Cardiac regeneration strategies: Staying young at heart

Dystrophin–glycoprotein complex sequesters Yap to inhibit cardiomyocyte proliferation

(2017) Yuka Morikawa et al.   NATURE

Hypoxia induces heart regeneration in adult mice

(2017) Yuji Nakada et al.   NATURE

The extracellular matrix protein agrin promotes heart regeneration in mice

(2017) Elad Bassat et al.   NATURE

Inflammation and metabolism in tissue repair and regeneration

(2017) Sabine A. Eming et al.   SCIENCE

In Vivo Cellular Reprogramming: The Next Generation

(2016) Deepak Srivastava et al.   CELL

Lineage Reprogramming of Fibroblasts into Proliferative Induced Cardiac Progenitor Cells by Defined Factors

(2016) Pratik A. Lalit et al.   Cell Stem Cell

Building and re-building the heart by cardiomyocyte proliferation

(2016) Matthew J. Foglia et al.   DEVELOPMENT

Developmental origin and lineage plasticity of endogenous cardiac stem cells

(2016) Maria Paola Santini et al.   DEVELOPMENT

Mechanisms of Cardiac Regeneration

(2016) Aysu Uygur et al.   DEVELOPMENTAL CELL

Allogeneic transplantation of iPS cell-derived cardiomyocytes regenerates primate hearts

(2016) Yuji Shiba et al.   NATURE

Conversion of human fibroblasts into functional cardiomyocytes by small molecules

(2016) Nan Cao et al.   SCIENCE

Distilling complexity to advance cardiac tissue engineering

(2016) Brenda M. Ogle et al.   Science Translational Medicine

Cardiomyocyte Cell-Cycle Activity during Preadolescence

(2015) Mark H. Soonpaa et al.   CELL

No Evidence for Cardiomyocyte Number Expansion in Preadolescent Mice

(2015) Kanar Alkass et al.   CELL

Dynamics of Cell Generation and Turnover in the Human Heart

(2015) Olaf Bergmann et al.   CELL

“String Theory” of c-kitposCardiac Cells

(2015) Matthew C.L. Keith et al.   CIRCULATION RESEARCH

Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart

(2015) Wataru Kimura et al.   NATURE

Epicardial regeneration is guided by cardiac outflow tract and Hedgehog signalling

(2015) Jinhu Wang et al.   NATURE

ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation

(2015) Gabriele D’Uva et al.   NATURE CELL BIOLOGY

Actin cytoskeletal remodeling with protrusion formation is essential for heart regeneration in Hippo-deficient mice

(2015) Yuka Morikawa et al.   Science Signaling

Neuregulin stimulation of cardiomyocyte regeneration in mice and human myocardium reveals a therapeutic window

(2015) Brian D. Polizzotti et al.   Science Translational Medicine

Developmental alterations in centrosome integrity contribute to the post-mitotic state of mammalian cardiomyocytes

(2015) David C Zebrowski et al.   eLife

Nrg1 is an injury-induced cardiomyocyte mitogen for the endogenous heart regeneration program in zebrafish

(2015) Matthew Gemberling et al.   eLife

Reduced matrix rigidity promotes neonatal cardiomyocyte dedifferentiation, proliferation and clonal expansion

(2015) Yfat Yahalom-Ronen et al.   eLife

Actin cytoskeletal remodeling with protrusion formation is essential for heart regeneration in Hippo-deficient mice

(2015) Yuka Morikawa et al.   Science Signaling

A Proliferative Burst during Preadolescence Establishes the Final Cardiomyocyte Number

(2014) Nawazish Naqvi et al.   CELL

Macrophages are required for neonatal heart regeneration

(2014) Arin B. Aurora et al.   JOURNAL OF CLINICAL INVESTIGATION

Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts

(2014) James J. H. Chong et al.   NATURE

c-kit+ cells minimally contribute cardiomyocytes to the heart

(2014) Jop H. van Berlo et al.   NATURE

Recombinant Neuregulin 1 Does Not Activate Cardiomyocyte DNA Synthesis in Normal or Infarcted Adult Mice

(2014) Sean Reuter et al.   PLoS One

Strategies for Cardiac Regeneration and Repair

(2014) Z. Lin et al.   Science Translational Medicine

Mammalian heart renewal by pre-existing cardiomyocytes

(2012) Samuel E. Senyo et al.   NATURE

Heart regeneration

(2011) Michael A. Laflamme et al.   NATURE

Hippo Pathway Inhibits Wnt Signaling to Restrain Cardiomyocyte Proliferation and Heart Size

(2011) T. Heallen et al.   SCIENCE

Transient Regenerative Potential of the Neonatal Mouse Heart

(2011) E. R. Porrello et al.   SCIENCE

Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors

(2010) Masaki Ieda et al.   CELL

A Phase II, Randomized, Double-Blind, Multicenter, Based on Standard Therapy, Placebo-Controlled Study of the Efficacy and Safety of Recombinant Human Neuregulin-1 in Patients With Chronic Heart Failure

(2010) Runlin Gao et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Primary contribution to zebrafish heart regeneration by gata4 + cardiomyocytes

(2010) Kazu Kikuchi et al.   NATURE

Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation

(2010) Chris Jopling et al.   NATURE

Neuregulin1/ErbB4 Signaling Induces Cardiomyocyte Proliferation and Repair of Heart Injury

(2009) Kevin Bersell et al.   CELL

Evidence for Cardiomyocyte Renewal in Humans

(2009) Olaf Bergmann et al.   SCIENCE

Lives of a Heart Cell: Tracing the Origins of Cardiac Progenitors

(2008) Silvia Martin-Puig et al.   Cell Stem Cell

Compensatory Growth of Healthy Cardiac Cells in the Presence of Diseased Cells Restores Tissue Homeostasis during Heart Development

(2008) Jörg-Detlef Drenckhahn et al.   DEVELOPMENTAL CELL