2010) M. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dnmt3a-Dependent Nonpromoter DNA Methylation Facilitates Transcription of Neurogenic Genes

(2010) H. Wu et al.   SCIENCE

Inactive yet indispensable: the tale of Jarid2

(2010) David Landeira et al.   TRENDS IN CELL BIOLOGY

EZH1 Mediates Methylation on Histone H3 Lysine 27 and Complements EZH2 in Maintaining Stem Cell Identity and Executing Pluripotency

(2008) Xiaohua Shen et al.   MOLECULAR CELL

Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains

(2008) Manching Ku et al.   PLoS Genetics