Understanding the cause of sporadic Alzheimer’s disease

Reexamining Alzheimer's Disease: Evidence for a Protective Role for Amyloid-β Protein Precursor and Amyloid-β

(2017) Rudy J. Castellani et al.   JOURNAL OF ALZHEIMERS DISEASE

Cerebrovascular Hypoperfusion Induces Spatial Memory Impairment, Synaptic Changes, and Amyloid-β Oligomerization in Rats

(2017) Xiaojuan Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease

(2014) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Reply: the early pathological process in sporadic Alzheimer’s disease

(2013) Heiko Braak et al.   ACTA NEUROPATHOLOGICA

Amyloid and tau: neither chicken nor egg but two partners in crime!

(2013) Johannes Attems et al.   ACTA NEUROPATHOLOGICA

CSF biomarker variability in the Alzheimer's Association quality control program

(2013) Niklas Mattsson et al.   Alzheimers & Dementia

Diverging patterns of amyloid deposition and hypometabolism in clinical variants of probable Alzheimer’s disease

(2013) Manja Lehmann et al.   BRAIN

Deciphering logopenic primary progressive aphasia: a clinical, imaging and biomarker investigation

(2013) M. Teichmann et al.   BRAIN

SnapShot: Genetics of Alzheimer’s Disease

(2013) Rita Guerreiro et al.   CELL

Redundancy and divergence in the amyloid precursor protein family

(2013) S. Ali M. Shariati et al.   FEBS LETTERS

Brain Changes in Older Adults at Very Low Risk for Alzheimer's Disease

(2013) A. M. Fjell et al.   JOURNAL OF NEUROSCIENCE

A two-decade comparison of prevalence of dementia in individuals aged 65 years and older from three geographical areas of England: results of the Cognitive Function and Ageing Study I and II

(2013) Fiona E Matthews et al.   LANCET

Preclinical Alzheimer's disease and its outcome: a longitudinal cohort study

(2013) Stephanie JB Vos et al.   LANCET NEUROLOGY

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

A 2-process model for neuropathology of Alzheimer's disease

(2013) Dan Mungas et al.   NEUROBIOLOGY OF AGING

Effects of cerebrospinal fluid proteins on brain atrophy rates in cognitively healthy older adults

(2013) Niklas Mattsson et al.   NEUROBIOLOGY OF AGING

Primary progressive aphasia and the language network: The 2013 H. Houston Merritt Lecture

(2013) M.- M. Mesulam   NEUROLOGY

Amyloid-first and neurodegeneration-first profiles characterize incident amyloid PET positivity

(2013) C. R. Jack et al.   NEUROLOGY

Twenty-year changes in dementia occurrence suggest decreasing incidence in central Stockholm, Sweden

(2013) C. Qiu et al.   NEUROLOGY

Alzheimer disease in the United States (2010-2050) estimated using the 2010 census

(2013) L. E. Hebert et al.   NEUROLOGY

The Pathobiology of Vascular Dementia

(2013) Costantino Iadecola   NEURON

A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease

(2013) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Intrinsic connectivity networks in healthy subjects explain clinical variability in Alzheimer's disease

(2013) M. Lehmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dominantly Inherited Alzheimer Network: facilitating research and clinical trials

(2013) Krista L Moulder et al.   Alzheimers Research & Therapy

Political drive to screen for pre-dementia: not evidence based and ignores the harms of diagnosis

(2013) D. G. L. Couteur et al.   BMJ-British Medical Journal

Amyloid Imaging With Carbon 11–Labeled Pittsburgh Compound B for Traumatic Brain Injury

(2013) Young T. Hong et al.   JAMA Neurology

Brain Differences in Infants at Differential Genetic Risk for Late-Onset Alzheimer Disease

(2013) Douglas C. Dean et al.   JAMA Neurology

CSF protein biomarkers predicting longitudinal reduction of CSF β-amyloid42 in cognitively healthy elders

(2013) N Mattsson et al.   Translational Psychiatry

Does amyloid deposition produce a specific atrophic signature in cognitively normal subjects?

(2013) Jennifer L. Whitwell et al.   NeuroImage-Clinical

Clinical and multimodal biomarker correlates of ADNI neuropathological findings

(2013) Jon B Toledo et al.   Acta Neuropathologica Communications

Cerebrospinal Fluid Levels ofβ-Amyloid 1-42, but Not of Tau, Are Fully Changed Already 5 to 10 Years Before the Onset of Alzheimer Dementia

(2012) Peder Buchhave   ARCHIVES OF GENERAL PSYCHIATRY

Clinically concordant variations of Alzheimer pathology in aphasic versus amnestic dementia

(2012) T. Gefen et al.   BRAIN

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

(2012) Lucía Chávez-Gutiérrez et al.   EMBO JOURNAL

Dementia From Alzheimer Disease and Mixed Pathologies in the Oldest Old

(2012) Bryan D. James   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Cerebrospinal fluid levels of complement proteins C3, C4 and CR1 in Alzheimer’s disease

(2012) Jonny Daborg et al.   JOURNAL OF NEURAL TRANSMISSION

Apolipoprotein E, Not Fibrillar  -Amyloid, Reduces Cerebral Glucose Metabolism in Normal Aging

(2012) W. J. Jagust et al.   JOURNAL OF NEUROSCIENCE

Characteristic clinical presentation and CSF biomarker pattern in cerebral small vessel disease

(2012) Anders Wallin et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Posterior cortical atrophy

(2012) Sebastian J Crutch et al.   LANCET NEUROLOGY

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

Accelerated cortical atrophy in cognitively normal elderly with high  -amyloid deposition

(2012) G. Chetelat et al.   NEUROLOGY

Early-onset Alzheimer disease clinical variants: Multivariate analyses of cortical thickness

(2012) G. R. Ridgway et al.   NEUROLOGY

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rare Variants in APP, PSEN1 and PSEN2 Increase Risk for AD in Late-Onset Alzheimer's Disease Families

(2012) Carlos Cruchaga et al.   PLoS One

TDP-43 pathological changes in early onset familial and sporadic Alzheimer’s disease, late onset Alzheimer’s disease and Down’s Syndrome: association with age, hippocampal sclerosis and clinical phenotype

(2011) Yvonne S. Davidson et al.   ACTA NEUROPATHOLOGICA

Clinicopathological correlations in corticobasal degeneration

(2011) Suzee E. Lee et al.   ANNALS OF NEUROLOGY

Prevalence and Pathology of Dementia with Lewy Bodies in the Oldest Old: A Comparison with Other Dementing Disorders

(2011) Kurt A. Jellinger et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Compounding artefacts with uncertainty, and an amyloid cascade hypothesis that is ‘too big to fail’

(2011) Rudy J Castellani et al.   JOURNAL OF PATHOLOGY

Neuroimaging Results Impose New Views on Alzheimer’s Disease—the Role of Amyloid Revised

(2011) Anders M. Fjell et al.   MOLECULAR NEUROBIOLOGY

Vascular risk factors promote conversion from mild cognitive impairment to Alzheimer disease

(2011) J. Li et al.   NEUROLOGY

Distinct clinical and metabolic deficits in PCA and AD are not related to amyloid distribution

(2011) M. H. Rosenbloom et al.   NEUROLOGY

Cerebrospinal Fluid Microglial Markers in Alzheimer’s Disease: Elevated Chitotriosidase Activity but Lack of Diagnostic Utility

(2011) Niklas Mattsson et al.   NEUROMOLECULAR MEDICINE

Hypoxia Due to Cardiac Arrest Induces a Time-Dependent Increase in Serum Amyloid β Levels in Humans

(2011) Henrik Zetterberg et al.   PLoS One

Human apoE Isoforms Differentially Regulate Brain Amyloid-  Peptide Clearance

(2011) J. M. Castellano et al.   Science Translational Medicine

The pathological process underlying Alzheimer’s disease in individuals under thirty

(2010) Heiko Braak et al.   ACTA NEUROPATHOLOGICA

Oligemic Hypoperfusion Differentially Affects Tau and Amyloid-β

(2010) Maya A. Koike et al.   AMERICAN JOURNAL OF PATHOLOGY

Increased brain atrophy rates in cognitively normal older adults with low cerebrospinal fluid Aβ1-42

(2010) Jonathan M. Schott et al.   ANNALS OF NEUROLOGY

Larger temporal volume in elderly with high versus low beta-amyloid deposition

(2010) Gaël Chételat et al.   BRAIN

Brain Atrophy in Healthy Aging Is Related to CSF Levels of Aβ1-42

(2010) Anders M. Fjell et al.   CEREBRAL CORTEX

CSF Biomarkers in Prediction of Cerebral and Clinical Change in Mild Cognitive Impairment and Alzheimer's Disease

(2010) A. M. Fjell et al.   JOURNAL OF NEUROSCIENCE

Primary progressive aphasia: clinicopathological correlations

(2010) Murray Grossman   Nature Reviews Neurology

Homocysteine and holotranscobalamin and the risk of Alzheimer disease: A longitudinal study

(2010) B. Hooshmand et al.   NEUROLOGY

Selective Disruption of the Cerebral Neocortex in Alzheimer's Disease

(2010) Rahul S. Desikan et al.   PLoS One

Genetic Evidence Implicates the Immune System and Cholesterol Metabolism in the Aetiology of Alzheimer's Disease

(2010) Lesley Jones et al.   PLoS One

The neuropathology of probable Alzheimer disease and mild cognitive impairment

(2009) Julie A. Schneider et al.   ANNALS OF NEUROLOGY

APOEpredicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging

(2009) John C. Morris et al.   ANNALS OF NEUROLOGY

Midlife Serum Cholesterol and Increased Risk of Alzheimer’s and Vascular Dementia Three Decades Later

(2009) Alina Solomon et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Blood Pressure Components and Changes in Relation to White Matter Lesions

(2009) Xinxin Guo et al.   HYPERTENSION

One-Year Brain Atrophy Evident in Healthy Aging

(2009) A. M. Fjell et al.   JOURNAL OF NEUROSCIENCE

Human APOE Isoform-Dependent Effects on Brain  -Amyloid Levels in PDAPP Transgenic Mice

(2009) K. R. Bales et al.   JOURNAL OF NEUROSCIENCE

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

(2009) Clifford R Jack et al.   LANCET NEUROLOGY

Baseline CSF p-tau levels independently predict progression of hippocampal atrophy in Alzheimer disease

(2009) W.J.P. Henneman et al.   NEUROLOGY

Clinical syndromes associated with posterior atrophy: Early age at onset AD spectrum

(2009) R. Migliaccio et al.   NEUROLOGY

Fibrillar amyloid-  burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease

(2009) E. M. Reiman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Revision of the apolipoprotein E compensatory mechanism recruitment hypothesis

(2008) S. Duke Han et al.   Alzheimers & Dementia

Increased Frequency of Learning Disability in Patients With Primary Progressive Aphasia and Their First-Degree Relatives

(2008) Emily Rogalski et al.   ARCHIVES OF NEUROLOGY

Episodic memory loss is related to hippocampal-mediated  -amyloid deposition in elderly subjects

(2008) E. C. Mormino et al.   BRAIN

11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment

(2008) Clifford R. Jack et al.   BRAIN

apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain

(2008) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

The up-regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1α

(2008) Michela Guglielmotto et al.   JOURNAL OF NEUROCHEMISTRY

Meta-Analysis of APOE4 Allele and Outcome after Traumatic Brain Injury

(2008) Weidong Zhou et al.   JOURNAL OF NEUROTRAUMA

Anatomically-distinct genetic associations of APOE ɛ4 allele load with regional cortical atrophy in Alzheimer's disease

(2008) Nicola Filippini et al.   NEUROIMAGE