Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3

Homogeneous Assay for Target Engagement Utilizing Bioluminescent Thermal Shift

(2018) Melanie L. Dart et al.   ACS Medicinal Chemistry Letters

Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor

(2016) Laetitia J. Martin et al.   JOURNAL OF MEDICINAL CHEMISTRY

The molecular hallmarks of epigenetic control

(2016) C. David Allis et al.   NATURE REVIEWS GENETICS

NanoBRET—A Novel BRET Platform for the Analysis of Protein–Protein Interactions

(2015) Thomas Machleidt et al.   ACS Chemical Biology

Open access chemical probes for epigenetic targets

(2015) Peter J Brown et al.   Future Medicinal Chemistry

NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler

(2015) Chen Shen et al.   MOLECULAR CELL

Probing the epigenome

(2015) Andrea Huston et al.   Nature Chemical Biology

The NSD family of protein methyltransferases in human cancer

(2015) Theodore Vougiouklakis et al.   Epigenomics

Target engagement and drug residence time can be observed in living cells with BRET

(2015) Matthew B. Robers et al.   Nature Communications

A scintillation proximity assay for histone demethylases

(2014) Wenyu Yu et al.   ANALYTICAL BIOCHEMISTRY

Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ

(2014) Jürgen Cox et al.   MOLECULAR & CELLULAR PROTEOMICS

The cellular thermal shift assay for evaluating drug target interactions in cells

(2014) Rozbeh Jafari et al.   Nature Protocols

Structure and function of the nucleosome-binding PWWP domain

(2014) Su Qin et al.   TRENDS IN BIOCHEMICAL SCIENCES

Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching

(2014) Martin Philpott et al.   Epigenetics & Chromatin

Combination of Similarity Rankings Using Data Fusion

(2013) Peter Willett   Journal of Chemical Information and Modeling

Hit Expansion Approaches Using Multiple Similarity Methods and Virtualized Query Structures

(2013) Andreas Bergner et al.   Journal of Chemical Information and Modeling

The histone methyltransferase Wolf-Hirschhorn syndrome candidate 1-like 1 (WHSC1L1) is involved in human carcinogenesis

(2012) Daechun Kang et al.   GENES CHROMOSOMES & CANCER

Epigenetic protein families: a new frontier for drug discovery

(2012) Cheryl H. Arrowsmith et al.   NATURE REVIEWS DRUG DISCOVERY

Data processing and analysis with theautoPROCtoolbox

(2011) Clemens Vonrhein et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

Structural and Histone Binding Ability Characterizations of Human PWWP Domains

(2011) Hong Wu et al.   PLoS One

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Human LSD2/KDM1b/AOF1 Regulates Gene Transcription by Modulating Intragenic H3K4me2 Methylation

(2010) Rui Fang et al.   MOLECULAR CELL

The art of the chemical probe

(2010) Stephen V Frye   Nature Chemical Biology

Molecular basis of histone H3K36me3 recognition by the PWWP domain of Brpf1

(2010) Alessandro Vezzoli et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Paradoxes and paradigms: why is quinoline less basic than pyridine or isoquinoline? A classical organic chemical perspective

(2009) Ramachandra S. Hosmane et al.   STRUCTURAL CHEMISTRY

FieldScreen: Virtual Screening Using Molecular Fields. Application to the DUD Data Set

(2008) Timothy J. Cheeseright et al.   Journal of Chemical Information and Modeling

Fragment approaches in structure-based drug discovery

(2008) Roderick E. Hubbard   JOURNAL OF SYNCHROTRON RADIATION